scholarly journals Surgical Treatment and Muscle Protein Analysis of V-pattern Exotropia in Craniosynostosis

2021 ◽  
Author(s):  
Qingyu Liu ◽  
Yuan Li ◽  
Siying Wang ◽  
Wenjing Zheng ◽  
Han Ye ◽  
...  
Keyword(s):  
Surgical Treatment ◽  
Extraocular Muscle ◽  
Muscle Protein ◽  
Protein Analysis ◽  
Strabismus Surgery ◽  
Extraocular Muscles ◽  
Prism Diopter ◽  
Control Group ◽  
Normal Children ◽  
Anterior Transposition

Abstract Purpose: The purpose of this study was to compare the differences of V-pattern exotropia in craniosynostosis and normal children.Methods: 39 children were included in this study, 19 craniosynostosis and 20 children in control group. They underwent comprehensive ocular examinations and received strabismus surgery. The extraocular muscle samples were analysed.Results: Compared with the control group, craniosynostosis group had larger deviation in primary and up gaze, larger V pattern, and more severe inferior oblique overaction. For 20-40, and 50-60 prism diopter exotropia, the lateral recession in the craniosynostosis group was larger than that in the control group, 7.13±0.44 mm vs 6.71±0.47 mm, 8.90±0.21 mm vs 7.75±0.46 mm (p=0.025, 0.000). The anterior transposition of craniosynostosis group was more anterior than that of control group, posterior 1.03±1.24 vs 2.68±0.94 mm (p=0.000). Compared with the control group, the extraocular muscle abnormality in craniosynostosis was significant, 32% vs 5% (p=0.031). There were 40 proteins in craniosynostosis group, which were different from those in control group.Conclusions: A larger V pattern and larger deviation is common in craniosynostosis children. For the same PD of deviation, it usually needs more recession in craniosynostosis because of the thinner and weaker extraocular muscles.

Limbal conjunctival approaches to extraocular muscles in the surgical treatment of previously operated strabismus

2021 ◽  
pp. 27-32
Author(s):  
V.N. Kurochkin ◽  
◽  
Y.I. Trilyudina ◽  
Keyword(s):  
Surgical Treatment ◽  
Strabismus Surgery ◽  
Main Group ◽  
Cosmetic Result ◽  
Control Group ◽  
Good Cosmetic Result ◽  
Tenon’S Capsule ◽  
Good Cosmetic ◽  
Tenon's Capsule

Purpose. Тo analyze clinical efficacy of the surgical treatment of previously operated strabismus using limbal incisions which are lengthening the conjunctiva and Tenon's capsule. Material and methods. The study included 440 patients (440 eyes) with previously operated strabismus at the age of 4 to 68 years old. The main group included 240 patients (240 eyes) who underwent strabismus surgery by limbal approach; the control group included 200 patients (200 eyes) who underwent surgery by paralimbal conjunctival approach. Horizontal strabismus occurred in 146 patients (60,8%) in the main group and in 158 (79%) in the control group. Horizontal strabismus in combination with vertical strabismus was found in 94 patients (39.2%) in the main group and in 42 patients (21%) in the control group respectively. The following approaches were applied: Y-shaped limbal approach, T-shaped incision of the conjunctiva, lower limbal peritomy, circular limbal approach with an additional horizontal incision towards the muscle being strengthened. Results. Good cosmetic result in the main group was achieved in 94.7% of cases, in the control group in 87% of cases, р<0.001. Re-surgery in the long term period was required for 39 patients (19.5%) in the control group and 14 patients (7%) in the main group, р<0.001. Conclusion. Limbal approaches performed to lengthening the conjunctiva and Tenon's capsule on the side of the weakened muscle and shortening on the side of the muscle being strengthened, are enhancing the effect of recession and resection, thereby contributing to the achievement of the state of orthotropy in 83% and have a good cosmetic result in 94.67% of cases. Key words: limbal conjunctival approaches, limbal conjunctival incisions, strabismus, children.

Botulinum A Toxin Injection into Extraocular Muscles as an Alternative to Strabismus Surgery

2020 ◽  
pp. 269-274
Author(s):  
Alan D. Penman ◽  
Kimberly W. Crowder ◽  
William M. Watkins
Keyword(s):  
Extraocular Muscle ◽  
Case Series ◽  
Strabismus Surgery ◽  
Extraocular Muscles ◽  
Effective Alternative ◽  
Botulinum A Toxin ◽  
First Case ◽  
Fda Approval ◽  
The Subject

In this chapter a case series is described of the use of botulinum A toxin for the treatment of strabismus in 19 patients with multiple types of strabismus with different etiologies. The maximum follow-up following botulinum injection was six months. Injection of botulinum A toxin into extraocular muscle to weaken the muscle was found to be a safe and effective alternative (or adjunct) to surgery for strabismus correction. The maximum time of paralysis occurred four to five days following the injection, and then gradually diminished, depending on the dose. The maximum correction of strabismus was 40 prism diopters. This was the first case series describing the use of botulinum A toxin for strabismus correction, and it led the way to further studies on the subject, which eventually led to FDA approval in 1990.

