scholarly journals A multicenter case-control study on non-genetic risk factors in infants with congenital heart disease

2019 ◽  
Author(s):  
Wei Ye ◽  
Xiao-Long Deng ◽  
Sheng Huang ◽  
Tong-Qiang Zhang ◽  
Qi-Zhu Tang
Keyword(s):  
Risk Factors ◽  
Congenital Heart Disease ◽  
Heart Disease ◽  
Genetic Risk ◽  
Congenital Heart ◽  
Perinatal Period ◽  
Genetic Risk Factors ◽  
General Situation ◽  
Control Group ◽  
Case Group

Abstract Background: The incidence of congenital heart disease (CHD) is growing at a rapid speed worldwide, which due to changes of both environmental and lifestyle exposures. This study aimed to explore how the non-genetic risk factors of maternal and perinatal conditions influenced onset of CHD in infants.Methods: Infants with congenital heart disease diagnosed by echocardiography from May 2012 to December 2013 were recruited as positive cases, while healthy individuals without congenital heart disease recruited at the same period were regarded as controls. The general situation of parents and the exposure to environmental factors during perinatal period in the case group and the control group were investigated by questionnaires.Results: A total of424 questionnaires of infants with congenital heart disease and 362 healthy controls were finally collected. We analyzed the risk factors during perinatal period of their mothers showed that their mothers took drugs in early pregnancy (odds ratio [OR]=4.41, 95 % confidence interval [CI]:2.41-6.73), viral infection (OR = 2.97, 95% CI: 1.62-5.73), house decoration (OR = 1.82, 95% CI: 1.43-3.75), hair dyeing and scalding (OR = 2.24, 95% CI:1.46-4.05), parents' exposures to work environment pollution (OR = 2.77, 95% CI: 2.03-5.38) were independent risk factors for cardiovascular malformations. With the increase of exposure factors, the risk of congenital heart disease increased significantly. When pregnant women were exposed to three or more risk factors at the same time, the risk of infants with congenital heart disease in was 17.24 times higher than that of single-factor exposure.Conclusions: Together, the incidence of CHD in infants is correlated with the exposure to perinatal risk factors.

scholarly journals Red Cell Distribution Width as a Prognostic Indicator in Pediatric Heart Disease and after Surgery

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Vural Polat ◽  
Sahin Iscan ◽  
Mustafa Etli ◽  
Helin El Kılıc ◽  
Özgür Gürsu ◽  
...  
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Hospital Stay ◽  
Congenital Heart ◽  
Red Cell Distribution Width ◽  
Control Group ◽  
Case Group ◽  
Red Cell ◽  
Cell Distribution ◽  
Distribution Width

Background. Red cell distribution width (RDW) is an important marker which reflects inflammatory activity in many chronic diseases. The objective of this study is to investigate the impact of RDW on morbidity and mortality before and after pediatric congenital heart surgery.Methods. 107 patients with congenital heart disease, cardiac case group, and 70 patients, control group, without heart disease were retrospectively analyzed. Pre-, and postoperative and at discharge RDW of the cardiac patients were determined. Lengths of hospital and intensive care unit (ICU) stay and exited patients were determined.Results. Mean lengths of ICU and hospital stay were3.3±2.7and7.3±2.9days. In control group, mean preoperative RDW was12.6±1.4, while in cardiac case group it was significantly higher (15.1±3.5). In cardiac case group, postoperative RDW were significantly higher than preoperative period, while RDW at discharge were significantly lower than postoperative estimates. A significant and a positive correlation was detected between lengths of ICU and hospital stay and RDW. RDW of the exited patients were significantly higher than the survivors.Conclusions. This study demonstrates that RDW can be used as an important indicator in the prediction of morbidity and mortality during pre-, and postoperative period of the pediatric congenital heart disease surgery.

scholarly journals Genome-wide association study in European patients with congenital heart disease identifies risk loci for transposition of the great arteries and anomalies of the thoracic arteries and veins and expression of discovered candidate genes in the developing heart

2020 ◽  
Author(s):  
Harald Lahm ◽  
Meiwen Jia ◽  
Martina Dreßen ◽  
Felix Wirth ◽  
Nazan Puluca ◽  
...  
Keyword(s):  
Risk Factors ◽  
Congenital Heart Disease ◽  
Heart Disease ◽  
Association Study ◽  
Candidate Genes ◽  
Genetic Risk ◽  
Congenital Heart ◽  
Septal Defects ◽  
Genome Wide ◽  
Arteries And Veins

