scholarly journals Obstructive sleep apnea-hypopnea syndrome patients prone to developing anisometropia

2019 ◽  
Author(s):  
Hua-Xuan Zhao ◽  
Ying-Ying Gao ◽  
Xiao-Yang Chen ◽  
Yi-Ming Zeng
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Asymmetry Index ◽  
Control Group ◽  
Positional Obstructive Sleep Apnea ◽  
Regularity Index ◽  
Obstructive Sleep ◽  
Contralateral Eye ◽  
Hypopnea Syndrome ◽  
Surface Regularity

Abstract Objective: This study aims to investigate anisometropia in obstructive sleep apnea-hypopnea syndrome patients. Methods: The obstructive sleep apnea-hypopnea syndrome cohort was divided into groups according to sleeping position: positional obstructive sleep apnea-hypopnea syndrome group (OSA-S group) (n=32), subjects who slept on their sides, and non-positional obstructive sleep apnea-hypopnea syndrome group (OSA-NS group) (n =29), subjects who did not sleep on their sides. The incidence of anisometropia, values of corneal topography, and ocular axial length were compared between groups, and the incidence of anisometropia at different degrees of obstructive sleep apnea-hypopnea syndrome severity was analyzed. Results: The obstructive sleep apnea-hypopnea syndrome groups had a significantly higher incidence of anisometropia than the control group. The OSA-S group had a significantly higher incidence of anisometropia compared with the other groups. There was a significant difference in the incidence of anisometropia between the two obstructive sleep apnea-hypopnea syndrome subgroups with different degrees of severity. The obstructive sleep apnea-hypopnea syndrome groups had significantly higher surface regularity index, surface asymmetry index and cylinder values than the control group. In the OSA-S group, the surface regularity index, surface asymmetry index and cylinder of the eye on the preferred sleeping side were significantly higher than those in the contralateral eye. The ocular axial length of the eye was significantly greater on the preferred sleeping side than in the contralateral eye in the 22 patients with anisometropia in the OSA-S group (P<0.05). Conclusions: obstructive sleep apnea-hypopnea syndrome patients who usually sleep on one side are prone to developing anisometropia, and the incidence of anisometropia is associated with the severity of obstructive sleep apnea-hypopnea syndrome.

scholarly journals Serum Uric Acid Is Independently Associated with Risk of Obstructive Sleep Apnea-Hypopnea Syndrome in Chinese Patients with Type 2 Diabetes

2019 ◽  
Vol 2019 ◽  
pp. 1-6 ◽  
Author(s):  
Caiyu Zheng ◽  
Haiqu Song ◽  
Shunhua Wang ◽  
Jing Liu ◽  
Tingting Lin ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Obstructive Sleep Apnea ◽  
Uric Acid ◽  
Sleep Apnea ◽  
Serum Uric Acid ◽  
Control Group ◽  
Apnea Hypopnea Index ◽  
Obstructive Sleep ◽  
Hypopnea Syndrome

Purpose. We aimed to investigate the association between serum uric acid (SUA) levels and obstructive sleep apnea-hypopnea syndrome (OSAHS) in patients with type 2 diabetes. Methods. A cross-sectional study of 212 type 2 diabetes mellitus (T2DM) patients was conducted in Xiamen, China. All patients underwent polysomnography (PSG) recordings for OSAHS diagnosis. Patients were grouped according to the apnea-hypopnea index (AHI) as mild (5-14.9), moderate (15-29.9), and severe (≧30) OSAHS. Patients with AHI≤4.9 served as the control group. Weight, body mass index (BMI), SUA, liver function, renal function, blood pressure, lipid profiles, and glycemic parameters were measured. Results. A total of 158 patients (101 men and 57 women) with complete data were analyzed in this study. 127 patients were identified as OSAHS. Among the 127 patients with OSAHS, 56 (44.1%), 37 (29.1%), and 34 (26.8%) had mild, moderate, and severe OSAHS, respectively. Correlation analyses showed that the SUA level was significantly related to the apnea-hypopnea index (AHI) (r=0.194, p=0.016). The level of SUA was significantly higher among OSAHS patients compared to the control group (control group: 333.14±80.52 μmol/L, mild group: 345.50±90.27 μmol/L, moderate group: 363.59±134.26 μmol/L, and severe group: 428.37±123.58 μmol/L and p=0.029). Multivariable logistic regression analyses showed that SUA was the independent risk factor for OSAHS (OR: 1.006, 95% CI: 1.001-1.011, p=0.020). Conclusions. The SUA level is significantly associated with the severity of OSAHS and should be controlled when managing OSAHS.

