scholarly journals Association between eating behavior, anthropometric and biochemical measurements, and pyy hormone levels in obese adolescents in outpatient care 

2019 ◽  
Author(s):  
Simone P. Fernandes ◽  
Janine Alessi ◽  
Zilda de Albuquerque Santos ◽  
Elza Daniel de Mello
Keyword(s):  
Eating Behavior ◽  
Eating Behaviors ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Self Control ◽  
Lipoprotein Cholesterol ◽  
Z Score ◽  
Obese Adolescents ◽  
Hormone Levels ◽  
Glucose Levels

Abstract Background: Food intake and energy expenditure, as well as short-term satiety signals, can be regulated by the peptide tyrosine tyrosine (PYY) secreted by the gastrointestinal tract. It is also unknown if changes in PYY hormone levels lead to changes in feeding behavior or in body composition. More comprehensive investigation of serum regulation of gut-derived hormone signals, with behavioral and clinical outcomes, are needed to understand the consequences of deregulating the appetite of obese adolescents.Objective: To evaluate the eating behavior of obese adolescents and its association with biochemical, anthropometric and PYY measures. Methods: 51 obese adolescents received counseling for weight management at 12 monthly appointments. Fasting serum PYY levels, total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), triglycerides (TG), low density lipoprotein cholesterol (LDL-C), insulin and glucose levels, waist circumference (WC) and results from the Three-Factor Eating Questionnaire (TFEQ-21) were assessed. Results: Over one year there was a significant increase in PYY levels (p = 0.026); reduction in TC (p = 0.003), TG (p = 0.022), BMI (p = 0.002), BMI z-score (p <0.001) and WC (p = 0.003). During this period there was a decrease in the Uncontrolled Eating score (UE), illustrating that adolescents displayed more self-control (p = 0.008) at the end of the study; however, this result was independent of BMI and BMI z-score (p = 0.407). The reduction in UE was associated with a significant improvement in insulin levels (rs = 0.326; p = 0.020). The reduction in UE was also associated with lower levels of blood glucose (r = 0.332; p = 0.017), and the increase of cognitive restriction, with the reduction of insulin insulin (rs = -0.294 p = 0.036) and TG (r = -0.368; p = 0.008) and an increase in Cognitive Restraint. Conclusions: Our results show that after a year of monitoring weight loss, adolescents had more controlled eating behaviors, increased PYY levels, and reduced weights.

Association between eating behavior, anthropometric and biochemical measurements, and peptide YY (PYY) hormone levels in obese adolescents in outpatient care

2020 ◽  
Vol 33 (7) ◽  
pp. 873-877
Author(s):  
Simone P. Fernandes ◽  
Janine Alessi ◽  
Zilda E. A. Santos ◽  
Elza D. de Mello
Keyword(s):  
Eating Behavior ◽  
Eating Behaviors ◽  
Peptide Yy ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Self Control ◽  
Lipoprotein Cholesterol ◽  
Z Score ◽  
Obese Adolescents ◽  
Glucose Levels

AbstractObjectiveTo evaluate the eating behavior of obese adolescents and its association with biochemical, anthropometric and peptide YY (PYY) measures.MethodsFifty-one obese adolescents received counseling for weight management at 12 monthly appointments. Fasting serum PYY levels, total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), triglycerides (TG), low density lipoprotein cholesterol (LDL-C), insulin and glucose levels, waist circumference (WC) and results from the Three-Factor Eating Questionnaire (TFEQ-21) were assessed.ResultsOver one year there was a significant increase in PYY levels (p = 0.026), reduction in TC (p = 0.003), TG (p = 0.022), BMI (p = 0.002), BMI z-score (p < 0.001) and WC (p = 0.003). During this period there was a decrease in the uncontrolled eating score (UE), illustrating that adolescents displayed more self-control (p = 0.008) at the end of the study; however, this result was independent of BMI and BMI z-score (p = 0.407). The reduction in UE was associated with a significant improvement in insulin levels (rs = 0.326; p = 0.020). The reduction in UE was also associated with lower levels of blood glucose (r = 0.332; p = 0.017), and the increase of cognitive restriction, with the reduction of insulin insulin (rs = −0.294; p = 0.036) and TG (r = −0.368; p = 0.008) and an increase in Cognitive Restraint.ConclusionsOur results show that after a year of monitoring weight loss, adolescents had more controlled eating behaviors, increased PYY levels, and reduced weights.

