Analysis of the relationship between serum amyloid protein A, procalcitonin, C-reactive protein, and peripherally inserted central catheter infection in patients with malignant tumor

Abstract We examined serum amyloid protein A (SAA) and C-reactive protein (CRP) as inflammatory markers of viral and bacterial infections. Both acute-phase reactants increased in the acute stage and thereafter decreased in the convalescent stage. In viral infections, the mean serum concentrations of SAA during the acute stage were 141 mg/L in infections with adenovirus, 77 mg/L with measles virus, 63 mg/L with influenza virus, 55 mg/L with parainfluenza virus, 31 mg/L with respiratory syncytial virus, and 31 mg/L in aseptic meningitis. The mean serum concentration of CRP was 19 mg/L for adenovirus infection and < 7 mg/L in all other viral infections. The SAA concentrations were 5- to 11-fold greater than the CRP concentrations. Both the SAA and the CRP concentrations were higher in bacterial infections than in viral infections. Changes in the concentrations of serum SAA paralleled those in serum CRP in bacterial infection; during the course of viral infection, however, serum SAA tended to disappear more quickly than CRP did. SAA appears to be a clinically useful marker of inflammation in acute viral infections, with or without significant changes in the CRP concentration.

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Serum Amyloid a Protein and C-Reactive Protein — a Comparison of Serum Levels in Cancer and Non-Malignant Disease

Protides of the Biological Fluids ◽

10.1016/b978-0-08-030764-0.50085-9 ◽

1984 ◽

pp. 375-378

Author(s):

J.G. RAYNES ◽

E.H. COOPER

Keyword(s):

Malignant Disease ◽

Serum Amyloid A ◽

Protein A ◽

Serum Levels ◽

Serum Amyloid ◽

C Reactive Protein ◽

Reactive Protein ◽

Amyloid A ◽

Serum Amyloid A Protein

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Analysis clinical features of COVID-19 infection in secondary epidemic area and report potential biomarkers in evaluation

10.1101/2020.03.10.20033613 ◽

2020 ◽

Author(s):

Weiping Ji ◽

Gautam Bishnu ◽

Zhenzhai Cai ◽

Xian Shen

Keyword(s):

Respiratory Tract ◽

Serum Amyloid ◽

Diagnosis And Treatment ◽

Amyloid Protein ◽

C Reactive Protein ◽

Reactive Protein ◽

Epidemic Area ◽

Systemic Symptoms ◽

Novel Coronavirus ◽

Potential Biomarkers

AbstractObjectiveBased on the clinical characteristics of infected patients with novel coronavirus in secondary epidemic areas, we aimed to identify potential biomarkers for the evaluation of novel coronavirus-infected patients, guide the diagnosis and treatment of this disease in secondary epidemic areas and provide a reference for the clinical prevention and control of this epidemic situation.MethodsThe clinical data of 33 patients with respiratory symptoms caused by the novel coronavirus in Wenzhou city from January 15 to February 12, 2020, were thoroughly reviewed. At the onset of the disease, we found that the primary symptoms were fever, cough, fatigue, chest tightness, chest pain and specific blood test results. According to the patients’ histories, the patients were divided into two groups: those who spent time in the main epidemic area and those who did not spend time in the main epidemic area. The differences in the clinical manifestations between these two groups were analyzed.ResultsThe main clinical symptoms of patients infected with novel coronavirus in the secondary epidemic area were respiratory tract ailments and systemic symptoms. After grouping patients based on the presence or absence of residency in or travel history to the main epidemic area, there was no significant difference between the baseline data of these two groups, and there were no significant differences in symptoms and signs between the two groups (P>0.05). Some patients had abnormally increased serum amyloid protein A (SAA). There were statistically significant differences in the leukocyte count/C-reactive protein, monocyte ratio/C-reactive protein, neutrophil count/C-reactive protein, monocyte count/C-reactive protein and hemoglobin/C-reactive protein values between the two groups (P < 0.05).ConclusionRespiratory tract ailments and systemic symptoms were the primary symptoms of novel coronavirus infection in the secondary epidemic area; these symptoms are not typical. The abnormal increase in serum amyloid protein (SAA) may be used as an auxiliary index for diagnosis and treatment. CRP changes before other blood parameters and thus may be an effective evaluation index for patients with COVID-19 infection.

