scholarly journals The Clinicopathological Features and Unusual Immunophenotype of Primary Tracheobronchial Granular Cell Tumors

2021 ◽  
Author(s):  
Ying Wan ◽  
Ying Zhang ◽  
Zhongguo Pang ◽  
Changli Lu ◽  
Lili Jiang
Keyword(s):  
Transcription Factor ◽  
S100 Protein ◽  
Tumor Resection ◽  
Granular Cell ◽  
Good Prognosis ◽  
Tracheobronchial Tree ◽  
Endoscopic Biopsy ◽  
Clinicopathological Features ◽  
Ki 67 ◽  
Exact Test

Abstract BackgroundPrimary tracheobronchial granular cell tumors (GCTs) are rare. The characteristics of these tumors are unclear, and they are easily misdiagnosed. Thus, the present study aimed to investigate the clinicopathological features and immunophenotype profile of these tumors of the tracheobronchial tree.MethodsFour patients were treated for GCTs of the tracheobronchial tree at our institution during 2009–2020. The clinicopathologic and immunohistochemical (IHC) findings were performed in all cases. In addition, seven typical GCTs involving the subcutaneous tissues (4/7) and esophagus (3/7) were also selected as control groups to evaluate the differences in IHC characteristics in different locations. Fisher’s exact test was adopted in analysis of categorical data.ResultsThere were four patients, two females and two males, aged 15, 22, 45 and 52. Three tracheobronchial tumors were solitary with a range from 2.0 to 3.1 cm (mean, 2.6 cm) in its large axis, while one sample was multiple. Chest computed tomography (CT) often suggested lung infectious lesions. On histopathology, three samples were typical GCTs, and the other sample was atypical with a fusiform or spindled morphology. All tumor cells stained positive for S100 protein, CD68, and Nestin and negative for Inhibin-α and thyroid transcription factor-1（TTF-1）. The Ki-67 index was less than 5%. Tracheobronchial GCTs exhibited occasional focal and weakly positive transcription factor E3 (TFE3) staining and had a lower ratio than those in other sites, while calretinin showed predominant subcutaneous expression. Two patients treated with tumor resection and the others only performed an endoscopic biopsy. Follow-up period ranged from 24 to 68 months with a mean of 42 months.ConclusionsPrimary tracheobronchial GCTs are rare and are often mimics pneumonia, which have a good prognosis even without surgical resections. Tracheobronchial GCTs had an unusual immunophenotype of TFE3 expression compared with other sites. This result may reflect a site-specific phenomenon distinguishing GCTs of the tracheobronchial tree.

Transition from meningeal melanocytoma to primary cerebral melanoma

2004 ◽  
Vol 101 (3) ◽  
pp. 528-531 ◽  
Author(s):  
Florian Roser ◽  
Makoto Nakamura ◽  
Almuth Brandis ◽  
Volkmar Hans ◽  
Peter Vorkapic ◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
Mitotic Activity ◽  
S100 Protein ◽  
Tumor Resection ◽  
Clinical Signs ◽  
Biological Behavior ◽  
Subtotal Resection ◽  
Ki 67 ◽  
Content Type ◽  
First Case

✓ The authors describe the first case of an intracranial transition of a melanocytoma into a primary malignant melanoma within a short time. A 37-year-old woman presented with progressive brainstem syndrome due to a tumor, originally diagnosed and treated 12 years earlier, that extended from the petroclival area to the anterior craniocervical junction. The histological workup following subtotal tumor resection of the initial tumor had revealed the typical features of a fibrous melanocytic meningioma without increased proliferation. Ten years after the patient had completed treatment for the melanocytic meningioma, control neuroimaging demonstrated growth of the residual tumor with compression of the brainstem. Another neurosurgical intervention revealed a dark tumor of hard consistency. At this time immunohistochemical examinations demonstrated melanocytic features (expression of vimentin, S100 protein, and melan A) of the lesion with focally increased proliferation (5% of Ki-67—positive cells) but no higher mitotic activity. Clinical signs of deterioration along with imaging-confirmed tumor progression precipitated another operation within 7 months. A neuropathological examination revealed epithelial and anaplastic changes and indicated that the MIB-1 indices were greater than 25%. Pleomorphic changes and a focal high mitotic activity led to the diagnosis of a primary cerebral malignant melanoma. The patient's later clinical course consisted of a rapid diffuse meningeal spread of the lesion throughout the entire brain and spine. Despite whole-brain and stereotactic radiation therapy as well as chemotherapy, the patient died 4 months after the last neuropathological diagnosis. Although grossly resembling a meningioma, melanocytomas lack the former's histological and immunohistochemical features. The biological behavior of a melanocytoma is variable and recurrence may happen after subtotal resection, but intracranial transition into a malignant melanoma has not been observed previously.

scholarly journals Mandibular odontogenic sarcoma (ameloblastic fibrodentinosarcoma) in an aged cat — Short communication

2017 ◽  
Vol 65 (1) ◽  
pp. 89-95
Author(s):  
Gustavo A. Ramírez ◽  
Lorenzo Ressel ◽  
Jaume Altimira ◽  
Miquel Vilafranca
Keyword(s):  
Alveolar Bone ◽  
S100 Protein ◽  
Final Diagnosis ◽  
Proliferation Index ◽  
Cell Component ◽  
Ki 67 ◽  
Histologic Subtype ◽  
Odontogenic Tumours ◽  
Odontogenic Epithelium ◽  
Shaped Cell

