scholarly journals Antibiotic resistance of Streptococcus pneumonia serotypes in Kisii, Kenya

2020 ◽  
Author(s):  
Vincent Obino Orucho ◽  
Cyrus Orucho Ochoi ◽  
Maureen Kerubo Nyangau
Keyword(s):  
Treatment Strategies ◽  
Bacterial Pathogen ◽  
High Sensitivity ◽  
The Elderly ◽  
Relevant Information ◽  
Current Treatment ◽  
High Rate ◽  
Pneumococcal Infections ◽  
Streptococcus Pneumonia ◽  
Prevention Of Infections

Abstract Background : Pneumonia remains the leading cause of death in children under five worldwide, accounting for about 1.6 million deaths a year. Streptococcus pneumonia , has proved to be the most competent bacterial pathogen causing pneumonia infections among the infants and the elderly, leading to great morbidity and mortality. Currently there are over 94 different serotypes of Streptococcus pneumonia , and quite a number have emerged as drug-resistant strains which introduce a twist to the current treatment strategies. Detailed information of current antibiotic susceptibilities, resistance and serotype distribution will be important in designing new strategies for treatment and management of pneumococcal infections. Methods: A total of 309 S. pneumoniae isolates were collected from patients attending the Kisii Teaching and Referral Hospital between 2017 and 2018. Nasopharyngeal samples collected and serotyped using PCR. The samples were cultured and their sensitivity to drugs tested using various concentrations of; Oxacilin, Erythromycin, Tetracycline, Ofloxacin, Trimethoprim/sulfamethoxazole and Chloramphenicol. Results: Out of the 309 samples collected, 235 were positive for S. pneumonia, although 10 of the samples had incomplete data. A total of 41 S. pneumonia serotypes isolated from the 309 samples with the most prevalent serotypes being; Non-typable (11%), 15B (7.6%), 19F (7.0%), 19A (6.7%), 23B (5.8%), 23F (5.3%), 6A (4.4%). All the serotypes were highly resistant to Oxacilin, and trimethoprim/sulfamethoxazole, while showing high sensitivity to Erythromycin, Ofloxacin and chloramphenicol. The rate of sensitivity to Tetracycline was 75% with the other 25% showing intermediate sensitivity. Conclusions: The data collected showed a high rate of S. pneumonia (76%) consisting of various serotypes for various ages. The various serotypes isolated showed a marked resistance routinely used antibiotics for patient samples of various ages. The isolated serotypes also consisted of serotypes 19A, 6A, and 5B that are lacking in the pneumococcal vaccine (PCV 10). This data will provide relevant information for a better approach to both clinical treatment, management and prevention of infections with S. pneumonia.

scholarly journals Antibiotic resistance of Streptococcus pneumonia serotypes in Kisii, Kenya

2019 ◽  
Author(s):  
Vincent Obino Orucho ◽  
Cyrus Orucho Ochoi ◽  
Maureen Kerubo Nyangau
Keyword(s):  
Antibiotic Resistance ◽  
Treatment Strategies ◽  
Bacterial Pathogen ◽  
High Sensitivity ◽  
The Elderly ◽  
Relevant Information ◽  
Current Treatment ◽  
High Rate ◽  
Pneumococcal Infections ◽  
Streptococcus Pneumonia

