scholarly journals Structural elucidation, thermal studies and antimicrobial screening of mixed ligans complexes of 4-benzylimino-2,3-dimethyl-1-phenylpyrazal-5-one and L-Lysine

2021 ◽  
Vol 12 (2) ◽  
pp. 96-103
Author(s):  
E.T. Omotade ◽  
A.P. Oviawe
Keyword(s):  
Thermal Stability ◽  
Antimicrobial Activity ◽  
Thermal Studies ◽  
Octahedral Geometry ◽  
Mixed Ligand ◽  
Mixed Ligand Complexes ◽  
Spectral Studies ◽  
Conductivity Measurements ◽  
Ft Ir ◽  
Bacteria And Fungi

The mixed ligand complexes involving Fe(II), Co(II) and Ni(II) ions, Schiff base 4 phenylpyrazal-5-one (L1) and L-lysine (Lys) were synthesized. The complexes were characterized on the basis of their elemental analysis, conductivity measurements, FT-IR, MS,1H-NMR and 13C-NMR spectral studies. All the synthesized complexes were subjected to simultaneous thermogravimetric analysis to study their decomposition mechanism and thermal stability. The mixed ligand complexes were screened against some strains of bacteria and fungi to study their antimicrobial activity. The complexes were found to be non-electrolytes and possessed octahedral geometry. The results showed that the metal complexes possessed better antimicrobial activity than the free ligands.

scholarly journals Syntheses, Characterization and Biological Activity of Coordination Compounds of Propanedioic Acid and its Mixed Ligand Complexes with N,N'-Dihydroxy-2,3-butanediimine

2021 ◽  
Vol 33 (8) ◽  
pp. 1911-1918
Author(s):  
T.O. Aiyelabola ◽  
E.O. Akinkunmi ◽  
O Osungunna
Keyword(s):  
Antimicrobial Activity ◽  
Metal Ions ◽  
Coordination Compounds ◽  
Mixed Ligand Complex ◽  
Octahedral Geometry ◽  
Mixed Ligand ◽  
Mixed Ligand Complexes ◽  
Planar Geometry ◽  
Acid Complex ◽  
Square Planar

The coordination compounds of propanedioic acid with cobalt(II), nickel(II) and copper(II) ions were synthesized using metal:ligand 1:2. In addition to this, mixed ligand complexes using the same metal ions with propanedioic acid as the primary ligand and N,N'-dihydroxy-2,3-butanediimine as the secondary ligand were also synthesized using M:L1:L2 (1:1:1) where L1 = propanedioic acid, L2 = N,N'-dihydroxy-2,3-butanediimine and M = Cu(II), Ni(II) and Cu(II). The synthesized compounds were characterized using FTIR, UV-vis, magnetic susceptibility measurement and percentage metal composition. The ligand and its metal complexes were tested for their cytotoxic and antibacterial activities. Results indicated that a dimeric square planar geometry was assumed by the cobalt(II) and nickel(II) propanedioic acid complexes. Octahedral geometry was proposed for both cobalt(II) and copper(II) mixed ligand complexes. A dinuclear square pyramidal geometry was suggested for the copper(II) propanedioic acid complex and square planar/octahedral geometry for the nickel(II) mixed ligand complex. The copper(II) propanedioic acid complex elicited the best cytotoxic activity. On the other hand, the nickel(II) propanedioic acid complex showed the remarkable antimicrobial activity. The compounds exhibited good antimicrobial activity in most of the cases with the exception of the cobalt(II) propanedioic acid complex. It was concluded that coordination of the ligands to the metal ions lowered the toxicity of the ligands. It was further concluded that the antimicrobial activity of the compounds was partly dependent on the synergism/additive effect of the intrinsic therapeutic properties of the metal ion and the ligands within the coordination sphere of the complexes synthesized. And this is also in part a function of the geometry assumed by the complexes.

scholarly journals Synthesis, spectral studies and antibacterial activity of Cu(II), Co(II) and Ni(II) complexes of 1-(2-hydroxyphenyl)-3-phenyl-2-propen-1-one, N2-[(3,5-dimethyl-1H-pyrazol- -1-yl)methyl]hydrazone