A 13-year-old male cat presented with an ill-defined mass in the rostral mandible causing destruction and loss of alveolar bone. Microscopically, the mass consisted of cords or islands of benign odontogenic epithelium and a malignant, pleomorphic spindle-shaped cell component with dysplastic dentine formation. Immunohistochemically, neoplastic mesenchymal cells proved to be strongly positive for vimentin and negative for cytokeratins, desmin, actin and S100 protein; the Ki67 proliferation index was high. Morphological and immunohistochemical features largely overlap those reported for ameloblastic fibrodentinosarcoma, an uncommon histologic subtype of odontogenic sarcoma recognised in humans but no reported previously in animals. Ki-67 expression assessment may help to discriminate between malignant and benign forms of odontogenic tumours but the final diagnosis is mainly morphological.

scholarly journals High expression of E-cadherin and Ki-67 associated with functional/dysfunctional phenotypes of tumor-infiltrating lymphocytes among Chinese patients with operable breast cancer

2018 ◽  
Vol 46 (12) ◽  
pp. 5219-5227 ◽  
Author(s):  
Ruibin Wang ◽  
Feng Shi ◽  
Lin Zhao ◽  
Yanjie Zhao ◽  
Guangjiang Wu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Tumor Infiltrating Lymphocytes ◽  
Cross Sectional Study ◽  
Clinicopathological Features ◽  
Chinese Patients ◽  
Ki 67 ◽  
Cross Sectional ◽  
Cell Counts ◽  
Infiltrating Lymphocytes ◽  
E Cadherin

Objective Breast cancer has become the most common cancer in women in China, and the clinicopathological features differ from those in Western patients. This study was performed to investigate the distribution of programmed cell death protein 1 (PD-1)+/PD-1− tumor-infiltrating lymphocytes (TILs) and its association with clinicopathological features among Chinese patients with breast cancer. Methods In total, 133 consecutive patients with primary breast cancer were recruited into this cross-sectional study from 2012 to 2013. TILs were measured by cell counts under high-power fields (HPFs). Immunohistochemistry was used to detect PD-1 expression on tumor-infiltrating lymphocytes in the microenvironment. Results The median cell counts of the overall TILs, PD-1+ TILs, and PD-1− TILs were 80, 18, and 55/HPF, respectively. The number of PD-1− TILs was significantly lower in older than younger patients (50 vs. 60/HPF). Patients with positive E-cadherin expression had more PD-1− TILs than patients with negative E-cadherin expression (57 vs. 27/HPF). The Ki-67 index was positively correlated with the cell counts of PD-1+ TILs, and the correlation coefficient was 0.29. Conclusions PD-1 expression on TILs had different clinicopathological features in Chinese patients with breast cancer. E-Cadherin expression was associated with PD-1− TILs; however, Ki-67 expression was associated with PD-1+ TILs.

scholarly journals Giant Cells Tumors of Synovial Sheaths of the Hand are Benign Tumors with a Good Prognosis

2017 ◽  
Vol 1 (3) ◽  
pp. 01-03
Author(s):  
Cesar Edgar ◽  
Trey Rafael ◽  
Robert Mason ◽  
Diego Luis
Keyword(s):  
Retrospective Study ◽  
Tumor Resection ◽  
Tumor Development ◽  
Epidemiological Data ◽  
Recurrence Risk ◽  
Giant Cells ◽  
Good Prognosis ◽  
Benign Tumors ◽  
Macroscopic Appearance ◽  
Quick Dash

Introduction: The giant cells tumors (GCT) of the hand are common benign tumors that pose a recurrence problem. The aim of our study is to analyze epidemiological and clinical data, evaluate results and determine the recurrence risk factors. Materials and Methods: This is a retrospective study of 50 patients operated between 2003 and 2015 for a (GCT) of the hand, we observed epidemiological data, clinical outcome (quotation TAM score Kapandji and quick DASH), the appearance of recurrence, the histological appearance, localization, excision margins and invasion of adjacent anatomical structures were analyzed. Results: We report a retrospective study over thirteen years of 50 cases of GCT of the hand, with a mean age of 42 years and a sex ratio of 1/3. The motive for consulting was the presence of a digital mass, followed by discomfort bending in 20%. Palmar localization was found in 54%, especially at the second ray (30%) and facing the distal phalanx (38%). The radiograph showed soft tissue opacity in 60% of cases. All patients underwent surgery, the macroscopic appearance showed an encapsulated, lobed and yellow chamois tumor in 80% of cases. The mean follow up was 30 months with extremes of 2 months to 10 years. We noted 5 recurrences one of which recurred twice; the average time to recurrence was 22 months and ranged from 6 months to 36 years. In each subsequent offense we noted an intra-articular tumor development in 4 cases and tendon erosion in one case. Functional complications type of stiffness in flexion in 2 cases and hypoesthesia of a finger in 2 cases. The quick way DASH was 2.2 on 100. Conclusion: The GCT of synovial sheaths of the hand are a benign tumors with a good prognosis, the main problem is the risk of recurrence that depends on the type of tumor, intra articular tumor development and quality of tumor resection.

Brain Tectal Tumors: A Flexible Approach

2018 ◽  
Vol 16 (3) ◽  
pp. E95-E100
Author(s):  
Alessandro Perin ◽  
Tommaso Francesco Galbiati ◽  
Cecilia Casali ◽  
Federico Giuseppe Legnani ◽  
Luca Mattei ◽  
...  
Keyword(s):  
Endoscopic Third Ventriculostomy ◽  
Good Prognosis ◽  
Endoscopic Biopsy ◽  
Third Ventriculostomy ◽  
Histopathological Diagnosis ◽  
Cerebrospinal Fluid Diversion ◽  
Oncological Patients ◽  
Slow Progression ◽  
Benign Histology ