scholarly journals The Change of GFAP or S100B Concentration in Serum Before and After Carotid Artery Stenting

2019 ◽  
Author(s):  
Xiaofan Yuan ◽  
Shu Yang ◽  
Duozi Wang ◽  
Lei Guo ◽  
Jianhong Wang ◽  
...  
Keyword(s):  
Carotid Artery ◽  
Stent Implantation ◽  
Carotid Artery Stenting ◽  
Biochemical Markers ◽  
Statistical Significance ◽  
Control Group ◽  
Serum Concentrations ◽  
Blood Samples ◽  
Before And After ◽  
Symptomatic Stenosis

Abstract In this study we monitored the concentration change of the cerebral biomarkers Glial fibrillary acidic protein (GFAP) and S100B Protein (S100B) in serum of the patients, who were performed with carotid artery stenosis before and after carotid artery stent implantation. In total, thirty patients with unilateral carotid stenosis who underwent carotid artery stenting and had no complications were enrolled in the carotid artery stenting (CAS) group. The blood samples of operation patients were collected on three different time points: T1: the day before operation; T2: one day after operation (24 hours); T3, three days after operation (72 hours). Thirty patients who were excluded for carotid artery stenosis by Digital Subtraction Angiography (DSA) were selected as the control group. The blood samples of patients in control group were collected at D1 (before DSA) and D2 (24 hours after DSA). The concentrations of GFAP and S100B in serum from patients of both groups were measured with ELISA. The results showed that the serum concentrations of GFAP and S100B in control group did not change significantly before and after DSA (P>0.05); while the serum concentrations of GFAP and S100B was higher in the CAS group before operation than those in DSA group（P<0.05）. In the operation group, GFAP and S100B increased significantly on the first day after operation (T2) and decreased gradually on the third day after operation (T3) but increased compared with that before operation (T1) with statistical significance (P < 0.05). For patients with symptomatic stenosis before operation, the concentrations of GFAP and S100B in serum were higher than those in patients without symptomatic stenosis, and there was statistical difference between them (P < 0.05), but there was no statistical significance between them after operation (P > 0.05). So we confirm the cerebral biochemical markers GFAP and S100B have a certain change trend after CAS, which can be used as the cerebral biochemical markers in the pre-operative evaluation and post-operative efficacy in monitoring of carotid stent implantation.

scholarly journals The Change of GFAP or S100B Concentration in Serum Before and After Carotid Artery Stenting

2020 ◽  
Author(s):  
Xiaofan Yuan ◽  
Shu Yang ◽  
Lei Guo ◽  
Duozi Wang ◽  
Jie Huang ◽  
...  
Keyword(s):  
Carotid Artery ◽  
Stent Implantation ◽  
Carotid Artery Stenting ◽  
Statistical Significance ◽  
Control Group ◽  
Blood Samples ◽  
Before And After ◽  
Operative Evaluation ◽  
Symptomatic Stenosis

Abstract Background：This study explored the role of GFAP and S100B as cerebral biomarkers in the pre-operative evaluation and post-operative efficacy in monitoring of carotid stent implantation. Method：32 with unilateral carotid stenosis who underwent carotid artery stenting (CAS) enrolled in the CAS group. The blood samples of operation patients were collected on three different time points: T1: the day before operation; T2: 24 hours after operation; T3, 72 hours after operation. 32 who were excluded for carotid artery stenosis by Digital Subtraction Angiography (DSA) were selected as the control group. The blood samples of patients in control group were collected at D1 (before DSA) and D2 (24 hours after DSA). Results：(1). The serum concentrations of GFAP and S100B was higher in the CAS group before operation than those in DSA group（P<0.05）. (2). In the operation group, GFAP and S100B increased significantly on the first day after operation (T2) and decreased gradually on the third day after operation (T3) but increased compared with that before operation (T1) with statistical significance (P < 0.05). (3). For patients with symptomatic stenosis before operation, the concentrations of GFAP and S100B in serum were higher than those in patients without symptomatic stenosis (P < 0.05). Conclusions： The cerebral biochemical markers GFAP and S100B have a certain change trend after CAS, which can be used as a method to evaluate and monitor the curative effect before and after carotid artery stent implantation combined with imaging tools.

scholarly journals The biochemical markers associated with TCD to evaluate the curative effect after Carotid Artery Stenting

2020 ◽  
Author(s):  
Xiaofan Yuan ◽  
Jianhong Wang ◽  
Lei Guo ◽  
Duozi Wang ◽  
Shu Yang ◽  
...  
Keyword(s):  
Carotid Artery ◽  
Biochemical Markers ◽  
Control Group ◽  
Serum Concentrations ◽  
Curative Effect ◽  
Severe Stenosis ◽  
Blood Samples ◽  
Surrogate Outcome ◽  
Post Operation

