Environmental Exposure to Cooking Oil Fume and Fatty Liver Disease: a cross-sectional study.
Abstract Background The effect of cooking oil fume on development of fatty liver disease is limited. The present study aims to investigate the association between exposure to cooking oil fume and the risk of fatty liver disease. Method A total of 55959 participants aged between 40 and 75 years old participated in a community-based survey in Ningbo, China. Multiple logistic regression analyses were conducted to investigate the association between cooking oil fume exposure and fatty liver risk. Furthermore, ordered logistic regression was conducted to investigate the association between cooking oil fume exposure and the severity of fatty liver disease. Results Cooking oil fume exposure were significantly associated with fatty liver disease after adjusting for confounding factors compared with participants in the none oil fume exposure group. Moreover, interaction analyses indicated that females with heavy oil fume exposure had the highest odds ratios of fatty liver disease and severer disease extent. In the stratified analysis, compared to participants in the smokeless group, males and females in light, moderate and heavy cooking oil fume exposure groups all had significantly higher risk of fatty liver disease and severer disease extent, while participants with heavier cooking oil fume exposure tended to have higher risk of fatty liver disease and severer disease extent. Conclusion Our findings indicated that exposure to cooking oil fume potentiated the risk of fatty liver disease, and the associations might be dose-responsive. Furthermore, heavy oil fume exposure and female sex might have a synergistic effect on fatty liver disease.