scholarly journals Efficacy of Velopharyngeal Surgery for Positional Obstructive Sleep Apnea Hypopnea Syndrome

2020 ◽  
pp. 014556132093195
Author(s):  
Nian Sun ◽  
Jingying Ye ◽  
Junbo Zhang ◽  
Dan Kang ◽  
Jun Tai ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Sleep Time ◽  
Apnea Hypopnea Index ◽  
Surgical Success ◽  
Positional Obstructive Sleep Apnea ◽  
Obstructive Sleep ◽  
Significant Difference ◽  
Definition Of ◽  
Hypopnea Syndrome

Background: Positional obstructive sleep apnea hypopnea syndrome (P-OSAHS) is a distinct OSAHS type. Whether velopharyngeal surgery is efficacious for patients with P-OSAHS remains unclear. Aim/Objective: To investigate the efficacy and factors influencing velopharyngeal surgery for treatment of patients with P-OSAHS, defined as the apnea hypopnea index (AHI) in different body postures (supine AHI ≥2*nonsupine AHI). Materials and Methods: A total of 44 patients with P-OSAHS who underwent velopharyngeal surgery were retrospectively studied. The clinical data of these patients, including polysomnography (PSG), physical examination, and surgical information, were collected for analysis. All patients underwent a PSG about 6 months after surgery to determine the treatment outcomes. Results: The overall AHI of the 44 patients decreased from 40.2 ± 18.7 events/h to 18.5 ± 17.5 events/h after surgery ( P < .001). There were 29 responders (65.9%) according to the classical definition of surgical success. The percentage of sleep time with oxygen saturation below 90% (CT90) was the only predictive parameter for surgical success ( P = .014, odds ratio value = 0.894). There was no significant difference between the change in supine AHI (−55.9 ± 35.2%) and the change in nonsupine AHI (−43.4 ± 74.1%; P = .167), and these 2 parameters were significantly correlated ( r = 0.616, P < .001). Among the 38 patients with residual OSAHS (residual AHI ≥5), 28 had persistent P-OSAHS, and the percentage was as high as 82.4%. Conclusions and Significance: Patients with P-OSAHS with a lower CT90 value are more likely to benefit from velopharyngeal surgery. Positional therapy could be indicated for most of the patients who are not cured by such surgery.

Risk factors for non-positional obstructive sleep apnea–hypopnea syndrome

2021 ◽  
Author(s):  
Xiao Jiao ◽  
Jianyin Zou ◽  
Lili Meng ◽  
Suru Liu ◽  
Jian Guan ◽  
...  
Keyword(s):  
Risk Factors ◽  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Positional Obstructive Sleep Apnea ◽  
Obstructive Sleep ◽  
Hypopnea Syndrome

scholarly journals The signal axis GATA2-EDN1-AGT induced hypertension from obstructive sleep apnea-hypopnea syndrome with the clinical and animal study

2022 ◽  
Vol 67 (4) ◽  
pp. 91-96
Author(s):  
Li Zhang ◽  
Shaokun Xu ◽  
Ning Zhou ◽  
Juanqin Shen ◽  
Jiaqing Huang ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Systolic Pressure ◽  
Strong Relationship ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Group ◽  
Case Group ◽  
Obstructive Sleep ◽  
Induced Hypertension ◽  
Hypopnea Syndrome