Abstract Introduction：This study associated the expression of GFAP and S100B in serum with the imaging tools (TCD and DWI) to confirm these cerebral biochemical markers as surrogate outcome methods for evaluating the curative effect after CAS.Methods and materials：72 patients with unilateral carotid stenosis who underwent CAS were enrolled in the operation group. The blood samples of the operation patients were collected on four different time points: T1: the day before operation; T2: 1 day (24 hours) after operation; T3: 3 days (72 hours) after operation; T4: 30 days after operation. The operation patients were performed on the MRI after CAS to evaluate the post-operative lesion and received the TCD to monitor the changes of hemodynamics. 47 patients who were excluded for carotid artery stenosis by DSA were selected as the control group. The blood samples of patients in control group were collected at D1 (before DSA) and D2 (24 hours after DSA). The concentrations of GFAP and S100B in serum were measured with ELISA.Results：(1) The MFV (pre-operation, post-operation, 30 days follow-up: 47.65±17.24, 62.37±18.25, 70.29±16.89; P<0.05) and PI (pre-operation, post-operation, 30 days follow-up: 0.78±0.21, 0.98±0.19, 1.02±0.20; P<0.05) increased significantly in the ipsilateral MCA after CAS. And at 30 days follow-up, the CVR improved significantly (post-operation, 30 days follow-up: 27.47±12.13, 31.92±10.94; P<0.05). Patients with different degrees of stenosis, the more severe stenosis in carotid artery, the more obvious improvement of CVR at the 30 days follow-up. (2) After CAS, the serum concentrations of GFAP and S100B increased to the peak at 24 hour after operation (T2), and then decrease gradually (T2>T3>T4; P < 0.05). Furthermore, the serum concentrations of GFAP (r=0.71, P<0.05) and S100B (r=0.78, P<0.05) correlated positively with CVR at 30 days after CAS. (3) 29/72 patients (40.28%) were shown the emerging hyperintense in DWI after CAS.Conclusion：Our finding proven that the trend of GFAP and S100B in serum after CAS had a positive correlation to the improved hemodynamics which was verified by TCD. We recommend the biochemical markers (GFAP and S100B) associated with TCD to evaluate the curative effect after CAS.

Abstract TMP37: The Biomakers Expression Following Reperfusion After Carotid Artery Stenting

Stroke ◽  
2020 ◽  
Vol 51 (Suppl_1) ◽  
Author(s):  
Fuqiang Guo
Keyword(s):  
Carotid Artery ◽  
Carotid Artery Stenosis ◽  
Carotid Artery Stenting ◽  
Artery Stenosis ◽  
Control Group ◽  
Digital Subtraction ◽  
Serum Concentrations ◽  
Blood Samples ◽  
Significant Difference ◽  
Cerebral Reperfusion

Objective: This study was to demonstrate the biomarkers (NSE,MMP9,S100B,HO-1,CO) in serum for their correlation with reperfusion after carotid artery stenting (CAS). Methods: In this study, a total of 44 patients who were diagnosed with carotid artery stenosis (symptomatic/ asymptomatic stenosis≥70%) by Digital Subtraction Angiography (DSA) and underwent CAS successfully, were selected as the operation groups. The patients’ blood samples were collected at three different time points: T1, prior to operation; T2, next morning after operation (24 hours); T3, three days after operation (72 hours); The second group of 30 patients, who were excluded for carotid artery stenosis by DSA, were assigned to be the control group; Blood samples of these patients were collected at T1. The concentrations of NSE, S100B, MMP9, HO-1 and CO in serum from patients of both groups were detected by ELISA. Results: (1) There was no significant difference between the control group and the operation group at T1 (P>0.05) on their concentrations of NSE, S100B, MMP9, HO-1 and CO in the serum. (2) All of the operations were implanted in stents successfully without complications and the reperfusion improved after CAS. The concentrations of NSE, S100B, MMP9 and CO in the serum decreased gradually.(T1: 378.53±187.74MU/ml, 20.04±9.27ng/ml, 3.28±1.62ng/ml, 2.21±1.98umol/l respectively; T2: 302.65±160.46MU/ml, 16.45±8.95ng/ml, 2.81±1.63ng/ml, 1.49±1.10umol/l respectively, T1 vs T2: P<0.01; T3: 280.60±159.22MU/ml, 12.62±8.32ng/ml, 2.59±1.55ng/ml, 1.22±1.04umol/l respectively,T1 vs T3: P<0.01). (3) The serum concentrations of HO-1 in the T2 increased when compared with T1 (P<0.05) and obviously increased in the T3 when compared with T1 (P<0.01). Conclusions: We concluded that the concentrations of NSE, S100B, MMP9 and CO in serum decreased with the improvement of cerebral reperfusion after CAS. NSE, S100B, MMP9 and CO can be used as biomarkers to evaluate the improvement of reperfusion after CAS. What’s more, the changes of HO-1 after CAS may be associated with hyper-perfusion syndrome. Key words: NSE; S100B; MMP9; CO; HO-1;reperfusion; carotid artery stenting

