scholarly journals Unilateral visual impairment in a patient undergoing chemotherapy: a case report and clinical findings

2019 ◽  
Author(s):  
Xia Yuan ◽  
Yuliang Feng ◽  
Dan Li ◽  
Mei Li
Keyword(s):  
Visual Acuity ◽  
Visual Impairment ◽  
Fluorescein Angiography ◽  
Vision Loss ◽  
Ischemic Optic Neuropathy ◽  
Fundus Photograph ◽  
Fundus Fluorescein Angiography ◽  
Intravenous Chemotherapy ◽  
Normal Dose ◽  
The Right

Abstract Abstract Background: Visual impairment occurred as an infrequent form of chemotherapeutic toxicity and was often underestimated despite of several reports. We described a case of acute unilateral visual impairment after one cycle of intravenous chemotherapy of a normal dose, aiming at raising attention to chemotherapy-induced ocular toxicity. Case presentation: The patient developed a progressive vision loss in the right eye during the chemotherapy. After one cycle of intravenous chemotherapy, her visual acuity decreased by 0.6 in the right eye (VOD=0.4) compared to the previous value of 1.0 (VOD=1.0). No evidence of ocular infiltration was observed from the cerebral magnetic resonance imaging (MRI). During her follow-up period, we documented the ophthalmologic examinations including visual acuity, visual field (VF), visual evoked potential (VEP), electroretinogram (ERG), fundus photograph (FP), fundus fluorescein angiography (FFA) and optical coherence tomography (OCT). Ophthalmoscope examination and fundus photograph showed optic disc edema, fuzzy boundary and linear hemorrhages in her right eye. Fundus fluorescein angiography (FFA) revealed capillary underdevelopment at the nasal and superior temporal area of the optic disc in the early phase and capillary fluorescein leakage in the late phase. The result of VEP test suggested the impaired function of the optic nerve. Thus, a diagnosis of nonarteritic anterior ischemic optic neuropathy (NAION) was made by the ophthalmologist according to these results. The patient was prescribed prednisone combined with neuroprotective drugs, which did not work. After the cessation of chemotherapy, her impaired vision gradually recovered. Conclusions: This is the first reported case of acute visual impairment in a patient who underwent chemotherapy of a normal dose. It is indicated that while receiving benefits from chemotherapy, cancer patients simultaneously suffer from the risk of vision loss. Key words: Vision loss, Chemotherapy, Nonarteritic anterior ischemic optic neuropathy

scholarly journals Unilateral visual impairment in a patient undergoing chemotherapy: a case report and clinical findings

2019 ◽  
Author(s):  
Xia Yuan ◽  
Yuliang Feng ◽  
Dan Li ◽  
Mei Li
Keyword(s):  
Visual Acuity ◽  
Visual Impairment ◽  
Fluorescein Angiography ◽  
Vision Loss ◽  
Ischemic Optic Neuropathy ◽  
Fundus Photograph ◽  
Fundus Fluorescein Angiography ◽  
Intravenous Chemotherapy ◽  
Normal Dose ◽  
The Right