2009 ◽  
Vol 74 (8-9) ◽  
pp. 927-938 ◽  
Author(s):  
Paulmony Tharmaraj ◽  
Deivasigamani Kodimunthiri ◽  
Clarence Sheela ◽  
Shanmuga Priya
Keyword(s):  
Antimicrobial Activity ◽  
Metal Complexes ◽  
Free Ligand ◽  
Esr Spectra ◽  
Octahedral Geometry ◽  
Diffusion Method ◽  
Spectral Studies ◽  
Conductivity Measurements ◽  
Hydrazone Ligand ◽  
Square Planar

A new series of Cu(II), Co(II) and Ni(II) complexes with the 1-(2- -hydroxyphenyl)-3-phenyl-2-propen-1-one, N2-[(3,5-dimethyl-1H-pyrazol-1- -yl)methyl]hydrazone ligand, C21H22N4O (LH), were synthesized by the reaction of 1-(2-hydroxyphenyl)-3-phenyl-2-propen-1-one, hydrazone with (3,5-dimethyl- 1H-pyrazol-1-yl)methanol and characterized. The nature of the bonding and geometry of the complexes were deduced from elemental analysis, IR, electronic and 1H-NMR spectroscopy, and magnetic susceptibility and conductivity measurements. The studies indicated square-planar, tetrahedral and octahedral geometry for the copper(II), cobalt(II) and nickel(II) complexes, respectively. The ESR spectra of the copper(II) complex in acetonitrile at 300 and 77 K were recorded and their salient features are reported. The electrochemical behavior of the copper (II) complex was studied by cyclic voltammetry. The antimicrobial activity of the ligand and its metal complexes were studied against the following strains of microorganism: Staphylococcus aureus, Salmonella enterica typhi, Escherichia coli and Bacillus subtilis by the well diffusion method. Metal complexes showed enhanced antimicrobial activity compared with that of the free ligand.

scholarly journals Transition metal M(II) complexes with isonicotinoylhydrazone-9-anthraldehyde

2010 ◽  
Vol 75 (11) ◽  
pp. 1515-1531 ◽  
Author(s):  
M.L. Dianu ◽  
A. Kriza ◽  
N. Stanica ◽  
A.M. Musuc
Keyword(s):  
Thermal Analyses ◽  
Thermal Studies ◽  
Octahedral Geometry ◽  
Spectral Studies ◽  
Conductivity Measurements ◽  
Tetrahedral Geometry ◽  
Physico Chemical ◽  
Pyridine Nitrogen ◽  
Infrared Spectral ◽  
Nitrate Complexes

New complexes of isonicotinoylhydrazone-9-anthraldehyde with Cu(II), Co(II) and Ni(II) have been prepared and characterized by analytical and physico-chemical techniques, such as elemental and thermal analyses, magnetic susceptibility and conductivity measurements, and electronic, EPR and IR spectral studies. The infrared spectral studies revealed the bidentate or monodentate nature of the Schiff base in the complexes; the pyridine nitrogen does not participate in the coordination. A tetrahedral geometry is suggested for the nitrate-complexes and an octahedral geometry for the others. Thermal studies support the chemical formulation of these complexes.

scholarly journals Synthesis, Characterization and Antimicrobial Activity of Mixed Schiff Base Ligand Complexes of Co(II), Ni(II), Cu(II) and Zn(II)

2011 ◽  
Vol 8 (3) ◽  
pp. 1258-1263 ◽  
Author(s):  
A. K. Mapari ◽  
M. S. Hate ◽  
K. V. Mangaonkar
Keyword(s):  
Antimicrobial Activity ◽  
Thermogravimetric Analysis ◽  
Schiff Bases ◽  
Free Ligand ◽  
Antimicrobial Activities ◽  
Mixed Ligand ◽  
Mixed Ligand Complexes ◽  
Azomethine Nitrogen ◽  
Diffusion Method ◽  
Spectral Studies