NSE, S100B and MMP9 Expression Following Reperfusion after Carotid Artery Stenting

2019 ◽  
Vol 16 (2) ◽  
pp. 129-134 ◽  
Author(s):  
Xiaofan Yuan ◽  
Jianhong Wang ◽  
Duozi Wang ◽  
Shu Yang ◽  
Nengwei Yu ◽  
...  
Keyword(s):  
Carotid Artery ◽  
Carotid Artery Stenosis ◽  
Carotid Artery Stenting ◽  
Neuron Specific Enolase ◽  
Artery Stenosis ◽  
Cerebral Injury ◽  
Control Group ◽  
Blood Samples ◽  
Mmp9 Expression ◽  
Significant Difference

Objective: Previous studies have shown that the neuron-specific- enolase (NSE), S100B protein (S100B) and matrix metalloproteinase-9 (MMP9) are specific markers for studying cerebral injury. This study was aimed to demonstrate these biomarkers for their correlation with reperfusion after carotid artery stenting (CAS). Methods: In this study, a total of 44 patients who were diagnosed unilateral carotid artery stenosis by digital subtraction angiography (DSA) and underwent CAS, were selected as the operation groups. The patients' blood samples were collected at three different time points: T1, prior to operation; T2, next morning after operation (24 hours); T3, three days after operation (72 hours); All of the patients with the operation received computed tomography perfusion (CTP) at T1 and T3. The second group of 12 patients, who were excluded for carotid artery stenosis by DSA, were assigned to be the control group; Blood samples of these patients were collected at T1. The concentrations of NSE, S100B and MMP9 in serum from patients of both groups were detected by ELISA. Results: All of the operations were implanted in stents successfully without complications. (1) After CAS, rCBF increased while rMTT and rTTP decreased. (2) The concentrations of NSE, S100B and MMP9 in the serum decreased gradually (T1>T2>T3). There was no significant difference between the control group and the operation group at T1 (P>0.05) on their concentrations of NSE, S100B and MMP9 in the serum. When compared among the operation groups, the concentrations of NSE, S100B and MMP9 in the serum at T1 and T3 showed significant difference (P < 0.05). (3) Correlation analysis among the operation groups indicated that NSE, S100B, MMP9 and rCBF were positively correlated before operation (r = 0.69, 0.58 and 0.72, respectively, P < 0.05), as well as after operation (r = 0.75, 0.65 and 0.60, respectively, P < 0.05). Conclusion: We concluded that the concentrations of NSE, S100B and MMP9 in serum decreased with the improvement of cerebral reperfusion after CAS. NSE, S100B and MMP9 can be used as laboratory biochemical markers to evaluate the improvement of reperfusion after CAS. The results very well complement the imaging methods, such as CTP.

Does Xbox 360 Kinect training improve postural balance in young healthy adults? A preliminary study. (Preprint)

2021 ◽  
Author(s):  
Marta Grabowicz ◽  
Anna Daniluk ◽  
Anna Hadamus ◽  
Dariusz Białoszewski
Keyword(s):  
Postural Balance ◽  
Statistical Significance ◽  
Balance Training ◽  
The Body ◽  
Control Group ◽  
Healthy Individuals ◽  
Unstable Surface ◽  
Baseline Group ◽  
Before And After ◽  
P Balance

BACKGROUND Balance training in young adults may increase coordination, cognitive function or the symmetry of strength on both sides of the body. It is an essential tool for injury or fall prevention and a precondition for becoming a professional athlete. OBJECTIVE The aim of this study was to assess the effect of Xbox 360 Kinect training on postural balance in young, healthy individuals. METHODS The study enrolled 75 individuals who were randomly assigned to three equal groups. The first group (Group VR) performed exercises on an Xbox 360 Kinect console, and the second group (Group T) performed conventional all-round exercises. The third group was a control group (Group C). Each group underwent balance assessments on the Biodex Balance posturographic platform, including the Balance Error Scoring System test, before and after the training cycle. The level of statistical significance was set at P<.05. RESULTS Group VR and Group T achieved statistically significant improvements in the sway index compared with baseline. Group T gained significant decrease in the sway index on the unstable surface (P=.002). Group VR and group T demonstrated significant decreases in the mean sway index on stable and unstable surfaces (group VR — P=.035; group T — P=.001) Group C did not achieve a statistically significant improvement in the sway index. None of the groups demonstrated a statistically significant decrease in the test error count. CONCLUSIONS Virtual reality in the form of video games played on an Xbox 360 Kinect console may be an effective method of balance training in healthy individuals.

scholarly journals Clowns Benefit Children Hospitalized for Respiratory Pathologies

