scholarly journals The Enigmatic Metallothioneins: A Case of Upward-Looking Research

2021 ◽  
Author(s):  
Ahmad Yaman Abdin ◽  
Claus Jacob ◽  
Lena Kästner
Keyword(s):  
Philosophy Of Science ◽  
Biological Function ◽  
Innovative Approach ◽  
Biochemical Research ◽  
Biological Organisms ◽  
Function Mapping

In the mid-1950s, Bert L. Vallee and his colleague Marvin Margoshes discovered a molecule known today as metallothionein (MT). Meanwhile MTs have been shown to be common in many biological organisms. Despite their prevalence, however, it remains unclear to date what exactly MTs do and how they contribute to the biological function of an organism or organ. Honoring Dr. Vallee’s sometimes innovative approach to research, this contribution sets out to show how philosophy of science can help us gain a clearer picture of biochemical research. We shall look into both the discovery of as well as recent research on Dr. Vallee’s beloved family of MT proteins to illustrate (i) how exploratory and upward-looking research play important roles in biochemical discoveries although they do not fit the paradigmatic approach of decomposition and struc-ture-function mapping. Besides, we shall suggest (ii) that while other biochemical molecules ex-hibit a clearly identifiable function, other research hypotheses might be worthy of pursuit in the case of MTs.

scholarly journals The Enigmatic Metallothioneins: A Case of Upward-Looking Research

2021 ◽  
Vol 22 (11) ◽  
pp. 5984
Author(s):  
Ahmad Yaman Abdin ◽  
Claus Jacob ◽  
Lena Kästner
Keyword(s):  
Structure Function ◽  
Philosophy Of Science ◽  
Biological Function ◽  
Research Strategies ◽  
Research Tradition ◽  
Yield Structure ◽  
Initial Work ◽  
Biochemical Research ◽  
The 1960S ◽  
Biological Organisms

In the mid-1950s, Bert Lester Vallee and his colleague Marvin Margoshes discovered a molecule referred to today as metallothionein (MT). Meanwhile, MTs have been shown to be common in many biological organisms. Despite their prevalence, however, it remains unclear to date what exactly MTs do and how they contribute to the biological function of an organism or organ. We investigate why biochemical research has not yet been able to pinpoint the function(s) of MTs. We shall systematically examine both the discovery of and recent research on Dr. Vallee’s beloved family of MT proteins utilizing tools from philosophy of science. Our analysis highlights that Vallee’s initial work exhibited features prototypical of a developing research tradition: it was upward-looking, exploratory, and utilized mere interactions. Since the 1960s, MT research has increasingly become intervention- and hypothesis-based while it remained largely upward-looking in character. Whilst there is no reason to think that upward-looking research cannot successfully yield structure-function mappings, it has not yet been successful in the case of MTs. Thus, we suggest it might be time to change track and consider other research strategies looking into the evolution of MTs. Recent studies in mollusks render research in this direction worthy of pursuit.

OZONE OXIDIZES OLEIC FATTY ACID WITH THE HIGHEST RATE CONSTANT AND DOES NOT OXIDIZE PALMITIC ACID. DIFFERENT PHYSICOCHEMICAL PARAMETERS OF SUBSTRATES AND THEIR ROLE IN PHYLOGENESIS

2019 ◽  
Vol 64 (3) ◽  
pp. 132-139
Author(s):  
Vladimir Nikolaevich Titov ◽  
N. N. Sazhina ◽  
N. M. Evteeva
Keyword(s):  
Physicochemical Parameters ◽  
Energy Production ◽  
Production Efficiency ◽  
Biological Function ◽  
Homo Sapiens ◽  
Mitochondrial Matrix ◽  
Oxidation Parameters ◽  
Nonalcoholic Liver Disease ◽  
Biological Organisms

Physicochemical differences between О3 oxidation parameters for palmitic and oleic fatty acids (FA) during phylogenesis (evolution) are fundamental for а) production of palmitoleic monounsaturated fatty (MFA), b) formation of carnitine palmitoyltransferase as a FA transporter to mitochondria, and c) in vivo production of oleic MFA under humoral regulatory effect of insulin. In the strive for the best kinetic parameters of biological organisms without a possibility of modifying physicochemical and biochemical reactions in the mitochondrial matrix, the mitochondria can be provided with a substrate that increases energy production efficiency and the amount of ATP. Physicochemical parameters of oleic MFA has become the standard of an oxidation substrate for in vivo energy production; this MFA was synthesized in organisms for millions of years. Environmental influences are the second factor which determines kinetic perfection of biological organisms during phylogenesis. Are these influences always beneficial? Mostly, they are not. However, they largely stimulate adaptive functions of the organism, including the biological function of locomotion, cognitive function and the function of positioning in the environment. Biological, energy and kinetic perfection formed in vivo can be easily destroyed if phylogenetically herbivorous Homo sapiens abuses the diet of carnivorous animals (meat) which was not consumed by him and his ancestors during phylogenesis. This abuse is the major cause of metabolic pandemias in human population. They are: insulin resistance, atherosclerosis and atheromatosis, obesity and nonalcoholic liver disease. The most effective measures preventing metabolic pandemias, cardiac heart disease and myocardial infarction are extremely simple. People should remain herbivorous.