Abstract Visual impairment occurred as an infrequent form of chemotherapeutic toxicity and was often underestimated despite of several reports. We described a case of acute unilateral visual impairment after one cycle of intravenous chemotherapy of a normal dose, aiming at raising attention to chemotherapy-induced ocular toxicity. Case presentation: The patient developed a progressive vision loss in the right eye during the chemotherapy. After one cycle of intravenous chemotherapy, her visual acuity decreased by 0.6 in the right eye (VOD=0.4) compared to the previous value of 1.0 (VOD=1.0). No evidence of ocular infiltration was observed from the cerebral magnetic resonance imaging (MRI). During her follow-up period, we documented the ophthalmologic examinations including visual acuity, visual field (VF), visual evoked potential (VEP), electroretinogram (ERG), fundus photograph (FP), fundus fluorescein angiography (FFA) and optical coherence tomography (OCT). Ophthalmoscope examination and fundus photograph showed optic disc edema, fuzzy boundary and linear hemorrhages in her right eye. Fundus fluorescein angiography (FFA) revealed capillary underdevelopment at the nasal and superior temporal area of the optic disc in the early phase and capillary fluorescein leakage in the late phase. The result of VEP test suggested the impaired function of the optic nerve. Thus, a diagnosis of nonarteritic anterior ischemic optic neuropathy (NAION) was made by the ophthalmologist according to these results. The patient was prescribed prednisone combined with neuroprotective drugs, which did not work. After the cessation of chemotherapy, her impaired vision gradually recovered. Conclusions: This is the first reported case of acute visual impairment in a patient who underwent chemotherapy of a normal dose. It is indicated that while receiving benefits from chemotherapy, cancer patients simultaneously suffer from the risk of vision loss. Key words: Vision loss, Chemotherapy, Nonarteritic anterior ischemic optic neuropathy

scholarly journals Unilateral visual impairment in a patient undergoing chemotherapy: a case report and clinical findings

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Xia Yuan ◽  
Yuliang Feng ◽  
Dan Li ◽  
Mei Li
Keyword(s):  
Visual Acuity ◽  
Visual Impairment ◽  
Fluorescein Angiography ◽  
Optic Disc ◽  
Vision Loss ◽  
Fundus Photograph ◽  
Fundus Fluorescein Angiography ◽  
Intravenous Chemotherapy ◽  
Normal Dose ◽  
The Right

Abstract Background Visual impairment occurred as an infrequent form of chemotherapeutic toxicity and was often underestimated despite of several reports. We described a case of acute unilateral visual impairment after one cycle of intravenous chemotherapy of a normal dose, aiming at raising attention to chemotherapy-induced ocular toxicity. Case presentation The patient developed a progressive vision loss in the right eye during the chemotherapy. After one cycle of intravenous chemotherapy, her visual acuity decreased by 0.6 in the right eye (VOD = 0.4) compared to the previous value of 1.0 (VOD = 1.0). No evidence of ocular infiltration was observed from the cerebral magnetic resonance imaging (MRI). During her follow-up period, we documented the ophthalmologic examinations including visual acuity, visual field (VF), visual evoked potential (VEP), electroretinogram (ERG), fundus photograph (FP), fundus fluorescein angiography (FFA) and optical coherence tomography (OCT). Ophthalmoscope examination and fundus photograph showed optic disc edema, fuzzy boundary and linear hemorrhages in her right eye. Fundus fluorescein angiography (FFA) revealed capillary underdevelopment at the nasal and superior temporal area of the optic disc in the early phase and capillary fluorescein leakage in the late phase. The result of VEP test suggested the impaired function of the optic nerve. Thus, a diagnosis of nonarteritic anterior ischemic optic neuropathy (NAION) was made by the ophthalmologist according to these results. The patient was prescribed prednisone combined with neuroprotective drugs, which did not work. After the cessation of chemotherapy, her impaired vision gradually recovered. Conclusions This is the first reported case of acute visual impairment in a patient who underwent chemotherapy of a normal dose. It is indicated that while receiving benefits from chemotherapy, cancer patients simultaneously suffer from the risk of vision loss.

scholarly journals Unilateral visual impairment in a patient undergoing chemotherapy: a case report and clinical findings

2019 ◽  
Author(s):  
Xia Yuan ◽  
Yuliang Feng ◽  
Dan Li ◽  
Mei Li
Keyword(s):  
Visual Acuity ◽  
Visual Impairment ◽  
Fluorescein Angiography ◽  
Optic Disc ◽  
Vision Loss ◽  
Fundus Photograph ◽  
Fundus Fluorescein Angiography ◽  
Intravenous Chemotherapy ◽  
Normal Dose ◽  
The Right