RESULTS OF POLARIZED LIGHT USE FOR STUDY OF STRESS-STRAIN STATE OF CORNEA IN PATHOLOGY OF EXTRAOCULAR MUSCLES

2020 ◽  
pp. 65-69
Author(s):  
Nataliia Mykhailivna Kovtun ◽  
Ihor Volodymyrovych Kaplin
Keyword(s):  
Interference Pattern ◽  
Optical Anisotropy ◽  
Extraocular Muscle ◽  
Strain State ◽  
Polarized Light ◽  
Attachment Site ◽  
Rectus Muscle ◽  
Extraocular Muscles ◽  
Asymmetric Distortion ◽  
Interference Picture

The parameters of interference patterns observed on the cornea in a polarized light in pathology of extraocular muscles were quantitatively evaluated. A study of the shape of 147 interference patterns observed on the cornea in a polarized light showed that the horizontal deviation of an eye in 56 % of cases was caused by the displacement of the attachment of the upper rectus muscle towards the inner rectus muscle. During illumination of the cornea of a live eye with polarized light, a specific interference pattern in the form of a rhombus formed by rainbow stripes (isochromes) is observed. It is established that such an interference pattern is the result of the influence of extraocular muscles on the cornea. The findings showed that the weakening of the force of one of muscles leads to asymmetric distortion of the shape of the interference rhombus, which is manifested with a reduced length of the corresponding section of the diagonal. On the contrary, as the force of the muscle increases, the corresponding section of the diagonal enhances. The displacement of the attachment site of direct extraocular muscle along the line of action is equivalent to a change in effort on its part, indicated appropriately by the shape of the interference rhombus. As the muscle moves away from the line of action, the angle of the interference rhombus is shifted away from the corresponding meridian. Key words: polarized light, optical anisotropy, cornea, extra−ocular muscles, interference picture.

scholarly journals Surgical Treatment of Vulvar HSIL: Adjuvant HPV Vaccine Reduces Recurrent Disease

Vaccines ◽  
2021 ◽  
Vol 9 (2) ◽  
pp. 83
Author(s):  
Alessandro Ghelardi ◽  
Roberto Marrai ◽  
Giorgio Bogani ◽  
Francesco Sopracordevole ◽  
Paola Bay ◽  
...  
Keyword(s):  
Surgical Treatment ◽  
Hpv Vaccine ◽  
Recurrent Disease ◽  
Current Knowledge ◽  
Hpv Vaccination ◽  
Clinical Effectiveness ◽  
Hpv Infection ◽  
Control Group ◽  
Hpv Test ◽  
Significant Difference

Data suggest that adjuvant human papillomavirus (HPV)-vaccination in women treated for cervical HPV diseases reduces recurrent disease. This study investigates adjuvant HPV-vaccination and the rate of recurrence in women undergoing surgery for vulvar high-grade squamous intraepithelial lesions (HSIL). From January 2013 to April 2020, we enrolled 149 women in a prospective case-control study. The control group (NV-group) was treated by standard surgery alone, while the study group received adjuvant vaccination soon after surgery (V-group). A follow-up was performed by vulvoscopy and HPV test. Statistical analysis was performed by Fisher’s exact test. HSIL recurrence was observed in 24/76 (32%) patients in NV-group and in 8/42 patients (19%) of the vaccinated group. By analysing the recurrence rate related to the incident and reactivated latent HPV infection, we found a significant difference between (17/76) 22.3% in NV-group and (2/42) 4.8% in V-group (p = 0.01). A reduction of 78.5% in incident/reactivated HPV infections was demonstrated. Data results add to the current knowledge about the mechanism of post-surgical adjuvant HPV vaccination. Our prospective study is the first to document the vaccine clinical effectiveness in preventing “reactivation” of latent HPV infections. Quadrivalent HPV vaccine administered after the surgical treatment for vulvar HSIL appears to be useful in preventing recurrent disease.

scholarly journals Unplanned hospital readmission after surgical treatment for thoracic spinal stenosis: incidence and causative factors

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Hui Wang ◽  
Longjie Wang ◽  
Zhuoran Sun ◽  
Shuai Jiang ◽  
Weishi Li
Keyword(s):  
Surgical Treatment ◽  
Spinal Stenosis ◽  
Hospital Readmission ◽  
Spinal Epidural Hematoma ◽  
Control Group ◽  
Unplanned Readmission ◽  
Thoracic Spinal Stenosis ◽  
Thoracic Spinal ◽  
Causative Factors ◽  
Csf Leakage

