scholarly journals KADAR INTERLEUKIN-8 KANKER PAYUDARA

2016 ◽  
Vol 20 (3) ◽  
pp. 205
Author(s):  
Juranah Juranah ◽  
Yuyun Widaningsih ◽  
William Hamdani ◽  
Ruland DN Pakasi ◽  
Uleng Bahrun
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast ◽  
Cross Sectional Study ◽  
Interleukin 8 ◽  
Research Centre ◽  
Cross Sectional ◽  
Whitney Test ◽  
Mann Whitney Test ◽  
Significant Difference ◽  
Laboratory Examinations

Metastasis is the major cause of increased morbidity and mortality in breast cancer. Interleukin-8 has a contribution in the spread of the tumour cells. This study was aimed to know IL-8 levels in patients with metastasic and non metasatic breast cancer by analyzing. A cross sectional study was performed at the Dr. Wahidin Sudirohusodo, Ibnu Sina and Labuang Baji hospitals during September to December 2011. Laboratory examinations were done in the Research Centre of the Medical Faculty, University of Hasanuddin. Fiftysix (56) subjects with breast cancer were examined. The results showed that the levels of IL-8 in metastatic and non metastatic breast cancer were 13.73 pg/mL and 10.48 pg/mL respectively. Mann-Whitney test showed no significant difference of IL-8 level between them, (p=0.09). When the subjects were divided into early and advance stages, the mean levels of IL-8 were 8.035 pg/mL and 12.052 pg/mL, respectively, showing a significant difference by Mann-Whitney test (p=0.009). Based on this research, the level of IL-8 can be considered as a marker in predicting the prognosis of breast cancer. A further research in cohort studies which specific metastasis crawl method is advised by the researchers, these are suggested to allow the determination of the risk factors.

scholarly journals 24-hour Holter findings in infants with in utero exposure to Zika virus: a cross-sectional study.

2019 ◽  
Author(s):  
Dulce Helena Gonçalves Orofino ◽  
Sonia Regina Lambert Passos ◽  
Sheila Moura Pone ◽  
Marcos Silva Pone ◽  
Elisa Barroso de Aguiar ◽  
...  
Keyword(s):  
Heart Rate ◽  
Zika Virus ◽  
Qt Interval ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Discharge Data ◽  
Whitney Test ◽  
Mann Whitney Test ◽  
Significant Difference

Abstract Background : Antenatal exposure to the Zika virus (ZIKV) is related to severe neurological, ophthalmological and orthopedic manifestations called congenital Zika syndrome (CZS), but no changes in the electrical activity of the heart have been found. A higher prevalence of structural cardiac changes has been described in CZS patients when compared to the general population of live births. To describe 24-hour Holter findings in infants with confirmed antenatal exposure to ZIKV. Methods : Cross-sectional study of 24-hour Holter findings in infants with antenatal exposure to ZIKV confirmed by positive polymerase chain reaction(PCR) . Patients of the cohort of newborns and infants exposed intrautero to the ZIKV which began in November 2015 and continues to date and were hospitalized for clinical or surgical reasons were included. The 24-hour Holter monitoring was performed the day before discharge. Data analysis was descriptive and included subgroups of patients according to the presence of CZS and severe microcephaly. Heart rate, ST segment, QT interval and arrhythmias were evaluated. To evaluate heart rate variability (HRV) we used time domain analysis. The Mann-Whitney test was performed to verify significant differences between the subgroups of patients. Results : The sample consisted of 15 infants with average age of 16 months and 12 were diagnosed with CZS (8 had severe microcephaly). PCR at birth was positive in 8 newborn and 7 had positive maternal PCR during pregnancy. No arrhythmias or QT interval changes were observed. The Mann-Whitney test showed a significant difference between patients with and without CZS and with and without severe microcephaly, with HRV being lower in the groups with severe microcephaly and CZS. Conclusions : The study suggests that the HRV evaluation can be used as a sentinel event to assess the possibility of progressive neurological impairment in newborns with antenatal exposure to ZIKV, allowing early initiation of stimulation therapies in addition to indicating that cardiovascular complications may arise in the medium and long term.

