scholarly journals Excessive alcohol consumption: a challenge for occupational health / El consumo excesivo de alcohol: un reto para la salud laboral

2003 ◽  
Vol 1 (1) ◽  
Author(s):  
Javier Fernández-Montalvo ◽  
Enrique Echeburúa
Keyword(s):  
Alcohol Consumption ◽  
Alcohol Abuse ◽  
Early Detection ◽  
Occupational Health ◽  
Alcohol Intake ◽  
Detection Methods ◽  
Prevalence Rates ◽  
Excessive Alcohol Consumption ◽  
Excessive Alcohol ◽  
The Relationship

En este trabajo se analiza la relación existente entre el abuso de alcohol y la actividad laboral. Se comentan las tasas de prevalencia del consumo de alcohol entre los trabajadores obtenidas en diferentes estudios y se describen los principales métodos de detección precoz (biológicos y psicológicos), así como las limitaciones de cada uno de ellos. Por último, se revisan los estudios sobre las principales repercusiones del abuso de alcohol en el ámbito laboral. AbstractThis paper analyses the relationship between alcohol abuse and labour activity. The prevalence rates about alcohol intake in workers are commented and the main early detection methods (biological and psychological) together with its limitations are described. Finally, studies about work consequences of alcohol are reviewed.

Is carbohydrate-deficient transferrin in serum useful for detecting excessive alcohol consumption in hypertensive patients?

1994 ◽  
Vol 40 (11) ◽  
pp. 2057-2063 ◽  
Author(s):  
B Fagerberg ◽  
S Agewall ◽  
A Berglund ◽  
M Wysocki ◽  
P A Lundberg ◽  
...  
Keyword(s):  
Alcohol Consumption ◽  
Alcohol Intake ◽  
High Alcohol ◽  
Clinical Value ◽  
Excessive Alcohol Consumption ◽  
Cross Sectional ◽  
Hypertensive Patients ◽  
Carbohydrate Deficient Transferrin ◽  
Excessive Alcohol ◽  
High Alcohol Intake

Abstract The aim of this study was to examine the diagnostic usefulness of carbohydrate-deficient transferrin (CDT) in serum in a cross-sectional study of 439 treated hypertensive men. We related the results to alcohol intake by questionnaire and to biochemical and hemodynamic measurements known to reflect excessive alcohol consumption. The diagnostic sensitivity and the specificity for high alcohol intake (> or = 24 g/day of ethanol) were 44% and 87%, respectively. The group with reported high alcohol intake (n = 32) was characterized by hemodynamic and biochemical changes typical of alcohol abuse. The corresponding profile for the patients with increased serum CDT concentrations (n = 70) was different in several respects, indicating a considerable number of false-positive tests. We conclude that serum CDT determination had low sensitivity and specificity for excessive alcohol consumption in this group of hypertensive patients. The results illustrate the importance of evaluating new laboratory methods in unselected patient populations before drawing any conclusions about their clinical value.

scholarly journals Changes in Alcohol Consumption Among a Population Who Underwent Medical Checkups During the First Wave of the Coronavirus Disease 2019 Pandemic in Japan: A Single-Center Retrospective Study

2022 ◽  
Vol 22 (3) ◽  
pp. 169-173
Author(s):  
Yusaku Kajihara
Keyword(s):  
Retrospective Study ◽  
Alcohol Consumption ◽  
Alcohol Intake ◽  
Drinking Behavior ◽  
Limited Information ◽  
Excessive Alcohol Consumption ◽  
Excessive Alcohol ◽  
Male Sex ◽  
Lifestyle Related Diseases

Background: Movement restrictions during the coronavirus disease 2019 (COVID-19) pandemic have inflicted stress and affected drinking behavior. However, limited information is available on the changes in alcohol use among the Japanese population.Method: This retrospective study included 371 subjects aged 20–74 years who underwent medical checkups at Fuyoukai Murakami Hospital before (April 1, 2019 to December 31, 2019) and during the COVID-19 pandemic (April 1, 2020 to May 31, 2020). All data were extracted from medical records. Changes in alcohol consumption and severity were also investigated. A logistic regression model was used to identify the risk factors associated with increased drinking, and seven variables were sequentially introduced into the model—age (≤ 49 years), male sex, prior instructions for alcohol restriction, medication for lifestyle-related diseases (e.g., hypertension, dyslipidemia, type 2 diabetes mellitus, and hyperuricemia), depression or insomnia, essential workers, and smoking.Results: The median age was 46 years, and 81.7% subjects were men. In total, 25.1% subjects increased their alcohol intake, and 24.5% subjects reduced their alcohol intake. The rates of excessive alcohol consumption (≥ 60 g ethanol per day) were 15.9% and 16.7% in the pre-COVID-19 period and during the COVID-19 pandemic, respectively. Multivariate analysis identified only age ≤ 49 years as a risk factor for increased drinking (adjusted odds ratio, 2.20; 95% confidence interval, 1.22–3.99; p = 0.009).Conclusion: Approximately one-fourth of the subjects reported increased drinking, although the overall severity remained stable. The importance of alcohol reduction, particularly among young people, should be emphasized.