Abstract Background: Visual impairment occurred as an infrequent form of chemotherapeutic toxicity and was often underestimated despite of several reports. We described a case of acute unilateral visual impairment after one cycle of intravenous chemotherapy of normal dose, aimed at raising attention to chemotherapy-induced ocular toxicity. Case presentation: During chemotherapy, the patient developed progressive vision loss in the right eye. She had worse visual acuity of 0.4 in the right eye (VOD0.4) than before (VOD1.0) after one cycle of intravenous chemotherapy. No evidence of ocular infiltration was observed from the cerebral magnetic resonance imaging (MRI). During her follow-up period we documented the ophthalmologic examinations including visual acuity, visual field (VF), visual evoked potential (VEP), electroretinogram (ERG), fundus photograph (FP), fundus fluorescein angiography (FFA) and optical coherence tomography (OCT). Ophthalmoscope examination and fundus photograph showed optic disc edema, fuzzy boundary and linear hemorrhages in the right eye. Fundus fluorescein angiography (FFA) revealed capillary underdevelopment at the nasal and superior temporal area of optic disc in the early phase and capillary fluorescein leakage in the late phase. The result of VEP test suggested that the function of optic nerve was impaired. A diagnosis of nonarteritic anterior ischemic optic neuropathy (NAION) was made by an ophthalmologist and the patient received prednisone combined with neuroprotective drugs, which did not work. After cessation of chemotherapy, her impaired vision gradually improved. Conclusions: This is the first reported case of acute visual impairment in a patient undergoing chemotherapy of normal dose. It is warranted that cancer patients benefiting from chemotherapy simultaneously suffer from the risk of vision loss.

scholarly journals Monocular visual impairment in a patient undergoing cisplatin-based chemotherapy: a case report and clinical findings

2019 ◽  
Author(s):  
Xia Yuan ◽  
Yuliang Feng ◽  
Dan Li ◽  
Mei Li
Keyword(s):  
Visual Impairment ◽  
Fluorescein Angiography ◽  
Optic Disc ◽  
Vision Loss ◽  
Ischemic Optic Neuropathy ◽  
Fundus Photograph ◽  
Fundus Fluorescein Angiography ◽  
Cerebral Magnetic Resonance Imaging ◽  
Normal Dose ◽  
The Right

Abstract Background Visual impairment occurred as an infrequent form of chemotherapeutic toxicity and was often underestimated despite of several reports. We described a case of acute monocular visual impairment after one cycle of intravenous cisplatin-based chemotherapy of normal dose, aimed at raising attention to chemotherapy-induced ocular toxicity. Case presentation The patient consulted to an ophthalmologist, and during her follow-up period we documented the ophthalmologic examinations including visual acuity, visual field (VF), visual evoked potential (VEP), electroretinogram (ERG), fundus photograph (FP), fundus fluorescein angiography (FFA) and optical coherence tomography (OCT). During chemotherapy, the patient developed progressive vision loss in the right eye. No evidence of ocular infiltration was observed from the cerebral magnetic resonance imaging (MRI). Ophthalmoscope examination and fundus photograph showed optic disc edema, fuzzy boundary and linear hemorrhages in the right eye. Fundus fluorescein angiography (FFA) revealed capillary underdevelopment at the nasal and superior temporal area of optic disc in the early phase and capillary fluorescein leakage in the late phase. The result of VEP test suggested that the function of optic nerve was impaired. A diagnosis of nonarteritic anterior ischemic optic neuropathy (NAION) was made by an ophthalmologist and the patient received prednisone combined with neuroprotective drugs, which did not work. After cessation of chemotherapy, her impaired vision gradually improved. Conclusions This is the first reported case of acute visual impairment in a patient undergoing cisplatin-based chemotherapy of normal dose. It is warranted that cancer patients benefiting from chemotherapy simultaneously suffer from the risk of vision loss.