Abstract Background : Pneumonia remains the leading cause of death in children under five worldwide, accounting for about 1.6 million deaths a year. Streptococcus pneumonia , has proved to be the most competent bacterial pathogen causing pneumonia infections among the infants and the elderly, leading to great morbidity and mortality. Currently there are over 94 different serotypes of Streptococcus pneumonia , and quite a number have emerged as drug-resistant strains which introduce a twist to the current treatment strategies. Detailed information of current antibiotic susceptibilities, resistance and serotype distribution will be important in designing new strategies for treatment and management of pneumococcal infections. Methods: A total of 309 S. pneumoniae isolates were collected from patients attending the Kisii Teaching and Referral Hospital between 2017 and 2018. Nasopharyngeal samples collected and serotyped using PCR. The samples were cultured and their sensitivity to drugs tested using various concentrations of; Oxacilin, Erythromycin, Tetracycline, Ofloxacin, Trimethoprim/sulfamethoxazole and Chloramphenicol. Results: Out of the 309 samples collected, 235 were positive for S. pneumonia, although 10 of the samples had incomplete data. A total of 41 S. pneumonia serotypes isolated from the 309 samples with the most prevalent serotypes being; Non-typable (11%), 15B (7.6%), 19F (7.0%), 19A (6.7%), 23B (5.8%), 23F (5.3%), 6A (4.4%). All the serotypes were highly resistant to Oxacilin, and trimethoprim/sulfamethoxazole, while showing high sensitivity to Erythromycin, Ofloxacin and chloramphenicol. The rate of sensitivity to Tetracycline was 75% with the other 25% showing intermediate sensitivity. Conclusions: The data collected showed a high rate of S. pneumonia (76%) consisting of various serotypes for various ages. The various serotypes isolated showed a marked resistance routinely used antibiotics for patient samples of various ages. The isolated serotypes also consisted of serotypes 19A, 6A, and 5B that are lacking in the pneumococcal vaccine (PCV 10). This data will provide relevant information for a better approach to both clinical treatment, management and prevention of infections with S. pneumonia. Keywords: Streptococcus pneumonia, Antibiotic resistance, serotypes, Drug sensitivity

scholarly journals Dermatillomania: Strategies for Developing Protective Biomaterials/Cloth

Pharmaceutics ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 341
Author(s):  
Priusha Ravipati ◽  
Bice Conti ◽  
Enrica Chiesa ◽  
Karine Andrieux
Keyword(s):  
Alternative Treatment ◽  
Negative Impact ◽  
Treatment Strategies ◽  
Current Treatment ◽  
Primary Objective ◽  
Neuropsychiatric Disorder ◽  
Physical Barrier ◽  
Physical Treatment ◽  
Pubmed Database ◽  
Prevention Of Infections

Dermatillomania or skin picking disorder (SPD) is a chronic, recurrent, and treatment resistant neuropsychiatric disorder with an underestimated prevalence that has a concerning negative impact on an individual’s health and quality of life. The current treatment strategies focus on behavioral and pharmacological therapies that are not very effective. Thus, the primary objective of this review is to provide an introduction to SPD and discuss its current treatment strategies as well as to propose biomaterial-based physical barrier strategies as a supporting or alternative treatment. To this end, searches were conducted within the PubMed database and Google Scholar, and the results obtained were organized and presented as per the following categories: prevalence, etiology, consequences, diagnostic criteria, and treatment strategies. Furthermore, special attention was provided to alternative treatment strategies and biomaterial-based physical treatment strategies. A total of six products with the potential to be applied as physical barrier strategies in supporting SPD treatment were shortlisted and discussed. The results indicated that SPD is a complex, underestimated, and underemphasized neuropsychiatric disorder that needs heightened attention, especially with regard to its treatment and care. Moreover, the high synergistic potential of biomaterials and nanosystems in this area remains to be explored. Certain strategies that are already being utilized for wound healing can also be further exploited, particularly as far as the prevention of infections is concerned.

scholarly journals Sexuality in Ageing Male: Review of Pathophysiology and Treatment Strategies for Various Male Sexual Dysfunctions

2019 ◽  
Vol 7 (10) ◽  
pp. 98 ◽  
Author(s):  
Chung
Keyword(s):  
Sexual Dysfunction ◽  
Sexual Function ◽  
Treatment Strategies ◽  
The Elderly ◽  
Older Men ◽  
Current Treatment ◽  
Poor Treatment ◽  
Ageing Male ◽  
Male Sexual Function ◽  
Normal Ageing