The mixed ligand complexes of Co(II), Ni(II), Cu(II) and Zn(II) with Schiff basesN-(2-hydroxy-1-naphthylidene)-4-methylaniline (L1H) andN-(2-hydroxybenzylidene)-2,3-dimethylaniline (L2H) have been synthesized and characterized. The resulting complexes were characterized by elemental analysis, thermogravimetric analysis, magnetic moment measurements, conductivity measurements,1H NMR, IR, UV-visible and ESR spectral studies. The Schiff bases acts as bidentate monobasic ligands, coordinating through deprotonated phenolic oxygen and azomethine nitrogen atoms. The complexes are non-electrolytic in DMSO. The presence of the two coordinated water molecules in these complexes was indicated by IR spectra and thermogravimetric analysis of the complexes. From the analytical and spectral data the stoichiometry of these complexes have been found to be [M(L1)(L2)(H2O)2] {where M = Co(II) , Ni(II), Cu(II) and Zn(II)}. It is found that Co(II), Ni(II), Cu(II) and Zn(II) complexes exhibited octahedral geometry. The antimicrobial activities of ligands and their mixed ligand complexes were screened by disc diffusion method. It is found that the metal complexes have higher antimicrobial activity than the free ligand.

scholarly journals Synthesis, Characterization and Antibacterial Activity from Mixed Ligand Complexes of 8-Hydroxyquinoline and Tributylphosphine for Some Metal Ions

2019 ◽  
Vol 70 (1) ◽  
pp. 36-40
Author(s):  
Rana Abdulilah Abbas ◽  
Amer J.jarad ◽  
Ion Marius Nafliu ◽  
Aurelia Cristina Nechifor
Keyword(s):  
Antibacterial Activity ◽  
Magnetic Susceptibility ◽  
Metal Ions ◽  
Atomic Absorption ◽  
Ethyl Alcohol ◽  
Octahedral Geometry ◽  
Mixed Ligand ◽  
Mixed Ligand Complexes ◽  
Antibacterial Efficiency ◽  
Ft Ir

Co+2, Ni+2, Cu+2 as well Zn+2 compounds mixed ligand from 8-hydroxyquinoline(8-HQ) also tributylphosphine (PBu3) have been attended at aquatic ethyl alcohol for (1:2:2) (M:8-HQ:PBu3). Produced complexes have been identified by utilizing atomic absorption flame, FT-IR as well UV-Vis spectrum manners also magnetic susceptibility as well as conductivity methods. At addendum antibacterial efficiency from the ligands as well complexes oboist three species about bacteria have been as well examined. Ligands and their complexes show good bacterial efficiencies. Of the gained datum the octahedral geometry was proposed into whole prepared complexes.

scholarly journals Synthesis of New Mixed-Ligand Complexes of Molybdenum (IV) and Tungsten(IV): Characterization, Structure, Thermal and Anti-microbial Studies

2019 ◽  
Vol 11 (1) ◽  
pp. 43
Author(s):  
Festus Sunday Fabiyi ◽  
Friday O. Nwosu
Keyword(s):  
1H Nmr ◽  
Antimicrobial Activities ◽  
Mixed Ligand ◽  
Mixed Ligand Complexes ◽  
Spectral Studies ◽  
Mass Spectral ◽  
Bacteria And Fungi ◽  
And Tungsten

Six new mixed-ligand complexes of Mo(IV) and W(IV) ions have been prepared and characterized. The three new complexes of Mo(IV) ions have the molecular formulae MoC12N2O5H18, MoC15N2O5H22 and MoC14N2O6H19 , while the W(II) ions are WC12N2O5H18, WC15N2O5H22 and WC14N2O6H19. The structures of the complexes were deduced from their ir, 1H nmr, and mass spectral studies. All the complexes were found to exhibit octahedral structures. Their antimicrobial activities against some bacteria and fungi species were found to be moderate.

scholarly journals Synthesis, Characterization, and Antimicrobial Activity of Methyl-2-aminopyridine-4-carboxylate Derivatives

2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
S. Nagashree ◽  
P. Mallu ◽  
L. Mallesha ◽  
S. Bindya
Keyword(s):  
Antimicrobial Activity ◽  
Spectral Studies ◽  
H Nmr ◽  
Chemical Structures ◽  
Elemental Analyses ◽  
Ft Ir

A series of methyl-2-aminopyridine-4-carboxylate derivatives,3a–f,were synthesized in order to determine theirin vitroantimicrobial activity. The chemical structures of the synthesized compounds were confirmed by elemental analyses, FT-IR, and1H NMR spectral studies. Among the synthesized compounds,3cand3dshowed good antimicrobial activity compared to other compounds in the series.

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