scholarly journals ASSOCIATION BETWEEN BLOOD LIPID PROFILE AND BLOOD GLUCOSE LEVELS IN MEN WITH CORONARY HEART DISEASE, METABOLIC SYNDROME, AND TYPE 2 DIABETES MELLITUS

2013 ◽  
Vol 12 (5) ◽  
pp. 29-33
Author(s):  
S. A. Matveeva
Keyword(s):  
Blood Glucose ◽  
Lipid Profile ◽  
Low Density Lipoprotein ◽  
Fasting Blood Glucose ◽  
Density Lipoprotein ◽  
Blood Lipid ◽  
Lipoprotein Cholesterol ◽  
Blood Lipid Profile ◽  
Glucose Levels ◽  
Blood Glucose Levels

Aim.To study the associations between blood lipid profile and blood glucose levels in men with coronary heart disease (CHD), stable effort angina (SEA), metabolic syndrome (MS), and Type 2 diabetes mellitus (DM-2).Material and methods.The study included 82 men (mean age 50,5±0,9 years) with CHD, Functional Class I–III SEA, MS, and DM-2. The following lipid profile parameters were assessed: total cholesterol (TCH), triglycerides (TG), low-density lipoprotein cholesterol (LDL–CH), very low-density lipoprotein cholesterol (VLDL–CH), high-density lipoprotein cholesterol (HDL–CH), atherogenic index (AI), and triglyceride index (TGI), together with fasting blood glucose.Results.There were positive (direct) associations between higher levels (>90th percentile) of lipid profile parameters (TCH, TG, LDL–CH, VLDL– CH, HDL–CH, AI, TGI) and blood glucose, as well as between lower levels (≤10th percentile) of lipid profile parameters (TCH, TG, LDL–CH, VLDL– CH, AI, TGI) and blood glucose. At the same time, there were negative (inverse) associations between lower lipid levels (≤10th percentile of TCH, TG, LDL–CH, VLDL–CH, HDL–CH, AI, TGI) and higher glucose levels (>90th percentile), as well as between higher lipid levels (>90th percentile of TCH, TG, LDL–CH, VLDL–CH, HDL–CH, AI, TGI) and lower glucose levels (≤10th percentile).Conclusion.Dyslipidemia and hyperglycemia demonstrate synergetic proatherogenic effects in patients with CHD, SEA, MS, and DM-2, as suggested by significant heterogeneous (direct and inverse) associations between lipid profile parameters and fasting blood glucose. The results obtained provide an opportunity for the assessment of risk levels, prognosis, and need for pharmacological prevention and treatment in patients with combined cardiovascular pathology. 

Effect of Curcumin on the Level of Blood Lipid and Blood Glucose in Diabetic Rat Model

2014 ◽  
Vol 1051 ◽  
pp. 419-422
Author(s):  
Ming San Miao ◽  
Lin Guo ◽  
Shuo Tian ◽  
Tan Wang
Keyword(s):  
Blood Glucose ◽  
Rat Model ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Blood Lipid ◽  
Lipoprotein Cholesterol ◽  
Diabetic Rat ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Diabetic Rat Model

Objective: To investigate the effects of curcumin on blood lipid and blood glucose levels and its mechanism in diabetic rat model. Method: After streptozotocin (STZ) induced diabetic rat model, large, medium and small doses of curcumin group were partly given curcumin solution 400,200,100mg·kg-1, administered once a day, continuously 30 days. In 30 th day, determine blood glucose (BG) value, after the last injection , determine the serum total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C) levels. Results: Compared with the model group rats, each dose of curcumin group rats’ BG, TC, TG and LDL-C levels were significantly decreased, HDL-C levels was increased significantly. Conclusion: Curcumin has a certain impact on blood lipids and blood glucose in diabetic rat model.

Effects of acrylamide graded doses on metallothioneins I and II induction and DNA fragmentation: Bochemical and histomorphological changes in the liver of adult rats

2017 ◽  
Vol 33 (8) ◽  
pp. 611-622 ◽  
Author(s):  
Imen Ghorbel ◽  
Awatef Elwej ◽  
Mariem Chaabene ◽  
Ons Boudawara ◽  
Rim marrakchi ◽  
...  
Keyword(s):  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Protein Carbonyl ◽  
Lipoprotein Cholesterol ◽  
Dependent Manner ◽  
Adult Rats ◽  
Glucose Levels ◽  
Hepatic Cells ◽  
Genes Expression ◽  
Histomorphological Changes

