scholarly journals Polymorphism at position T-129C in the promoter region of ABCB1 gene in peptic ulcer patients: a case control study

2019 ◽  
Author(s):  
Marta Żebrowska-Nawrocka ◽  
Agnieszka Jeleń ◽  
Jacek Pietrzak ◽  
Agata Lisowska ◽  
Dagmara Szmajda ◽  
...  
Keyword(s):  
Peptic Ulcer ◽  
Peptic Ulcer Disease ◽  
Protein Function ◽  
Blood Donation ◽  
Control Group ◽  
Healthy Individuals ◽  
Abcb1 Gene ◽  
Ulcer Disease ◽  
H Pylori

Abstract Background Peptic ulcer disease is one of the most common diseases worldwide. P-glycoprotein encoded by ABCB1 gene is located on the surface of gastric tract cells. Changes in its protein function, as a consequence of polymorphism like T-129C (rs3213619), may have impact the development of some diseases. The aim of this study was to evaluate the potential role of T-129C of ABCB1 gene in peptic ulcer development. To the best of our knowledge, this is the first this kind of research in peptic ulcer diseases. Methods Patients, having attended gastroduodenoscopy because of dyspepsia symptoms and diagnosed at that time as peptic ulcer patients, were enrolled in the study. In all investigated cases, gastric mucosa specimens were taken from the antrum of the stomach. The control group consisted of healthy blood donors from local blood donation center. Overall DNA from 204 patients with peptic ulcer disease and from 94 healthy individuals was tested. The RFLP PCR technique was used for genotype analysis. Results All 204 DNA samples form investigated group and 94 DNA samples form healthy individuals were successfully analyzed. All genotypes for polymorphism in position T-129C of the ABCB1 gene in both groups were in agreement with Hardy-Weinberg equation. Statistical analysis showed no significant differences in frequency of T-129C genotypes between peptic ulcer patients and healthy individuals (p=0.3977). Also, there were no statistically significant differences in the frequency of occurrence of T-129C genotypes between patients infected and uninfected with H. pylori infection (p=0.1743). Conclusion Investigated polymorphism at position T-129C of ABCB1 gene is not associated with H. pylori infection nor with the risk of peptic ulcer disease development.

Peptic Ulcer Disease

2014 ◽  
pp. 710-718
Author(s):  
Tyler M. Berzin ◽  
Kenneth R. Falchuk
Keyword(s):  
Peptic Ulcer ◽  
Peptic Ulcer Disease ◽  
The United States ◽  
Dietary Factors ◽  
Pathogenic Agent ◽  
Ulcer Disease ◽  
History Of ◽  
Ulcer Complications ◽  
H Pylori

Peptic ulcer disease (PUD) involves the stomach or duodenum and is a significant cause of morbidity and mortality both in the United States and worldwide, with a lifetime prevalence estimated at 5–15%. For a good part of the 20th century PUD was felt to be a condition related to stress and dietary factors. More recently, our understanding of PUD has been advanced by research into the role of gastric acid secretion and the benefits of various classes of antisecretory medications and, perhaps most importantly, in 1984, by Warren and Marshall, who identified Helicobacter pylori (H. pylori) as a pathogenic agent in this disease. Proton pump inhibitor (PPI) therapy and H. pylori eradication regimens have altered the natural history of what once was a chronic disease, and they have also reduced peptic ulcer complications, limiting the need for surgery.

scholarly journals The Human Gastric Pathogen Helicobacter pylori and Its Association with Gastric Cancer and Ulcer Disease

Ulcers ◽  
2011 ◽  
Vol 2011 ◽  
pp. 1-23 ◽  
Author(s):  
Bianca Bauer ◽  
Thomas F. Meyer
Keyword(s):  
Gastric Cancer ◽  
Helicobacter Pylori ◽  
Peptic Ulcer ◽  
Peptic Ulcer Disease ◽  
Strain Differences ◽  
Protective Effects ◽  
Ulcer Disease ◽  
Prophylactic Measures ◽  
H Pylori

