scholarly journals Protection to Six Vaccinable Pathogens in Paired Plasma/DBS and HIV Impact in Infected and Uninfected Children From Kinshasa

2021 ◽  
Author(s):  
Rodríguez-Galet Ana ◽  
Rubio-Garrido Marina ◽  
Valadés-Alcaraz Ana ◽  
Rodríguez-Domínguez Mario ◽  
Galán Juan Carlos ◽  
...  
Keyword(s):  
Vaccination Coverage ◽  
Test Performance ◽  
Herd Immunity ◽  
Roc Curves ◽  
Paediatric Population ◽  
Vaccine Preventable Diseases ◽  
Resource Limited ◽  
Republic Of The Congo ◽  
Coverage Rates ◽  
The Impact

Abstract Child vaccination reduces infant mortality rates. HIV-infected children present higher risk of diseases than non-infected. We report the protection coverage rates to 6 vaccine-preventable diseases in a paediatric population from the Democratic Republic of the Congo (DRC) and the impact of HIV infection, providing the first data on the validity of dried blood samples (DBS) to monitor the immune protection. During 2016-2018 DBS from 143 children/adolescents were collected in Kinshasa (DRC), being 52 HIV-infected. Forty-two had a paired plasma sample. Protective IgG was quantified (VirClia®IgG,Vircell) to obtain the optimal cut-off in IgG detection in DBS. ROC curves were generated with R software and statistical analyses with Stata. Protective IgG levels varied across pathogens, not reaching the herd immunity. HIV-infected presented lower vaccine protection than uninfected for all analysed pathogens, except rubella, with statistically significant differences for measles (30.8% vs. 53.8%;p=0.008) and tetanus (3.8% vs. 22%;p=0.004). New cut-offs were calculated when using DBS to improve test performance. We reinforce the necessity to increase pediatric vaccination coverage in Kinshasa, specially in HIV seropositive, with less capacity to maintain adequate antibody levels. DBS were useful to monitor vaccination coverage in seroprevalence studies in resource-limited settings, after optimizing the cut-off value for each pathogen.

scholarly journals Improved Temporal Trends of Vaccination Coverage Rates in Childhood after the Mandatory Vaccination Act, Italy 2014–2019

2021 ◽  
Vol 10 (12) ◽  
pp. 2540
Author(s):  
Michela Sabbatucci ◽  
Anna Odone ◽  
Carlo Signorelli ◽  
Andrea Siddu ◽  
Francesco Maraglino ◽  
...  
Keyword(s):  
Vaccine Coverage ◽  
Temporal Trends ◽  
Herd Immunity ◽  
Haemophilus Influenzae Type ◽  
Childhood Immunization ◽  
Vaccine Preventable Diseases ◽  
Immunization Rates ◽  
Health Strategy ◽  
Coverage Rates ◽  
The Impact

Maintaining high vaccine coverage (VC) for pediatric vaccinations is crucial to ensure herd immunity, reducing the risk of vaccine-preventable diseases (VPD). The Italian vaccination Law (n. 119/2017) reinforced mandates for polio, diphtheria, tetanus, and hepatitis B, extending the mandate to pertussis, Haemophilus influenzae type b, chickenpox, measles, mumps, and rubella, for children up to 16 years of age. We analyzed the national temporal trends of childhood immunization rates from 2014 to 2019 to evaluate the impact of the mandatory reinforcement law set in 2017 as a sustainable public health strategy in Italy. In a 3-year period, 9 of the 10 compulsory vaccinations reached the threshold of 95% and VC for chicken pox increased up to 90.5%, significantly. During the same period, the recommended vaccinations (against meningococcus B and C, pneumococcus, and rotavirus) also recorded a significant increase in VC trends. In conclusion, although the reinforcement of compulsory vaccination generated a wide public debate that was amplified by traditional and social media, the 3-year evaluation highlights positive results.

Effect of COVID-19 on vaccination coverage in Brazil

2021 ◽  
Vol 70 (11) ◽  
Author(s):  
Marcelle Moura Silveira ◽  
Neida Lucia Conrad ◽  
Fábio Pereira Leivas Leite
Keyword(s):  
Vaccination Coverage ◽  
Physical Distance ◽  
Disease Notification ◽  
Notification System ◽  
Vaccination Programs ◽  
Vaccine Preventable Diseases ◽  
Antigen Vaccine ◽  
Restricted Mobility ◽  
Consistent Information ◽  
The Impact

