scholarly journals THE ADVANCED TACTICS OF THE MANAGEMENT OF PATIENTS WITH VENOUS THROMBOEMBOLISM: THE ROLE OF RIVAROXABAN AT VARIOUS STAGES OF TREATMENT

2016 ◽  
Vol 12 (3) ◽  
pp. 337-343
Author(s):  
S. R. Gilyarevskiy
Keyword(s):  
Venous Thromboembolism

scholarly journals Inflammatory Biomarkers in the Short-Term Prognosis of Venous Thromboembolism: A Narrative Review

2021 ◽  
Vol 22 (5) ◽  
pp. 2627
Author(s):  
Francisco Galeano-Valle ◽  
Lucía Ordieres-Ortega ◽  
Crhistian Mario Oblitas ◽  
Jorge del-Toro-Cervera ◽  
Luis Alvarez-Sala-Walther ◽  
...  
Keyword(s):  
Venous Thromboembolism ◽  
Risk Stratification ◽  
Hemodynamic Instability ◽  
Inflammatory Biomarkers ◽  
Right Ventricle Dysfunction ◽  
Reactive Protein ◽  
Cancer Associated Thrombosis ◽  
The Relationship ◽  
Acute Pe

The relationship between inflammation and venous thrombosis is not well understood. An inflammatory response may be both the cause and consequence of venous thromboembolism (VTE). In fact, several risk factors of VTE modulate thrombosis through inflammatory markers. Acute pulmonary embolism (PE) is burdened by a remarkable mortality rate, up to 34% in severely ill patients presenting with hemodynamic instability. Initial mortality risk stratification is based on hemodynamic instability. Patients with a situation of hemodynamic stability require immediate further risk assessment based on clinical, imaging, and circulating biomarkers, as well as the presence of comorbidities. Some inflammatory biomarkers have shown potential usefulness in the risk stratification of patients with VTE, especially acute PE. C-reactive protein on admission is associated with 30-day mortality and bleeding in VTE patients. P-selectin is associated with right ventricle dysfunction in PE patients and might be associated with VTE recurrences and the extension of thrombosis. Tissue factor microparticles are associated with VTE recurrence in cancer-associated thrombosis. Other inflammatory biomarkers present scarce evidence (inflammatory cytokines, erythrocyte sedimentation rate, fibrinogen, leukocyte count). In this manuscript, we will review the prognostic role of different inflammatory biomarkers available both for clinical practice and research in VTE patients.

High frequency of factor V Leiden in surgical patients with symptomatic venous thromboembolism despite prophylaxis

2007 ◽  
Vol 97 (02) ◽  
pp. 171-175 ◽  
Author(s):  
Mohamed Baba-Ahmed ◽  
Grégoire Le Gal ◽  
Francis Couturaud ◽  
Karine Lacut ◽  
Emmanuel Oger ◽  
...  
Keyword(s):  
Venous Thromboembolism ◽  
Close Association ◽  
Factor V Leiden ◽  
Plaster Cast ◽  
Case Control ◽  
Factor V ◽  
Potential Significance ◽  
Control Study ◽  
Fvl Mutation

SummaryAmong candidate risk factors associated with postoperative venous thromboembolism (VTE), the role of factorV Leiden (FVL) mutation remains unclear. We performed a case-control study to assess the potential significance of FVL mutation in postoperative VTE cases despite prophylaxis. We used data from the ongoing case-control “EDITH” study. We extracted 133VTE cases and 144 controls who had undergone either surgery or had plaster cast in the previous three months. Prophylaxis adequacy with regard to the recommendations published by theAmerican College of Chest Physicians was retrospectively assessed. FVL mutation was present in 20VTE cases and four controls (OR 5.9, 95% CI 2–18). Prophylaxis was judged as adequate in 116 cases (88.5 %) and in 129 controls (87.2 %) (p = 0.66). The frequency of FVL mutation was not different in VTE cases occurring while on adequate prophylaxis and in VTE cases occurring after the end of adequate prophylaxis (p = 0.27). FVL mutation was closely associated with postoperative VTE in patients classified as having received an adequate prophylaxis (8.4; 95% CI, 2.4 to 29). This study shows a close association between the presence of factorV Leiden mutation in symptomaticVTE occurring after surgery despite prophylaxis.

scholarly journals Regular Physical Activity and Risk of Venous Thromboembolism

2018 ◽  
Vol 44 (08) ◽  
pp. 765-779 ◽  
Author(s):  
Sigrid Brækkan ◽  
John-Bjarne Hansen ◽  
Line Evensen
Keyword(s):  
Physical Activity ◽  
Venous Thromboembolism ◽  
Current Knowledge ◽  
Objective Assessment ◽  
Operational Definition ◽  
Assessment Method ◽  
Health Concern ◽  
Future Research ◽  
Dependent Manner

AbstractVenous thromboembolism (VTE) is a complex multifactorial disease that represents a growing public health concern. Identification of modifiable risk factors at the population level may provide a measure to reduce the burden of VTE. In this review, we summarize current knowledge of the role of physical activity on the risk of VTE and VTE-related complications. We also discuss methodological challenges related to research on physical activity, and put forward plausible mechanisms for an association between physical activity and VTE. Up to now, published studies have reported diverging results on the relationship between physical activity and VTE, and a complex picture has emerged. However, the available evidence appears to be balanced toward a small beneficial effect of physical activity on the risk of incident VTE, but not in a dose-dependent manner. Still, the lack of an operational definition and standardized assessment method for physical activity, as well as several sources of bias, impairs the interpretation of the available literature. Additional work is necessary to understand the role and how to apply physical activity in the VTE setting. Future research should utilize objective assessment strategies of physical activity and physical fitness, account for the fluctuating nature in habitual activity levels, and explore the role of physical activity in the areas of secondary prevention and VTE-related complications.

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