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Randomized controlled trials investigating the relationship between dietary pattern and high-sensitivity C-reactive protein: a systematic review

Nutrition Reviews ◽

10.1093/nutrit/nuz003 ◽

2019 ◽

Vol 77 (6) ◽

pp. 363-375 ◽

Cited By ~ 5

Author(s):

Courtney K Pickworth ◽

David A Deichert ◽

Jamie Corroon ◽

Ryan D Bradley

Keyword(s):

Systematic Review ◽

Randomized Controlled Trials ◽

Dietary Pattern ◽

Protein A ◽

High Sensitivity ◽

Controlled Trials ◽

C Reactive Protein ◽

Reactive Protein ◽

Randomized Controlled ◽

The Relationship

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Analysis clinical features of COVID-19 infection in secondary epidemic area and report potential biomarkers in evaluation

10.21203/rs.3.rs-16658/v1 ◽

2020 ◽

Cited By ~ 2

Author(s):

Weiping Ji ◽

Gautam Bishnu ◽

Xian Shen ◽

Zhenzhai Cai

Keyword(s):

Respiratory Tract ◽

Serum Amyloid ◽

Diagnosis And Treatment ◽

Amyloid Protein ◽

C Reactive Protein ◽

Reactive Protein ◽

Epidemic Area ◽

Systemic Symptoms ◽

Novel Coronavirus ◽

Potential Biomarkers

Abstract Objective: Based on the clinical characteristics of infected patients with novel coronavirus in secondary epidemic areas, we aimed to identify potential biomarkers for the evaluation of novel coronavirus-infected patients, guide the diagnosis and treatment of this disease in secondary epidemic areas and provide a reference for the clinical prevention and control of this epidemic situation.Methods: The clinical data of 33 patients with respiratory symptoms caused by the novel coronavirus in Wenzhou city from January 15 to February 12, 2020, were thoroughly reviewed. At the onset of the disease, we found that the primary symptoms were fever, cough, fatigue, chest tightness, chest pain and specific blood test results. According to the patients’ histories, the patients were divided into two groups: those who spent time in the main epidemic area and those who did not spend time in the main epidemic area. The differences in the clinical manifestations between these two groups were analyzed.Results: The main clinical symptoms of patients infected with novel coronavirus in the secondary epidemic area were respiratory tract ailments and systemic symptoms. After grouping patients based on the presence or absence of residency in or travel history to the main epidemic area, there was no significant difference between the baseline data of these two groups, and there were no significant differences in symptoms and signs between the two groups (P>0.05). Some patients had abnormally increased serum amyloid protein A (SAA). There were statistically significant differences in the leukocyte count/C-reactive protein, monocyte ratio/C-reactive protein, neutrophil count/C-reactive protein, monocyte count/C-reactive protein and hemoglobin/C-reactive protein values between the two groups (P < 0.05).Conclusion: Respiratory tract ailments and systemic symptoms were the primary symptoms of novel coronavirus infection in the secondary epidemic area; these symptoms are not typical. The abnormal increase in serum amyloid protein (SAA) may be used as an auxiliary index for diagnosis and treatment. CRP changes before other blood parameters and thus may be an effective evaluation index for patients with COVID-19 infection.

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Investigating interactions of the pentraxins serum amyloid P component and C-reactive protein by mass spectrometry

Biochemical Journal ◽

10.1042/bj20030541 ◽

2003 ◽

Vol 375 (2) ◽

pp. 323-328 ◽

Cited By ~ 22

Author(s):

J. Andrew AQUILINA ◽

Carol V. ROBINSON

Keyword(s):

Protein A ◽

Serum Amyloid ◽

C Reactive Protein ◽

Oligomeric State ◽

Amyloid P Component ◽

Reactive Protein ◽

Serum Amyloid P ◽

Serum Amyloid P Component ◽

Amyloid P

The oligomeric state of human SAP (serum amyloid P component) in the absence and presence of known ligands has been investigated using nanoelectrospray ionization MS. At pH 8.0, in the absence of Ca2+, SAP has been shown to consist of pentameric and decameric forms. In the presence of physiological levels of Ca2+, SAP was observed to exist primarily as a pentamer, reflecting its in vivo state. dAMP was shown not only to promote decamerization, but also to lead to decamer stacking involving up to 30 monomers. A mechanism for this finding is proposed. CRP (C-reactive protein), a pentraxin closely related to SAP, exists as a pentamer in the presence or absence of Ca2+. Pentamers of CRP and SAP were shown to form mixed decamers in Ca2+-free buffer; however, in the presence of Ca2+, this interaction was not observed. Furthermore, no exchange of monomeric subunits was observed between the SAP and CRP oligomers, suggesting a remarkable stability of the individual pentameric complexes.

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THE RELATIONSHIP BETWEEN THE ACUTE PHASE RESPONSE AND ANTIBODY PRODUCTION IN THE RABBIT

Journal of Experimental Medicine ◽

10.1084/jem.98.4.311 ◽

1953 ◽

Vol 98 (4) ◽

pp. 311-319 ◽

Cited By ~ 17

Author(s):

Harrison F. Wood

Keyword(s):

Acute Phase ◽

Antibody Production ◽

Acute Phase Response ◽

Gamma Globulin ◽

Protein A ◽

Phase Response ◽

C Reactive Protein ◽

Reactive Protein ◽

Human Gamma Globulin ◽

The Relationship

It has been found that some rabbits respond to the administration of either human C-reactive protein or human gamma globulin with the production of an acute phase substance, Cx-reactive protein. A correlation was found to exist between the amount of Cx-protein produced and the subsequent production of significant titers of precipitating antibody to the two antigens employed.

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