Alcohol consumption among students and its relationship with nutritional intake: a cross-sectional study

2020 ◽  
pp. 1-12
Author(s):  
Elisabet R Hillesund ◽  
Nina C Øverby ◽  
Erlend L Valen ◽  
Dagrun Engeset
Keyword(s):  
Alcohol Consumption ◽  
Alcohol Use ◽  
Alcohol Intake ◽  
Alcoholic Beverages ◽  
Inverse Association ◽  
Excessive Alcohol Consumption ◽  
Cross Sectional ◽  
Consumption Level ◽  
Micronutrient Intake ◽  
Excessive Alcohol

Abstract Objective: Excessive alcohol consumption during reproductive years may impact the integrity of developing eggs and sperm, potentially affecting the life-long health of future children. Inadequate diets could aggravate these preconception effects of alcohol. The aim of the present study was to assess the prevalence of excessive alcohol consumption and explore whether weekly alcohol intake is associated with energy and nutrient intake and adequacy of micronutrient intake among students. Design: Cross-sectional survey using a validated and reproducibility-tested FFQ. Setting: University of Agder, Norway, in 2018. Participants: 622 students (71 % female). Results: More than 80 % reported having consumed alcoholic beverages the past 4 weeks. One-third of men and 13 % of women exceeded the upper recommended limit of 14 UK alcohol units/week. An inverse association between increasing alcohol intake and energy-adjusted micronutrient intake was evident for thiamine, phosphate, Fe, Zn and Se in men, and for vitamin A, β-carotene, vitamin E and C, thiamine, vitamin B6, folate, P, Mg, K, Fe, Zn and Cu in women. A substantial proportion had vitamin D, folate, Fe and I intakes below average requirement regardless of alcohol consumption level. The combination of prevalent alcohol use, decreasing micronutrient density of diet across alcohol consumption level and a high probability of micronutrient inadequacy indicate reason for concern in a preconception public health perspective. Conclusions: Our findings call for investigations into young adults’ knowledge, reflections and beliefs regarding diet and alcohol use to understand how these behaviours could be improved ahead of parenthood.

scholarly journals Analysis of the relationship between nutrition and cancer: Gastronomic options for prevention

2021 ◽  
Vol 04 (5) ◽  
pp. 01-05
Author(s):  
Mahendra Pal
Keyword(s):  
Alcohol Consumption ◽  
Protein Intake ◽  
Tumor Formation ◽  
High Fat ◽  
Excessive Alcohol Consumption ◽  
Nutritional Factors ◽  
Active Defence ◽  
Excessive Alcohol ◽  
Direct Acting ◽  
The Relationship

The relationships between tumorigenesis and nutrition are difficult to analyse. In addition to the composition of foods, a number of environmental and other factors modify the results of dietary observations. The nutritional factors can also be direct acting carcinogens, promoters and anti-promoters in the process of tumor formation. The most important promoters are excessive energy, high fat and animal protein intake, low fibre intake, and excessive alcohol consumption. The dietary fibre, antioxidant vitamins, antioxidant minerals and other elements play a prominent role among anti-promoters in foods. The primary purpose of the manuscript is to analyse these promoters, anti-promoters, and direct acting carcinogens. Furthermore, we prepare and present foods that significantly contribute to a tumor preventive diet and support the active defence of the human body with the help of gastronomic science.

scholarly journals The Relationship Between Excessive Alcohol Consumption and Alcohol Use Disorders According to DSM-IV and DSM-5

2013 ◽  
Vol 38 (1) ◽  
pp. 249-256 ◽  
Author(s):  
Marlous Tuithof ◽  
Margreet ten Have ◽  
Wim van den Brink ◽  
Wilma Vollebergh ◽  
Ron de Graaf
Keyword(s):  
Alcohol Consumption ◽  
Alcohol Use ◽  
Alcohol Use Disorders ◽  
Excessive Alcohol Consumption ◽  
Dsm 5 ◽  
Excessive Alcohol ◽  
Dsm Iv ◽  
The Relationship

scholarly journals cAMP-Fyn signaling in the dorsomedial striatum direct pathway drives excessive alcohol use

2020 ◽  
Author(s):  
Yann Ehinger ◽  
Nadege Morisot ◽  
Khanhky Phamluong ◽  
Samuel A. Sakhai ◽  
Drishti Soneja ◽  
...  
Keyword(s):  
Alcohol Consumption ◽  
Alcohol Use ◽  
Alcohol Intake ◽  
Camp Signaling ◽  
Cell Type Specificity ◽  
Excessive Alcohol Consumption ◽  
Saccharin Intake ◽  
Fyn Kinase ◽  
Excessive Alcohol ◽  
Dorsomedial Striatum