scholarly journals Valsalva Retinopathy Associated with Sexual Activity

2014 ◽  
Vol 2014 ◽  
pp. 1-3 ◽  
Author(s):  
Khalid Al Rubaie ◽  
J. Fernando Arevalo
Keyword(s):  
Visual Acuity ◽  
Sexual Activity ◽  
Vision Loss ◽  
Internal Limiting Membrane ◽  
Internal Limiting Membrane Peeling ◽  
Sudden Loss ◽  
Initial Visual Acuity ◽  
Pars Plana ◽  
23 Gauge ◽  
The Right

A 54-year-old healthy male presented complaining of sudden loss of vision in the right eye. Initial visual acuity was counting fingers. The patient’s acute vision loss developed after sexual activity. Color fundus photos and fluorescein angiography were performed showing a large subinternal limiting membrane hemorrhage in the macular area. A 23-gauge sutureless pars plana vitrectomy with brilliant blue assisted internal limiting membrane peeling was performed with best-corrected visual acuity recovery to 20/50 at 6 months of followup.

scholarly journals Prevalence and causes of visual impairment and blindness among school children in Muzaffarabad, Pakistan

2018 ◽  
Vol 4 (4) ◽  
pp. 93
Author(s):  
Abdul Rauf Awan ◽  
Junaid Jamshed ◽  
Muhammad Mushtaq Khan ◽  
Zahid Latif
Keyword(s):  
Visual Acuity ◽  
Public Schools ◽  
Visual Impairment ◽  
Private Schools ◽  
School Children ◽  
School Health ◽  
Vision Loss ◽  
Screening Program ◽  
Sampling Technique ◽  
Cross Sectional

<p class="abstract"><strong>Background:</strong> Vision loss<strong> </strong>in childhood has serious implications in all stages of child’s growth and development. It poses social, educational and occupational challenges, with affected children being at greater risk of developing behavioral, psychological and emotional problems, lower self-esteem and poorer social integration. The aim of this study was to assess the prevalence and identify the causes of visual impairment and blindness in school children of UC Gojra, Muzaffarabad, Pakistan so that prevention strategies could be implemented.</p><p class="abstract"><strong>Methods:</strong> This was a<strong> </strong>school-based descriptive cross-sectional study conducted among public and private schools. A multi-stage stratified random sampling technique was used for selecting study participants aged 5-20 years from 24 schools in Muzaffarabad. The vision of school children was examined for visual acuity using standard Snellen chart. Those participants who had visual acuity of &lt;6/18 in either eye underwent a more detailed ophthalmic examination to diagnose the causes of VI. An exploration of demographic variables was conducted using Chi-square test.  </p><p class="abstract"><strong>Results:</strong> The mean age of participants was 10±2.83.<strong> </strong>The prevalence of visual impairment was 19.6% and 2.3% for severe visual impairment. The age group most affected by VI was 11-15 years (74.2%). There were increased chances of developing VI with advancing age of the participants. Males contributed 88.7% of the cases of VI while females contributed only 11.3%. The class category 5-6 had higher percentage of VI cases (32.7%). Public schools contributed 52.8% of the cases of VI while for private schools the corresponding percentage was 47.2%. The leading cause of VI was refractive error (89.3%) followed by amblyopia (5.0%). Other causes of VI included cataract (1.2%), corneal disease (1.8%), strabismus (1.8%) and nystagmus (0.6%).</p><p class="abstract"><strong>Conclusions:</strong> There is a need to implement school health policy on visual screening prior to admissions in schools and annual eye screening program for early detection and prompt treatment of eye problems among school children in Muzaffarabad.</p>

scholarly journals Prevalence and risk factors for visual impairment among elderly residents in ‘homes for the aged’ in India: the Hyderabad Ocular Morbidity in Elderly Study (HOMES)

