EVALUATION OF DIURETIC ACTIVITY OF AQUEOUS EXTRACT OF LEAVES OF CENTELLA ASIATICA

Author(s):  
Jiban Debnath
INDIAN DRUGS ◽  
2013 ◽  
Vol 50 (04) ◽  
pp. 34-38
Author(s):  
P Bommannavar ◽  
◽  
K. Patil

The present study was undertaken to establish the diuretic activity of alcoholic and aqueous extract of dried rhizomes of Curcuma amada Roxb in rats. Alcoholic and aqueous extracts of rhizomes were administered to experimental male Wistar rats orally at doses of 250 and 500 mg/kg and compared with furosemide (10 mg/kg) as the reference standard. The parameters measured for diuretic activity were total urine volume, urine electrolyte concentration such as sodium, potassium and chloride have been evaluated. The rats treated with alcoholic and aqueous extract of Curcuma amada in a dose of 250 and 500 mg/kg showed higher urine output when compared to the respective control. Both alcoholic and aqueous extracts have showed a significant dose-dependent increase in the excretion of electrolytes when compared to the control group. The result indicates that alcoholic and aqueous extract is an effective natriuretic and kaliuretic diuretic, which supports the traditional claim about the Curcuma amada Roxb being used as diuretics.


Author(s):  
Ntchapda Fidèle ◽  
Talla Ernest Rodrigue ◽  
Bonabe Christian ◽  
Kemeta Azambou David Romain ◽  
Talla Emmanuel

Author(s):  
Kemeta Azambou David Romain ◽  
Ntchapda Fidele ◽  
Dongmo Alain Bertrand ◽  
Talla Ernest Rodrigue ◽  
Bayang Houli Nicolas ◽  
...  

2012 ◽  
Vol 15 (7) ◽  
pp. A644 ◽  
Author(s):  
M. Asif ◽  
M. Atif ◽  
S.A.S. Sulaiman ◽  
M.A. Hassali ◽  
A.A. Shafie ◽  
...  

2020 ◽  
Vol 28 (6) ◽  
pp. 1599-1622
Author(s):  
Nelli Giribabu ◽  
Kamarulzaman Karim ◽  
Eswar Kumar Kilari ◽  
Srinivasa Rao Nelli ◽  
Naguib Salleh

2012 ◽  
Vol 140 (2) ◽  
pp. 424-427 ◽  
Author(s):  
Arul Amuthan ◽  
Bharti Chogtu ◽  
K.L. Bairy ◽  
Sudhakar ◽  
Mungli Prakash

RSC Advances ◽  
2015 ◽  
Vol 5 (27) ◽  
pp. 21074-21083 ◽  
Author(s):  
Vandana Sankar ◽  
Palayyan SalinRaj ◽  
Raj Athira ◽  
Rema Sreenivasan Soumya ◽  
Kozhiparambil Gopalan Raghu

Cerium nanoparticles synthesized usingCentella asiaticawere characterized, and tested for radical scavenging activities, cellular uptake, cytotoxicity and efficacy against cardiomyoblast hypertrophy and calcium overload.


Phytomedicine ◽  
1999 ◽  
Vol 6 (3) ◽  
pp. 177-179 ◽  
Author(s):  
O. Hnatyszyn ◽  
J. Miño ◽  
S. Gorzalczany ◽  
J. Opezzo ◽  
G. Ferraro ◽  
...  

2013 ◽  
Vol 3 (4) ◽  
pp. 1023-1026 ◽  
Author(s):  
M.T. Deshmukh . ◽  
R.V. Shete . ◽  
V.T. Deshmukh . ◽  
S.R. Borate . ◽  
S.V. Deshmukh .

Author(s):  
Dipjyoti Deka ◽  
Pinaki Chakravarty ◽  
Ayan Purkayastha

<p><strong>Objective: </strong>To evaluate the antiepileptic activity of aqueous extract of <em>Centella asciatica</em> in maximal electroshock (MES) and pentylenetetrazole (PTZ) induced convulsions. <strong></strong></p><p><strong>Methods</strong><strong>: </strong>The anticonvulsant activity of leaves of <em>Centella asciatica </em>(200 mg/kg and 400 mg/kg) in mice was assessed using MES and PTZ induced seizure models. Abolition of tonic hind limb extension (MES and PTZ) and increase in seizure latency (PTZ) when compared to control group, were taken as a measure of protection. Statistical analysis was done using one-way ANOVA followed by Tukey-Kramer multiple comparisons test. The test was considered to be significant at p&lt;0.05.</p><p><strong>Results</strong><strong>: </strong>The aqueous extract of <em>Centella asiatica</em> at a dose of 200 mg/kg has abolished tonic hind limb extension in 1 out of 6 animals in MES while there was no anticonvulsant action in PTZ convulsions. At a dose of 400 mg/kg body weight, the aqueous extract of <em>Centella asiatica</em> has shown a significant anticonvulsant effect against both MES and PTZ convulsions, where it has abolished tonic hind limb extension in 4 mice in MES method and in all 6 mices in PTZ method.</p><p><strong>Conclusion</strong><strong>: </strong>The aqueous extract of <em>Centella asiatica</em> showed efficacy in both MES and PTZ convulsions in mice at a dose of 400 mg/kg. Since the clinical correlates of MES seizures are tonic-clonic convulsions and correlates of PTZ seizures are absence seizures, the aqueous extract of <em>Centella asiatica</em> is likely to be useful in the treatment of tonic-clonic and absence seizures.</p>


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