Sexual function among older men is often thought to decrease as part of normal ageing biology despite the fact that sexuality remains an important issue in the elderly. Sexual dysfunction in the aged male is likely multifactorial in nature, with the development and/or progression of medical comorbidities often resulting in decline in male sexual function and poor treatment response. At present, sexual dysfunction in the ageing male is poorly investigated and understood, and current treatment strategies aim at improving sexual desire and erectile function with limited data on ejaculatory and orgasmic dysfunctions. In addition, men are often reticent to seek help for health concerns including sexual dysfunction. The following article provides a narrative review of strategies to address various aspects of sexual dysfunction in the ageing male. Clinicians need to be educated to be sensitive when discussing sexuality issues among older men and to present practical solutions that take into account individual and cultural differences.

Current Treatment Strategies for Pancreatic Cancer in the Elderly

Drugs & Aging ◽  
2006 ◽  
Vol 23 (5) ◽  
pp. 403-410 ◽  
Author(s):  
Keiji Hanada ◽  
Fumiaki Hino ◽  
Hajime Amano ◽  
Toshikatsu Fukuda ◽  
Yoshinori Kuroda
Keyword(s):  
Pancreatic Cancer ◽  
Treatment Strategies ◽  
The Elderly ◽  
Current Treatment

scholarly journals Animal Models of Pneumococcal pneumonia

2019 ◽  
Vol 20 (17) ◽  
pp. 4220 ◽  
Author(s):  
Borsa ◽  
Pasquale ◽  
Restrepo
Keyword(s):  
Animal Models ◽  
Pneumococcal Disease ◽  
Pneumococcal Pneumonia ◽  
Respiratory Tract Infections ◽  
Bacterial Pathogen ◽  
The Elderly ◽  
Lower Respiratory Tract Infections ◽  
Bacterial Inoculation ◽  
Pneumococcal Infections ◽  
Tract Infections

Streptococcus pneumoniae remains the most common bacterial pathogen causing lower respiratory tract infections and is a leading cause of morbidity and mortality worldwide, especially in children and the elderly. Another important aspect related to pneumococcal infections is the persistent rate of penicillin and macrolide resistance. Therefore, animal models have been developed to better understand the pathogenesis of pneumococcal disease and test new therapeutic agents and vaccines. This narrative review will focus on the characteristics of the different animal pneumococcal pneumonia models. The assessment of the different animal models will include considerations regarding pneumococcal strains, microbiology properties, procedures used for bacterial inoculation, pathogenesis, clinical characteristics, diagnosis, treatment, and preventive approaches.

Current concepts of the interventional treatment of proximal supraaortic vessel stenosis

VASA ◽  
2012 ◽  
Vol 41 (5) ◽  
pp. 313-318 ◽  
Author(s):  
Ernemann ◽  
Bender ◽  
Melms ◽  
Brechtel ◽  
Kobba ◽  
...  
Keyword(s):  
Treatment Strategies ◽  
Carotid Bifurcation ◽  
Current Treatment ◽  
Long Term Results ◽  
Clinical Indication ◽  
Interventional Treatment ◽  
Special Focus ◽  
Brachiocephalic Artery ◽  
Treatment Concepts ◽  
Angioplasty And Stenting

Interventional therapies using angioplasty and stenting of symptomatic stenosis of the proximal supraaortic vessels have evolved as safe and effective treatment strategies. The aim of this paper is to summarize the current treatment concepts for stenosis in the subclavian and brachiocephalic artery with regard to clinical indication, interventional technique including selection of the appropriate vascular approach and type of stent, angiographic and clinical short-term and long-term results and follow-up. The role of hybrid interventions for tandem stenoses of the carotid bifurcation and brachiocephalic artery is analysed. A systematic review of data for angioplasty and stenting of symptomatic extracranial vertebral artery stenosis is discussed with a special focus on restenosis rate.

