scholarly journals Interactions of Metal ions withTrimethoprim and Metformin

2020 ◽  
Vol 13 (2) ◽  
pp. 38-46
Author(s):  
Olawale Folorunso AKINYELE ◽  
Sunday Babatunde ADEJAYAN ◽  
Lateefah Moyosore DUROSINMI ◽  
Ayowole Olaolu AYENI ◽  
Temitope Adekunle AJAYEOBA
Keyword(s):  
Antimicrobial Activity ◽  
Metal Ions ◽  
Bidentate Ligand ◽  
Mixed Ligand ◽  
Conductivity Measurements ◽  
Metal Analysis ◽  
Monodentate Ligand ◽  
Antibacterial Studies ◽  
Vis Spectroscopy ◽  
Solubility Studies

In this work, metal complexes of trimethoprim mixed metformin were synthesized and characterized by solubility studies, percentage metal analysis, UV-Vis spectroscopy, IR spectroscopy and magnetic susceptibility and conductivity measurements. The IR spectra showedthat the trimethoprim coordinated as a monodentate ligand coordinating to the metal ions via the pyrimidine N(1), metformin acts as a bidentate ligand coordinating through the iminonitrogens. The infrared spectra bands at 450 cm-1 and 530 cm-1 is ascribed to M –N and M –O bond respectively indicating the formation of these complexes. The magnetic moment data showed that all the complexes were paramagnetic with values ranging from 1.39 to 6.0 B.M, except [Zn(TMP)(MET)(H2O)Cl2] which was diamagnetic. The conductivity results revealed that all the synthesised complexes were non-electrolytes, while the antibacterial studies of the mixed ligand complexes displayed moderate antimicrobial activity in comparison with the free ligands.

scholarly journals Syntheses, Characterization and Biological Activity of Coordination Compounds of Propanedioic Acid and its Mixed Ligand Complexes with N,N'-Dihydroxy-2,3-butanediimine

2021 ◽  
Vol 33 (8) ◽  
pp. 1911-1918
Author(s):  
T.O. Aiyelabola ◽  
E.O. Akinkunmi ◽  
O Osungunna
Keyword(s):  
Antimicrobial Activity ◽  
Metal Ions ◽  
Coordination Compounds ◽  
Mixed Ligand Complex ◽  
Octahedral Geometry ◽  
Mixed Ligand ◽  
Mixed Ligand Complexes ◽  
Planar Geometry ◽  
Acid Complex ◽  
Square Planar

The coordination compounds of propanedioic acid with cobalt(II), nickel(II) and copper(II) ions were synthesized using metal:ligand 1:2. In addition to this, mixed ligand complexes using the same metal ions with propanedioic acid as the primary ligand and N,N'-dihydroxy-2,3-butanediimine as the secondary ligand were also synthesized using M:L1:L2 (1:1:1) where L1 = propanedioic acid, L2 = N,N'-dihydroxy-2,3-butanediimine and M = Cu(II), Ni(II) and Cu(II). The synthesized compounds were characterized using FTIR, UV-vis, magnetic susceptibility measurement and percentage metal composition. The ligand and its metal complexes were tested for their cytotoxic and antibacterial activities. Results indicated that a dimeric square planar geometry was assumed by the cobalt(II) and nickel(II) propanedioic acid complexes. Octahedral geometry was proposed for both cobalt(II) and copper(II) mixed ligand complexes. A dinuclear square pyramidal geometry was suggested for the copper(II) propanedioic acid complex and square planar/octahedral geometry for the nickel(II) mixed ligand complex. The copper(II) propanedioic acid complex elicited the best cytotoxic activity. On the other hand, the nickel(II) propanedioic acid complex showed the remarkable antimicrobial activity. The compounds exhibited good antimicrobial activity in most of the cases with the exception of the cobalt(II) propanedioic acid complex. It was concluded that coordination of the ligands to the metal ions lowered the toxicity of the ligands. It was further concluded that the antimicrobial activity of the compounds was partly dependent on the synergism/additive effect of the intrinsic therapeutic properties of the metal ion and the ligands within the coordination sphere of the complexes synthesized. And this is also in part a function of the geometry assumed by the complexes.

