scholarly journals 3'-daidzein sulfonate protects myocardial cells from hypoxic-ischemic injury via the NRF2/HO-1 signaling pathway

2021 ◽  
Vol 13 (12) ◽  
pp. 6897-6910
Author(s):  
Xueliang Zeng ◽  
Junjian Yu ◽  
Taohui Zeng ◽  
Yuan Liu ◽  
Bei Li
Keyword(s):  
Signaling Pathway ◽  
Ischemic Injury ◽  
Myocardial Cells ◽  
Hypoxic Ischemic Injury

Neuroprotection of hypoxic/ischemic preconditioning in neonatal brain with hypoxic-ischemic injury

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Xue Fan ◽  
Huiqing Wang ◽  
Li Zhang ◽  
Jun Tang ◽  
Yi Qu ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Ischemic Preconditioning ◽  
Hypoxia Inducible Factor ◽  
Ischemic Injury ◽  
Neonatal Brain ◽  
Protective Mechanisms ◽  
Promote Cell Proliferation ◽  
Vascular Regulation ◽  
Hypoxia Ischemia ◽  
Hypoxic Ischemic Injury

AbstractThe neonatal brain is susceptible to hypoxic-ischemic injury due to its developmental characteristics. Hypoxia-ischemia means a decreased perfusion of oxygen and glucose, which can lead to severe encephalopathy. Although early initiation of therapeutic hypothermia was reported to provide neuroprotection for infants after HI, hypothermia administered alone after the acute insult cannot reverse the severe damage that already has occurred or improve the prognosis of severe hypoxic-ischemic encephalopathy. Therefore, exploring new protective mechanisms for treating hypoxic-ischemic brain damage are imperative. Until now, many studies reported the neuroprotective mechanisms of hypoxic/ischemic preconditioning in protecting the hypoxic-ischemic newborn brains. After hypoxia and ischemia, hypoxia-inducible factor signaling pathway is involved in the transcriptional regulation of many genes and is also play a number of different roles in protecting brains during hypoxic/ischemic preconditioning. Hypoxic/ischemic preconditioning could protect neonatal brain by several mechanisms, including vascular regulation, anti-apoptosis, anti-oxidation, suppression of excitotoxicity, immune regulation, hormone levels regulation, and promote cell proliferation. This review focused on the protective mechanisms underlying hypoxic/ischemic preconditioning for neonatal brain after hypoxia-ischemia and emphasized on the important roles of hypoxia inducible factor 1 signaling pathway.

scholarly journals Prostaglandin D2 Protects Neonatal Mouse Brain from Hypoxic Ischemic Injury

2007 ◽  
Vol 27 (16) ◽  
pp. 4303-4312 ◽  
Author(s):  
H. Taniguchi ◽  
I. Mohri ◽  
H. Okabe-Arahori ◽  
K. Aritake ◽  
K. Wada ◽  
...  
Keyword(s):  
Mouse Brain ◽  
Ischemic Injury ◽  
Neonatal Mouse ◽  
Prostaglandin D2 ◽  
Hypoxic Ischemic Injury

Oxytocin mediates neuroprotection against hypoxic-ischemic injury in hippocampal CA1 neuron of neonatal rats

2021 ◽  
Vol 187 ◽  
pp. 108488
Author(s):  
Zhihong Wu ◽  
Changning Xie ◽  
Haixia Kuang ◽  
Jian Wu ◽  
Xiao Chen ◽  
...  
Keyword(s):  
Ischemic Injury ◽  
Neonatal Rats ◽  
Hippocampal Ca1 ◽  
Hypoxic Ischemic Injury

scholarly journals Artemether confers neuroprotection on cerebral ischemic injury through stimulation of the Erk1/2-P90rsk-CREB signaling pathway

Redox Biology ◽  
2021 ◽  
pp. 102069
Author(s):  
Shuai Li ◽  
Tangming Peng ◽  
Xia Zhao ◽  
Marta Silva ◽  
Linlin Liu ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Ischemic Injury ◽  
Cerebral Ischemic Injury ◽  
Cerebral Ischemic ◽  
Stimulation Of
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