With the momentous discovery in the 1980's that a bacterium, Helicobacter pylori, can cause peptic ulcer disease and gastric cancer, antibiotic therapies and prophylactic measures have been successful, only in part, in reducing the global burden of these diseases. To date, ~700,000 deaths worldwide are still attributable annually to gastric cancer alone. Here, we review H. pylori's contribution to the epidemiology and histopathology of both gastric cancer and peptic ulcer disease. Furthermore, we examine the host-pathogen relationship and H. pylori biology in context of these diseases, focusing on strain differences, virulence factors (CagA and VacA), immune activation and the challenges posed by resistance to existing therapies. We consider also the important role of host-genetic variants, for example, in inflammatory response genes, in determining infection outcome and the role of H. pylori in other pathologies—some accepted, for example, MALT lymphoma, and others more controversial, for example, idiopathic thrombocytic purpura. More recently, intriguing suggestions that H. pylori has protective effects in GERD and autoimmune diseases, such as asthma, have gained momentum. Therefore, we consider the basis for these suggestions and discuss the potential impact for future therapeutic rationales.

scholarly journals Double pylorus: case report and review of the literature

1999 ◽  
Vol 54 (4) ◽  
pp. 131-134 ◽  
Author(s):  
Adriana Vaz Safatle-Ribeiro ◽  
Ulysses Ribeiro Júnior ◽  
Angelita Habr-Gama ◽  
Joaquim J. Gama-Rodrigues
Keyword(s):  
Peptic Ulcer ◽  
Peptic Ulcer Disease ◽  
Epigastric Pain ◽  
Duodenal Bulb ◽  
Previous History ◽  
Review Of The Literature ◽  
Ulcer Disease ◽  
Double Pylorus ◽  
H Pylori

Double pylorus is an unusual condition in which a double communication between the gastric antrum and the duodenal bulb occurs. It may be congenital, or it may be acquired complication of peptic ulcer disease. We present a case of double pylorus in a gentleman with epigastric pain and previous history of peptic ulcer disease. The relationship between Helicobacter pylori and this disease was assessed. A review of the literature, the role of associated diseases and the role of H. pylori are discussed.

Eradication ofHelicobacter pylori in the Treatment of Peptic Ulcer Disease

1999 ◽  
Vol 12 (5) ◽  
pp. 380-390
Author(s):  
Heather Tangeman ◽  
Mary T. Roth
Keyword(s):  
Helicobacter Pylori ◽  
Peptic Ulcer ◽  
Peptic Ulcer Disease ◽  
Current Clinical Practice ◽  
Ulcer Disease ◽  
Infection Treatment ◽  
Ulcer Relapse ◽  
H Pylori ◽  
Common Infection

Helicobacter pylori is responsible for the majority of cases of peptic ulcer disease. Peptic ulcer disease should no longer be regarded as a “chronic, recurring, lifelong disease, but rather a curable infection.” Treatment and eradication of H. pylori infection in patients with peptic ulcer disease has been shown to resolve the chronic inflammation present and prevent further ulcer relapse. Despite the vast amount of literature on H. pylori infection in peptic ulcer disease, the diagnosis and management of this common infection have become increasingly straightforward. This article will summarize the role of H. pylori in patients with peptic ulcer disease and will address the current clinical practice guidelines for diagnosis and treatment of H. pylori in the subset of patients.

The role of microcirculation disorders in the pathogenesis of peptic ulcer disease

1982 ◽  
Vol 63 (3) ◽  
pp. 21-23
Author(s):  
V. F. Bogoyavlenskiy ◽  
A. G. Oparin ◽  
R. M. Gazizov ◽  
T. I. Rupasova
Keyword(s):  
Duodenal Ulcer ◽  
Peptic Ulcer ◽  
Gastric Ulcer ◽  
Peptic Ulcer Disease ◽  
Gastric Juice ◽  
The State ◽  
Healthy Individuals ◽  
Ulcer Disease

In 60 healthy individuals and 85 patients with gastric ulcer and duodenal ulcer, the state of microcirculation of the conjunctiva of the eye and the level of glycoproteins in the gastric juice were studied. It has been shown that one of the reasons leading to a decrease in the level of mucins in gastric juice may be mucosal hypoxia caused by impaired microcirculation.

scholarly journals Risk of head and neck cancer in patients with peptic ulcers and the effect of Helicobacter pylori treatment

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Yen-Ting Lu ◽  
Chung-Han Hsin ◽  
Ying-Chou Lu ◽  
Meng-Che Wu ◽  
Jing-Yang Huang ◽  
...  
Keyword(s):  
Peptic Ulcer ◽  
Head And Neck Cancer ◽  
Relative Risk ◽  
Peptic Ulcer Disease ◽  
Head And Neck ◽  
Hypopharyngeal Cancer ◽  
Control Group ◽  
Peptic Ulcers ◽  
Ulcer Disease ◽  
H Pylori