Association of CYP2D6*10 (c. 100 C>T) Genotype with Z-END Concentration in Patients with Breast Cancer Receiving Tamoxifen Therapy in Indonesian Population

2019 ◽  
Vol 19 (8) ◽  
pp. 1198-1206 ◽  
Author(s):  
Yenny ◽  
Sonar S. Panigoro ◽  
Denni J. Purwanto ◽  
Adi Hidayat ◽  
Melva Louisa ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Steady State ◽  
Ultra Performance Liquid Chromatography ◽  
Cross Sectional Study ◽  
Threshold Concentration ◽  
Breast Cancer Patients ◽  
Cross Sectional ◽  
Significant Difference ◽  
Pcr Rflp ◽  
Liquid Chromatography Tandem Mass

Background: Tamoxifen (TAM) is a frequently used hormonal prodrug for patients with breast cancer that needs to be activated by cytochrome P450 2D6 (CYP2D6) into Zusammen-endoxifen (Z-END). Objective: The purpose of the study was to determine the association between CYP2D6*10 (c.100C>T) genotype and attainment of the plasma steady-state Z-END minimal threshold concentration (MTC) in Indonesian women with breast cancer. Methods: A cross-sectional study was performed in 125 ambulatory patients with breast cancer consuming TAM at 20 mg/day for at least 4 months. The frequency distribution of CYP2D6*10 (c.100C>T) genotypes (C/C: wild type; C/T: heterozygous mutant; T/T: homozygous mutant) was detected using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), the results of which were subsequently confirmed by sequencing. The genotypes were categorized into plasma Z- END concentrations of <5.9 ng/mL and ≥5.9 ng/mL, which were measured using ultra performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS). Results: Percentages of C/C, CT, and T/T genotypes were 22.4%, 29.6%, and 48.8%, respectively. Median (25-75%) Z-END concentrations in C/C, C/T, and T/T genotypes were 9.58 (0.7-6.0), 9.86 (0.7-26.6), and 3.76 (0.9-26.6) ng/mL, respectively. Statistical analysis showed a significant difference in median Z-END concentration between patients with T/T genotype and those with C/C or C/T genotypes (p<0.001). There was a significant association between CYP2D6*10 (c.100C>T) genotypes and attainment of plasma steady-state Z-END MTC (p<0.001). Conclusion: There was a significant association between CYP2D6*10 (c.100C>T) and attainment of plasma steady-state Z-END MTC in Indonesian breast cancer patients receiving TAM at a dose of 20 mg/day.

Injury rates in recreational tennis players do not differ between different playing surfaces

2017 ◽  
Vol 52 (9) ◽  
pp. 611-615 ◽  
Author(s):  
Babette M Pluim ◽  
Benjamin Clarsen ◽  
Evert Verhagen
Keyword(s):  
Cross Sectional Study ◽  
Research Centre ◽  
Overuse Injuries ◽  
Cross Sectional ◽  
Injury Rates ◽  
Tennis Players ◽  
Trauma Research ◽  
Natural Grass ◽  
Significant Difference ◽  
Artificial Grass

ObjectiveThe aim of this study was to determine whether there is a difference in the prevalence of tennis injuries between the four most common court surfaces in the Netherlands, including hard court, clay, sand-fill artificial grass and red-sand-fill artificial grass. Natural grass was not included in this study.MethodsThis was a repeated cross-sectional study over 6 months, involving members of the Royal Netherlands Lawn Tennis Association (KNLTB). A monthly questionnaire was sent to a random sample of 20 000 KNLTB members, stratified by their club’s playing surface. The questionnaire included questions on court surface, tennis exposure and physical complaints, using the Oslo Sports Trauma Research Centre questionnaire on health problems.ResultsA total of 3656 (18%) of the 20 000 invited members completed at least one of the monthly questionnaires [mean age 49 years (15)]. A total of 4047 injuries were reported by 1957 respondents. Of these injuries, 3246 (80%) were overuse and 801 (20%) were acute. There were no statistically significant differences in injury prevalence between groups who played primarily on any one of the four court surfaces. However, players who played on multiple surfaces had a higher injury prevalence, particularly of overuse injuries, than those who primarily played on one court surface. Compared with the other court surfaces, there was a higher prevalence of lower limb overuse injuries when playing on hard court.ConclusionThere is no significant difference in the overall prevalence of injury on clay, hard court, sand-fill artificial grass and red-sand-fill artificial grass.

