scholarly journals 24-hour Holter findings in infants with in utero exposure to Zika virus: a cross-sectional study.

2019 ◽  
Author(s):  
Dulce Helena Gonçalves Orofino ◽  
Sonia Regina Lambert Passos ◽  
Sheila Moura Pone ◽  
Marcos Silva Pone ◽  
Elisa Barroso de Aguiar ◽  
...  

Abstract Background : Antenatal exposure to the Zika virus (ZIKV) is related to severe neurological, ophthalmological and orthopedic manifestations called congenital Zika syndrome (CZS), but no changes in the electrical activity of the heart have been found. A higher prevalence of structural cardiac changes has been described in CZS patients when compared to the general population of live births. To describe 24-hour Holter findings in infants with confirmed antenatal exposure to ZIKV. Methods : Cross-sectional study of 24-hour Holter findings in infants with antenatal exposure to ZIKV confirmed by positive polymerase chain reaction(PCR) . Patients of the cohort of newborns and infants exposed intrautero to the ZIKV which began in November 2015 and continues to date and were hospitalized for clinical or surgical reasons were included. The 24-hour Holter monitoring was performed the day before discharge. Data analysis was descriptive and included subgroups of patients according to the presence of CZS and severe microcephaly. Heart rate, ST segment, QT interval and arrhythmias were evaluated. To evaluate heart rate variability (HRV) we used time domain analysis. The Mann-Whitney test was performed to verify significant differences between the subgroups of patients. Results : The sample consisted of 15 infants with average age of 16 months and 12 were diagnosed with CZS (8 had severe microcephaly). PCR at birth was positive in 8 newborn and 7 had positive maternal PCR during pregnancy. No arrhythmias or QT interval changes were observed. The Mann-Whitney test showed a significant difference between patients with and without CZS and with and without severe microcephaly, with HRV being lower in the groups with severe microcephaly and CZS. Conclusions : The study suggests that the HRV evaluation can be used as a sentinel event to assess the possibility of progressive neurological impairment in newborns with antenatal exposure to ZIKV, allowing early initiation of stimulation therapies in addition to indicating that cardiovascular complications may arise in the medium and long term.

2020 ◽  
Vol 3 (2) ◽  
pp. 163-171
Author(s):  
Mohamad Guntur Nangi ◽  
Yulli Fety ◽  
Alianto

Tuberkulosis masih merupakan masalah kesehatan di Indonesia, khususnya di Wilayah Kerja Puskesmas Benu-Benua Kota Kendari (daerah pesisir) dan Wilayah Kerja Puskesmas Anggaberi Kabupaten Konawe (daerah pegunungan). Tujuan penelitian ini untuk mengetahui perbedaan faktor risiko kejadian TB paru BTA Positif di Daerah Pesisir dan Daerah Pegunungan. Jenis penelitian adalah observasional analitik menggunakan studi perbandingan dengan rancangan Cross Sectional Study dari bulan September-Oktober 2019. Populasi penelitian ini adalah 57 kasus, dengan tehnik penarikan sampel secara Random Sampling, jumlah sampel sebanyak 32 kasus di daerah pesisir dan 25 kasus di daerah pegunungan. Metode analisis menggunakan uji Statistik Mann-Whitney Test. Hasil penelitian menunjukkan ada perbedaan faktor risiko kebiasaan tidur kejadian TB paru BTA positif di daerah pesisir dan daerah pegunungan dengan p-value= 0,003 < α = 0,005), tidak ada perbedaan faktor risiko kebiasaan membuang dahak dengan p-value = 0,253 > α = 0,005, dan ada perbedaan faktor risiko kebiasaan membuka jendela kejadian TB paru BTA positif di daerah pesisir dan daerah pegunungan dengan nilai p-value = 0,003 < α = 0,005. Saran dalam penelitian ini menjadi bahan masukan bagi pengelola program pencegahan dan penanggulangan penyakit khususnya penyakit TB.


2021 ◽  
Author(s):  
Caroline Donini Rodrigues ◽  
Elisiane Lorenzini ◽  
Manuel Portela Romero ◽  
Nelly Donszelmann Oelke ◽  
Vanessa Dalsasso Batista Winter ◽  
...  

