scholarly journals Isoniazid preventive therapy utilization rate and associated factors in adult HIV/AIDS patients in Jimma University Specialized Hospital ART clinic: A cross-sectional study.

2019 ◽  
Author(s):  
Gudeta Imana ◽  
Vinodhini Rajamanickam ◽  
Kifle Woldemichael

Abstract Background: Tuberculosis (TB) is the most frequent life-threatening infection and a common cause of death for people living with HIV (PLHIV).The influence of TB and HIV infection has enhanced the magnitude of both epidemics. IPT is one of the several key interventions recommended by the world health organization (WHO) for the prevention of TB in patients infected with HIV. Hence, the present study aimed to determine the IPT utilization rate and to explore the determinant factors among PLHIV under follow-up, Health care providers (HCP’s) and TB/HIV coordinators working in Jimma University Specialized Hospital (JUSH) ART clinic, Ethiopia. Methods: An Institution based cross-sectional study was conducted in JUSH ART clinic, Oromia region, Ethiopia. The target groups were enrolled by a systematic sampling technique from the registered medical records of JUSH HIV care. Semi-structured questioners and in-depth interviews were designed for quantitative analysis from PLHIV, HCP’s and TB/HIV coordinators working in JUSH, ART clinic. All statistical analysis was compiled by Epi data 3.1 and SPSS 20. Results: The overall estimated IPT utilization rate in JUSH ART clinic was 59.2%.Demographic and clinical factors are not significant, but ethnicity was highly significant with IPT use in PLHIV. All respondents, HCP’s and TB/HIV coordinators were interviewed on identifying the factors and barriers that increase the utilization of IPT. The results of in-depth interviews are grouped into three core categories as patient perceptions, HCP’s and TB/HIV coordinator perspectives. Discussion and conclusion:PLHIV, HCP’s and TB/HIV coordinators suggested their overall response as periodic counseling for target groups, educating the benefits of IPT and increasing public awareness on TB prophylaxis in PLHIV. Higher attention should be provided in linking all HIV patients to the nearest health facilities for receiving free service packages and medical care. Administrative managers could improve the capacity building by increasingthe number of health care professionals, maintaining data base on patient records and continuous supply of pyridoxine and IPT for all PLHIV. HCP’s and TB/HIV coordinators responded that disclosure to the patient families and occupational independence will increase the acceptance and implementation of IPT in large scale.

2019 ◽  
Author(s):  
Gudeta Imana Jaleta ◽  
Vinodhini Rajamanickam ◽  
Kifle Woldemichael

Abstract Background: Tuberculosis (TB) is the most frequent life-threatening infection and a common cause of death for people living with HIV (PLHIV). The influence of TB and HIV infection has enhanced the magnitude of both epidemics. Several clinical interventions recommended early diagnosis in PLHIV and treating latent TB infection (LTBI) with Isoniazid preventive therapy (IPT) along with antiretroviral therapy (ART). IPT is one of the key interventions recommended by the world health organization (WHO) for the prevention of TB in patients infected with HIV. Hence, this study aimed to determine IPT utilization rate among adult HIV infected patients enrolled in HIV care and qualitative analysis, which explore the factors that influence IPT use among PLHIV under follow-up, Health care providers (HCPs) and TB/HIV coordinators working in Jimma University Specialized Hospital (JUSH) ART clinic. Methods: An Institution based mixed cross-sectional study was conducted in JUSH ART clinic. Adult HIV infected patients were enrolled by a systematic sampling technique from the registered medical records of JUSH HIV care. PLHIV who were on follow-up and eligible for IPT during the study period, permanent HCPs and TB/HIV coordinators working in ART clinic were included in the qualitative investigation using semi-structured questioners and in-depth interviews. All statistical analysis was compiled by Epi data 3.1 and SPSS 20. Results: Demographic and clinical factors are not significantly associated with IPT use but ethnicity (P≤ 0.02**) was highly significant with IPT use in logistic regression model. Overall, 59.2% of the patients have been prescribed and taken at least one-month course of IPT. The results of in-depth interviews are grouped into three core categories as patient perceptions, HCPs and TB/HIV coordinator perspectives. Discussion and conclusion: PLHIV, HCPs and TB/HIV coordinators suggested their overall response as periodic counseling for target groups, educating the benefits of IPT and increasing public awareness on TB prophylaxis in PLHIV will increase the acceptance and implementation of IPT in large scale. Higher attention should be provided in linking all HIV patients to the nearest health facilities for receiving free service packages and medical care. Key words: IPT, TB /HIV, PLHIV, ART, INH prophylaxis


