scholarly journals Association Between Socioeconomic Status and Severity of Oral Epithelial Dysplasia Using a Taiwanese Nationwide Oral Mucosal Screening Program: A Retrospective Analysis

2021 ◽  
Author(s):  
Tien-En Chiang ◽  
Yu-Chun Lin ◽  
Chi-Tsung Wu ◽  
Sheng-Tang Wu ◽  
Yuan-Wu Chen
Keyword(s):  
High School ◽  
Socioeconomic Status ◽  
Tobacco Use ◽  
Screening Program ◽  
Background Information ◽  
Self Awareness ◽  
Oral Epithelial Dysplasia ◽  
Education Status ◽  
History Of ◽  
Oral Epithelial

Abstract Background: The study aimed to investigate the association between socioeconomic status and severity of oral epithelial dysplasia (OED) using current data from the Taiwanese Nationwide Oral Mucosal Screening Program (TNOMSP). Methods: This retrospective analysis was conducted in the Department of Oral and Maxillofacial Surgery at a general hospital in Taipei, Taiwan. A total of 134 participants were analysed from a previous study database of 150 patients. The inclusion criteria included age over 20 years and a history of either tobacco or betel nut use. Background information, including para-habits such as betel and tobacco use, was analysed using Pearson chi-square (χ2) test, furthermore, the correlation of background information with OED severity was investigated using logistic regression (mild or moderate/high).Results: High school education level (P<0.001), poor self-awareness (P=0.002), current betel use (P<0.001), and tobacco use (P=0.003) were highly correlated with moderate- and high-grade OED (P<0.05). The odds ratio (OR) of education status above senior high school was 0.03 (95% confidence interval [CI]: 0.01–0.15, P<0.001), while that of junior high school was 1. Current betel chewing (OR=6.57 [95% CI: 1.17–37.0], P=0.033) was significantly associated with OED severity compared with never or ex-use of betel.Conclusions: We found a strong correlation between the severity of OED and current betel use and low education status. The current study revealed the socioeconomic status, poor self-awareness, and para-habits history of the patients with OED should be evaluated to identify high-risk individuals using TNOMSP.

scholarly journals Smokeless tobacco use and oral epithelial dysplasia

Cancer ◽  
1989 ◽  
Vol 64 (7) ◽  
pp. 1527-1530 ◽  
Author(s):  
George E. Kaugars ◽  
Wanda L. Mehailescu ◽  
John C. Gunsolley
Keyword(s):  
Tobacco Use ◽  
Smokeless Tobacco ◽  
Epithelial Dysplasia ◽  
Oral Epithelial Dysplasia ◽  
Smokeless Tobacco Use ◽  
Oral Epithelial

Opportunistic Colorectal Cancer Screening using Colonoscopy. Comparative Results between two Historical Cohorts in Bucharest, Romania

2015 ◽  
Vol 24 (2) ◽  
pp. 171-176 ◽  
Author(s):  
Elena Mirela Ionescu ◽  
Tudor Nicolaie ◽  
Serban Ion Gologan ◽  
Ana Mocanu ◽  
Cristina Ditescu ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Screening Program ◽  
Advanced Adenoma ◽  
Detection Rates ◽  
Incidence And Mortality ◽  
Organized Screening Program ◽  
History Of ◽  
Comparative Results ◽  
Asymptomatic Individuals ◽  
Second Period