Abstract Purpose To analyze the transition of care from the perspective of cancer patients, in a hospital in southern Brazil, correlating perspectives with sociodemographic and clinical characteristics. Methods Cross-sectional study using the Care Transitions Measure (CTM) with cancer patients undergoing clinical or surgical treatment following hospital discharge. Data collection was completed by telephone between June and September 2019. Data analysis was performed using descriptive and inferential statistics. Results The average CTM score was 74.1, which was considered satisfactory. The CTM factors, understanding about medications (83.3) and preparation for self-management (77.7) were satisfactory, while secured preferences (69.4) and care plan (66.1) were unsatisfactory for an effective and safe care transition. No statistically significant difference was found between sociodemographic variables and the CTM. Among the clinical variables, primary cancer and the secured preferences factor showed a significant difference (p = 0.044). Conclusion The transition from hospital care to the community was considered satisfactory in the overall assessment.


Author(s):  
Juranah Juranah ◽  
Yuyun Widaningsih ◽  
William Hamdani ◽  
Ruland DN Pakasi ◽  
Uleng Bahrun

Metastasis is the major cause of increased morbidity and mortality in breast cancer. Interleukin-8 has a contribution in the spread of the tumour cells. This study was aimed to know IL-8 levels in patients with metastasic and non metasatic breast cancer by analyzing. A cross sectional study was performed at the Dr. Wahidin Sudirohusodo, Ibnu Sina and Labuang Baji hospitals during September to December 2011. Laboratory examinations were done in the Research Centre of the Medical Faculty, University of Hasanuddin. Fiftysix (56) subjects with breast cancer were examined. The results showed that the levels of IL-8 in metastatic and non metastatic breast cancer were 13.73 pg/mL and 10.48 pg/mL respectively. Mann-Whitney test showed no significant difference of IL-8 level between them, (p=0.09). When the subjects were divided into early and advance stages, the mean levels of IL-8 were 8.035 pg/mL and 12.052 pg/mL, respectively, showing a significant difference by Mann-Whitney test (p=0.009). Based on this research, the level of IL-8 can be considered as a marker in predicting the prognosis of breast cancer. A further research in cohort studies which specific metastasis crawl method is advised by the researchers, these are suggested to allow the determination of the risk factors.


2018 ◽  
Vol 6 (1) ◽  
pp. 49-61
Author(s):  
Nada Rania ◽  
Nila Kusuma ◽  
Murniwati Murniwati

  Palatal rugae or plica palatinae transversae are irregular and asymmetrical ridges on mucosa membrane which extend laterally from incisive papilla and anterior of palatal raphe. Palatal rugae are protected by cheeks, lips, tongue and buccal pad from incineration and trauma. The use of palatal rugae as an alternative way to identify human is needed in many occurrences such as accident, criminal and disaster. Palatal rugae patterns are vary and not identical in each person but have some similarities within family. This can be caused by hereditary and polygenic inheritance mechanism of palatal rugae. This study aimed to identify palatal rugae pattern similarities between father and his biological son in Minangkabau ethnic. This study is a cross-sectional study. The samples used in this study were 78 pairs of fathers and their biological sons. Alginate impression material was used to record the upper jaw. The impressions were casted by type III dental stone . Palatal rugae were marked and the amount of rugae based on their shape and length classifications were recorded. The data were analyzed using Mann -Whitney test. Result showed that there was no significant difference between fathers’ and their biological sons’ palatal rugae amount based on their shape (p>0,05), but there was significant difference between the amount of primary rugae of fathers and their biological sons (p<0,05). The conclusion is there are no significant differences between fathers’ and th eir biological sons’ palatal rugae amount based on their shape. Palatal rugae pattern can be used as an alternative in human identification because of its individual characteristic and uniqueness. Keywords: palatal rugae, Minangkabau ethnic, father and biological son


Author(s):  
Sriwati Atjo ◽  
Uleng Bahrun ◽  
Hardjoeno Hardjoeno

Carcinoma Mammae is a malignant disease originating from mammary parenchyma, and the second largest cause of death inthe world. Ferritin is a marker of neoplasia, which levels are increased in non-metastatic carcinoma mammae and more increased inmetastatic carcinoma mammae. This cross sectional study was conducted during June 2012 in carcinoma mammae patients of theWahidin Sudirohusodo Hospital, Ibnu Sina Hospital and Labuang Baji Hospital in Makassar. The aim of this study was to know theserum ferritin levels in metastatic and non-metastatic carcinoma mammae. In this study, 56 samples were obtained and grouped intometastatic and non-metastatic carcinoma mammae patients based on the Tumor, Node, Metastasis (TNM). Ferritin test was conductedby ECLIA method using Elecsys Analyzer Kit 2010 (Roche, USA). The study showed that the average ferritin concentration in advancedstage of carcinoma mammae (155.45 ng/mL) was higher than in the early stage (82.74 ng/m). The Mann Whitney test showed significantdifferences between the early and advanced stage (p=0.01), the median ferritin value in metastatic carcinoma mammae was higherthan non-metastatic (79.85 ng/mL). The Mann Whitney test showed significant differences between metastatic and non - metastaticcarcinoma mammae patients (p=0.00). Based on this study, it can be concluded, that ferritin levels can be used as a biomarker to predictthe progressivity of carcinoma mammae.