AbstractRationaleGenetic factors undoubtedly contribute to the development of congenital heart disease (CHD), but still remain mostly ill-defined.ObjectiveIdentification of genetic risk factors associated with CHD and functional analysis of SNP-carrying genes.Methods and ResultsGenetic association study of 1,440 Caucasian CHD patients from the German Heart Center Munich collected from March 2009 to June 2016, 2,594 patients of previous studies provided by the Newcastle University and 8,486 controls underwent meta-analysis to detect single nucleotide polymorphisms (SNPs) associated with CHD.Results4,034 Caucasian CHD patients strictly classified according to the Society of Thoracic Surgeons nomenclature and 8,486 controls were included. One SNP on chromosome 5 reached genome-wide significance across all CHD phenotypes (rs185531658,OR:2.16, p=5.28×10−9) and was also indicative for septal defects (OR:2.16, p=6.15×10−8). One region on chromosome 20 pointing to the MACROD2 locus, identified four SNPs (rs150246290,OR:3.78, p=1.27×10−10; rs149890280,OR:3.74, p=1.8×10−10; rs149467721,OR:3.53; p=1.39×10−9, rs77094733,OR:3.53, p=1.73×10−9) in patients with transposition of the great arteries (TGA). A second region was detected on chromosome 8 located at ZBTB10 (rs148563140,OR:3.42, p=3.28×10−8; rs143638934,OR:3.42, p=3.51×10−8) in the same subgroup. Three highly significant risk variants on chromosome 17 (rs76774446,OR:1.60, p=9.95×10−8; rs11874,OR:1.60, p=6.64×10−8; rs17677363,OR:1.60, p=9.81×10−8) within the GOSR2 locus were identified in patients with anomalies of thoracic arteries and veins (ATAV). Genetic variants associated with ATAV are suggested to influence expression of WNT3, and variant rs870142 related to septal defects is proposed to influence expression of MSX1. Cardiac differentiation of human and murine induced pluripotent stem cells and single cell RNAseq analyses of developing murine and human hearts show essential functional roles for MACROD2, GOSR2, WNT3 and MSX1 at all developmental stages.ConclusionsFor the first time genetic risk factors in CHD patients with TGA and ATAV were identified. Several candidate genes play an essential functional role in heart development at the embryonic, newborn and adult stage.

scholarly journals Identification of Genetic Risk Factors for Neonatal Hyperbilirubinemia in Fujian Province, Southeastern China: A Case-Control Study

2018 ◽  
Vol 2018 ◽  
pp. 1-8 ◽  
Author(s):  
Jinfu Zhou ◽  
Changyi Yang ◽  
Wenbin Zhu ◽  
Shuwei Chen ◽  
Yinglin Zeng ◽  
...  
Keyword(s):  
Risk Factors ◽  
Genetic Risk ◽  
G6pd Deficiency ◽  
Genetic Risk Factors ◽  
Neonatal Hyperbilirubinemia ◽  
Control Group ◽  
Case Group ◽  
Southeastern China ◽  
Abo Incompatibility ◽  
Control Study

To date, the genetic risk factors for neonatal hyperbilirubinemia remain unknown in Southeastern China. This case-control study aimed to identify the genetic risk factors for neonatal hyperbilirubinemia in Fujian, Southeastern China. A total of 286 hyperbilirubinemic newborns were enrolled as a case group, and 250 randomly selected newborns without jaundice or with a bilirubin level that was lower than the threshold required for phototherapy served as controls. The serum levels of total bilirubin, unconjugated bilirubin, and direct bilirubin were measured, and the common genetic loci in UGT1A1, OATP1B1, and HO-1 genes were genotyped. Higher incidence of ABO incompatibility and G6PD deficiency was detected in the case group compared to the control group (P < 0.01). There were significant differences in the frequencies of rs4148323 and rs1805173 genotypes between the case and control groups (P < 0.05). At the rs4148323 locus, the frequencies of GA heterozygotes and AA mutant homozygotes were higher in the case group than in the control group (P < 0.05), and at the rs1805173 locus, the frequencies of LS, MS, and SS genotypes were higher in the case group than in the control group (P < 0.05). A higher frequency of rs4148323 A allele and rs1805173 S allele was detected in the case group compared to the control group (P = 0). Additionally, multivariate logistic regression analysis identified that the mutant genotype of rs4148323 in the UGT1A1 gene, ABO incompatibility, G6PD deficiency, and SS genotype at rs1805173 locus of the HO-1 gene were genetic risk factors of neonatal hyperbilirubinemia. Our data demonstrate that G211 mutation in the UGT1A1 gene, ABO incompatibility, G6PD deficiency, and the SS genotype of the repeats in the promoter region of the HO-1 gene are risk factors for neonatal hyperbilirubinemia in Fujian, Southeastern China.