Abstract Background To assess the incidence and causative factors of unplanned hospital readmission within 90 days after surgical treatment of thoracic spinal stenosis (TSS). Methods Hospital administrative database was queried to identify patients who underwent surgical treatment of TSS from July 2010 through December 2017. All unplanned readmissions within 90 days of discharge were reviewed for causes and the rate of unplanned readmissions was calculated. Patients of unplanned readmission were matched 1:3 to a control cohort without readmission. Results Twenty-one patients (incidence of 1.7 % in 1239 patients) presented unplanned hospital readmission within a 90-day period and enrolled as the study group, 63 non-readmission patients (a proportion of 1: 3) were randomly selected as the control group. Causes of readmission include pseudomeningocele (8 patients; 38 %), CSF leakage combined with poor incision healing (6 patients; 29 %), wound dehiscence (2 patient; 9 %), surgical site infection (2 patients; 9 %), spinal epidural hematoma (1 patient; 5 %), inadequate original surgical decompression (2 patients; 9 %). Mean duration from re-admission to the first surgery was 39.6 ± 28.2 days, most of the patients readmitted at the first 40 days (66.7 %, 14/21 patients). When compared to the non-readmitted patients, diagnosis of OPLL + OFL, circumferential decompression, dural injury, long hospital stay were more to be seen in readmitted patients. Conclusions The incidence of 90-day unplanned readmission after surgical treatment for TSS is 1.7 %, CSF leakage and pseudomeningocele were the most common causes of readmission, the peak period of readmission occurred from 10 to 40 days after surgery, patients should be closely followed up within this period.

EEG and Behavioral Changes following Neurofeedback Treatment in Learning Disabled Children

2003 ◽  
Vol 34 (3) ◽  
pp. 145-152 ◽  
Author(s):  
T. Fernández ◽  
W. Herrera ◽  
T. Harmony ◽  
L Díaz-Comas ◽  
E. Santiago ◽  
...  
Keyword(s):  
Threshold Value ◽  
Learning Disabled ◽  
The Other ◽  
Control Group ◽  
Relative Power ◽  
Normal Children ◽  
Absolute Power ◽  
And Gender ◽  
Socioeconomical Status ◽  
Experimental Group

Neurofeedback (NFB) is an operant conditioning procedure, by which the subject learns to control his/her EEG activity. On one hand, Learning Disabled (LD) children have higher values of theta EEG absolute and relative power than normal children, and on the other hand, it has been shown that minimum alpha absolute power is necessary for adequate performance. Ten LD children were selected with higher than normal ratios of theta to alpha absolute power (theta/alpha). The Test Of Variables of Attention (TOVA) was applied. Children were divided into two groups in order to maintain similar IQ values, TOVA values, socioeconomical status, and gender for each group. In the experimental group, NFB was applied in the region with highest ratio, triggering a sound each time the ratio fell below a threshold value. Noncontingent reinforcement was given to the other group. Twenty half-hour sessions were applied, at a rate of 2 per week. At the end of the 20 sessions, TOVA, WISC and EEG were obtained. There was significant improvement in WISC performance in the experimental group that was not observed in the control group. EEG absolute power decreased in delta, theta, alpha and beta bands in the experimental group. Control children only showed a decrease in relative power in the delta band. All changes observed in the experimental group and not observed in the control group indicate better cognitive performance and the presence of greater EEG maturation in the experimental group, which suggests that changes were due not only to development but also to NFB treatment.

scholarly journals PSVII-2 Differentially expressed genes and their biological function in skeletal muscle of calves born from cows with or without protein supplementation during mid-gestation

2020 ◽  
Vol 98 (Supplement_3) ◽  
pp. 165-166
Author(s):  
Elisa B Carvalho ◽  
Letícia P Sanglard ◽  
Karolina B Nascimento ◽  
Javier M Meneses ◽  
Daniel R Casagrande ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Differentially Expressed Genes ◽  
Muscle Development ◽  
Negative Binomial ◽  
Muscle Protein ◽  
Basal Diet ◽  
Protein Supplementation ◽  
Differentially Expressed ◽  
Control Group ◽  
Q Value