The present study investigates the toxic effects of acrylamide (ACR) administered to rats at two doses on (i) oxidative stress and disruption of pro-oxidant/antioxidant balance in hepatic cells and (ii) its correlation with metallothioneins (MTs) genes expression, DNA damage and histomorphological changes. Treated rats with 20 and 40 mg/kg body weight of ACR led to an increase in malondialdehyde, hydrogen peroxide, advanced oxidation protein products, protein carbonyl levels as well as an alteration in the antioxidant status. Total MT content in the liver and MT I and MT II genes induction were increased. Plasma transaminases activities, albumin, total protein and glucose levels were also increased, while alkaline phosphatase activity was decreased. Moreover, total cholesterol (TC), triglyceride, low-density lipoprotein cholesterol (LDL-C) levels, TC/high-density lipoprotein cholesterol (HDL-C) and LDL-C/HDL-C ratios were increased, while HDL-C decreased in a dose-dependent manner. A random DNA degradation was observed only in the liver of ACR-treated rats with the highest dose. These changes were confirmed by histopathological observations.

scholarly journals Anthropometric and Metabolic Responses in FTO rs9939609 Gene Polymorphism after a Multidisciplinary Lifestyle Intervention in Overweight and Obese Adolescents

2019 ◽  
Vol 09 (01) ◽  
pp. 019-026
Author(s):  
Cláudia Daniela Barbian ◽  
Cézane Priscila Reuter ◽  
Jane Dagmar Pollo Renner ◽  
Priscila Tatiana da Silva ◽  
Elisa Inês Klinger ◽  
...  
Keyword(s):  
Gene Polymorphism ◽  
Lifestyle Intervention ◽  
Intervention Program ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Low Density Lipoprotein Cholesterol ◽  
Obese Adolescents ◽  
Quasi Experimental ◽  
Fto Rs9939609

AbstractFew studies show the potential changing effect of fat-mass and obesity-associated (FTO) rs9939609 gene on cardiometabolic risk after a lifestyle intervention. This study aims to evaluate whether overweight and obese adolescents, carriers of the risk genotypes for obesity of the FTO rs9939609 gene polymorphism, have different anthropometric and biochemical responses to an interdisciplinary intervention program. The quasi-experimental study involved 34 adolescents aged 10 to 15 years. Schoolchildren with AA/AT genotype decreased glucose, total cholesterol, low-density lipoprotein cholesterol, and increased high-density lipoprotein cholesterol. However, there were no differences between the genotypes, suggesting that the “A” allele did not modify the subject's response to the intervention program.

scholarly journals Technology-based methods in the improvement of therapy compliance among ambulatory cardiac patients: one-year follow-up data

2012 ◽  
Vol 11 (4) ◽  
pp. 36-41 ◽  
Author(s):  
F. T. Ageev ◽  
T. V. Fofanova ◽  
M. D. Smirnova ◽  
A. Sh. Tkhostov ◽  
A. S. Nelubina ◽  
...  
Keyword(s):  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Self Control ◽  
Lipoprotein Cholesterol ◽  
Lipid Lowering ◽  
Telephone Reminder ◽  
Therapy Compliance ◽  
One Year ◽  
The Impact

Aim. To assess the impact of automatic telephone survey with a differentiated reminder text, as well as of the survey combination with the self-control dairy, on the compliance with lipid-lowering and antihypertensive therapy and on therapy effectiveness during the longterm ambulatory follow-up. Material and methods. The study included 604 patients: 323 individuals with high or very high cardiovascular risk levels by SCORE scale and 281 participants with coronary heart disease (CHD). The patients were divided into two groups, according to their agreement to participate in the automatic telephone reminder survey (“Survey” and “Refusal”). All participants were also given a self-control diary. At baseline and one year later, the patients underwent general clinical examination, office blood pressure (BP) measurement, blood biochemistry assessment, and the measurement of therapy compliance (Morisky-Green test), anxiety, and depression levels (HADS scale). Results. The reduction in diastolic BP levels was significantly larger in the Survey group (p=0,04). This group also demonstrated a significantly larger decrease in the levels of total cholesterol (TCH) (p=0,0003) and low-density lipoprotein cholesterol (LDL-CH) (p=0,001), as well as a significantly larger increase in the levels of high-density lipoprotein cholesterol (HDL-CH) (p=0,04). The therapy compliance, assessed by the Morisky-Green test, improved in both groups; however, among CHD patients, a significant improvement was observed only in the Survey group (p<0,00001). The percentage of patients submitting their self-control diaries was higher for the Survey group (p<0,0001). Conclusion. The automatic telephone reminder method provides an opportunity to significantly increase the therapy compliance.