Hypertension occurred in 50% obstructive sleep apnea-hypopnea syndrome (OSAHS) patients meanwhile OSAHS occurred in 30% hypertension patients. The present study aimed to explore the molecular mechanism of GATA2-EDN1-AGT induced hypertension in the development of obstructive sleep apnea-hypopnea syndrome. OSAHS patients (56 cases: 36 cases of male, 20 cases of female, 42~60 years old) were divided into two groups (case group: patients with hypertension monitored by 24 h ambulatory blood pressure and polysomnography; control group: patients without hypertension). Wistar rats were used to establish the OSAHS model (narrow pharyngeal cavity). PaO2 and PaCO2 of patients and rats were measured by an automatic blood gas analyzer. The profile of total protein in the OSAHS group and normal group was evaluated. Protein-protein-interaction (PPI) was carried out to show all matter proteins related. The levels of EDN-1, AGTII and atrial natriuretic peptide (ANP) in blood samples of patients and rats were analyzed by enzyme-linked immunosorbent assay (ELISA). The expression of GATA2, EDN1, endothelin-converting enzyme 1 (ECE-1) and AGTⅡ was measured. The results showed that SaO2 and AHI were positively associated with systolic pressure (P<0.05) in OSAHS patients. There was no correlation among other indexes (P>0.05). It was also observed that GATA2 had a strong relationship with AGTⅡ and EDN1. The results of ELISA presented that the levels of EDN1, AGTⅡ and ANP in the OSAHS group of human and animal models were significantly increased (P<0.05). The results of immunochemistry showed that the expression of GATA2 and AGTⅡ in the vascular of OSAHS group was upregulated manifestly (P<0.05). It was concluded that OSAHS can induce AHI, which increases hypertension via the GATA2-EDN1-AGT Ⅱ axis.

scholarly journals Effect of Cooling Irrigating Saline in Tongue Base Ablation in Obstructive Sleep Apnea

OTO Open ◽  
2021 ◽  
Vol 5 (1) ◽  
pp. 2473974X2198959
Author(s):  
Ahmed Yassin Bahgat
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Controlled Trial ◽  
Tongue Base ◽  
Control Group ◽  
University Hospitals ◽  
Energy Field ◽  
Obstructive Sleep ◽  
Prospective Randomized Controlled Trial ◽  
Significant Difference

Objective Plasma is formed by creating a high-density energy field within an electrically conductive fluid such as saline. Sometimes ablated bits of tissue get stuck between the electrodes of the wand, obstructing the suction channel. The purpose of this study is to investigate the effect of cooling the irrigating saline during ablation of the hypertrophied tongue base in patients with obstructive sleep apnea. Study Design Prospective randomized controlled trial. Setting An otorhinolaryngology department in Main University hospitals. Methods Sixty adult patients with obstructive sleep apnea and tongue base hypertrophy underwent tongue base ablation surgery. Patients were randomly divided into 2 groups of 30 patients each: cooled saline and room temperature saline. The Coblation wand used was the EVac 70 Xtra HP (Smith & Nephew). Results In this study, a significant difference in operative time (mean ± SD) was seen between groups: 21.2 ± 5.5 minutes in the cold group and 47 ± 9.5 minutes in the control group ( P = .001). The wands in the cold group did not obstruct, while all the wands in the control group were obstructed by tissue clogs with variable degrees, hence wasting more time to clean the wands’ tips. Conclusion Cooling the irrigating saline overcame the problem of wand clogs, and the wand tip did not occlude at all during the procedures, thus saving time lost in wand cleaning and demonstrating a faster and safer surgical procedure. Further studies are needed to identify the hemostatic effect of the cooled saline over the regular one.

Evaluation of corneal endothelium using specular microscopy in patients with obstructive sleep apnea syndrome

2021 ◽  
pp. 112067212110065
Author(s):  
Murat Serkan Songur ◽  
Yavuz Selim İntepe ◽  
Seray Aslan Bayhan ◽  
Hasan Ali Bayhan ◽  
Ender Şahin ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Coefficient Of Variation ◽  
Corneal Endothelium ◽  
Corneal Thickness ◽  
Sleep Apnea Syndrome ◽  
Control Group ◽  
Specular Microscopy ◽  
Obstructive Sleep ◽  
Apnea Syndrome

Purpose: In the present study we evaluate the corneal endothelium using specular microscopy in patients with obstructive sleep apnea syndrome (OSAS). Methods: The study included a total of 100 patients including 35 patients with mild OSAS, 34 patients with moderate OSAS and 31 patients with severe OSAS, and the right eyes of 30 patients as a control group. Patients were examined to exclude the possibility of ocular diseases. Cellular density in the cornea epithelium (cell/mm2), corneal thickness (µ), percentage of hexagonal cells (%) and the coefficient of variation were evaluated using a specular microscope. Results: Corneal thickness was significantly decreased in all OSAS groups when compared to the control group ( p = 0.002), while no significant difference was identified among the OSAS groups. The corneal endothelial cell density, percentage of hexagonal cells and coefficient of variation were significantly different between the OSAS groups and the control group ( p < 0.001). Conclusion: More significant impairments were noted in the corneal endothelium of the patients in the OSAS group than in the control group, and specular microscopy is in valuable in the follow-up and treatment of such patients.

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