Background & Aims: Even though Romania has one of the highest incidence and mortality in colorectal cancer (CRC) in Europe, there is currently no organized screening program. We aimed to assess the results of our opportunistic CRC screening using colonoscopy.Methods: A single center retrospective study to include all opportunistic screening colonoscopies performed in two 18 month periods (2007-2008 and 2012-2013) was designed. All asymptomatic individuals without a personal or family history of adenoma or CRC and with complete colonoscopy performed in these two time periods were included.Results: We included 1,807 individuals, 882 in the first period, 925 in the second period. There were 389 individuals aged below 50, 1,351 between 50 and 75 and 67 older than 75 years. There were 956 women (52.9%), with a mean age of 58.5 (median 59, range 23-97). The detection rates were 12.6% for adenomas (6.1% for advanced adenoma) and 3.4% for adenocarcinoma. Adenoma incidence (4.9% in subjects under 50, 14.7% in those aged 50 to 75, and 16.4% in those older than 75, p<0.0001) and size (6.3mm in subjects younger than 50, 9.2mm in those 50 to 75 and 10.8mm in those older than 75, p=0.015) significantly increased with age. Adenoma incidence increased in the second period (14.8% vs. 10.3%, p=0.005), while adenoma size decreased in the second period (8.4mm vs. 10mm, p=0.006). There were no procedure related complications.Conclusions: The neoplasia detection rate was 16% (12.6% adenoma, 3.4% adenocarcinoma). Adenoma incidence and size increased with age in both cohorts. In the second screening period significantly more and smaller adenomas were detected.

Eksplorasi Kesadaran Diri, Persepsi Dan Sikap Pada Individu Yang Memiliki Riwayat Keluarga Diabetes Melitus Tipe 2

2019 ◽  
Vol 1 (1) ◽  
pp. 52-62
Author(s):  
Mulia Mayangsari
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Family History ◽  
Diabetes Type 2 ◽  
Diabetes Type ◽  
Self Awareness ◽  
Perceptions And Attitudes ◽  
History Of ◽  
Diabetes Melitus

 Individuals who have a family history oftype 2 diabetes mellitus (DM) have a highrisk for type 2 diabetes. Type 2 diabetescan be prevented by improving modifiablerisk factors, supported by self-awareness,perceptions and attitudes of individualswho have a high family history of DM. Thisstudy used a qualitative phenomenologicaldesign. A Purposive Sampling techiniquewas applied to determine individuals whohad parents with type 2 diabetes. Nineindividuals participated in this study. AQualitative content analysis with Collaiziapproach used as a data analysis method.The main themes depicted individuals selfawareness,perceptions, & attitudes were:denials that diabetes caused by heredityfactors; misperception about diabetes;“traditional modalities” as a preventionmeasurement toward type 2 diabetes; andDM is perceived as a “threatening disease”.Further study is needed to examine indepth the themes that have been identifiedon the number of participants are morenumerous and varied.

Sobre Educação, Arte e Vídeoarte: rupturas, resiliência e práticas de ensino/aprendizagem na sala de aula

2020 ◽  
Author(s):  
Nélia Lúcia Fonseca
Keyword(s):  
High School ◽  
High School Students ◽  
Video Art ◽  
Theory And Practice ◽  
First Year ◽  
School Students ◽  
Forest School ◽  
Moving Images ◽  
History Of ◽  
Teaching Learning

This study first approaches the history of the observer’s gaze, that is, as observers, we are forming or constructing our way of visualizing moving images. Secondly, it reaffirms the importance and need of resistance of the teaching / learning of Art as a compulsory curricular component for high school. Finally, the third part reports an experience with video art production in a class of first year high school students, establishing an interrelationship between theory and practice, that is, we study video art content to reach the production of videos, aiming as a final result, the art videos created by the students of the Reference Center in Environmental Education Forest School Prof. Eidorfe Moreira High School. The first and second stages of this research share a theoretical part of the Master ‘s thesis, Making films on the Island: audiovisual production as an escape line in Cotijuba, periphery of Belem, completed in 2013.