scholarly journals The level of superoxide dismutase and catalase in acyanotic congenital heart disease children with heart failur

2021 ◽  
Vol 16 (1) ◽  
pp. 150-156
Author(s):  
Henry Wicaksono ◽  
Mahrus A Rahman ◽  
Roedi Irawan ◽  
I Ketut Alit Utamayasa ◽  
Teddy Ontoseno ◽  
...  
Keyword(s):  
Heart Failure ◽  
Congenital Heart Disease ◽  
Superoxide Dismutase ◽  
Heart Disease ◽  
Congenital Heart ◽  
Control Group ◽  
Case Group ◽  
Significant Difference ◽  
The Difference ◽  
Acyanotic Congenital Heart Disease

Background: The most common complication in acyanotic congenital heart disease (CHD) is heart failure which definitive diagnosis and therapy remain unsatisfactory. Heart failure’s progression is often associated with oxidative stress process. Superoxide dismutase (SOD) is the first line antioxidant of defense against superoxide anion. While Catalase (CAT) breaks down hydrogen peroxide into water and oxygen molecules which complements previous detoxification carried out by SOD. Objective: This study aimed to compare the differences of SOD and CAT levels in acyanotic CHD patients between those with and without heart failure. Methods: A case-control study was conducted on three to ten years old children with a left-to-right shunt acyanotic CHD with and without heart failure in the Pediatric Cardiology outpatient clinic, ward, and emergency room of Dr. Soetomo Hospital Surabaya from April-July 2020. Echocardiography was used to establish the diagnosis of CHD, while Pediatric Heart Failure Score (PHFS) criteria was used to indicate heart failure. T-test was undertaken for analysing the difference between both groups. Results: The total samples were 41 children, consisted of 29 subjects in the case group (CHD with heart failure) and 12 subjects in the control group (without heart failure). The level of SOD in CHD with heart failure was lower (74.670+15.705) than those without it (109.163+3.111) (p<0.05). In contrast, level of CAT in CHD with heart failure was higher (25.895) than those without it (13.976) (p<0.05). Conclusion: There was a significant difference of SOD and CAT levels in acyanotic CHD between those with and without heart failure.

scholarly journals Consanguinity and congenital heart disease in offspring

2018 ◽  
Vol 58 (2) ◽  
pp. 75-9
Author(s):  
Aris Fazeriandy ◽  
Muhammad Ali ◽  
Johannes H. Saing ◽  
Tina Christina L. Tobing ◽  
Rizky Adriansyah
Keyword(s):  
Congenital Heart Disease ◽  
Risk Factor ◽  
Heart Disease ◽  
Congenital Heart ◽  
Disease Incidence ◽  
Consanguineous Marriage ◽  
Control Group ◽  
P Value ◽  
Case Group ◽  
Consanguineous Marriages

Background Congenital heart disease (CHD) is a common congenital abnormality in children. Consanguineous marriage has been identified as a risk factor of  CHD. There was an autosomal recessive pattern of inheritance seen in children with some forms of congenital heart disease.Objective To assess the possible association between consanguineous marriage and congenital heart disease incidence in the offspring.Methods A case-control study was conducted from March to May 2016 on pediatric patients at H. Adam Malik General Hospital, Medan. Subjects were allocated into two groups, 100 children with CHD in the case group, and the rest in the control group. Data were analyzed using Chi-square and logistic regression tests. In the present study, P value less than 0.05 was considered statistically significant.Results In the case group, 14 patients (14%) were born of consanguineous marriages. In the control group, only 5 patients (5%) were born of consanguineous marriages. There was a significant association between consanguineous marriage and CHD (OR 1.551; 95%CI 1.138 to 2.113). Based on the result of multivariate analysis, consanguineous marriage was a risk factor for CHD in offspring (Wald=4.525; P=0.033).Conclusion  Consanguineous marriage is a risk factor for CHD in offspring.

scholarly journals Oral contraceptive use and conotruncal congenital heart disease