scholarly journals EFEKTIVITAS POSISI TANGAN PENOLONG DALAM PENCEGAHAN RUPTUR PERINEUM PADA PERSALINAN NORMAL

2017 ◽  
Vol 9 (01) ◽  
pp. 68
Author(s):  
Mulyati Priyantini ◽  
Yuli Trisnawati
Keyword(s):  
Maternal Morbidity ◽  
P Value ◽  
Cross Sectional ◽  
Second Stage Of Labor ◽  
Whitney Test ◽  
Second Stage ◽  
Mann Whitney Test ◽  
Significant Difference ◽  
U Value ◽  
Quota Sampling

ABSTRAKFokus utama asuhan persalinan adalah pencegahan komplikasi untuk mengurangi angka kesakitan dan kematian ibu. Salah satu upaya adalah mencegah terjadinya ruptur perineum. Posisi tangan yang dipakai penolong persalinan kala II untuk mencegah ruptur perineum antara lain posisi tangan APN dan Varney. Penelitian ini bertujuan untuk mengetahui efektivitas antara posisi tangan penolong menurut APN dan menurut Varney dalam mencegah ruptur perineum spontan pada kala II persalinan di RSIA ‘Bunda arif’ Purwokerto. Penelitian ini merupakan penelitian observasional analitik, menggunakan pendekatan cross sectional dengan populasi seluruh persalinan spontan di RSIA ‘Bunda arif’ Purwokerto. Sampel yang digunakan adalah quota sampling  sebanyak 30 sampel yang memenuhi kriteria inklusi. Metode analisis data menggunakan uji U Mann-Whitney. Hasil penelitian ini adalah Kejadian ruptur perineum pada posisi tangan menurut APN sebanyak 93,3%, sedangkan menurut Varney sebanyak 86,7%. Hasil analisa statistik uji U Mann-Whitney didapatkan p value = 0,550 (p>0,005) sedangkan U value  = 33,000 (Uh < U t ), artinya tidak ada perbedaan bermakna, tetapi posisi tangan Varney lebih baik dengan selisih ruptur 6,6%. Posisi tangan penolong menurut Varney lebih efektif daripada posisi tangan menurut APN dalam pencegahan ruptur perineum spontan pada kala II persalinan, tetapi keduanya tidak memberikan perbedaan yang bermakna terhadap kejadian ruptur perineum. Penolong persalinan dapat menemukan metode yang paling tepat dalam meminimalisir kejadian ruptur perineum spontan untuk menurunkan angka kesakitan dan kematian ibu.Keyword : Posisi tangan penolong, ruptur perineumEFFECTIVENESS OF HANDLING POSITION IN PREVENTION OF PERINEUM RUPTURE IN NORMAL LABORABSTRACTMain focus of delivery care is preventing the complication to reduce the maternal morbidity and mortality. One of the efforts to prevent the occurance of perineal rupture. The position hand which is used birth attendant in the second stage of labor to prevent perineal rupture among others APN and Varney hands position. The goal of this reasearch is to know the effectiveness between APN and Varney hands position to prevent spontanoeus perineal rupture in the second stage of labor in RSIA ‘Bunda arif’ Purwokerto. This reasearch was observational analytic by approachment cross sectional with population of this reasearch was all of spontaneous delivery in RSIA ‘Bunda arif’ Purwokerto and the sample used quota sampling, it’s about 30 sample can be a inclusion criteria. The analyze method data used U Mann-Whitney test. The result of this experiment are precentage of spontaneous perineal rupture by  APN hands position is 93,3%, while by Varney is 86,7%. Result of statistic analysis used U Mann-Whitney test is p value = 0,550 (p>0.005) and U value  = 33,000 (Uh < U t). It means, not significant difference, but Varney hands position better by a margin of 6.6%. the conclusion are varney hands position is more effective than APN hands position in  prevention spontaneous perineal rupture in the second stage of labor, but both not significant for perinel rupture. Suggestion : Birth attendants can find the most appopriate method to minimize perineal ruptured to reduce maternal morbidity and mortalityKeyword : APN & Varney hands position, and perineal rupture.

scholarly journals Effect of Flavor Enhancement on the Appreciation of Food in Breast Cancer Patients Undergoing Chemotherapy

