An Explaining Theory for Diuretic-Induced-Diabetes Incidences

2018 ◽  
Author(s):  
Farah Yousef ◽  
Oussama Mansour ◽  
Jehad Herbali
Keyword(s):  
Diabetes Mellitus ◽  
Binding Site ◽  
Type Ii Diabetes ◽  
Type Ii Diabetes Mellitus ◽  
The Other ◽  
Hypoglycemic Agents ◽  
Type Ii ◽  
Sulfonylurea Receptor ◽  
Lead Compound ◽  
Sulfonylurea Drugs

Many patients with hypertension are also suffering from Type II Diabetes Mellitus (TIIDM). Different studies argued the fact if these patients can use Hydrochlorothiazide (HCTZ) group or not to treat hyper-tension as these diuretics are accused with diuretic-induced diabetes especially Chlorthalidone and Bendroflumethiazide. As nothing is definite yet; in this paper, we are jotting down a new theory. In other words, we are seeking to study HCTZ interactions with sulfonylurea receptor Kir 6.2\SUR1 considering the chemical fact that HCTZ are also sulfonamide derivates like sulfonylurea drugs which are hypoglycemic agents used in the treatment of TIIDM. Therefore, we have studied in-silico 12 HCTZ compounds’ interactions with the binding site of sulfonylurea in its receptor Kir6.2\SUR1. Then, we compared the results to the interactions of Glibenclamide (GBM); a sulfonylurea agent, with the named receptor.  As a result, three compounds of this family (Chlorthalidone 1-1, Bendroflumethiazide 4-1, Metholazone 6-1) had bound to Kir6.2\SUR1 receptor in the same binding site of GBM. The rest members were almost close to the GBM binding site. These findings may explain the adverse effect that chlorthalidone and Bendroflumethiazide are accused with. We suggest that they are agonists for Kir6.1\SUR1 receptor, which results in decreasing insulin secretion from pancreas which consequences with hyper-glycemica. On the other hand, our results confirm that developing new anti hyperglycemia agents from HCTZ as a lead compound is also possible and promising.

scholarly journals Prescription Pattern Analysis of Type II Diabetes Mellitus Inpatients and Associated Co-Morbidities

2020 ◽  
Vol 10 (3) ◽  
pp. 42-47
Author(s):  
Purnima Ashok ◽  
Vijesh Thollur Subrahmanian ◽  
Rinju Raj ◽  
Rahul Rajendra Babu ◽  
Ramshad T. P. ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type Ii Diabetes ◽  
Pattern Analysis ◽  
Essential Medicine ◽  
Type Ii Diabetes Mellitus ◽  
Hypoglycemic Agents ◽  
Type Ii ◽  
Oral Hypoglycemic Agents ◽  
Prescription Pattern ◽  
Essential Medicine List

Background: The present study was planned to assess the prescription pattern analysis of Type II Diabetes Mellitus and associated co-morbidities. As per WHO, the worldwide prevalence of DM will reach 366 million by 2030. Evaluating drug prescription pattern is a major aspect of patient care, which is used as a measure of the quality of care provided. Objectives: Primary objectives of the study were to highlight the current prescription pattern trends in patients having diabetes mellitus with or without other co-morbid conditions, to ensure safety and rational use of prescribed regimen. And the secondary objectives of the study were to analyse the demographic information of the enrolled patients and also to identify and analyse the prescriptions with polypharmacy. Materials and Methods: A prospective observational study was conducted to analyse the prescribing pattern of anti-diabetic drugs. The study incorporated 100 Type II DM inpatients having comorbid conditions. The study has been conducted with the help of WHO prescribing indicator scale. It is used to analyse drug class, generic and branded drugs, fixed dose combination and dosage form. Patient data was collected and medical data records were analysed daily till discharge from hospital. Results: It was found that most of the drugs have been prescribed are purely from Karnataka Essential Medicine list (KEML). And percentages of medicines prescribed on their generic name were 76%. About 51% of patients were treated only with oral hypoglycemic agents. Whereas, 38% were treated with Insulin and 11% were treated with both oral hypoglycemic agents and Insulin. Conclusion: Improved rational use of prescription by using Essential Medicine List (EML).And also ensured the appropriateness of prescription by using WHO scale. Several Adverse Drug Reactions (ADR)have been reported and which leads to improved  prescription pattern. Keywords: Type II Diabetes Mellitus, Prescribing Indicator, Co-Morbidities.