AbstractIt remained inconclusive whether patients with peptic ulcer disease had a higher risk of head and neck cancer (HNC). Therefore, we enrolled 109,360 patients with peptic ulcer disease and matched for age and sex with 218,720 controls from the Taiwan National Health Insurance Research Database between January 1, 1997 and December 31, 2013.The HNC incidence rate was 1.33-fold higher in the peptic ulcer group than in the control group (7.52 vs. 5.68 per 100,00 person-years; crude relative risk: 1.33; 95% confidence interval [CI]: 1.08–1.63) after > 6 years of follow-up. However, in the peptic ulcer subgroup with H. pylori treatment, HNC risk was not significantly different from that of the control group (crude relative risk: 1.12; 95% CI: 0.86–1.46). Moreover, the population with peptic ulcers had the highest risk of laryngeal and hypopharyngeal cancer (adjusted HR: 2.27 [95% CI: 1.16–4.44] and 2.00 [95% CI, 1.13–3.55]), respectively. This observational study suggested that peptic ulcer disease is associated with an increased incidence of laryngeal and hypopharyngeal cancer and H. pylori treatment may have a role in preventing HNC in patients with peptic ulcer disease.

Role of herpes simplex virus type 1 (HSV-1) in the pathogenesis of peptic ulcer disease

2001 ◽  
Vol 120 (5) ◽  
pp. A136-A137
Author(s):  
K TSAMAKIDES ◽  
E PANOTOPOULOU ◽  
D DIMITROULOPOULOS ◽  
M CHRISTOPOULO ◽  
D XINOPOULOS ◽  
...  
Keyword(s):  
Peptic Ulcer ◽  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Peptic Ulcer Disease ◽  
Virus Type ◽  
Herpes Simplex Virus Type ◽  
Ulcer Disease ◽  
Simplex Virus

Lifestyle and Peptic Ulcer Disease

2018 ◽  
Vol 24 (18) ◽  
pp. 2034-2040 ◽  
Author(s):  
Berrak C. Yegen
Keyword(s):  
Peptic Ulcer ◽  
Peptic Ulcer Disease ◽  
Alcohol Intake ◽  
Night Sleep ◽  
Unhealthy Lifestyle ◽  
Coping With Stress ◽  
Analgesic Drugs ◽  
Ulcer Disease ◽  
Balanced Diet ◽  
H Pylori

The risk of developing Peptic Ulcer Disease (PUD) was shown to be associated with genetic inheritance, lifestyle and social status of the patients. Unhealthy lifestyle habits and failure in coping with stress have been closely associated with the occurrence of PUD. In contrary, limiting the use of analgesic drugs and glucocorticoids, controlling environmental and socioeconomic factors that predispose to H. Pylori infection, having a balanced diet, exercising regularly, coping successfully with stress, avoiding smoking, limiting alcohol intake and getting sufficient night sleep are essential in prevention and healing of PUD.

scholarly journals The number of household members as a risk factor for peptic ulcer disease

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Mi Hong Yim ◽  
Keun Ho Kim ◽  
Bum Ju Lee
Keyword(s):  
Peptic Ulcer ◽  
Peptic Ulcer Disease ◽  
Binary Logistic Regression ◽  
Cross Sectional Study ◽  
Living Alone ◽  
Cross Sectional ◽  
Ulcer Disease ◽  
Logistic Regression Models ◽  
Household Members ◽  
H Pylori

AbstractPeptic ulcer disease (PUD) is caused by many sociodemographic and economic risk factors other than H. pylori infection. However, no studies reported an association between PUD and the number of household members. We showed the number of family members affected by PUD based on sex in a Korean population. This cross-sectional study used 1998–2009 data from the Korea National Health and Nutrition Examination Survey of the Korea Centers for Disease Control and Prevention. Multiple binary logistic regression models adjusted for confounders were constructed to analyze the association of PUD with the number of household members. The number of household members was associated with PUD, age, body mass index (BMI), waist circumference, systolic blood pressure, hemoglobin, glucose, location (urban/rural), income, education level, stress, current drinking, and smoking in both sexes. Men with other household members had a higher PUD risk compared to men or women living alone (reference), and the opposite was observed for women. Men with 4 household members had a higher PUD risk than men living alone in the model adjusted for age, BMI, income, location, education, and stress (OR = 2.04 [95% CI 1.28–3.27], p value = .003). Women with more than 6 household members had a lower PUD risk than women living alone in the adjusted model (OR = 0.50 [0.33–0.75], p value = .001). Women with more household members had a lower PUD risk. However, more men had PUD than women regardless of the number of household members.

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