2022 ◽  
Author(s):  
Yair Blumberg ◽  
Michael Edelstein ◽  
Kamal Abu Jabal ◽  
Ron Golan ◽  
Yuval Perets ◽  
...  

There is increasing evidence that patients who were infected with SARS-CoV-2 may experience adverse health outcomes months after the acute infection has resolved including reduction in aerobic capacity and fatigue. In this study, we compared aerobic capacity and exercise performance of 28 unvaccinated participants to 15 vaccinated ones who performed a symptom limited cardio-pulmonary exercise test (CPET) after acute COVID-19. We identified a significant difference in aerobic capacity between vaccinated and unvaccinated individuals, with a lower V'O2 peak percentage of predicted in the unvaccinated group. In addition, the unvaccinated group had a reduction in the peak-exercise heart rate and lower ventilation values. Our results suggest objective limitations to exercise capacity in the months following acute COVID19 illness, mitigated by vaccination


2017 ◽  
Vol 5 (2) ◽  
pp. 136-148
Author(s):  
Nada Rania ◽  
Nila Kusuma ◽  
Murniwati Murniwati

  Palatal rugae or plica palatinae transversae are irregular and asymmetrical ridges on mucosa membrane which extend laterally from incisive papilla and anterior of palatal raphe. Palatal rugae are protected by cheeks, lips, tongue and buccal pad from incineration and trauma. The use of palatal rugae as an alternative way to identify human is needed in many occurrences such as accident, criminal and disaster. Palatal rugae patterns are vary and not identical in each person but have some similarities within family. This can be caused by hereditary and polygenic inheritance mechanism of palatal rugae. This study aimed to identify palatal rugae pattern similarities between father and his biological son in Minangkabau ethnic. This study is a cross-sectional study. The samples used in this study were 78 pairs of fathers and their biological sons. Alginate impression material was used to record the upper jaw. The impressions were casted by type III dental stone . Palatal rugae were marked and the amount of rugae based on their shape and length classifications were recorded. The data were analyzed using Mann -Whitney test. Result showed that there was no significant difference between fathers’ and their biological sons’ palatal rugae amount based on their shape (p>0,05), but there was significant difference between the amount of primary rugae of fathers and their biological sons (p<0,05). The conclusion is there are no significant differences between fathers’ and th eir biological sons’ palatal rugae amount based on their shape. Palatal rugae pattern can be used as an alternative in human identification because of its individual characteristic and uniqueness. Keywords: palatal rugae, Minangkabau ethnic, father and biological son


BMJ Open ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. e046265
Author(s):  
Shotaro Doki ◽  
Shinichiro Sasahara ◽  
Daisuke Hori ◽  
Yuichi Oi ◽  
Tsukasa Takahashi ◽  
...  

ObjectivesPsychological distress is a worldwide problem and a serious problem that needs to be addressed in the field of occupational health. This study aimed to use artificial intelligence (AI) to predict psychological distress among workers using sociodemographic, lifestyle and sleep factors, not subjective information such as mood and emotion, and to examine the performance of the AI models through a comparison with psychiatrists.DesignCross-sectional study.SettingWe conducted a survey on psychological distress and living conditions among workers. An AI model for predicting psychological distress was created and then the results were compared in terms of accuracy with predictions made by psychiatrists.ParticipantsAn AI model of the neural network and six psychiatrists.Primary outcomeThe accuracies of the AI model and psychiatrists for predicting psychological distress.MethodsIn total, data from 7251 workers were analysed to predict moderate and severe psychological distress. An AI model of the neural network was created and accuracy, sensitivity and specificity were calculated. Six psychiatrists used the same data as the AI model to predict psychological distress and conduct a comparison with the AI model.ResultsThe accuracies of the AI model and psychiatrists for predicting moderate psychological distress were 65.2% and 64.4%, respectively, showing no significant difference. The accuracies of the AI model and psychiatrists for predicting severe psychological distress were 89.9% and 85.5%, respectively, indicating that the AI model had significantly higher accuracy.ConclusionsA machine learning model was successfully developed to screen workers with depressed mood. The explanatory variables used for the predictions did not directly ask about mood. Therefore, this newly developed model appears to be able to predict psychological distress among workers easily, regardless of their subjective views.