scholarly journals Comparative assessment of the effects of glurenorm and some sulfonylurea preparations on microcirculation in type II diabetes mellitus

1993 ◽  
Vol 39 (2) ◽  
pp. 7-9 ◽  
Author(s):  
I. M. Kakhnovsky ◽  
T. V. Koroleva ◽  
V. N. Zakharchenko ◽  
S. N. Larionov
Keyword(s):  
Type Ii Diabetes ◽  
Type Ii Diabetes Mellitus ◽  
Cellular Component ◽  
Hypoglycemic Agents ◽  
Red Cell ◽  
Type Ii ◽  
Drug Of Choice ◽  
Severe Diabetes ◽  
The Status ◽  
Sulfonylurea Drugs

Analysis of the effects of glurenorm and some sulfonylurea drugs, such as maninil, minidiab, chlorpropamid, on some parameters of intravascular microcirculation has demonstrated the specific features of this drug. Though all these hypoglycemic agents favorably influence the microcirculation when carbohydrate metabolism compensation is attained, glurenorm improved the status of formed elements of the blood (red cell and platelet aggregation) more noticeably than the rest drugs, which fact recommends it as a drug of choice for patients with type II medium-severe diabetes with the predominant involvement of the cellular component of the microcirculation.

scholarly journals Laser-acupuntura no controle da glicemia na Diabetes tipo II: ensaio clínico randomizado

2021 ◽  
Vol 20 (2) ◽  
pp. 492-530
Author(s):  
Claudia Dayube Pereira ◽  
Neide Aparecida Titonelli Alvim ◽  
Raphael Dias de Mello Pereira ◽  
Leila Brito Bergold ◽  
Saint Clair Dos Santos Gomes Junior ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Clinical Trials ◽  
Nursing Care ◽  
Type Ii Diabetes ◽  
Type Ii Diabetes Mellitus ◽  
Repeated Measurements ◽  
Hypoglycemic Agents ◽  
Laser Acupuncture ◽  
Type Ii ◽  
Oral Hypoglycemic Agents

