scholarly journals Development of Artificial Skin Using Keratin Film for Evaluation of Puncture Performance of Microneedle

2020 ◽  
Vol 32 (2) ◽  
pp. 351-361
Author(s):  
Ryo Nishino ◽  
Seiji Aoyagi ◽  
Masato Suzuki ◽  
Atsushi Ueda ◽  
Yuki Okumura ◽  
...  
Keyword(s):  
Stratum Corneum ◽  
Human Skin ◽  
Human Hair ◽  
Subcutaneous Tissue ◽  
Artificial Skin ◽  
Resistance Force ◽  
Stick Slip ◽  
Silicon Rubber ◽  
Animal Skin ◽  
Slip Phenomenon

Humans do not feel pain when bitten by mosquitos; therefore, we have attempted to develop a microneedle that mimics the puncturing mechanism of mosquitos. We have quantitatively evaluated the puncturing performance of the developed microneedle by puncturing an artificial skin made from polydimethylsiloxane (PDMS), a kind of silicon rubber. Unlike the mono-layered PDMS, however, animal skin including human skin is structured to have a hard stratum corneum, epidermis and dermis over soft subcutaneous tissue. In this paper, we propose an artificial skin having a two-layered hard/soft structure, constructed from PDMS with a human-hair-derived keratin film adhered onto the top surface. We evaluated the hardness of the keratin film (Young’s modulus) and found that it could qualitatively simulate the hard layers of the skin including the stratum corneum. The artificial skin we developed reproduced the following phenomena: the decrease in resistance force of animal skin at the point when the needle penetrates the surface followed by variation in resistance due to the stick-slip phenomenon as the needle penetrates more deeply.

Changes in corneocyte element concentrations occur in skin inner stratum corneum

1990 ◽  
Vol 48 (2) ◽  
pp. 146-147
Author(s):  
R. R. Warner
Keyword(s):  
Stratum Corneum ◽  
Human Skin ◽  
Element Concentration ◽  
Skin Barrier ◽  
Barrier Properties ◽  
Brick Wall ◽  
Inorganic Elements ◽  
Dry Skin ◽  
Skin Biopsies ◽  
Intercellular Lipid

Keratinocytes undergo maturation during their transit through the viable layers of skin, and then abruptly transform into flattened, anuclear corneocytes that constitute the cellular component of the skin barrier, the stratum corneum (SC). The SC is generally considered to be homogeneous in its structure and barrier properties, and is often shown schematically as a featureless brick wall, the “bricks” being the corneocytes, the “mortar” being intercellular lipid. Previously we showed the outer SC was not homogeneous in its composition, but contained steep gradients of the physiological inorganic elements Na, K and Cl, likely originating from sweat salts. Here we show the innermost corneocytes in human skin are also heterogeneous in composition, undergoing systematic changes in intracellular element concentration during transit into the interior of the SC.Human skin biopsies were taken from the lower leg of individuals with both “good” and “dry” skin and plunge-frozen in a stirred, cooled isopentane/propane mixture.

Preliminary Study on Stick-Slip in Drillstring With Analytical Model Expressed With Neutral Delay Differential Equation

2014 ◽  
Author(s):  
Tomoya Inoue ◽  
Tokihiro Katsui ◽  
Chang-Kyu Rheem ◽  
Zengo Yoshida ◽  
Miki Y. Matsuo
Keyword(s):  
Differential Equation ◽  
Analytical Model ◽  
Delay Differential Equation ◽  
Drill Bit ◽  
Neutral Delay ◽  
Stick Slip ◽  
Scientific Drilling ◽  
Neutral Delay Differential Equation ◽  
Delay Differential ◽  
Slip Phenomenon

Stick-slip is a major problem in offshore drilling because it may cause damage to the drill bit as well as crushing or grinding the sediment layer, which is crucial problem in scientific drilling because the purpose of the scientific drilling is to recover core samples from the layers. To mitigate stick-slip, first of all it is necessary to establish a model of the torsional motion of the drill bit and express the stick-slip phenomenon. Toward this end, the present study proposes a model of torsional waves propagating in a drillstring. An analytical model is developed and used to derive a neutral delay differential equation (NDDE), a special type of equation that requires time history, and an analytical model of stick-slip is derived for friction models between the drill bit and the layer as well as the rotation speed applied to the uppermost part of the drill string. In this study, the stick-slip model is numerically analyzed for several conditions and a time series of the bit motions is obtained. Based on the analytical results, the appearance of stick-slip and its severity are discussed. A small-scale model experiment was conducted in a water tank to observe the stick-slip phenomenon, and the result is discussed with numerical analysis. In addition, utilizing surface drilling data acquired from the actual drilling operations of the scientific drillship Chikyu, occurrence of stick-slip phenomenon is discussed.