scholarly journals Synthesis, characterisation and antimicrobial activities of mixed ligand complexes of Mn (II), Fe (II) and Co(II) containing N,N'-bis (o-anisaldehyde) p-phenylenediamine (tetradentate schiff base) and gylcine

2018 ◽  
Vol 11 (1) ◽  
pp. 32-36
Author(s):  
I.T. Siraj ◽  
M Sule
Keyword(s):  
Antimicrobial Activity ◽  
Schiff Base ◽  
Mixed Ligand Complex ◽  
Antimicrobial Activities ◽  
Molar Conductance ◽  
Bidentate Ligand ◽  
Mixed Ligand ◽  
Mixed Ligand Complexes ◽  
Ligand Complex ◽  
Tetradentate Schiff Base

Complexes of Mn(II), Fe(II) and Co(II) containing N, N’-bis[o-anisaldehyde]p-phenylenediamine tetradentate Schiff base as primary ligand and glycine as secondary bidentate ligand have been synthesized by reflux in 1:1:1 mole ratio and characterized both analytically and spectroscopically. Molar conductance measurement (69.02 to 86.30Ω–1 cm2 mol–1) of the complexes indicated they are weak electrolyte and magnetic susceptibility measurement shows values in range of 4.53 to 5.59BM indicating their paramagnetism. The infrared data suggested that the Schiff base coordinated via the two nitrogen atoms of the azomethine groups (1628 to 1680 cm-1) and the oxygen atoms of the adjacent methoxy groups (1341 to 1389 cm-1), while glycine coordinated via the nitrogen atom of the amino group (3060-3324 cm-1) and the oxygen atom of the carboxylate anion. Based on the analytical and spectroscopic data the complexes may be assigned an octahedral geometries and molecular formulae of the form [M(L)Gly], where M = Mn, Fe and Co, L=Schiff base and Gly = glycine. The Schiff base and its mixed ligand complexes were screened for antimicrobial activity against Staphylococcus aureus, Escherichia coli, Salmonella typhi, Mucor inducus and Aspergillus fumigatus. The complexes exhibited enhanced antimicrobial activity (10mm to 18mm) at 60 µg/disc as compared to 10mm activity of the uncoordinated Schiff base at the same concentration.Keywords: Mixed ligand complex; Schiff base, Glycine, p-phenylenediamine, o-anisaldehyde

scholarly journals Synthesis, Characterization and Antimicrobial Activity of Mixed-Ligand Complexes of Cu(II) with 1,2,4, Triazole and Amino Acids

2014 ◽  
Vol 6 (3) ◽  
pp. 487-496
Author(s):  
B. Anupama ◽  
C. G. Kumari
Keyword(s):  
Amino Acids ◽  
Antimicrobial Activity ◽  
Molecular Modeling ◽  
Elemental Analysis ◽  
Metal Ion ◽  
Ternary Complexes ◽  
Mixed Ligand ◽  
Conductivity Measurements ◽  
Tetrahedral Geometry ◽  
Molecular Modeling Studies

Mixed-ligand ternary complexes of Cu (II) metal ion with 1,2,4 triazole (TRZ) and amino acids (histidine (L1), threonine (L2), proline (L3) and hydroxyl proline (L4)) have been synthesized. The prepared ternary chelates were characterized by elemental analysis, IR and electronic spectra, as well as conductivity measurements. The general formula [Cu(TRZ)L]H2O were found for the ternary chelates containing TRZ. From the analytical and spectral data, the stoichiometry has been found to be 1:1:1 for all the complexes. A tetrahedral geometry has been proposed. Molecular modeling studies were also carried out to confirm the geometries of the complexes. All the new complexes were found to be active against bacteria. © 2014 JSR Publications. ISSN: 2070-0237 (Print); 2070-0245 (Online). All rights reserved. doi: http://dx.doi.org/10.3329/jsr.v6i3.16993 J. Sci. Res. 6 (3), 487-496 (2014)

scholarly journals Synthesis, characterization and antimicrobial activities of heteroleptic metal chelates of isoniazid and 2,2’-bipyridine