scholarly journals “It’s all discursive!” Crossing boundaries and crossing words with Rom Harré

2015 ◽  
Vol 14 (2) ◽  
Author(s):  
Simone Belli ◽  
Juan C Aceros ◽  
Rom Harré
Keyword(s):  
Social Sciences ◽  
Social Psychology ◽  
New Zealand ◽  
Philosophy Of Science ◽  
Ludwig Wittgenstein ◽  
Logical Empiricism ◽  
Innovative Approach ◽  
The Social ◽  
Key Concepts ◽  
Humanities And Social Sciences

Rom Harré is one of the most important figures in academia of recent decades. Born in New Zealand he developed most of his career in Oxford. Influenced by authors such as John Austin, Ludwig Wittgenstein and Lev Vygotsky, Harré has produced his own and innovative approach to humanities and social sciences topics. His writings on philosophy of science have been focused on destabilizing the central doctrines of logical empiricism and positivism. However, his work has been not only influential in philosophy but also in other fields. This paper introduces his main contributions to psychology in general and social psychology in particular. It presents an interview with Rom Harré which outlines an approach to the author and his contributions to the social psychology crisis. Some key concepts in social sciences and in Rom's own work are also addressed, and research lines he advises to follow in the next decade are examined. The interview depicts Rom Harré as a scholar who crosses the boundaries between different disciplines and places.

Bachelard, Lacan and the Impurity of Scientific Formalization

Paragraph ◽  
2012 ◽  
Vol 35 (3) ◽  
pp. 320-337
Author(s):  
Tom Eyers
Keyword(s):  
Critical Theory ◽  
Philosophy Of Science ◽  
Scientific Knowledge ◽  
Innovative Approach ◽  
Historical Epistemology ◽  
Gaston Bachelard ◽  
French Philosophy ◽  
Lacanian Theory

This essay examines the conjunction of French historical epistemology and Lacanian theory in postwar France. In particular, Lacan's account of scientific formalization is scrutinized insofar as it develops aspects of the prior epistemological research of Gaston Bachelard, whose innovative approach to the problem of the nature and limits of scientific knowledge proved so influential on the subsequent field of French structuralism. Lacan's reflections on formalization will be shown, in contrast to Bachelard, to place an emphasis on the constitutive and limiting role of language in its interaction with logical and scientific projects. In asking how Lacan's structural psychoanalysis extends and subverts the rationalist emphasis of French philosophy of science, I hope to provide a new optic through which to assess the role of formalization in critical theory today.

The limits of human performance

2008 ◽  
Vol 44 ◽  
pp. 11-26 ◽  
Author(s):  
Ralph Beneke ◽  
Dieter Böning
Keyword(s):  
Human Performance ◽  
Safety Margin ◽  
Afferent Input ◽  
Metabolic Energy ◽  
Human Organism ◽  
Mechanical Resistance ◽  
As Doping ◽  
Gene And Protein Expression ◽  
Underlying Mechanisms ◽  
Biochemical Research

Human performance, defined by mechanical resistance and distance per time, includes human, task and environmental factors, all interrelated. It requires metabolic energy provided by anaerobic and aerobic metabolic energy sources. These sources have specific limitations in the capacity and rate to provide re-phosphorylation energy, which determines individual ratios of aerobic and anaerobic metabolic power and their sustainability. In healthy athletes, limits to provide and utilize metabolic energy are multifactorial, carefully matched and include a safety margin imposed in order to protect the integrity of the human organism under maximal effort. Perception of afferent input associated with effort leads to conscious or unconscious decisions to modulate or terminate performance; however, the underlying mechanisms of cerebral control are not fully understood. The idea to move borders of performance with the help of biochemicals is two millennia old. Biochemical findings resulted in highly effective substances widely used to increase performance in daily life, during preparation for sport events and during competition, but many of them must be considered as doping and therefore illegal. Supplements and food have ergogenic potential; however, numerous concepts are controversially discussed with respect to legality and particularly evidence in terms of usefulness and risks. The effect of evidence-based nutritional strategies on adaptations in terms of gene and protein expression that occur in skeletal muscle during and after exercise training sessions is widely unknown. Biochemical research is essential for better understanding of the basic mechanisms causing fatigue and the regulation of the dynamic adaptation to physical and mental training.

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