A50 A COMPARISON OF BOLUS DROPERIDOL, METOCLOPRAMIDE, ONDANSETRON AND PROPOFOL ON POST OPERATIVE NAUSEA AND VOMITING FOLLOWING OUTPATIENT LAPAROSCOPIC SURGERY

1997 ◽  
Vol 87 (Supplement) ◽  
pp. 50A ◽  
Author(s):  
Robert D'Angelo ◽  
Marilyn Goldstein ◽  
J.C. Gerancher ◽  
Medge Owen
Keyword(s):  
Laparoscopic Surgery ◽  
Nausea And Vomiting ◽  
Post Operative Nausea

Low-dose haloperidol prevents post-operative nausea and vomiting after ambulatory laparoscopic surgery

2008 ◽  
Vol 52 (2) ◽  
pp. 280-284 ◽  
Author(s):  
T. F. WANG ◽  
Y. H. LIU ◽  
C. C. CHU ◽  
J. P. SHIEH ◽  
J. I. TZENG ◽  
...  
Keyword(s):  
Laparoscopic Surgery ◽  
Low Dose ◽  
Nausea And Vomiting ◽  
Post Operative Nausea

RANDOMIZED COMPARATIVE STUDY OF ONDANSETRON AND COMBINATION OF ONDANSETRON AND DEXAMETHASONE, AS A PROPHYLAXIS OF POST-OPERATIVE NAUSEAAND VOMITING IN ADULTS UNDERGOING ELECTIVE LAPAROSCOPIC SURGERIES

2021 ◽  
pp. 48-49
Author(s):  
Rumani Ruku ◽  
Jasmeen Chowdhary
Keyword(s):  
Laparoscopic Surgery ◽  
Surgical Care ◽  
Demographic Variables ◽  
Nausea And Vomiting ◽  
Age Group ◽  
Patient Response ◽  
High Incidence ◽  
Group A ◽  
Group B ◽  
Post Operative Nausea

Background: Post-operative nausea and vomiting (PONV) is quite associated with laparoscopic surgery. In-spite of advances in surgery and post surgical care, nausea and vomiting still has a high incidence. This study was planned to explore the efcacy of a combination therapy of ondansetron with dexamethasone against PONVand compare the results with the efcacy of ondensetron-only. Method:Arandomized clinical trial study was conducted in the Department of Anesthesia, GMC Jammu, over a period of 6 months, on 50 patients in the age group of 18-50 years, of either gender, undergoing laparoscopic surgeries under general anesthesia. Patients were divided into two groups of 25 each: Group A received 4 mg of Ondansetron intravenously, while Group B received 4 mg of Ondansetron and 8 mg of Dexamethasone intravenously, soon after intubation. Results: The demographic variables of two groups were similar. While 19 (76%) patients showed post-operative nausea in Group A, while in Group B, only 8 (32%) patients experienced nausea, which was very signicant. Similarly, 11 (44%) patients showed post-operative vomiting in GroupAand only 2 (8%) complained of vomiting. 24% patients did not complain about any kind of nausea or vomiting in GroupA. Mild nausea was observedin60%patientsinGroupA,while amongonly32%patientsingroupB.Nocomplications of anykindwereobservedduringthisstudy. Conclusion: Ondensetron and dexamethasone, administered intravenously, after intubation, in laparoscopic surgery, is safe and has a better patient response in preventing post-operative nausea and vomiting.

scholarly journals Post-operative nausea and vomiting after gynecologic laparoscopic surgery: comparison between propofol and sevoflurane

2011 ◽  
Vol 60 (1) ◽  
pp. 36 ◽  
Author(s):  
Helen Ki Shinn ◽  
Mi Hyeon Lee ◽  
Sin Yeong Moon ◽  
Sung-Il Hwang ◽  
Choon Soo Lee ◽  
...  
Keyword(s):  
Laparoscopic Surgery ◽  
Nausea And Vomiting ◽  
Post Operative Nausea

Comparison of Dexamethasone with Ondansetron for Prevention of Post-Operative Nausea and Vomiting

2021 ◽  
Vol 15 (11) ◽  
pp. 3464-3466
Author(s):  
Nazeer Ahmed ◽  
Muhammad Arif Baloch ◽  
Muhammad Sharif ◽  
Zafar ullah ◽  
Yasir Reda Toble
Keyword(s):  
Laparoscopic Surgery ◽  
Tertiary Care ◽  
Cost Effective ◽  
Nausea And Vomiting ◽  
P Value ◽  
Care Hospital ◽  
Group I ◽  
Anesthesia Group ◽  
Cost Effective Alternative ◽  
Post Operative Nausea

Objective: To examine the effectiveness of dexamethasone and ondansetron in reducing the incidence of post-operative nausea and vomiting (PONV) in patients following laparoscopic surgery. Patients and Methods: A total number of 100 patients who were planned for laparoscopic surgery under general anesthesia having age 20-60 years were included in this study from a tertiary care hospital from Dec-2019 to June-2021. Patients were divided in to two group using Draw randomization technique. Group I; in these patients IV dexamethasone 8 mg was given at the time of induction of anesthesia. Group II; in these patients Ondansetron (4 mg IV) was given at induction of anesthesia. After completing the surgery and shifting the patient to the recovery room frequency of PONV within 6 hours after surgery was noted. Results: Mean age of the patients was 43.31±10.41 years. There were 54 (54.00%) male patients and 46 (46.00%) female patients. There were 75 (75.00%) patients with ASA I and 25 (25.00%) patients with ASA II. PONV occurred in 11 (22.00%) patients in dexamethasone group and in 21 (42.00%) patients in ondansetron group (p-value 0.03). Conclusion: After laparoscopic surgery, dexamethasone decreased the prevalence of nausea and vomiting. A single dosage of dexamethasone was proven to be a safe and cost-effective alternative to a single dose of ondansetron. Keywords: Dexamethasone, Ondansetron, post-operative Nausea and vomiting.