Relations of Sociodemographic Variables and Cognitive Ability: A Comparative Analysis of the Cognitive Scores of High School Seniors

1989 ◽  
Vol 69 (3-2) ◽  
pp. 1139-1157
Author(s):  
Hardeo Sahai
Keyword(s):  
High School ◽  
Socioeconomic Status ◽  
White Students ◽  
Mexican Americans ◽  
Minority Groups ◽  
High School Seniors ◽  
Or Education ◽  
Central Pacific ◽  
North Central ◽  
South Central

This paper compares subgroups using cognitive scores from a test battery administered to high school seniors in the base year survey in 1980. The procedures used to select the sample were designed to yield a data base that can be statistically projected to represent the national population of about 3,040,000 high school seniors. Comparisons were performed to examine differences in cognitive scores by age, sex, race/ethnicity, socioeconomic status, and census region. Boys scored higher than girls on mathematics and visualization tests, but lower on the picture-number and mosaic comparison tests. Mean scores of the two sexes on the vocabulary and reading tests differed by less than 0.1 SD. Asian/Pacific Islanders had higher means than white students and other minority groups on the mathematics, mosaic comparisons, and visualization test, but their scores did not differ significantly from those of white students on the other three tests. Means for Hispanics were lower than those for white students but higher than those for black students, except on reading. Mean scores of Cubans exceeded those of Mexican Americans, Puerto Ricans or other Hispanics. A positive correlation 0.40 obtained between test scores and the socioeconomic status or education attained by the examinees’ mothers. Students in New England had the highest means except on visualization for which the highest scores were in the West, followed in order by those in the Middle Atlantic, West North Central, East North Central, Pacific, Mountain, South Atlantic, East South Central, and West South Central regions.

scholarly journals SAVER: sodium valproate for the epigenetic reprogramming of high-risk oral epithelial dysplasia—a phase II randomised control trial study protocol

Trials ◽  
2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Caroline McCarthy ◽  
Joseph Sacco ◽  
Stefano Fedele ◽  
Michael Ho ◽  
Stephen Porter ◽  
...  
Keyword(s):  
High Risk ◽  
Sodium Valproate ◽  
Study Protocol ◽  
Epigenetic Reprogramming ◽  
Epithelial Dysplasia ◽  
Phase Iii ◽  
Cancer Development ◽  
Randomised Control Trial ◽  
Oral Epithelial Dysplasia ◽  
Oral Epithelial

Abstract Background Sodium valproate (VPA) has been associated with a reduced risk of head and neck cancer development. The potential protective mechanism of action is believed to be via inhibition of histone deacetylase and subsequent epigenetic reprogramming. SAVER is a phase IIb open-label, randomised control trial of VPA as a chemopreventive agent in patients with high-risk oral epithelial dysplasia (OED). The aim of the trial is to gather preliminary evidence of the clinical and biological effects of VPA upon OED and assess the feasibility and acceptability of such a trial, with a view to inform a future definitive phase III study. Methods One hundred and ten patients with high-risk OED will be recruited from up to 10 secondary care sites in the UK and randomised into either VPA or observation only for 4 months. Women of childbearing potential will be excluded due to the teratogenic properties of VPA. Tissue and blood samples will be collected prior to randomisation and on the last day of the intervention/observation-only period (end of 4 months). Clinical measurement and additional safety bloods will be taken at multiple time points during the trial. The primary outcome will be a composite, surrogate endpoint of change in lesion size, change in grade of dysplasia and change in LOH profile at 8 key microsatellite regions. Feasibility outcomes will include recruitment targets, compliance with the study protocol and adverse effects. A qualitative sub-study will explore patient experience and perception of the trial. Discussion The current management options for patients with high-risk OED are limited and mostly include surgical resection and clinical surveillance. However, there remains little evidence whether surgery can effectively lead to a notable reduction in the risk of oral cancer development. Similarly, surveillance is associated with concerns regarding delayed diagnosis of OED progressing to malignancy. The SAVER trial provides an opportunity to investigate the effects of a repurposed, inexpensive and well-tolerated medication as a potential chemopreventive strategy for patients with high-risk OED. The clinical and biological findings of SAVER will inform the appropriateness, design and feasibility of a definitive phase III trial. Trial registration The trial is registered with the European Clinical Trials Database (Eudra-CT 2018-000197-30). (http://www.isrctn.com/ISRCTN12448611). The trial was prospectively registered on 24/04/2018.

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