scholarly journals Hairy cells to recognize a chronic leukemia

2021 ◽  
Author(s):  
Beatriz Nafría Jiménez
Keyword(s):  
Chronic Leukemia ◽  
Hairy Cells

Prolonged T1 Relaxation of the Hemopoietic Bone Marrow in Patients with Chronic Leukemia

1990 ◽  
Vol 31 (5) ◽  
pp. 445-448 ◽  
Author(s):  
K. E. Jensen ◽  
P. G. Sørensen ◽  
C. Thomsen ◽  
P. Christoffersen ◽  
O. Henriksen ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Chronic Leukemia ◽  
T1 Relaxation

scholarly journals Alterations in the phenotype of hairy cells during culture in the presence of PHA: requirement for T cells

Blood ◽  
1982 ◽  
Vol 59 (5) ◽  
pp. 895-899 ◽  
Author(s):  
CP Worman ◽  
PC Beverley ◽  
JC Cawley
Keyword(s):  
T Cells ◽  
Hairy Cell Leukemia ◽  
Mononuclear Cells ◽  
Cultured Cells ◽  
Phenotypic Change ◽  
Cell Contact ◽  
Hairy Cell ◽  
Cell Leukemia ◽  
Peripheral Blood Mononuclear ◽  
Hairy Cells

Abstract Culture studies of peripheral blood mononuclear cells from 7 entirely typical cases of hairy cell leukemia showed that after culture in the presence of PHA for 2--5 days, the predominant cell type changed from E- SIg+ CIg+ gamma FcR+ muFcR+ hairy cells to an E+ SIg- CIg- gamma FcR- muFcR- population of transformed cells derived from hairy cells. Depletion and readdition experiments demonstrated that cell-to-cell contact with T cells was necessary for the phenotypic change, while several observations indicated that the E+ population was not derived from T cells present before culture. The E positivity of the cultured cells was shown to be due to the possession of E receptor not acquired from the culture fluid, but the cells differed from true T cells in lacking both mature and immature T-cell antigens. The relevance of these in vitro observations to the continuing controversy concerning the nature of the hairy cell and to the in vivo fluctuations in immunologic phenotype not infrequently observed in hairy cell leukemia is briefly discussed.

scholarly journals Antileukemic Effect of Tualang Honey on Acute and Chronic Leukemia Cell Lines

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Nik Muhd Khuzaimi Nik Man ◽  
Rosline Hassan ◽  
Cheng Yong Ang ◽  
Abu Dzarr Abdullah ◽  
Muhammad Amiro Rasheeq Mohd Radzi ◽  
...  
Keyword(s):  
Cell Lines ◽  
Mononuclear Cell ◽  
Therapeutic Potential ◽  
Morphological Changes ◽  
Leukemia Cell ◽  
Chronic Leukemia ◽  
Human Mononuclear Cell ◽  
Leukemia Cell Lines ◽  
Antileukemic Effect ◽  
Tualang Honey

Complementary medicine using natural product as antitumor is on the rise. Much research has been performed on Tualang Honey and it was shown to have therapeutic potential in wound healing, and antimicrobial activity and be antiproliferative against several cancer models such as human osteosarcoma (HOS), human breast (MCF-7 and MDA-MB-231), and cervical (HeLa) cancer cell lines. To date, there was limited study on antileukemic properties of Tualang (Koompassia excelsa) Honey. The aim of this study was to evaluate the antileukemic effect of Tualang Honey on acute and chronic leukemia cell lines. Leukemia cell lines (K562 and MV4-11) and human mononuclear cell isolated from peripheral blood were grown in RPM1 1640 culture medium. The cells were incubated with increasing concentrations of Tualang Honey. After incubation, the evaluation of viability and apoptosis was performed. The morphological changes of leukemia cells were the presence of cytoplasmic blebs followed by apoptotic bodies and round shape of cells. IC50against K562 and MV4-11 was determined. Tualang Honey gave 53.9% and 50.6% apoptosis activity on K562 and MV4-11, respectively, while on human mononuclear cell it was 37.4%. Tualang Honey has the apoptosis-inducing ability for acute and chronic myeloid leukemia (K562 and MV4-11) cell lines.