scholarly journals Comparison of Dexamethasone and Ondansetrone Use in Prevention of Post-operative Nausea and Vomiting

2021 ◽  
pp. 279-286
Author(s):  
Shakil Alam ◽  
Haris Rashid ◽  
Sagufta Khan ◽  
Mir Arsalan Ali ◽  
Obaidul Haseeb ◽  
...  
Keyword(s):  
Single Dose ◽  
Laparoscopic Surgery ◽  
Nausea And Vomiting ◽  
P Value ◽  
Chi Square ◽  
Common Procedure ◽  
Quasi Experimental ◽  
Chi Square Test ◽  
Risk Patients ◽  
Post Operative Nausea

Background: PONV remained the common cause of patient’s discomfort after anaesthesia 30% in all post-surgical patients and 80% in high-risk patients. With other common and serious complications of surgeries vomiting and nausea remained unpleasant trigger for patients who underwent the surgeries that prolongs the hospital stay and also leads to recurrent admissions. Therefore in this study we want to compare the effectiveness of pre-operative single-dose dexamethasone versus ondansetron in reducing post-operative nausea and vomiting after laparoscopic surgeries. Methods: Patients admitted for laparoscopic procedures at Ziauddin Hospital North site were recruited for this quasi-experimental study. All consecutive patients were assigned to one of the two groups (1 or 2) using computer generated simple randomised numbers and given either of the two treatments: single dose dexamethasone (5-8mg) or ondansetron (4mg). Researcher assessed post-operative nausea and vomiting at thirty minutes, two, four, eight, and twenty-four hours after the procedure. For statistical association the chi-square test and independent t-test were applied. Significant was defined as a P-value of less than 0.05. Results: The mean age of patients was 42.9±16.6years with mean weight of 62.9±8.8 kilograms. All the operation performed as laparoscopic and common procedure was cholecystectomy (72/98: 73.5%), followed by appendectomy (17/98: 17.3%). Patients with ondansetron had more episodes of vomiting after 30 minutes of laparoscopic surgery. In addition, we discovered a correlation between the two groups' nausea episodes 30 minutes after surgery. After 30 minutes of laparoscopic surgery, patients who took ondansetron reported more nausea episodes. Conclusion:  Prophylactic dexamethasone 8 mg i.v. significantly reduced the incidence of PONV in patients undergoing laparoscopic surgery.

scholarly journals A Randomized, Double Blind Study to Evaluate the Efficacy of Palonosetron with Dexamethasone Versus Palonosetron Alone for Prevention of Post-Operative Nausea and Vomiting in Subjects Undergoing Bariatric Surgeries with High Emetogenic Risk

2013 ◽  
Vol 7 (1) ◽  
pp. 30-36 ◽  
Author(s):  
S. Didehvar ◽  
J.D. Viola-Blitz ◽  
M. Haile ◽  
L. Franco ◽  
R. Kline ◽  
...  
Keyword(s):  
Laparoscopic Surgery ◽  
Combination Therapy ◽  
Nausea And Vomiting ◽  
Ordinal Scale ◽  
Double Blind Study ◽  
Time Intervals ◽  
Double Blind ◽  
Duration Of Action ◽  
Low Incidence ◽  
Post Operative Nausea

Introduction: Postoperative (PONV) and postdischarge (PDNV) nausea and vomiting are common (60-70%) after bariatric surgery. Palonosetron (Pal), a novel 5-HT3 antagonist, is an effective antiemetic with a prolonged duration of action in the setting of PDNV. We hypothesized that combination therapy with Palonosetron (Pal) and dexamethasone (Dex) would improve treatment in comparison to Palonosetron alone in patients at high risk for PONV. Methods: In this study, patients undergoing bariatric laparoscopic surgery under general anesthesia, a subgroup of a larger Phase IV clinical trial of patients who had laparoscopic surgery, were randomized to 8 mg Dex + 0.075mg Pal or saline + 0.075mg Pal. Data was collected postoperatively at 2, 6, 24 and 72 hrs. A Functional Living Index-Emesis (QOL-FLIE) test was administered at 96 hrs. Results: We enrolled 76 ASA 1-2 patients with at least 3 PONV risk factors. Both randomization groups had a low incidence of vomiting in the PACU (Pal, 0.0%; Pal + Dex, 5.4%) as well as at 72 hours (0.0% both groups). Complete response (no vomiting, no rescue medication) was not different between treatment groups at any time intervals. Cumulative success rates over the entire 72 hrs were 60.4% (Pal alone) vs. 60.0% (Pal + Dex). Nausea scores (4 point ordinal scale) were not different between groups for any time intervals. Cumulative success scores for nausea (score = “none”; 0-72 hrs) were 41.9% for the Pal group, and 55.2% for the Pal+ Dex group. The Pal + Dex group showed a trend toward greater satisfaction on the QOL-FLIE scores with the greatest differences in the “nausea domain”. Discussion: The combination therapy (Pal + Dex) did not significantly reduce the incidence of PONV or PDNV when compared with Pal alone although a trend was observed indicating the possible increased efficacy of multi-drug therapy. There was no change in comparative efficacy over 72 hrs, possibly due to the low incidence of PDNV in both groups.

Sign in / Sign up

Export Citation Format

Share Document