BMJ Open ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. e043814
Author(s):  
Mesfin Tadese ◽  
Andargachew Kassa ◽  
Abebaw Abeje Muluneh ◽  
Girma Altaye

ObjectivesThe study aimed to provide an association between dysmenorrhoea and academic performance among university students in Ethiopia. Further, the study attempts to determine the prevalence and associated risk factors of dysmenorrhoea.Design and methodInstitution-based cross-sectional study was conducted from 1 April to 28 April 2019. A semistructured and pretested self-administered questionnaire was used to collect data. Binary logistic regression analysis and one-way analysis of variance were performed to model dysmenorrhoea and academic performance, respectively.Setting and participantsEthiopia (2019: n=647 female university students).OutcomesThe primary outcome is dysmenorrhoea, which has been defined as painful menses that prevents normal activity and requires medication. The self-reported cumulative grade point average of students was used as a proxy measure of academic performance, which is the secondary outcome.ResultsThe prevalence of dysmenorrhoea was 317 (51.5%). The educational status of father (adjusted OR (AOR) (95% CI) 2.64 (1.04 to 6.66)), chocolate consumption (AOR (95% CI) 3.39 (95% 1.28 to 8.93)), daily breakfast intake (<5 days/week) (AOR (95% CI) 0.63 (0.42 to 0.95)), irregular menstrual cycle AOR (95% CI) 2.34 (1.55 to 3.54)) and positive family history of dysmenorrhoea AOR (95% CI) 3.29 (2.25 to 4.81)) had statistically significant association with dysmenorrhoea. There was no statistically significant difference in academic performance among students with and without dysmenorrhoea (F (3611)=1.276, p=0.28)).ConclusionsDysmenorrhoea was a common health problem among graduating University students. However, it has no statistically significant impact on academic performance. Reproductive health officers should educate and undermine the negative academic consequences of dysmenorrhoea to reduce the physical and psychological stress that happens to females and their families.


2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Abeer Alharbi ◽  
Joharah Alzuwaed ◽  
Hind Qasem

Abstract Background The Ministry of Health in Saudi Arabia is expanding the country’s telemedicine services by using advanced technology in health services. In doing so, an e-health application (app), Seha, was introduced in 2018 that allows individuals to have face-to-face visual medical consultations with their doctors on their smartphones. Objective This study evaluated the effectiveness of the app in improving healthcare delivery by ensuring patient satisfaction with the care given, increasing access to care, and improving efficiency in the healthcare system. Methods A cross-sectional study design was used to assess the perceptions of users of the Seha app and non-users who continued with traditional health services. The data were collected using an online survey via Google Forms between June 2020 and September 2020. Independent t tests and chi-square (χ2) tests were conducted to answer the research questions. Results There was a significant difference between users and non-users in terms of ease of access to health services (t =  − 9.38, p < 0.05), with app users having a higher mean score (4.19 ± 0.91) than non-users (3.41 ± 1.00); satisfaction with health services (t =  − 6.33, p < 0.05), with users having a higher mean score (3.96 ± 0.91) than non-users (3.45 ± 0.94); and efficiency (only one visit needed for treatment) (t =  − 3.20, p < 0.05), with users having a higher mean score (3.71 ± 0.93) than non-users (3.45 ± 0.93). There were significant associations between the use of the Seha app and age (χ2 = 8.79, p < 0.05), gender (χ2 = 22.19, p < 0.05), region (χ2 = 19.74, p < 0.05), and occupation (χ2 = 22.05, p < 0.05). There were significant relationships between the three items (on access, satisfaction, and efficiency) and experiencing technical issues (t = 4.47, t = 8.11, and t = 3.24, respectively, p < 0.05), with users who faced technical problems having significantly lower mean scores for all three items. Conclusion This study provided evidence that the Seha app improved the delivery of healthcare in Saudi Arabia. Users of the app had a better health experience in terms of their perceived ease of access to healthcare services; their satisfaction with healthcare services; and the efficiency of the system, measured by the number of required doctor visits. Other factors that appeared to influence the use of the app included age, gender, usual source of care, and technical difficulties.


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