Objetivo: Evaluar la efectividad de la acupuntura-laser aplicada al cuidado de enfermería de personas con diabetes mellitus tipo II. Métodos: Ensayo clínico aleatorizado, triple ciego, con 42 participantes diabéticos tipo II, ambos sexos, con edades comprendidas entre 30 y 75 años, con hipoglucemiantes orales y dificultades para mantener la glucemia posprandial ≤ 180mg/ dl. Los participantes fueron asignados aleatoriamente a dos grupos diferentes y sometidos a láser-acupuntura estándar, brazo experimental o brazo de control simulado. Se utilizaron análisis descriptivos y de asociación entre variables, con un nivel de significancia del 5% (p <0,05). Para comparar los resultados de glucosa en sangre, se utilizó la prueba t de Student para muestras pareadas y Anova para mediciones repetidas. Resultados: Se observó una disminución significativa de la glucemia capilar en los participantes del brazo experimental, fenómeno no verificado en los del brazo control. Conclusiones: Se infiere la plausibilidad de utilizar la técnica como tecnología para el cuidado de enfermería de personas con diabetes mellitus tipo II. Registro Brasileño de Ensayos Clínicos. UTN: U1111-1181-1675. Ensayos clínicos NCT02605889. Objective: To evaluate the effectiveness of laser-acupuncture applied to nursing care for people with type II diabetes mellitus. Methods: Randomized, triple-blinded clinical trial, with 42 type II diabetic participants, both genders, aged between 30 and 75 years, using oral hypoglycemic agents and difficulties in maintaining postprandial glycaemia ≤ 180mg/dl. Participants were randomly assigned to two different groups and submitted to standard laser-acupuncture, experimental arm, or simulated, control arm. Descriptive and association analyses between variables were used, with a significance level of 5% (p <0,05). To compare blood glucose results, Student’s t test was used for paired samples and Anova for repeated measurements. Results: A significant decrease in capillary glycaemia was observed in the participants in the experimental arm, a phenomenon not verified in those in the control arm. Conclusions: the plausibility of using the technique as a technology for nursing care for people with type II diabetes mellitus is inferred. Brazilian Registry of Clinical Trials. UTN: U1111-1181-1675. Clinical Trials NCT02605889. Objetivo: Avaliar a eficácia da laser-acupuntura aplicada ao cuidado de enfermagem à pessoas com diabetes mellitus tipo II. Métodos: Ensaio clínico randomizado, triplo cego, com 42 participantes diabéticos do tipo II, ambos os sexos, idades entre 30 a 75 anos, em uso de hipoglicemiantes orais e dificuldades para manter a glicemia pós prandial ≤ 180mg/dl. Os participantes foram distribuídos aleatoriamente em dois grupos distintos e submetidos a laser-acupuntura padrão, braço experimental, ou simulada, braço controle. Empregaram-se análises descritivas e de associação entre variáveis, com nível de significância de 5% (p<0,05). Para comparação entre os resultados da glicemia empregou-se teste t de Student para amostras pareadas e Anova para medidas repetidas. Resultados: Observou-se diminuição significativa na glicemia capilar dos participantes do braço experimental, fenômeno não verificado naqueles do braço controle. Conclusões: Infere-se a plausibilidade da utilização da técnica como tecnologia para o cuidado de enfermagem às pessoas com diabetes mellitus do tipo II. Registro Brasileiro de Ensaios Clínicos. UTN: U1111-1181-1675. Clinical Trials NCT02605889.

Plasma Resistin, Insulin Concentration in Non-Diabetic and Diabetic, Overweight/Obese Thai

2006 ◽  
Vol 76 (3) ◽  
pp. 125-131 ◽  
Author(s):  
Siriporn Chanchay ◽  
Rungsunn Tungtrongchitr ◽  
Talabporn Harnroongroj ◽  
Benjaluck Phonrat ◽  
Orapin Rungseesakorn ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Type Ii Diabetes ◽  
Central Obesity ◽  
Type Ii Diabetes Mellitus ◽  
The Other ◽  
Type Ii ◽  
Waist To Hip Ratio ◽  
Median Plasma ◽  
Homa Score

This study investigated levels of fasting plasma glucose (FBS), homeostasis model of the assessment of the insulin resistance (HOMA), lipid profile, insulin, and resistin hormones in 202 individuals, divided into four groups. Two groups had type II diabetes mellitus (DM): one group had been overnourished (DM/OB) (body mass index: BMI equal or above 25) and the other had not (DM/nOB). Two additional groups not suffering from diabetes were either overnourished (nDM/OB) or of normal nutritional status (nDM/nOB). Only the DM/OB group had insulin levels elevated above the other three groups. Resistin levels had been lowest in the nDM/nOB group. When participants of the two nOB groups were pooled into one group and the subjects of the two OB groups were combined into another group, the median plasma resistin levels of the OB groups were significantly higher compared with the nOB groups. Likewise the DM groups had higher resistin levels than the nDM groups. A significant correlation of plasma resistin with BMI, waist circumference, waist-to-hip ratio, FBS, and HOMA score had been observed. The result suggests that plasma resistin has a role in linking central obesity and obesity-related insulin resistance to type II diabetes mellitus.

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