Analysis of function of the pair-rule genes hairy, even-skipped and fushi tarazu in mosaic Drosophila embryos

Development ◽  
1989 ◽  
Vol 107 (4) ◽  
pp. 847-853 ◽  
Author(s):  
P.A. Lawrence ◽  
P. Johnston
Keyword(s):  
Genetic Interactions ◽  
Nuclear Transplantation ◽  
Fushi Tarazu ◽  
Segmentation Gene ◽  
Hairy Cells ◽  
Analysis Of Function ◽  
Mutant Cells ◽  
Pair Rule ◽  
Drosophila Embryos

We report the first attempt of its kind to study genetic interactions using young Drosophila embryos that are mosaic for wildtype and mutant cells. Using nuclear transplantation we make mosaic embryos in which a patch of cells lacks a particular segmentation gene, A. With antibodies, we than look at the expression of another gene that is known to be downstream of gene A, with respect to the cells in the patch. We have examples of patches of hairy cells (where we monitor the effect on fushi tarazu (ftz) expression), even-skipped (monitoring ftz) and ftz (monitoring engrailed and Ultrabithorax). Our main finding is that the dependence of engrailed expression on the ftz gene is strictly cell-autonomous. This result goes some way towards explaining the dependence of Ultrabithorax expression on ftz, a dependence we show to be locally cell-autonomous within parts of parasegments 6 and 8 but non autonomous within parasegment 7.

scholarly journals Structural and functional properties of the „hairy” cells of leukemic reticuloendotheliosis

Cancer ◽  
1978 ◽  
Vol 41 (1) ◽  
pp. 210-227 ◽  
Author(s):  
Raul C. Braylan ◽  
Elaine S. Jaffe ◽  
Timothy J. Triche ◽  
Koji Nanba ◽  
Betty J. Fowlkes ◽  
...  
Keyword(s):  
Functional Properties ◽  
Structural And Functional Properties ◽  
Hairy Cells

HAIRY CELLS OF LEUKÆMIC RETICULOENDOTHELIOSIS

The Lancet ◽  
1976 ◽  
Vol 308 (7975) ◽  
pp. 39 ◽  
Author(s):  
H.M. Golomb ◽  
R. Ganapathy
Keyword(s):  
Hairy Cells

scholarly journals Cell markers in hairy cell leukemia studied in cells from 51 patients

Blood ◽  
1982 ◽  
Vol 59 (1) ◽  
pp. 52-60 ◽  
Author(s):  
J Jansen ◽  
HR Schuit ◽  
CJ Meijer ◽  
JA van Nieuwkoop ◽  
W Hijmans
Keyword(s):  
Heavy Chain ◽  
Hairy Cell Leukemia ◽  
Lymphocytic Leukemia ◽  
Mature Stage ◽  
Hairy Cell ◽  
Cell Leukemia ◽  
Neoplastic Cells ◽  
Hairy Cells ◽  
Immunoglobulin Levels ◽  
Chain Type

Abstract To determine the maturation arrest of the neoplastic cells of hairy- cell leukemia (HCL) and the spectrum of the surface markers on these cells, a series of 51 patients with this disease was studied. The cells of all but two of the patients showed monoclonal surface Ig with respect to light chains. In about one-third of the cases, only gamma heavy chain determinants were present on the cells; the majority carried multiple heavy chain determinants as documented by the application of different fluorochromes. Two patients each showed two different clones of cells, both of the same light chain type. In one of these two patients, two paraproteins were present in the serum. Intracytoplasmic Ig was found in only 4 of 39 cases, in all instances being IgM. All cases studied concerned cells with FclgG receptors; however, the density of this receptor varied. FcIgM receptors also showed a spectrum of density, with some cases showing very few FcIgM- positive cells. Receptors C3 were not observed on the hairy cells. Serum immunoglobulin levels were normal or increased. Paraproteins were found in the sera of 4 of 38 patients. These data suggest that HCL is a neoplasm of B lymphocytes. The neoplastic cells are probably arrested at a more mature stage than the cells of chronic lymphocytic leukemia. The multiple isotypes on the cells indicate a block at the “switch” phase from the small micro-carrying lymphocyte to the larger Ig- producing lymphocyte or plasma cell.

Sign in / Sign up

Export Citation Format

Share Document