ABSTRACTFyn kinase in the dorsomedial striatum (DMS) of rodents plays a central role in mechanisms underlying excessive alcohol intake. The DMS is comprised of medium spiny neurons (MSNs) that project directly (dMSNs) or indirectly (iMSNs) to the substantia nigra. Here, we examined the cell-type specificity of Fyn’s actions on alcohol use. First, we knocked down Fyn selectively in DMS dMSNs or iMSNs of mice and measured the level of alcohol consumption. We found that downregulation of Fyn in dMSNs, but not in iMSNs, reduces excessive alcohol but not saccharin intake. D1Rs are coupled to Gαs/olf, which activate cAMP signaling. To examine whether Fyn’s actions are mediated through cAMP signaling, DMS dMSNs were infected with GαsDREADD, and the activation of Fyn signaling was measured following CNO treatment. We found that remote stimulation of cAMP signaling in DMS dMSNs activates Fyn and promotes the phosphorylation of the Fyn substrate, GluN2B. In contract, remote activation of GαsDREADD in DLS dMSNs did not alter Fyn signaling. We then tested whether activation of GαsDREADD in DMS dMSNs or iMSNs alters alcohol intake and observed that CNO-dependent activation of GαsDREADD in DMS dMSNs but not iMSNs increases alcohol but not saccharin intake. Finally, we examined the contribution of Fyn to GαsDREADD-dependent increase in alcohol intake, and found that systemic administration of the Fyn inhibitor, AZD0503 blocks GαsDREADD-dependent increase in alcohol consumption. Our results suggest that the cAMP-Fyn axis in the DMS dMSNs is a molecular transducer of mechanisms underlying the development of excessive alcohol consumption.

scholarly journals Relationship between the Severity of Anxiety Symptoms, Aggression and Alcohol Consumption during the COVID-19 Pandemic Period

Medicina ◽  
2021 ◽  
Vol 57 (9) ◽  
pp. 959
Author(s):  
Szymon Florek ◽  
Paweł Dębski ◽  
Magdalena Piegza ◽  
Piotr Gorczyca ◽  
Robert Pudlo
Keyword(s):  
Alcohol Consumption ◽  
Online Survey ◽  
Psychiatric Treatment ◽  
Social Consequences ◽  
Excessive Alcohol Consumption ◽  
Entire Study ◽  
Aggression Questionnaire ◽  
Excessive Alcohol ◽  
Psychological Scales ◽  
The Relationship

Background and objectives: There have been many reports of mental health in the pandemic period. The research conducted so far has indicated an increase in the severity of anxiety and aggression and an escalation of alcohol consumption during the COVID-19 pandemic. The aim of this study was to determine the relationship between the severity of anxiety, the amount of alcohol consumed and the severity of aggression. Materials and Methods: A total of 538 Polish residents—413 women (76.77%) and 125 men (23.23%)—participated in the study via an online survey. It included socio-demographic parameters and psychological scales: AUDIT—to determine the model of alcohol consumption, GAD-7—to measure the severity of anxiety and the Buss–Perry Aggression Questionnaire. Results: There was a correlation between the severity of anxiety and generalized aggression, and its two components—anger and hostility—in the entire study group. Moreover, relations were found between the intensity of alcohol consumption and generalized aggression and its components—anger and verbal and physical aggression. Those relationships turned out to be gender specific. The increased anxiety intensity affected the pattern of alcohol consumption and the severity of aggression. Conclusions: Psychotherapeutic and psychoeducational interactions and some elements of psychiatric treatment should aim at reducing the severity of anxiety in society, and thus minimizing the health and social consequences—aggressive behaviour and excessive alcohol consumption.

scholarly journals Ethanol’s action at BK channels accelerates the transition from moderate to excessive alcohol consumption

2020 ◽  
Author(s):  
Agbonlahor Okhuarobo ◽  
Max Kreifeldt ◽  
Pushpita Bhattacharyya ◽  
Alex M Dopico ◽  
Amanda J Roberts ◽  
...  
Keyword(s):  
Alcohol Consumption ◽  
Alcohol Intake ◽  
Mouse Genome ◽  
Physiological Function ◽  
Alcohol Intoxication ◽  
Bk Channels ◽  
Bk Channel ◽  
Excessive Alcohol Consumption ◽  
Excessive Alcohol ◽  
Ethanol Sensing

AbstractLarge conductance potassium (BK) channels are among the most sensitive molecular targets of ethanol. Whether the action of ethanol at BK channels influences the motivation to drink alcohol remains to be determined. In the present study, we sought to investigate the behavioral relevance of this interaction by introducing in the mouse genome a point mutation (BK α K361N) known to render BK channels insensitive to ethanol while preserving their physiological function. We demonstrate that preventing ethanol’s interaction with BK channels at this site hinders the escalation of voluntary alcohol intake induced by repeated cycles of alcohol intoxication and withdrawal. In contrast, the mutation does not alter ethanol’s acute behavioral effects, nor the metabolic and activity changes induced by chronic exposure to alcohol. Our findings point at BK channel ethanol-sensing capacity as a vulnerability mechanism in the transition from moderate alcohol consumption to pathological patterns of alcohol abuse.

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