2011 ◽  
Vol 2011 ◽  
pp. 1-9 ◽  
Author(s):  
Mario Bertini ◽  
Elena Isola ◽  
Giuseppe Paolone ◽  
Giuseppe Curcio
Keyword(s):  
Statistical Significance ◽  
Systolic Pressure ◽  
Therapeutic Modality ◽  
Control Group ◽  
Self Evaluation ◽  
Positive Effects ◽  
Before And After ◽  
Two Parameters ◽  
Therapeutic Settings ◽  
Experimental Group

The study aims at evaluating health-generating function of humor therapy in a hospital ward hosting children suffering from respiratory pathologies. The main scope of this study is to investigate possible positive effects of the presence of a clown on both the clinical evolution of the on-going disease, and on some physiological and pain parameters. Forty-three children with respiratory pathologies participated in the study: 21 of them belonged to the experimental group (EG) and 22 children to the control group (CG). During their hospitalization, the children of the EG interacted with two clowns who were experienced in the field of pediatric intervention. All participants were evaluated with respect to clinical progress and to a series of physiological and pain measures both before and after the clown interaction. When compared with the CG, EG children showed an earlier disappearance of the pathological symptoms. Moreover, the interaction of the clown with the children led to a statistically significant lowering of diastolic blood pressure, respiratory frequency and temperature in the EG as compared with the control group. The other two parameters of systolic pressure and heart frequency yielded results in the same direction, without reaching statistical significance. A similar health-inducing effect of clown presence was observed on pain parameters, both by self evaluation and assessment by nurses. Taken together, our data indicate that the presence of clowns in the ward has a possible health-inducing effect. Thus, humor can be seen as an easy-to-use, inexpensive and natural therapeutic modality to be used within different therapeutic settings.

scholarly journals Reviewing the Effect of 10 Days of Intense Exercise Period on Certain Blood Parameters of Tennis Players

2018 ◽  
Vol 6 (11) ◽  
pp. 95
Author(s):  
Muzaffer Selcuk ◽  
Vedat Cinar ◽  
Mucahit Sarikaya ◽  
Salih Oner
Keyword(s):  
Statistical Significance ◽  
Exercise Program ◽  
Blood Parameters ◽  
Intense Exercise ◽  
Negative Effects ◽  
Blood Samples ◽  
Tennis Players ◽  
Before And After ◽  
Exercise Period ◽  
Competition Period

This study aims to observe the possible negative effects that might occur on bio-chemistry and hemogram values of tennis players during the intense competition period by comparing the blood values of pre-competition period with 10 days of intense exercise. Blood samples were obtained from tennis team players who do not have any specific health problems and who study in university and regularly exercise. Mean age of the athletes are 22,40 ± 3,20 years and mean height is 179,83 ± 7,57 cm. This study is performed with 14 volunteer tennis players. Blood samples are obtained during the first day of the intense exercise program after the exercise, last day of the exercises and also right after the exercises. As per the obtained data, descriptive statistics are run (mean and standard deviation) and in order to compare the values of before and after the 10 days of intense exercise, Wilcoxon two related sample test was used. As per the results of the blood tests from before and after the exercise period, it is seen that values such as AST, ALT, MCH, MCHC and CK showed statistical significance (P<0.05). The athletes who prepared for the competitions with these values showed positive increases in bio-chemistry and hemogram values.

scholarly journals Effects of Presentation- Assimilation- Discussion (PAD) Class Teaching Model on Learning Attitudes of Nursing Students --- Taking the “Nursing Psychology” Course as an Example

2018 ◽  
Vol 2 (2) ◽  
pp. 33
Author(s):  
Zhiping Liu ◽  
Menglin Yue
Keyword(s):  
Nursing Students ◽  
Statistical Significance ◽  
Junior Colleges ◽  
Control Group ◽  
Teaching Model ◽  
Teaching Mode ◽  
Learning Attitudes ◽  
Before And After ◽  
Psychology Course ◽  
Experimental Group

 Purpose: to explore and discuss the effects of PAD Class Teaching Model on nursing students who are expected to enter undergraduate schools from junior colleges. Method: Randomly select 112 students from two classes (2016) who are expected to enter undergraduate schools from junior colleges in a medical school in Pingdingshan, and divide them into a control group and an experimental group using a method of cluster randomization. In the teaching process of “Nursing Psychology”, the control group and the experimental group respectively adopted the traditional teaching mode and the PAD class teaching mode. After the implementation of one semester, compare the nursing students’ learning attitudes change before and after the implementation. Results: The scores of the nursing students in the experimental group at the three latitudes of learning interests, learning habits, and professional cognition were significantly higher than those of the control group, and the differences have statistical significance (P<0.05). Conclusions: PAD class teaching mode helps improve nursing students’ learning attitudes.

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