Socio Demographic and Clinical Profile of Indoor Female Patients of RINPAS

2017 ◽  
Vol 8 (1) ◽  
pp. 33
Author(s):  
Rajni Suri ◽  
Anshu Suri ◽  
Neelam Kumari ◽  
Amool R. Singh ◽  
Manisha Kiran
Keyword(s):  
Mental Health ◽  
Mental Illness ◽  
Mentally Ill ◽  
Mental Health Problems ◽  
Demographic Data ◽  
Relevant Information ◽  
Health Problems ◽  
High Rate ◽  
Physical And Mental Health ◽  
Cross Sectional

The role of women is very crucial in our society. She cares for her parents, partner, children and other relatives. She performs all types of duties in family and also in the society without any expectations. Because of playing many roles, women often face many challenges in their life including both physical and mental. Mental health problems affect women and men equally, but some problems are more common among women including both physical and mental health problems. Aim of the study - The present study is aimed to describe and compare the clinical and socio-demographic correlates of female mentally ill patients. Methods and Materials: The study includes 180 female mentally ill patients based on cross sectional design and the sample for the study was drawn purposively. A semi structured socio-demographic data sheet was prepared to collect relevant information as per the need of the study. Result: The present study reveals that the socio-demographic factors contribute a vital role in mental illness. Findings also showed that majority of patients had mental problems in the age range of 20-30 have high rate. Illiterate and primary level of education and daily wage working women as well as low and middle socio-economic status women are more prone to have mental illness. Other factors like marital status, type of family and religion etc also important factors for mental illness. Keywords: Socio demographic profile, female, psychiatric patient

Infections caused by medical products at longterm nursing care

2020 ◽  
pp. 7-10
Author(s):  
Hardy Thorsten Panknin
Keyword(s):  
Nursing Care ◽  
Nursing Staff ◽  
Nosocomial Infections ◽  
The Elderly ◽  
Relevant Information ◽  
Medical Products ◽  
The Disabled ◽  
The Usa ◽  
Therapeutic Measures

Nosocomial infections in the elderly, often suffering from many ailments, patients in homes for the disabled and the old are among the problematic diseases that specialized nursing staff and doctors have to deal with more often in such institutions. Review work from the USA introduces relevant information about infectious risks, as well as possible preventive and therapeutic measures.

Treatment of Anderson-Fabry Disease

2020 ◽  
Vol 26 (40) ◽  
pp. 5089-5099 ◽  
Author(s):  
Irene Simonetta ◽  
Antonino Tuttolomondo ◽  
Mario Daidone ◽  
Salvatore Miceli ◽  
Antonio Pinto
Keyword(s):  
Fabry Disease ◽  
Treatment Strategies ◽  
Signs And Symptoms ◽  
Current Treatment ◽  
Viral Gene ◽  
Pharmacological Chaperone ◽  
Enzyme Replacement ◽  
Cell Based Therapy ◽  
Organ Manifestations ◽  
Alpha Galactosidase

: Fabry disease is an X-linked disorder of glycosphingolipid metabolism that results in progressive accumulation of neutral glycosphingolipids, predominantly globotriaosylsphingosine (Gb3) in lysosomes, as well as other cellular compartments of several tissues, causing multi-organ manifestations (acroparesthesias, hypohidrosis, angiokeratomas, signs and symptoms of cardiac, renal, cerebrovascular involvement). Pathogenic mutations lead to a deficiency of the lysosomal enzyme alpha-galactosidase A (GLA). In the presence of high clinical suspicion, a careful physical examination and specific laboratory tests are required. Finally, the diagnosis of Fabry’s disease is confirmed by the demonstration of the absence of or reduced alpha-galactosidase A enzyme activity in hemizygous men and gene typing in heterozygous females. Measurement of the biomarkers Gb3 and Lyso Gb3 in biological specimens may facilitate diagnosis. The current treatment of Anderson-Fabry disease is represented by enzyme replacement therapy (ERT) and oral pharmacological chaperone. Future treatments are based on new strategic approaches such as stem cell-based therapy, pharmacological approaches chaperones, mRNA therapy, and viral gene therapy. : This review outlines the current therapeutic approaches and emerging treatment strategies for Anderson-Fabry disease.

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