2021 ◽  
Vol 34 (3) ◽  
pp. 471-478
Author(s):  
O. F. Akinyele ◽  
E. G. Fakola ◽  
L. M. Durosinmi ◽  
T. A. Ajayeoba ◽  
A. O. Ayeni
Keyword(s):  
Antimicrobial Activity ◽  
Magnetic Moment ◽  
Antibacterial Activities ◽  
Antimicrobial Activities ◽  
Carbonyl Oxygen ◽  
Bidentate Ligand ◽  
Magnetic Data ◽  
Diffusion Method ◽  
Vis Spectroscopy ◽  
Structure Geometry

The Mn(II), Co(II), Ni(II), Cu(II) and Zn(II) complexes of isoniazid (L1) mixed with 2,2-bipyridine (L2) were synthesized and characterized by solubility studies, percentage metal analysis, UV-Vis spectroscopy, IR spectroscopy, conductivity measurements and magnetic moment measurements. The IR spectra revealed that the isoniazid coordinated as a bidentate ligand. In Co(II) and Ni(II) complex it coordinated  via the carbonyl oxygen (C=O) and the amide nitrogen, while in the Cu(II), Mn(II) and Zn(II) complexes it coordinated using the amide and carbonyl oxygen via enolization. Bipyridine also bonded to the metals as a bidentate ligand through the pyridinic nitrogen atoms. The magnetic data showed that all the complexes were paramagnetic with values ranging from 1.70 to 5.0 B.M., except [Zn(Is)(Bipy)(H2O)Cl2] which was diamagnetic. The conductivity results revealed that the Cu(II), Mn(II), Zn(II) complexes were 1:1 electrolytes while Co(II) was 1:2 electrolyte and [Ni(Is)(Bipy)Cl2] was non-electrolytic in nature. The antibacterial activities of the ligands and the complexes as evaluated via the agar diffusion method showed that the complexes displayed moderately high antimicrobial activity in comparison with the free ligands when tested against ten strains of bacteria.                     KEY WORDS: Isoniazid, Electronic structure, Geometry, Antimicrobial activity, Electrolytic nature, Magnetic moment   Bull. Chem. Soc. Ethiop. 2020, 34(3), 471-478. DOI: https://dx.doi.org/10.4314/bcse.v34i3.4

scholarly journals Synthesis and characterization of some biological active transition metal complexes of Schiff base derived from cefixime with mixed ligand 8-hydroxy quinoline

2015 ◽  
Vol 12 (4) ◽  
pp. 797-807
Author(s):  
Baghdad Science Journal
Keyword(s):  
Melting Point ◽  
Metal Ion ◽  
Bidentate Ligand ◽  
Mixed Ligand ◽  
Molar Ratio ◽  
Synthesis And Characterization ◽  
Vis Spectroscopy ◽  
Ft Ir ◽  
Hydroxy Quinoline

The aim of the work is synthesis and characterization of bidentate ligand [dipotassium sodium7-((E)-2-(2-((Z)-1-carboxylatoethylideneamino)thiazol-4-yl)-2 (carboxylatemethoxyimino) acet amido)-8-oxo-3-vinyl-5- thia-1-azabicyclo[4.2.0] oct-2- ene-2- carboxylate] [Nak2L], from the reaction of cefixime with sodium pyruvet to produce the ligand [Nak2L], the reaction was carried out in methanol as a solvent under reflux. The prepared ligand [Nak2L] which was characterized by FT-IR, UV-Vis spectroscopy, 1H, 13C-NMR spectra, Mass spectra, (C.H.N) and melting point. The mixed ligand complexes were prepared from ligand [Nak2L] was used as a primary ligand while 8-hydroxy quinoline [Q] was used as a secondary ligand with metal ion M(?).Where M(?) = (Mn ,Co ,Ni ,Cu ,Zn and Cd) at reflux ,using methanol as a solvent, KOH as a base. Complexes of the composition [(M)2(Q)2(KL)(H2O)4] with (2:2:1) molar ratio were prepared. All the complexes were characterized by spectroscopic methods (FT-IR, UV-Vis spectroscopy) along with elemental analysis (A.A), chloride content and melting point measurements were carried out, together with conductivity and magnetic susceptibility. These measurements showed octahedral geometry around (Mn??, Co??, Ni??, Cu??, Zn?? and Cd??) ions. The biological activity of the ligands [NaK2L], [Q] and complexes [(M)2(Q)2(KL)(H2O)4] were studied by using inhibition method.

