DEVELOPMENT AND EVALUATION OF POLYHERBAL OINTMENT FOR HAIR GROWTH PROMOTING ACTIVITY

Author(s):  
Vinitha Edula
Keyword(s):  
Heliyon ◽  
2021 ◽  
Vol 7 (4) ◽  
pp. e06903
Author(s):  
Somnath D. Bhinge ◽  
Mangesh A. Bhutkar ◽  
Dheeraj S. Randive ◽  
Ganesh H. Wadkar ◽  
Sachin S. Todkar ◽  
...  

Author(s):  
Cho Sho ◽  
Kuniaki Kawano ◽  
Rie Kurata ◽  
Makoto Yoshimoto ◽  
Hironori Okuno

2017 ◽  
Vol 89 ◽  
pp. 438-446 ◽  
Author(s):  
Zhan-di Wang ◽  
Ying Feng ◽  
Li-yi Ma ◽  
Xian Li ◽  
Wei-feng Ding ◽  
...  

2019 ◽  
Vol 9 (2) ◽  
pp. 330-335
Author(s):  
Namrata Omhare ◽  
Pratibha Sahu ◽  
Shailee Gautam ◽  
Nidhi Jain

In present investigation was carried out to screening of hair growth promoting potentiality of petroleum ether extract of Abrus precatorius leaf. Preliminary chemical tests and TLC analysis revealed the presence flavonoids and saponins. Hair growth promoting activity of petroleum ether of Abrus precatorius was screened by considering different parameters which included time taken for covering bald patch, length of hair produced, percentage of hair follicles in anagen and telogen phases, time of hair growth initiation and completion and level of minerals in blood. The petroleum ether extract of Abrus precatorius showed a very good hair growth promoting activity at a dose of 300 mg/kg which was comparable to that of 2% minoxidil. After 30 days of treatment with test and standard drugs it was observed that, time taken for covering the bald patch, hair growth initiation and completion time and quantitative hair growth were found to be comparable to that of the standard drug. An increase in percentage of hair follicles turning from telogen phase to anagen phase was noted. The control treated group of animals showed poor hair growth for all the parameters. Keywords: Abrus precatorius Linn, Anagen, Catagen, Telogen, Minoxidil


2021 ◽  
pp. 118811
Author(s):  
Yingna Li ◽  
Wanwen Yu ◽  
Qingwen Cui ◽  
Jiuyue Liu ◽  
Xuechun Lu ◽  
...  

2013 ◽  
Vol 28 (7) ◽  
pp. 1030-1036 ◽  
Author(s):  
Jintana Junlatat ◽  
Bungorn Sripanidkulchai

2018 ◽  
Vol 19 (9) ◽  
pp. 2703 ◽  
Author(s):  
Bu Choi

The functional aspect of scalp hair is not only to protect from solar radiation and heat/cold exposure but also to contribute to one’s appearance and personality. Progressive hair loss has a cosmetic and social impact. Hair undergoes three stages of hair cycle: the anagen, catagen, and telogen phases. Through cyclical loss and new-hair growth, the number of hairs remains relatively constant. A variety of factors, such as hormones, nutritional status, and exposure to radiations, environmental toxicants, and medications, may affect hair growth. Androgens are the most important of these factors that cause androgenic alopecia. Other forms of hair loss include immunogenic hair loss, that is, alopecia areata. Although a number of therapies, such as finasteride and minoxidil, are approved medications, and a few others (e.g., tofacitinib) are in progress, a wide variety of structurally diverse classes of phytochemicals, including those present in ginseng, have demonstrated hair growth-promoting effects in a large number of preclinical studies. The purpose of this review is to focus on the potential of ginseng and its metabolites on the prevention of hair loss and its underlying mechanisms.


2011 ◽  
Vol 21 (6) ◽  
pp. 1012-1014 ◽  
Author(s):  
Sang-Cheol Kim ◽  
Jung-Il Kang ◽  
Min-Kyoung Kim ◽  
Hye-Jin Boo ◽  
Doek-Bae Park ◽  
...  

Author(s):  
Sunhyae Jang ◽  
Jungyoon Ohn ◽  
Bo Mi Kang ◽  
Minji Park ◽  
Kyu Han Kim ◽  
...  

Alopecia arises due to inadequate hair follicle (HF) stem cell activation or proliferation, resulting in prolongation of the telogen phase of the hair cycle. Increasing therapeutic and cosmetic demand for alleviating alopecia has driven research toward the discovery or synthesis of novel compounds that can promote hair growth by inducing HF stem cell activation or proliferation and initiating the anagen phase. Although several methods for evaluating the hair growth-promoting effects of candidate compounds are being used, most of these methods are difficult to use for large scale simultaneous screening of various compounds. Herein, we introduce a simple and reliable in vitro assay for the simultaneous screening of the hair growth-promoting effects of candidate compounds on a large scale. In this study, we first established a 3D co-culture system of human dermal papilla (hDP) cells and human outer root sheath (hORS) cells in an ultra-low attachment 96-well plate, where the two cell types constituted a polar elongated structure, named “two-cell assemblage (TCA).” We observed that the long axis length of the TCA gradually increased for 5 days, maintaining biological functional integrity as reflected by the increased expression levels of hair growth-associated genes after treatment with hair growth-promoting molecules. Interestingly, the elongation of the TCA was more prominent following treatment with the hair growth-promoting molecules (which occurred in a dose-dependent manner), compared to the control group (p < 0.05). Accordingly, we set the long axis length of the TCA as an endpoint of this assay, using a micro confocal high-content imaging system to measure the length, which can provide reproducible and reliable results in an adequate timescale. The advantages of this assay are: (i) it is physiologically and practically advantageous as it uses 3D cultured two-type human cells which are easily available; (ii) it is simple as it uses length as the only endpoint; and (iii) it is a high throughput system, which screens various compounds simultaneously. In conclusion, the “TCA” assay could serve as an easy and reliable method to validate the hair growth-promoting effect of a large volume of library molecules.


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