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 320-320
Author(s):  
Kenza Drareni ◽  
Moustafa Bensafi ◽  
Helene Lusson ◽  
Damien Vansteene ◽  
Agnès Giboreau ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Hierarchical Cluster ◽  
Cross Sectional Study ◽  
Control Group ◽  
Breast Cancer Patients ◽  
Cross Sectional ◽  
Funding Sources ◽  
Significant Difference ◽  
The Impact

Abstract Objectives Given the influence of sensory signals on food intake regulation and the subsequent nutritional status, it is important to reduce the impact of commonly observed smell and taste alterations on the pleasure of eating during chemotherapy. This study aimed to examine the effect of various types of flavor enhancement on the appreciation of an appetizer by a group of patients undergoing chemotherapy. Methods Five eggplant appetizers with no seasoning (REF) or enhanced with either salt, lemon, garlic or cumin were developed. In this cross-sectional study, 36 healthy female subjects (age 58 ± 7 y) (control group) and 84 breast cancer patients (age 56 ± 11 y) treated with chemotherapy were recruited. A hierarchical cluster analysis based on patients' self-reported smell and taste abilities classified the patients in two groups: the ‘unaltered, (high sensory abilities) n = 49’ and the ‘altered, (poor sensory abilities), n = 35’ group. Participants tasted and assessed the appreciation of the reference appetizer on a visual analog scale and performed a randomized comparative liking task, by rating the appreciation for each flavor-enhanced appetizer relative to the REF (one-sample t-test). Results There was no significant difference in the appreciation of the REF appetizer between the three groups (P &gt; 0.05). In the comparative liking task, the control group rated similarly the appreciation between the flavor-enhanced and the REF appetizers except for the cumin-enhanced appetizer, which was appreciated significantly more than the REF (P &lt; 0.001). Patients in both ‘altered’ and ‘unaltered’ groups appreciated similarly the cumin appetizer (P &gt; 0.05), more the salt and garlic-enhanced appetizers (P ≤ 0.001, P = 0.005, respectively) and significantly less the lemon-enhanced appetizer relative to the REF (P = 0.029), confirming a tendency for patients to reject acid-flavored foods. Conclusions The salt and garlic enhancements were appreciated by the patients independent of the stage of chemotherapy or the severity of smell and taste alterations. Flavor enhancement seems a good strategy to maintain the pleasure of eating in patients undergoing chemotherapy. Further research is still needed on the appreciation and intake of a complete meal (starter, main course, dessert). Funding Sources APICIL and ELIOR groups.

scholarly journals Knowledge and Awareness of Breast Self-Examination among Secondary School Girls in Seremban, Negeri Sembilan

2019 ◽  
Vol 4 (2) ◽  
pp. 39-43
Author(s):  
Nur Anis Izzati Che Mut ◽  
Noor Hidayah Abu Bakar ◽  
Izdihar Kamal ◽  
Siti Aisyah Abdullah Suhaimi ◽  
Nurul Mawaddah Mohammad ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Secondary School ◽  
Demographic Data ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Breast Self Examination ◽  
Significant Difference ◽  
Level Of Knowledge ◽  
School Girls ◽  
Self Examination

Objective: Breast Self-Examination (BSE) is an early detection method of breast cancer. It is able to develop responsibility for breast health among women to always aware of any changes in the breast. Thus, secondary school girls age is the perfect age to start practice the BSE. The purpose of this study is to determine the level of knowledge and awareness on BSE among secondary school girls in Seremban, Negeri Sembilan. Methods: A cross-sectional study was conducted among 502 secondary school girls using self-administered questionnaire covering socio-demographic data, knowledge and awareness of breast cancer and knowledge and awareness of BSE. Results: The mean age of the participants is 14.9 ± 0.06 years. The majority of the participants were Malays (86.5%). A total of 6.1% of the participants had a family history of breast cancer. Nine percent of participants had a good knowledge and 91.0% had poor knowledge regarding BSE. There is a significant difference between the age of participants with the level of knowledge and awareness (p = 0.014). Conclusion: The knowledge and awareness of BSE were poor among secondary school girls in Seremban, Negeri Sembilan.

scholarly journals Comparison of Motor Skills and Postures of Elite Male Teenage Volleyball and Basketball Players

