scholarly journals Evaluation of the Genomic Basis for Alzheimer’s and Parkinson’s Diseases

2019 ◽  
Author(s):  
Pratip Rana ◽  
Edian F. Franco ◽  
Yug Rao ◽  
Khajamoinuddin Syed ◽  
Debmalya Barh ◽  
...  
Keyword(s):  
Neurodegenerative Disorders ◽  
Literature Search ◽  
Genome Wide Association ◽  
Extensive Literature ◽  
Gene Coexpression Network ◽  
Genome Wide ◽  
Major Genome ◽  
Extensive Literature Search ◽  
Exact Relationship ◽  
Genomic Basis

Alzheimer's disease (AD) and Parkinson's disease (PD) are the most common neurodegenerative disorders related to aging. Though several risk factors are shared between these two diseases, the exact relationship between these two diseases is still unknown. In this paper, we analyzed how these diseases relate to each other from a genomics viewpoint. Using an extensive literature search, we accumulated the list of genes from the major genome-wide association (GWAS) studies. However, we found only one gene (HLA-DRB5) reported in these GWAS studies that are common between AD and PD. We also listed all the miRNAs that have been previously reported for AD and PD. Here we found 15 different miRNAs that were reported in both diseases. In order to get better insights, we predicted the gene coexpression network for both AD and PD. Network analysis on these networks show six clusters of genes related to AD and four clusters of genes related to PD.

scholarly journals Evaluation of the Common Molecular Basis in Alzheimer’s and Parkinson’s Diseases

2019 ◽  
Vol 20 (15) ◽  
pp. 3730 ◽  
Author(s):  
Pratip Rana ◽  
Edian F. Franco ◽  
Yug Rao ◽  
Khajamoinuddin Syed ◽  
Debmalya Barh ◽  
...  
Keyword(s):  
Network Analysis ◽  
Literature Mining ◽  
Extensive Literature ◽  
Genome Wide ◽  
Parkinson’S Diseases ◽  
Epigenetic Regulator ◽  
Major Genome ◽  
The Common ◽  
Exact Relationship ◽  
Subsequent Literature

Alzheimer’s disease (AD) and Parkinson’s disease (PD) are the most common neurodegenerative disorders related to aging. Though several risk factors are shared between these two diseases, the exact relationship between them is still unknown. In this paper, we analyzed how these two diseases relate to each other from the genomic, epigenomic, and transcriptomic viewpoints. Using an extensive literature mining, we first accumulated the list of genes from major genome-wide association (GWAS) studies. Based on these GWAS studies, we observed that only one gene (HLA-DRB5) was shared between AD and PD. A subsequent literature search identified a few other genes involved in these two diseases, among which SIRT1 seemed to be the most prominent one. While we listed all the miRNAs that have been previously reported for AD and PD separately, we found only 15 different miRNAs that were reported in both diseases. In order to get better insights, we predicted the gene co-expression network for both AD and PD using network analysis algorithms applied to two GEO datasets. The network analysis revealed six clusters of genes related to AD and four clusters of genes related to PD; however, there was very low functional similarity between these clusters, pointing to insignificant similarity between AD and PD even at the level of affected biological processes. Finally, we postulated the putative epigenetic regulator modules that are common to AD and PD.

scholarly journals Magnetic Suspension with Motorization to Measure the Speed of Gravity

2017 ◽  
Vol 45 ◽  
pp. 1760020
Author(s):  
Henrique Linares ◽  
Carlos Frajuca ◽  
Fabio S. Bortoli ◽  
Givanildo A. Santos ◽  
Francisco Y. Nakamoto
Keyword(s):  
High Speed ◽  
Literature Search ◽  
Magnetic Bearing ◽  
Magnetic Suspension ◽  
Extensive Literature ◽  
Sliding Bearing ◽  
Speed Of Gravity ◽  
Engineering Problems ◽  
Extensive Literature Search ◽  
Hybrid Bearing

This work aims to design a magnetic suspension for an experiment to measure gravitys velocity. Such device must rotate two objects symmetrically with the greatest mass and largest radius as possible, at the speed of [Formula: see text], which means this device falls into the high-speed machines category. The guidelines and solutions proposed in this paper constitute a contribution to this class of engineering problems and were based on an extensive literature search, contacts with experts, the tutors and author’s experience, as well as on experimental results. The main solution proposed is a hybrid bearing that combines a radial passive magnetic bearing with an axial sliding bearing, here called MPS (Magnetic Passive and Sliding) bearing.

The genus Carex (Cyperaceae) in Armenia

Phytotaxa ◽  
2021 ◽  
Vol 494 (1) ◽  
pp. 1-41
Author(s):  
JACOB KOOPMAN ◽  
TARON ALEKSANYAN ◽  
ALLA ALEKSANYAN ◽  
GEORGE FAYVUSH ◽  
MARINA OGANESIAN ◽  
...  
Keyword(s):  
Literature Search ◽  
Field Research ◽  
Extensive Literature ◽  
Extensive Literature Search

In this paper we present an updated checklist, key and maps for all the currently known Carex taxa present in Armenia. The present work is based on the revision of the vouchers in herbaria ERE, W and MW, extensive literature search, and field research carried out in 2015–2019. As a result, 71 species of Carex are known from Armenia. Besides, the first Carex hybrid in Armenia has been found and provided here with a binomial name.

scholarly journals A Rare Case of Advanced Urethral Diverticular Adenocarcinoma and a Review of Treatment Modalities