2020 ◽  
Vol 105 (1) ◽  
pp. 32-36 ◽  
Author(s):  
Srinivas Marmamula ◽  
Navya Rekha Barrenakala ◽  
Rajesh Challa ◽  
Thirupathi Reddy Kumbham ◽  
Satya Brahmanandam Modepalli ◽  
...  
Keyword(s):  
Risk Factors ◽  
Visual Acuity ◽  
Logistic Regression ◽  
Visual Impairment ◽  
Vision Loss ◽  
The Elderly ◽  
Posterior Capsular Opacification ◽  
Routine Practice ◽  
Homes For The Aged ◽  
Uncorrected Refractive Error

Background/AimTo investigate the prevalence, causes and risk factors of visual impairment (VI) among the elderly in ‘home for the aged’ in Hyderabad, India.MethodsIndividuals aged ≥60 years were recruited from 41 ‘homes for the aged’. All participants had complete eye examinations including presenting visual acuity, refraction, slit-lamp examination, intraocular pressure measurement and fundus imaging by trained clinicians. VI was defined as presenting visual acuity worse than 6/18 in the better eye. Multivariate logistic regression was used to determine the risk factors associated with VI.Results1512 elderly residents from 41 homes for the aged were enumerated, of whom 1182 (78.1%) were examined. The mean age of examined participants was 75.0 years (SD 8.8 years; range: 60–108 years); 35.4% of those examined were men. The prevalence of VI was 30.1% (95% CI 27.5 to 32.8). The leading cause of VI was cataract (46.3%, n=165), followed by uncorrected refractive error (27.0%, n=96), posterior capsular opacification (14.9%, n=53) and posterior segment disease (6.5%, n=23). Overall, 88.2% of the VI was either treatable or correctable. In multiple logistic regression, those aged 80 years and older (OR: 1.7, p<0.01), living in ‘free’ homes (OR: 1.5, p<0.01) and who were immobile/bedridden (OR: 3.02, p<0.01) had significantly higher odds of VI. Gender was not associated with VI.ConclusionsVI was common and largely avoidable in residents of ‘homes for the aged’ in Hyderabad, India. Screening for vision loss in ‘homes for aged’ and the provision of appropriate services should become routine practice to achieve the goal of healthy ageing in India.

Lyme disease atypically presenting with a singular symptom: Unilateral chorioretinitis

2020 ◽  
pp. 112067212096205
Author(s):  
Erol Havuz ◽  
Seda Güdül Havuz
Keyword(s):  
Visual Acuity ◽  
Lyme Disease ◽  
Retinal Vasculitis ◽  
Ocular Involvement ◽  
Ischemic Optic Neuropathy ◽  
Sudden Loss ◽  
Patient Reported ◽  
History Of ◽  
Verification Test ◽  
The Right

Background: Lyme disease, caused by Borrelia burgdorferi, is a spirochetal disease. Lyme disease-related ocular findings may also provide important clues. Ocular involvement is most commonly seen as uveitis, chorioretinitis, conjunctivitis, keratitis, episcleritis, papillitis, panuveitis, ischemic optic neuropathy, papilledema, and retinal vasculitis. Case: A 27-year-old male patient was admitted with a history of fatigue, malaise, and sudden loss of vision in his left eye for 3 days. The best visual acuity was found 20/20 in the right eye and 20/400 in the left eye. Fluorescein fundus angiography showed no pathological findings in the right eye; but hyperfluorescence that was compatible with choroiditis foci was seen in the left eye. Optical coherence tomography (OCT) showed choroidal thickening in the left eye compared to the right eye. Lyme IgM antibody was found to be positive, explaining choroiditis etiology, while IgG values were found to be negative. Western blot verification test was positive. The patient was treated with 2 × 100 mg doxycycline (21 days) with a diagnosis of Lyme disease, prednol 1 mg/kg/day (10 days) for choroiditis. Omeprazole tablets were given 1 × 1 during the period of cortisone intake. On the third day of treatment, visual acuity increased to 20/200 and continued to increase until reaching 20/20 in the second week. Conclusions: Lyme disease is rare, but must be kept in mind when investigating the etiology of chorioretinitis and retinal vasculitis. The patient reported here is, to our knowledge, the second case reported in literature that shows atypical clinic for Lyme disease with unilateral chorioretinitis without Erythema chronicum migrans (ECM).