During the COVID-19 pandemic, recommendations for maintaining physical distance, restricted mobility measures, as well as fear of mass transmission by going to health centers have significantly contributed to the general vaccination coverage, which by and large is decreasing worldwide; thus, favoring the potential re-emergence of vaccine-preventable diseases. In this study, we have used the existing data on vaccination coverage during the pre-pandemic (2019) as well as the pandemic (2020) period to evaluate the impact of coronavirus outbreaks during the vaccination drive in Brazil. Furthermore, we have accumulated data since 2015 among the different regions of the country to acquire more consistent information. The various vaccines analyzed in our study were meningococcal C conjugate, Triple antigen vaccine, 10-valent pneumococcal conjugate, and BCG; subsequently, the data were obtained from the National Disease Notification System. This study revealed that the ongoing immunization drive saw a steep decline of around 10 to 20% during the (2019–2020) pandemic period in Brazil. These results provide strong evidence towards the decreasing trends following the vaccination programs during the COVID-19 pandemic period in Brazil. Furthermore, our results also highlight the importance of adopting widespread multi-component interventions to improve vaccination uptake rates.

scholarly journals The effect of opinion clustering on disease outbreaks

2008 ◽  
Vol 5 (29) ◽  
pp. 1505-1508 ◽  
Author(s):  
Marcel Salathé ◽  
Sebastian Bonhoeffer
Keyword(s):  
Vaccination Coverage ◽  
Belief Systems ◽  
Herd Immunity ◽  
Disease Outbreaks ◽  
Disease Outbreak ◽  
High Income ◽  
Opinion Formation ◽  
Vaccine Preventable Diseases ◽  
Vaccination Rates ◽  
High Level

Many high-income countries currently experience large outbreaks of vaccine-preventable diseases such as measles despite the availability of highly effective vaccines. This phenomenon lacks an explanation in countries where vaccination rates are rising on an already high level. Here, we build on the growing evidence that belief systems, rather than access to vaccines, are the primary barrier to vaccination in high-income countries, and show how a simple opinion formation process can lead to clusters of unvaccinated individuals, leading to a dramatic increase in disease outbreak probability. In particular, the effect of clustering on outbreak probabilities is strongest when the vaccination coverage is close to the level required to provide herd immunity under the assumption of random mixing. Our results based on computer simulations suggest that the current estimates of vaccination coverage necessary to avoid outbreaks of vaccine-preventable diseases might be too low.

scholarly journals Sustained Vaccination Coverage during the Coronavirus Disease 2019 Epidemic in the Republic of Korea

Vaccines ◽  
2020 ◽  
Vol 9 (1) ◽  
pp. 2
Author(s):  
Jeong Hee Yu ◽  
Hang jin Jeong ◽  
Seon Ju Kim ◽  
Jae Young Lee ◽  
Young June Choe ◽  
...  
Keyword(s):  
Vaccination Coverage ◽  
Vaccination Rate ◽  
Republic Of Korea ◽  
Korean Children ◽  
Vaccine Preventable Diseases ◽  
The Republic ◽  
The Impact

Amid the COVID-19 pandemic, vaccination coverage may decline due to limited accessibility to healthcare. We assessed the impact of the COVID-19 pandemic on vaccination coverage and the incidence of vaccine-preventable diseases (VPDs) in the Republic of Korea. National vaccination coverage of 10 essential vaccines administered to children between January–June 2019 and January–June 2020 was analyzed. The national incidence of selected VPDs was compared for the corresponding periods. During the COVID-19 outbreak, the vaccination rate in children aged 0–35 months in Korea did not decrease significantly, whereas the vaccination rate for children aged 4–6 years decreased by 1.4–1.9%. The overall incidence of VPDs decreased by 10–50% between 2019 and 2020, especially with varicella. Thus, the COVID-19 pandemic did not result in a decrease in vaccination coverage among Korean children, which prevented a surge in VPD incidence. Maintaining essential vaccination coverage without interruption is important during the response to the COVID-19 pandemic.

scholarly journals VACCINATION COVERAGE RATES AND THE INCIDENCE OF VACCINE PREVENTABLE DISEASES AMONG CHILDREN IN SUMY REGION OF UKRAINE

2019 ◽  
Vol 72 (2) ◽  
pp. 255-260
Author(s):  
Vladyslav A. Smiianov ◽  
Halyna S. Zaitseva ◽  
Victorya A. Kurganskaya ◽  
Anatoly G. Dyachenko ◽  
Volodymyr P. Zbarazhskyi ◽  
...  
Keyword(s):  
World Health Organization ◽  
Vaccination Coverage ◽  
Statistical Data ◽  
Routine Immunization ◽  
World Health ◽  
Vaccine Preventable Diseases ◽  
Medical Institutions ◽  
Measles Outbreak ◽  
Health Organization ◽  
Coverage Rates