scholarly journals PO-164 Effect of exercise intervention on appetite regulating hormones in obese children

2018 ◽  
Vol 1 (4) ◽  
Author(s):  
Jingwen Liao ◽  
Min Hu
Keyword(s):  
Eating Behavior ◽  
Exercise Intervention ◽  
Statistical Significance ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Regulatory System ◽  
Lipoprotein Cholesterol ◽  
Obese Children ◽  
Significant Difference ◽  
Circulating Levels

Objective Obesity in children usually develops from early age and is due to chronic energy imbalance, and long-term exercise has been shown to have the capacity to alter the sensitivity of the appetite regulatory system. Therefore, the current study was designed to examine the circulating levels of appetite regulating hormones after exercise intervention in obese children. Methods 24 obese children were subjected to exercise training program lasted for 6 weeks, and eating behavior of the children were evaluated using the Children Eating Behavior Questionnaire (CEBQ) before and after intervention. Plasma leptin and ghrelin were also determined using ELISA kits. Results Circulating levels of cholesterol, triglycerides, and low-density lipoprotein cholesterol were also decreased with significant difference (P<0.05), while high-density lipoprotein cholesterol was significantly increased (P<0.05). Fasting plasma glucose was also decrease but with no significant difference. The level of leptin was decreased after 6 weeks intervention with no statistical significance, while the circulating level of ghrelin was significantly enhanced (P<0.05). The scores of FR and EF were significantly decreased (P<0.05) after intervention. No significant change was found on SR and SE of CEBQ, even though they were observed increased compared with that of baseline. Conclusions The current study found that there were obvious effects of 6 weeks exercise intervention on appetite regulating hormones and subjective appetite changes in obese children.

scholarly journals ANTIHYPERGLYCEMIC, ANTIOXIDANT, AND ANTIHYPERLIPIDEMIC ACTIVITIES OF EXTRACT FROM COCCINIA GRANDIS (L.) VOIGT. LEAVES BY METHANOL ON ALLOXAN INDUCED HYPERGLYCEMIC MICE

2018 ◽  
Vol 16 (2) ◽  
pp. 311-318
Author(s):  
Dai Thi Xuan Trang ◽  
Vo Chi Linh ◽  
Nguyen Thi Ai Lan
Keyword(s):  
Body Weight ◽  
Antioxidant Activities ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Glucose Levels ◽  
Coccinia Grandis ◽  
Blood Glucose Levels ◽  
Alloxan Monohydrate ◽  
Antioxidant Effects

The aim of this study was to investigate antihyperglycemic, antihyperlipidemic and antioxidant activities of the extract of Coccinia grandis leaves (CGL) by methanol in alloxan induced diabetic mice. Hyperglycemic was induced in mice by administration of alloxan monohydrate (135 mg/kg, ip.). CGL was orally given to the normal mice (100 and 1000 mg/kg body weight) to determine the toxicity of CGL. Hyperglycemic mice were treated with the extract of CGL (100 mg/kg body weight/ twice a day). Glucophage, diabetic commercially available drug, was used as a possitive control with dose of 108 mg/kg body weight/twice a day. Mice were administered with both glucophage and CGL extract orally during 21 days. On the 21st day of the experiment, mice blood, liver and brain samples were collected to test biochemical parameters and antioxidant levels. CGL did not show toxicity and death up to dose 1000 mg/kg in mice. Administration of CGL 100 mg/kg significantly (p<0.05) reduced blood glucose levels in alloxan induced hyperglycemic mice. Besides, several serum lipid values including total cholecterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C) reduced while high density lipoprotein cholesterol (HDL-C) increased. Malondialdehyde (MDA) in a group of untreated hyperglycemic mice was statistically higher than that of nomal mice. The MDA levels of livers and brains in the CGL treated hyperglycemic mice were lower than that of hyperglycemic control. The effects of hypoglycemic, antihyperlipidemic and antioxidant of CGL were higher than that of glucophage. The total polyphenols and flavonoids contents of the leaf extract were 607,41 + 14,44 mg gallic acid or quercetin equivalents/g and 111,72 + 1,94 mg equivalents/g, respectively. In conclusion, the antihyperglycemic, antihyperlipidemic and antioxidant effects of the CGL suggest a potential therapeutictreatment for hyperglycemic conditions.

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