scholarly journals Evans syndrome in child with sudden blindness

2021 ◽  
Vol 3 (1) ◽  
pp. 64-68
Author(s):  
Muhammad Fadhli Ab Hamid ◽  
May May Choo ◽  
Nurliza Khaliddin ◽  
Norlina Mohd Ramli
Keyword(s):  
Visual Acuity ◽  
Vision Loss ◽  
Oral Prednisolone ◽  
Sudden Onset ◽  
Sterile Inflammation ◽  
Evans Syndrome ◽  
Waking Up ◽  
The Right ◽  
Sudden Blindness ◽  
Rule Out

A 3-year-old girl presented with sudden onset of bilateral vision loss on waking up from sleep. There had been no associated eye pain, eye redness, fever or history of trauma in the days leading up to the presentation. She had been diagnosed with Evans syndrome at the age of 18 months and started on a regular dose of oral prednisolone under regular follow-up at the paediatric clinic. Upon presentation, her visual acuity was light perception bilaterally, with relative afferent pupillary defect in the right eye and sluggish pupils bilaterally. Bilateral fundus examination showed normal macula and pink optic discs without papilloedema. Other systemic examinations were unremarkable. The provisional diagnosis was severe bilateral retrobulbar optic neuritis, prompting further investigations to rule out infectious or vasculitic causes. Extensive investigations were carried out during admission including infective screenings of blood and urine, all of which were negative. A contrasted magnetic resonance image of the brain showed both orbital segments were swollen and appeared hyperintense, with involvement of the intracanalicular and intracranial segments, suggesting an inflammatory or demyelinating aetiology. A visual evoked potential test to rule out demyelination disease was also normal. As intravenous methylprednisolone treatment appeared to have a slow effect, the treatment was switched to intravenous gammaglobulin. The patient responded well to treatment, and her latest visual acuity assessment 1 month after presentation showed bilateral vision of 6/24. This is the first-ever Evans syndrome patient to be reported worldwide with bilateral optic nerve sterile inflammation.

scholarly journals A Case of Streptococcus Suis Meningitis With Visual Impairment and Hearing Loss Diagnosed by Metagenomic Next-generation Sequencing

2021 ◽  
Author(s):  
Haina Zhao ◽  
Lanlan Chen ◽  
Lin Zhu ◽  
Tingting Qiao ◽  
Peipei Liu ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Hearing Loss ◽  
Next Generation Sequencing ◽  
Infectious Diseases ◽  
Visual Impairment ◽  
Vision Loss ◽  
Streptococcus Suis ◽  
Next Generation ◽  
The Right ◽  
Generation Sequencing

Abstract Background: Streptococcus suis is responsible for several kinds of zoonosis worldwide. It can cause meningitis, sepsis, osteoarthritis, endocarditis, endophthalmitis, and other diseases. Human infection typically occurs in occupational settings associated with pig husbandry or pork processing. At present, metagenomic next-generation sequencing (mNGS) is prominent testing method for achieving an early and rapid diagnosis of some infectious diseases. Case presentation: A 48-year-old Chinese man who denied exposure to pigs or pork was to admitted the hospital because he had experienced a fever for three days, visual impairment, and hearing loss for one day. After a series of examinations and laboratory tests, Streptococcus suis was detected in the aqueous humor culture as well as the vitreous humor and cerebrospinal fluid with mNGS. But bacteria were not detected in the blood or cerebrospinal fluid culture. The patient's condition improved, and he was discharged after 2 weeks of active treatment. However, at present, poor vision in the right eye, poor hearing in the right ear and recurrent vertigo remain.Conclusions: In a patient presenting with meningitis, vision loss, and/or hearing loss, Streptococcus suis infection should be strongly suspected regardless of the patient's occupation. mNGS has excellent diagnostic value to determine which was the etiological agent for infectious diseases.

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