Background: Post-operative nausea and vomiting (PONV) is quite associated with laparoscopic surgery. In-spite of advances in surgery and post
surgical care, nausea and vomiting still has a high incidence. This study was planned to explore the efcacy of a combination therapy of
ondansetron with dexamethasone against PONVand compare the results with the efcacy of ondensetron-only.
Method:Arandomized clinical trial study was conducted in the Department of Anesthesia, GMC Jammu, over a period of 6 months, on 50 patients
in the age group of 18-50 years, of either gender, undergoing laparoscopic surgeries under general anesthesia. Patients were divided into two groups
of 25 each: Group A received 4 mg of Ondansetron intravenously, while Group B received 4 mg of Ondansetron and 8 mg of Dexamethasone
intravenously, soon after intubation.
Results: The demographic variables of two groups were similar. While 19 (76%) patients showed post-operative nausea in Group A, while in
Group B, only 8 (32%) patients experienced nausea, which was very signicant. Similarly, 11 (44%) patients showed post-operative vomiting in
GroupAand only 2 (8%) complained of vomiting. 24% patients did not complain about any kind of nausea or vomiting in GroupA. Mild nausea was
observedin60%patientsinGroupA,while amongonly32%patientsingroupB.Nocomplications of anykindwereobservedduringthisstudy.
Conclusion: Ondensetron and dexamethasone, administered intravenously, after intubation, in laparoscopic surgery, is safe and has a better patient
response in preventing post-operative nausea and vomiting.
DEXAMETHASONE, METOCLOPRAMIDE, AND THEIR COMBINATION FOR THE PREVENTION OF POSTOPERATIVE NAUSEA AND VOMITING IN FEMALE PATIENTS WITH MODERATE-TO-HIGH RISK FOR PONV UNDERGOING LAPAROSCOPIC SURGERY