1970 ◽  
Vol 29 (2) ◽  
Author(s):  
Debebe Asrat ◽  
Girum Tesfaye ◽  
Lealem Gedefaw ◽  
Wondimagegn Addisu ◽  
Tilahun Yemane

BACKGROUND: Diabetes mellitus is a group of heterogeneous disorders of multiple etiologies characterized by chronic hyperglycemia resulting from defects in insulin secretion and/or insulin action. Diabetes mellitus has been reported to disturb normal hemostasis by various mechanisms. However, data on hemostasis of diabetic patients in the study area are lacking. This study was aimed at determining hemostatic profile and associated factors of hemostatic abnormality in diabetic patients.METHODS: A comparative cross-sectional study was conducted involving a total of 238 (119 diabetic and 119 apparently healthy) individuals who came to the chronic care clinic, Jimma University Specialized Hospital. Socio-demographic and clinical data were collected through a structured questionnaire. A blood sample of 10ml was collected in EDTA (4ml), citrate (3ml) and chemistry (3ml) tubes to do platelet count, coagulation tests, and glucose and lipid profile analysis, respectively. Descriptive statistics as well as the median (25th,75th) percentile and Mann Whitney U test were used during data analysis.RESULTS: The overall hemostatic abnormality in diabetes individuals was 58.8%. The median (25th, 75th percentile) prothrombin time for diabetic and non-diabetic subjects was (12.8, 15.6) vs. (12.8, 14.2), respectively, and the difference was not statistically significant (p>0.05). The median (25th, 75th percentile) activated partial thromboplastin time was significantly different between the two groups (p<0.0001); (24, 36.8) vs. (36, 39.6). The median (25th, 75th percentile) fibrinogen level was significantly different between the two groups (p<0.0001); (277, 462) vs. (243, 328). The median (25th, 75th percentile) platelet count was also significantly different between the two groups (p<0.0001); (146,248) vs. (190,319). All variables were not significantly associated with hemostatic abnormality in multivariate regression analysis.CONCLUSION: An overall hemostatic abnormality in diabetic patients was found to be high. The APTT and platelet count were lower in diabetic patients whilst the fibrinogen level was higher. Routine coagulation tests should be part of tests among diabetic patients. Advanced coagulation tests should also be considered to identify specific markers so as to pinpoint the particular problem.


10.2196/19913 ◽  
2020 ◽  
Vol 22 (9) ◽  
pp. e19913 ◽  
Author(s):  
Khawla F Ali ◽  
Simon Whitebridge ◽  
Mohammad H Jamal ◽  
Mohammad Alsafy ◽  
Stephen L Atkin