2021 ◽  
Vol 6 (4) ◽  
pp. 226-239
Author(s):  
Ali Fatahi ◽  
◽  
Behshad Panjehzadeh ◽  
Zahrah Koreli ◽  
Haniyeh Zehtab Asghari ◽  
...  
Keyword(s):  
Motor Skills ◽  
T Test ◽  
The Body ◽  
Basketball Players ◽  
Cross Sectional ◽  
Statistical Population ◽  
Whitney Test ◽  
Mann Whitney Test ◽  
Significant Difference ◽  
Volleyball Players

Objective: To achieve the excellent levels of athletic performance, professional athletes need to do continuous exercises and strengthen special muscles of the body and have to spend a lot of time training in that sport. As a result, depending on the prevailing condition of each sport, the physical orientation and the degree of abnormalities of the athletes in that sport are affected. Methods: The current study is descriptive and cross-sectional. The statistical population was 12-14 years old boys in middle and high school. The statistical sample of this study included 30 people (13 volleyball players and 17 basketball players) with a targeted training rate of at least three sessions per week. The Chippaux Smirak Index (CSI) method was used to evaluate the arch of the foot and to determine the angles and degrees of kyphosis and lordosis in radiographs. Independent t-test and Mann-Whitney test were used to compare the variables of motor skills and posture by SPSS V. 18 at a significant level of 0.05. Results: The results of independent t-test to compare the variables of motor skills in the two groups of volleyball and basketball show that there is a significant difference between the two groups in the Sargent test and 4mX9m (P=0.000) (P≥0.05). The results were different in strength test (P=0.41) and Sit-up (P=0.75) so that there was no significant difference between the two groups (P≥0.05). The results of Mann-Whitney test to compare posture-related variables showed that there was no significant difference between the two groups in any of the parameters of varus, valgus, pronation, supination, lordosis, kyphosis, foot flat (P≥0.05). Conclusion: The results showed that volleyball players have more impressive and explosive power than basketball players, but in terms of muscle strength and endurance, there is not much difference between these two groups, which is probably due to the nature and specific characteristics of their sports. Therefore, it seems necessary to pay more attention to athletes’ training programs to improve their motor skills and physical condition. In this study, the behavior and common habits of the subjects in interaction with the environment and hereditary characteristics have not been studied, so more research is needed in the etiology of musculoskeletal abnormalities.

scholarly journals Energy System Assessment in Metastatic Breast Cancer: A Cross-Sectional Study

2020 ◽  
Author(s):  
Antonio I Cuesta-Vargas ◽  
Jena Buchan ◽  
Bella Pajares ◽  
Ruiz-Medina Sofía ◽  
Emilio Alba ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Heart Rate ◽  
Metastatic Breast Cancer ◽  
Lower Limb ◽  
Metastatic Breast ◽  
Energy System ◽  
Cross Sectional Study ◽  
Baseline Assessment ◽  
Sectional Study ◽  
Cross Sectional

Abstract Background: Metastasis breast cancer commonly report physical and psychosocial side effects, which requires a supervised exercise prescription with an individualized assessment. This cross-sectional study examined the feasibility of energy system-based assessment, also generating descriptive values for assessment performance in this population.Methods: This cross-sectional study recruited 70 women diagnosed with metastatic breast cancer. After baseline assessment, participants attempted up to three energy system assessments: submaximal aerobic (multi-stage treadmill); anaerobic alactic (30-second sit-to-stand [30-STS]); and anaerobic lactic (adapted burpees). Heart rate and rating of perceived exertion (RPE) were recorded. Secondary outcomes included body composition, CRF and upper- and lower-limb functionality. Results: 64 and 70 of the participants performed the submaximal aerobic test and the 30-STS, respectively, and 5 completed the adapted burpees task. Heart rate and RPE specific to each task were correlated, reflecting increased intensity. Women reported low-moderate levels of CRF [3(2.1)] and moderate-high functionality levels [upper-limb: 65.8% (23.3); lower-limb: 63.7% (34.7)]. Conclusions: Using a combination of heart rate and RPE, as well as baseline assessment of each energy system, clinicians may improve ability to prescribe personalized exercise and give patients greater ability to self-monitor intensity and progress.Trial registration: ClinicalTrials.gov ID NCT03879096

Sign in / Sign up

Export Citation Format

Share Document