Introduction: Routine immunization contributes immensely to decline the incidence of vaccine preventable diseases among children. Statistical data shown the sharply decrease the vaccination coverage rates in Sumy region of Ukraine. The aim: Assess routine immunization uptake and its effect on the incidence of vaccine preventable diseases among children in Sumy region of Ukraine. Review: During some years, only 50-60 % of Sumy region children had received all recommended vaccines, which is far below World Health Organization target of 80 %. This has led to an increase of morbidity associated with some infectious diseases. Outbreaks of measles were registered in 2006 and 2012, when were ill 9346 and 7931 children respectively. Massive measles outbreak ongoing nowadays. Total number infected have already exceeded 35,000 cases. Conclusions: RI uptake in Ukraine is still below World Health Organization target. The main reason for the ongoing measles outbreak was low vaccination coverage for routine immunization antigens as a result of which collective immunity decreased to a critical level. Strict monitoring of the implementation of the immunization schedule by medical institutions at all levels are recommended to improve vaccination status of Ukrainian children.

scholarly journals Vaccination Coverage for Infants: Cross-Sectional Studies in Two Regions of Belgium

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Emmanuelle Robert ◽  
Michèle Dramaix ◽  
Béatrice Swennen
Keyword(s):  
Vaccination Coverage ◽  
Herd Immunity ◽  
Vaccine Uptake ◽  
Mmr Vaccine ◽  
Cross Sectional ◽  
Infant Vaccination ◽  
French Speaking ◽  
Fourth Dose ◽  
Cross Sectional Studies ◽  
Coverage Rates

Methods and Objectives.To estimate infant vaccination coverage in the French-speaking region of Belgium (Wallonia) and in the Brussels-Capital Region, two cross-sectional studies were performed in 2012. A face-to-face questionnaire was administered by trained investigators. The objective was to evaluate infant vaccination coverage retrospectively in 18- to 24-month-old children. These studies offered the opportunity to assess some factors influencing vaccine uptake in infants.Results and Discussion.Approximately 99% of the children had received the first dose of IPV-DTaP, 90% the fourth dose, 94% the MMR vaccine, 97% the first dose of pneumococcal vaccine, and 90% the third dose. In both regions, when fitting a logistic model, the most associated factor was attendance at maternal and child clinics (MCH). No association was observed between vaccination coverage and the mother’s level of education. For the last immunization session, where the mother was a Belgian native and when she worked more hours, child was better immunized, but only in Brussels.Conclusion.Coverage for the fourth dose of hexavalent vaccine (DTaP-IPV-HBV/Hib) needs to be increased. Indeed, additional effort is needed to increase HIB and pertussis coverage rates because the herd immunity threshold for these two diseases has not been reached.

scholarly journals Vaccination and Vaccine Effectiveness: A Commentary of Special Issue Editors

Vaccines ◽  
2020 ◽  
Vol 8 (3) ◽  
pp. 545
Author(s):  
Claudio Costantino ◽  
Alessandra Casuccio ◽  
Vincenzo Restivo
Keyword(s):  
Vaccination Coverage ◽  
Healthcare Workers ◽  
Vaccine Effectiveness ◽  
Vaccine Hesitancy ◽  
Special Issue ◽  
Vaccine Preventable Diseases ◽  
At Risk Populations ◽  
Personal Risk Factors ◽  
Coverage Rates

The Special Issue “Vaccination and Vaccine Effectiveness”, published in the journal Vaccines, has the main aim to increase international literature data on vaccine effectiveness and safety and on vaccination strategies in order to reduce vaccine hesitancy and improve vaccination coverage rates. The main topics included in the call for papers were vaccines administered to infants, adolescents, adults, elderly people, at-risk populations (due to comorbidities and personal risk factors) and healthcare workers and strategies adopted to promote vaccination adherence among these categories. This Special Issue started from the assumption that, despite vaccination being universally recognized as one of the best strategies to increase duration and quality of life during the last centuries, vaccination coverage rates are often under the levels recommended to reduce circulation and to extinguish vaccine-preventable diseases. Vaccine hesitancy involves at least 15% of the general population, and healthcare workers also sometimes demonstrate doubts on vaccination effectiveness and safety. At the end of the six-month submission period, 16 articles (15 research article and one review) were accepted after the peer-review processes and published online.

scholarly journals 2742. The Impact of Influenza Vaccination on Antibiotic Use in the United States, 2010–2017