Background Social media is one of the most rapid and impactful ways of obtaining and delivering information in the modern era. Objective The aim of this study was to rapidly obtain information on public perceptions, knowledge, and behaviors related to COVID-19 in order to identify deficiencies in key areas of public education. Methods Using a cross-sectional study design, a survey web link was posted on the social media and messaging platforms Instagram, Twitter, and WhatsApp by the study investigators. Participants, aged ≥18 years, filled out the survey on a voluntary basis. The main outcomes measured were knowledge of COVID-19 symptoms, protective measures against COVID-19, and source(s) of information about COVID-19. Subgroup analyses were conducted to determine the effects of age, gender, underlying illness, and working or studying in the health care industry on the perceived likelihood of acquiring COVID-19 and getting vaccinated. Results A total of 5677 subjects completed the survey over the course of 1 week. “Fever or chills” (n=4973, 87.6%) and “shortness of breath” (n=4695, 82.7%) were identified as the main symptoms of COVID-19. Washing and sanitizing hands (n=4990, 87.9%) and avoiding public places and crowds (n=4865, 85.7%) were identified as the protective measures most frequently used against COVID-19. Social media was the most utilized source for information on the disease (n=4740, 83.5%), followed by the World Health Organization (n=2844, 50.1%). Subgroup analysis revealed that younger subjects (<35 years), males, and those working or studying in health care reported a higher perceived likelihood of acquiring COVID-19, whereas older subjects, females, and those working or studying in non–health care areas reported a lower perceived likelihood of acquiring COVID-19. Similar trends were observed for vaccination against COVID-19, with older subjects, females, and those working or studying in non–health care sectors reporting a lower likelihood of vaccinating against COVID-19. Conclusions Our results are indicative of a relatively well-informed cohort implementing appropriate protective measures. However, key knowledge deficiencies exist with regards to vaccination against COVID-19, which future efforts should aim at correcting.


2020 ◽  
Author(s):  
Gaspard HABIMANA ◽  
Theogene Nyandwi ◽  
Jean Claude Kabayiza ◽  
Pierre Claver Kayumba

Abstract Background Irrational drug use is a worldwide problem at all levels of health care, especially in hospitals. Prescribers in community tend to omit hospital prescribing practices, thus this problem is present at all levels of health care. Use of medicines can be greatly improved and wastage reduced if simple principles of drug management are followed. To help in solving this problem, World Health Organization (WHO) has designed prescribing core indicators that were used to evaluate drug prescription patterns in Rwanda Social Security Board (RSSB) affiliated patients.Material and Methods A retrospective cross-sectional study with quantitative analysis was carried out for a period of six months. Among the 1000 prescriptions collected, 18 of them were rejected for not fulfilling the inclusion criteria, the remaining 982 prescriptions were almost distributed equally from either private and public hospital or clinics. The study analyzed prescriptions from health facilities located in Kigali City, Rwanda. The results were presented in table with comparisons with the WHO prescription indicators.Results The average number of drugs per prescription is 2.4 which is higher than 1.8 recommended by WHO. The percentages of drugs prescribed with a generic name and those from National Essential drug List are 28.5% and 61.1% respectively, which are very low compared to WHO target of 100% for both core prescribing indicators. The percentage of encounters with an antibiotic prescribed is 42.5% and the encounters who received an injections account 1.2%.Conclusion This study revealed that there is a big gap in implementing WHO core indicators of prescription and concerned stakeholders should take measures to address this issue.


2021 ◽  
Author(s):  
Hamdia Mirkhan Ahmed

Abstract Background: Having a positive childbirth experience is highlighted as being important by the World Health Organization (WHO). One way of achieving this goal is to fulfill the expectations of women. This study aimed to find out women’s expectations in the delivery room and to determine the association between their overall level of expectation and sociodemographic and obstetrical characteristics. Methods: A cross-sectional study was conducted with 1196 women who agreed to participate and who met the inclusion criteria through convenient sampling. Data were collected through direct interviews after receiving informed consent. Sociodemographic and obstetric data, along with expectations items, were summarized by frequency and percentage. A chi-square test was used to find the association between overall expectation and sociodemographic and obstetric variables, general satisfaction with birth care, and communication of health care providers. Results: A majority of the study sample expected the following from health care providers in the delivery room: presence (78.6%), positive and calming verbal (76.3%) and nonverbal expressions (72.3%), environmental control (74.6%), encouragement of different positions and mobilization (75.9%), hygiene (77.5%), promotion of urinary elimination (75.8%), and instruction on breathing and relaxation (71.9%). The overall expectation level was divided into “high expectations” (68.6), “slight expectation” (29.9), and “no expectation” (1.4). Conclusion: Knowing the women’s expectations in the delivery room and how to effectuate them helps to inform plans of care and may also increase women’s satisfaction level, providing them with a more positive birth experience.


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