scholarly journals Spectroscopic Characterization and Biological Activity of Mixed Ligand Complexes of Ni(II) with 1,10-Phenanthroline and Heterocyclic Schiff Bases

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Y. Prashanthi ◽  
K. Kiranmai ◽  
Ira ◽  
Sathish kumar K ◽  
Vijay kumar Chityala ◽  
...  
Keyword(s):  
Schiff Bases ◽  
Metal Ion ◽  
Magnetic Moments ◽  
Spectroscopic Characterization ◽  
Bidentate Ligand ◽  
Mixed Ligand ◽  
Mixed Ligand Complexes ◽  
Binding Studies ◽  
No Donor ◽  
Vis Spectroscopy

Mixed ligand complexes of Ni(II) with 1,10-phenanthroline (1,10-Phen) and Schiff bases L1(MIIMP); L2(CMIIMP); L3(EMIIMP); L4(MIIMNP); L5(MEMIIMP); L6(BMIIMP); L7(MMIIMP); L8(MIIBD) have been synthesized. These metal chelates have been characterized by elemental analysis, IR,1H-NMR,13C-NMR, Mass, UV-Vis, magnetic moments, and thermogravimetric (TG&DTA) analysis. Spectral data showed that the 1,10-phenanthroline act as neutral bidentate ligand coordinating to the metal ion through two nitrogen donor atoms and Schiff bases acts as monobasic bidentate coordinating through NO donor atoms. All Ni(II) complexes appear to have an octahedral geometry. The antimicrobial activity of mixed ligand complexes has been studied by screening against various microorganisms, it is observed that the activity enhances upon coordination. The DNA binding studies have been investigated by UV-Vis spectroscopy, and the experimental results indicate that these complexes bind to CT DNA with the intrinsic binding constantKb=2.5±0.2×105 M−1. MTT is used to test the anticancer effect of the complexes with HL60 tumor cell. The inhibition ratio was accelerated by increasing the dosage, and it had significant positive correlation with the medication dosage.

scholarly journals Synthesis and Characterization of some Mixed Ligand Complexes Containing (8-hydroxyquinoline) and (2 - picoline) with some Metal Ions

2013 ◽  
Vol 10 (2) ◽  
pp. 396-404
Author(s):  
Baghdad Science Journal
Keyword(s):  
Magnetic Susceptibility ◽  
Metal Ions ◽  
Molar Conductivity ◽  
Mixed Ligand ◽  
Synthesis And Characterization ◽  
Conductivity Measurements ◽  
Visible Spectroscopy ◽  
Ft Ir ◽  
Uv Visible

Complexes of some metal ions ( Mn(I? ) , Co(??) , Ni(??) ,Cu (??) , Zn(I?) , Cd (??) , and Hg(??) ) with 8-hydroxyquinoline (Oxine) and 2- Picoline (2-pic ) have been synthesized and characterized on the basis of their FT-IR. and Uv-visible spectroscopy ,atomic absorption molar conductivity measurements and magnetic susceptibility ,from the results obtained the following general formula has been given for prepared complexes [M (oxine)2 (2-pic)2]where M = M(??) = Mn , Co , Ni , Cu , Zn , Cd , Hg(oxine)- = ionic ligand 8-hydroxyquinolin (oxinato)(2- pic) = 2- picoline

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