2019 ◽  
Vol 7 ◽  
pp. 232470961982840
Author(s):  
Fatai Oluyadi ◽  
Preethi Ramachandran ◽  
Vladmir Gotlieb
Keyword(s):  
Literature Search ◽  
Treatment Approach ◽  
Urethral Diverticulum ◽  
Treatment Modalities ◽  
Final Decision ◽  
Extensive Literature ◽  
Platinum Based Chemotherapy ◽  
Advanced Stages ◽  
Extensive Literature Search ◽  
Tract Infections

Female urethral diverticular cancer is a very rare entity with only around 100 cases reported so far in literature and accounts for <1% of all malignancies. In this article, we present a 47-year-old African American female with repeated hospital visits for urinary retention, hematuria, and urinary tract infections. Initial computed tomography imaging and cystoscopy was unremarkable except for a distended urinary bladder. Subsequent magnetic resonance imaging and corresponding cystoscopy eventually indicated the presence of a urethral diverticulum. She underwent urethral diverticulectomy and was found to have a mass arising from urethral diverticulum extending to vaginal walls. Her biopsy was suggestive of invasive adenocarcinoma in advanced stages, for which she subsequently underwent a total pelvic exenteration. Next-generation sequencing of the tumor showed CDKN2A/B loss, MSI-stable, and low TMB, thereby ruling out the options for targeted therapies. Extensive literature search and expert opinions were sought for her case since no consensus exists regarding the optimal therapeutic approach due to the rarity of this tumor. A final decision was made to treat her with platinum-based chemotherapy. Different treatment approaches including neoadjuvant chemoradiation followed by surgery, surgery followed by adjuvant chemotherapy, and surgery followed by chemoradiation have been tried. Platinum-based chemotherapy has generally been preferred based on an extensive literature search. Multimodality treatment approach seems to be the current approach to management for advanced stages for better overall survival. This case illustrates the challenges faced in making diagnosis and treatment decisions due to the rarity of this type of tumor and lack of consensus in the treatment approach.

On the value of taxonomic standardization in evolutionary studies

Paleobiology ◽  
1987 ◽  
Vol 13 (2) ◽  
pp. 169-176 ◽  
Author(s):  
Stephen J. Culver ◽  
Martin A. Buzas ◽  
Laurel S. Collins
Keyword(s):  
Benthic Foraminifera ◽  
Literature Search ◽  
Extensive Literature ◽  
Museum Collections ◽  
Duration Data ◽  
Evolutionary Studies ◽  
Extensive Literature Search

Species duration data for living benthic foraminifera derived from an extensive literature search have been compiled and analyzed to investigate rates and patterns of species origination. The same data subjected to taxonomic standardization through examination of many specimens lodged in museum collections indicate strikingly different, and more realistic, rates and patterns.Evolutionary generalizations based on data generated from the literature only are often unreliable and may be directly in opposition to reality. Extensive attempts at taxonomic standardization should be the norm in paleobiological investigations.

scholarly journals Macrolide Allergic Reactions

Pharmacy ◽  
2019 ◽  
Vol 7 (3) ◽  
pp. 135 ◽  
Author(s):  
Kristy M. Shaeer ◽  
Elias B. Chahine ◽  
Sheeba Varghese Gupta ◽  
Jonathan C. Cho
Keyword(s):  
Literature Search ◽  
Antimicrobial Agents ◽  
Cross Reactivity ◽  
Extensive Literature ◽  
Allergic Reactions ◽  
Hypersensitivity Reactions ◽  
Chemical Structures ◽  
Life Threatening ◽  
Cutaneous Reactions ◽  
Extensive Literature Search

Macrolides are antimicrobial agents that can be used to treat a variety of infections. Allergic reactions to macrolides occur infrequently but can include minor to severe cutaneous reactions as well as systemic life-threatening reactions such as anaphylaxis. Most reports of allergic reactions occurred in patients without prior exposure to a macrolide. Cross-reactivity among macrolides may occur due to the similarities in their chemical structures; however, some published literature indicates that some patients can tolerate a different macrolide. Most published reports detailed an allergic reaction to erythromycin. Desensitization protocols to clarithromycin and azithromycin have been described in the literature. The purpose of this article is to summarize macrolide-associated allergic reactions reported in published literature. An extensive literature search was conducted to identify publications linking macrolides to hypersensitivity reactions.

Cardiopulmonary bypass on a patient with malaria

Perfusion ◽  
1999 ◽  
Vol 14 (3) ◽  
pp. 219-221 ◽  
Author(s):  
Thomas J Coley ◽  
James C Hart
Keyword(s):  
Cardiopulmonary Bypass ◽  
Aortic Valve ◽  
Aortic Stenosis ◽  
Blood Cells ◽  
Literature Search ◽  
Severe Aortic Stenosis ◽  
Extensive Literature ◽  
History Of ◽  
Extensive Literature Search ◽  
Primaquine Phosphate

There are special considerations when performing cardiopulmonary bypass (CPB) on a patient with malaria. A 70-year-old female with a recent history of severe aortic stenosis was scheduled to undergo elective aortic valve replacement. One week prior to surgery, the patient developed shaking chills and fever, with a positive malaria smear. An extensive literature search was undertaken to determine the effect of CPB on a patient with active malaria, but no prior reference was found. One major concern was the lysis of red blood cells while on bypass. The surgery was performed uneventfully, following 2 weeks of treatment with primaquine phosphate.

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