2014 ◽  
Vol 54 (6) ◽  
pp. 309
Author(s):  
Mars Nashrah Abdullah ◽  
Muhammad Ali ◽  
Melda Deliana ◽  
Tina Christina L. Tobing
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Oral Contraceptive ◽  
Congenital Heart ◽  
Contraceptive Use ◽  
Control Group ◽  
Case Group ◽  
Oral Contraceptive Use ◽  
Student’S T ◽  
Control Study

Background Congenital heart disease (CHD) represents some of the more prevalent malformations among live births andremains the leading cause of death from congenital malformations.Conotruncal anomalies comprise a diverse group of CHDinvolving the outflow tracts of the heart and the great vessels.Oral contraceptive exposure before pregnancy may be one of therisk factors for conotruncal CHD.Objective To evaluate the effect of oral contraceptive use beforepregnancy on the risk of conotruncal CHD in children.Methods A case-control study was conducted from July 2010until July 2011 in Haji Adam Malik Hospital, Medan. Subjectswith CHD were divided into two groups: conotruncal CHD asthe case group and non-conotruncal CHD as the control group.Both groups had mothers with and without histories of oralcontraceptive use before pregnancy. Parents were interviewedusing questionnaires. Statistical analyses were performed usingChi-square test, student’s T-test, and Mann Whitney test.Results A total of 80 subjects were eligible, with 40 subjects ineach group. The percentages of subjects whose mothers used oralcontraceptives were 62% of the conotruncal CHD group and60% of the non-conotruncal CHD group (OR 0.82; 95%CI 0.33to 1.98). The mean duration of maternal oral contraceptive usebefore pregnancy was 19.1 months for the case group and 18.8months for the control group (P=0.87).Conclusion In children with CHD, maternal oral contraceptiveuse before pregnancy does not appear to increase the risk ofconotruncal CHD.

Risk Factors for Gross Motor Dysfunction in Infants With Congenital Heart Disease

2011 ◽  
Vol 24 (3) ◽  
pp. 246-258 ◽  
Author(s):  
Suzanne H. Long ◽  
Bev J. Eldridge ◽  
Mary P. Galea ◽  
Susan R. Harris
Keyword(s):  
Risk Factors ◽  
Congenital Heart Disease ◽  
Heart Disease ◽  
Congenital Heart ◽  
Motor Dysfunction ◽  
Gross Motor

Nineteen Years of Adult Congenital Heart Surgery in a Single Center

2017 ◽  
Vol 8 (2) ◽  
pp. 182-188
Author(s):  
Madurra Perinpanayagam ◽  
Signe H. Larsen ◽  
Kristian Emmertsen ◽  
Marianne B. Møller ◽  
Vibeke E. Hjortdal
Keyword(s):  
Risk Factors ◽  
Congenital Heart Disease ◽  
Cardiac Surgery ◽  
Heart Disease ◽  
Postoperative Complications ◽  
Adverse Events ◽  
Congenital Heart ◽  
Postoperative Bleeding ◽  
Registration System ◽  
Growing Population

Background: Adults with congenital heart disease are a growing population. We describe surgical interventions, short- and long-term mortality and morbidity, and risk factors for adverse events in a population-based cohort. Methods: Patients over or equal to 18 years with congenital heart disease who underwent cardiac surgery at Aarhus University Hospital, Denmark, from 1994 to 2012 were included in the study. Diagnoses, surgical procedures, postoperative complications, and survival were identified in hospital databases, medical records, and the Danish Civil Registration System. Results: Four hundred seventy-four surgeries were performed in 445 adults (50% men). The median age was 39 years (range 18-83). Thirty-nine percent had previous surgical or catheter-based interventions. Thirty-day and in-hospital mortality were 1.1%. Postoperative complications occurred in 50% of cases, most were minor such as temporary arrhythmias and pneumonia. Major complications included postoperative bleeding necessitating intervention (6%), stroke (2%), and acute temporary renal failure (1%). Multivariate analysis identified RACHS-1 categories over or equal to 3 compared to category 1 (odds ratio (OR) = 2.3; 95% confidence interval (CI): 1.5-3.7), New York Heart Association functional class III and IV compared to class I (OR = 2.2; 95% CI: 1.3-3.7) and age at surgery (OR = 1.03, 95% CI: 1.01-1.04), as risk factors for adverse events. Survival during a median follow-up of 7.8 years (range 0 days-21.4 years) was 85% (95% CI: 80%-89%). Conclusion: Adults with congenital heart disease constitute a growing population with the need for cardiac surgery. Postoperative complications are frequent but early and late mortality are low.

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