2019 ◽  
Vol 6 (Supplement_2) ◽  
pp. S965-S966
Author(s):  
Eili Klein ◽  
Emily Schueller ◽  
Katie K Tseng ◽  
Arindam Nandi
Keyword(s):  
United States ◽  
Antibiotic Resistance ◽  
Influenza Vaccination ◽  
Vaccination Coverage ◽  
Seasonal Influenza ◽  
Antibiotic Use ◽  
The United States ◽  
Antibiotic Prescribing ◽  
Coverage Rates ◽  
The Impact

Abstract Background Antibiotic resistance is a cause of morbidity and mortality driven by inappropriate prescribing. In the United States, a third of all outpatient antibiotic prescriptions may be inappropriate. Seasonal influenza rates are significantly associated with antibiotic prescribing rates. The impact of influenza vaccination coverage on antibiotic prescribing is unknown. Methods We conducted a retrospective analysis of state-level vaccination coverage and antibiotic prescribing rates from 2010 to 2017. We used fixed effects regression to analyze the relationship between cumulative vaccine coverage rates for a season and the per capita number of prescriptions for systemic antibiotics for the corresponding season (January–March) controlling for temperature, poverty, healthcare infrastructure, population structure, and vaccine effectiveness. Results Rates of vaccination coverage ranged from 33% in Nevada to 52% in Rhode Island for the 2016–2017 season, while antibiotic use rates ranged from 25 prescriptions per 1,000 inhabitants in Alaska to 377 prescriptions per 1,000 inhabitants in West Virginia (Figure 1). Vaccination coverage rates were highly correlated with reduced prescribing rates, and controlling for other factors, we found that a one percent increase in the influenza vaccination rate was associated with 1.40 (95% CI: 2.22–0.57, P < 0.01) fewer antibiotic prescriptions per 1,000 inhabitants (Table 1). Increases in the vaccination coverage rate in the pediatric population (aged 0–18) had the strongest effect, followed by the elderly (aged 65+). Conclusion Vaccination can reduce morbidity and mortality from seasonal influenza. Though coverage rates are far below levels necessary to generate herd immunity, we found that higher coverage rates in a state were associated with lower antibiotic prescribing rates. While the effectiveness of the vaccine varies from year to year and the factors that drive antibiotic prescribing rates are multi-factorial, these results suggest that increased vaccination coverage for influenza would have significant benefit in terms of reducing antibiotic overuse and correspondingly antibiotic resistance. Disclosures All authors: No reported disclosures.

scholarly journals Serosurveillance for vaccine-preventable diseases: A look inside the pertussis experience

Biomédica ◽  
2019 ◽  
Vol 39 (Supl. 2) ◽  
pp. 130-143
Author(s):  
Doracelly Hincapié ◽  
Marcela Acevedo ◽  
María Cristina Hoyos ◽  
Jesús Ochoa ◽  
Catalina González ◽  
...  
Keyword(s):  
Umbilical Cord ◽  
Herd Immunity ◽  
Population Based ◽  
Care Process ◽  
High Coverage ◽  
Vaccine Preventable Diseases ◽  
Serological Surveillance ◽  
The Impact ◽  
Selection Of

Introduction: Serological surveillance (serosurveillance) provides the most direct measure of herd immunity of vaccine-preventable diseases. Little is known about the opportunities and challenges of serosurveillance experiences, particularly pertussis.Objective: To describe the process of serosurveillance for vaccine-preventable diseases with an emphasis on the experience of pertussis in the metropolitan area of Antioquia (Valle de Aburrá) in 2015 and 2016 and analyze the contributions and challenges for its sustainability.Materials and methods: We described the planning and conduction of serosurveillance of pertussis antibodies of mothers and in the umbilical cord at the time of delivery in eight hospitals based on random sampling and their capacity to advance the serosurveillance periodically. We compared the contributions and the challenges of this experience with other probabilistic and non-probabilistic programs.Results: We achieved the participation of hospitals and mothers respecting the delivery care process. We established a serum bank following ethical and technical guidelines. This program based on the random selection of hospitals and mothers has enabled the estimation of antibodies prevalence in mothers and in the umbilical cord, which has been possible given the high coverage of hospital care during childbirth at a lower cost and fewer risks than a population-based survey in conflictive areas. The main challenges for the sustainability of this program are the creation of stable jobs and access to funding and legal and methodological long-term frameworks.Conclusions: Hospital serosurveillance as described is an option to monitor the impact of vaccination on the population. Our experience could be reproduced in other regions under similar conditions if the above-mentioned challenges are solved.

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