Abstract Gestating cows have an increased nutrient demand to meet the needs of developing the fetus and the mid-gestation is a critical period for the fetal skeletal muscle development. The aim of this study was to evaluate the skeletal muscle transcriptome in the progeny as a function of the maternal protein nutrition during mid-gestation. Eleven Tabapuã cows and their male calves were used in this study. In the first third of gestation (0 to 100 days of gestation; dg), all cows were kept on pasture. From 100 to 200 dg, the control group (CTRL; 7 animals) received a basal diet achieving 5.5% crude protein (CP), whereas the supplemented group (SUPPL; 4 animals) received a basal diet plus protein supplementation (40% CP). After 200 dg, all animals received the same diet. Weaning was performed at 205 ± 7.5 days of age and animals were kept on pasture until reaching 240 days of age, when they were transferred to a feedlot. Muscle samples were collected at 260 days of age and RNA was extracted for RNA-seq analysis. Gene expression data was analyzed with a negative binomial model to identify (q-value ≤ 0.05) differentially expressed genes (DEG) between treatments. A total of 716 DEG were identified (289 DEG up-regulated and 427 down-regulated in SUPPL group; q-value ≤ 0.05). From the 10 most significant down-regulated DEG in the SUPPL group, two genes associated with apoptotic process were identified: MAPK8IP1 and GRINA, with log2 Fold-Changes (log2FC) of 1.04 and 0.49, respectively. From the 10 most significant up-regulated DEG in the SUPPL group, mTOR was identified, with log2FC=0.31. This is a well-known gene involved in muscle protein synthesis. In conclusion, maternal protein supplementation during mid-gestation affects the expression of genes related to energy metabolism and muscle development, which can lead to long-term impacts on production efficiency.

scholarly journals Parenting Stress and Need Assessment of Families with Disabled Children across Himachal Himalaya

2015 ◽  
Vol 3 (2) ◽  
pp. 38 ◽  
Author(s):  
Randhir S. Ranta ◽  
Vijay Kumar Sharma ◽  
Pankaj Gupta
Keyword(s):  
Parenting Stress ◽  
Assessment Scale ◽  
Control Group ◽  
Disabled Children ◽  
Normal Children ◽  
Need Assessment ◽  
Significant Difference ◽  
Group A ◽  
And Control ◽  
Experimental Group

The study pertains to the parenting stress, which is believed to be the resultant of child disability and further assesses the needs of the families across selected pockets of Himachal Himalaya. Perceived Stress Questionnaire (PSQ) and Need Assessment Scale were used for the purpose. For assessing the stress level among the parents, PQS was administered among two hundred parents having disabled children, herein called experimental group and two hundred parents with normal children, herein called control group. A three point Need assessment scale was used to measure the needs of 200 families on five different parameters. The result of t-test shows the significant difference between experimental and control groups indicating that the parents of disabled children experience more stress than their control counterpart. The study indicates that people need proper guidance and information regarding a child’s disability, nutritional requirements of a child, vocational training and child management. There is a need for proper counselling for parents suffering from stress and creating consciousness among parents of children with disabilities and in the society.

Reduced volume and increased training intensity elevate muscle Na+-K+pump α2-subunit expression as well as short- and long-term work capacity in humans

2009 ◽  
Vol 107 (6) ◽  
pp. 1771-1780 ◽  
Author(s):  
Jens Bangsbo ◽  
Thomas P. Gunnarsson ◽  
Jesper Wendell ◽  
Lars Nybo ◽  
Martin Thomassen
Keyword(s):  
Endurance Training ◽  
Muscle Protein ◽  
Work Capacity ◽  
Control Group ◽  
Muscle Adaptations ◽  
Subunit Expression ◽  
Short And Long Term ◽  
And Performance ◽  
Trained Runners

The present study examined muscle adaptations and alterations in work capacity in endurance-trained runners as a result of a reduced amount of training combined with speed endurance training. For a 6- to 9-wk period, 17 runners were assigned to either a speed endurance group with a 25% reduction in the amount of training but including speed endurance training consisting of six to twelve 30-s sprint runs 3–4 times/wk (SET group n = 12) or a control group ( n = 5), which continued the endurance training (∼55 km/wk). For the SET group, the expression of the muscle Na+-K+pump α2-subunit was 68% higher ( P < 0.05) and the plasma K+level was reduced ( P < 0.05) during repeated intense running after 9 wk. Performance in a 30-s sprint test and the first of the supramaximal exhaustive runs was improved ( P < 0.05) by 7% and 36%, respectively, after the speed endurance training period. In the SET group, maximal O2uptake was unaltered, but the 3-km (3,000-m) time was reduced ( P < 0.05) from 10.4 ± 0.1 to 10.1 ± 0.1 min and the 10-km (10,000-m) time was improved from 37.3 ± 0.4 to 36.3 ± 0.4 min (means ± SE). Muscle protein expression and performance remained unaltered in the control group. The present data suggest that both short- and long-term exercise performances can be improved with a reduction in training volume if speed endurance training is performed and that the Na+-K+pump plays a role in the control of K+homeostasis and in the development of fatigue during repeated high-intensity exercise.

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