Effect of laser-textured micro dimples on inhibition of stick-slip phenomenon of sliding guideway

2022 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Yonghong Fu ◽  
Jie Yang ◽  
Hao Wang ◽  
Yuyang He
Keyword(s):  
Hydrodynamic Lubrication ◽  
Textured Surface ◽  
Stick Slip ◽  
Content Type ◽  
Speed Range ◽  
Lubrication Condition ◽  
Micro Dimples ◽  
Pin On Disk ◽  
Micro Dimple ◽  
Slip Phenomenon

Purpose This study aims to investigate the efficacy of micro dimple in inhibiting stick-slip phenomenon on the sliding guideway. Design/methodology/approach In this study, micro-dimples were fabricated by laser on surfaces of steel disk and guideway. The disks and guideways were respectively performed pin-on-disk tribological tests and working condition experiments to study differences in lubrication condition and friction stability between textured and untextured surfaces. Findings Micro-dimples help reduce critical sliding speed that allows contact surfaces to enter in hydrodynamic lubrication regime. This increases hydrodynamic lubrication range and narrows speed range where stick-slip phenomenon can occur, enhancing sliding guideway’s adaptability for broader working conditions. Furthermore, friction stability on the textured surface improved, lowering the occurrence possibility of stick-slip phenomenon. Finally, difference between static and kinetic frictions on the textured surface is lower relative to the untextured surface, which decreases the critical velocity when the stick-slip phenomenon occurs. Originality/value The results indicate that laser-textured micro-dimples are significantly conducive to inhibit stick-slip phenomenon, thus providing smoother movement for the guideway and eventually increasing precision of the machine.

3D Printing of Artificial Skin Patches with Bioactive and Optically Active Polymer Materials for Anti-Infection and Augmenting Wound Repair

2021 ◽  
Author(s):  
Hao Zhao ◽  
Jingwen Xu ◽  
Haitao Yuan ◽  
Endong Zhang ◽  
Nan Dai ◽  
...  
Keyword(s):  
3D Printing ◽  
Human Skin ◽  
Wound Repair ◽  
Optically Active ◽  
The Body ◽  
Polymer Materials ◽  
Artificial Skin ◽  
Optically Active Polymer ◽  
Cell Affinity

Inspired by the skin biofunction of protecting the body from microorganism invasion, artificially manufacturing human skin in vitro with promising antibacterial capability and cell affinity is urgently required in wound...

Enhanced optical clearing of human skin at topical application of immersion agents to stratum corneum pretreated by a lattice-like photothermal ablation

2006 ◽  
Author(s):  
Valery V. Tuchin ◽  
Gregory B. Altshuler ◽  
Anna A. Gavrilova ◽  
Alexander B. Pravdin ◽  
David Tabatadze ◽  
...  
Keyword(s):  
Stratum Corneum ◽  
Human Skin ◽  
Topical Application ◽  
Optical Clearing ◽  
Photothermal Ablation

Human Skin Binding and Absorption of Contaminants from Ground and Surface Water During Swimming and Bathing

1989 ◽  
Vol 8 (5) ◽  
pp. 853-859 ◽  
Author(s):  
Ronald C. Wester ◽  
Howard I. Maibach
Keyword(s):  
Surface Water ◽  
Stratum Corneum ◽  
Human Skin ◽  
The Body ◽  
Water Soluble ◽  
Exposure Effect ◽  
Human Stratum Corneum ◽  
Water Dilution

Contaminants exist in ground and surface water. Human skin has the capacity to bind and then absorb these contaminants into the body during swimming and bathing. Powdered human stratum corneum will bind both lipid-soluble (alachlor, polychlorinated biphenyls [PCBs], benzene) and water-soluble (nitroaniline) chemicals. In vitro (human skin) and in vivo (Rhesus monkey) studies show that these chemicals readily distribute into skin, and then some of the chemical is absorbed into the body. Linearity in binding and absorption exists for nitroaniline over a 10-fold concentration range. Multiple exposure to benzene is at least cumulative. Binding and absorption can be significant for exposures as short as 30 min, and will increase with time. Absorption with water dilution increased for alachlor, but not for dinoseb. Soap reversed the partitioning of alachlor between human stratum corneum and water. The PCBs could be removed from skin by soap and water (70% efficiency) for up to 3 h and then decontamination potential decreased, due to continuing skin absorption. The model in vitro and in vivo systems used should permit easy estimation of this area of extensive human exposure effect on risk assessment.

scholarly journals FRICTION ANALYSIS IN CASE OF THE CARRIAGE- FEED SHAFT CINEMATIC COUPLING AT CNC LATHE

2020 ◽  
Vol 7 (5) ◽  
pp. 30-37
Author(s):  
Daniel Popescu
Keyword(s):  
Mathematical Model ◽  
Rational Design ◽  
Normal Force ◽  
Stick Slip ◽  
Disturbing Force ◽  
Dimensional Precision ◽  
Cnc Lathe ◽  
Elastic Systems ◽  
Friction Analysis ◽  
Slip Phenomenon

The paper presents a mathematical model for analysis of friction between the tool bearing saddle and conductor at CNC lathe. The analysis of longitudinal advance movement laws is performed taking into account the appearance and development of disturbing harmonic forces created by auto-vibrations determined by the interaction between the partial elastic systems of tool and workpiece. The friction force is emphasized as product of two components depending on the sliding speed and on the normal disturbing force. By establishing the dynamic response of the system, when the normal force depends linearly on speed, acceleration and mobile ensemble position, the premises are created for stability analysis of the friction movement, obtaining the limit speeds under which the stick-slip phenomenon occurs. Thus, it is provided for a rational design of CNC lathe elastic structure, in order to improve the surface quality and the dimensional precision.

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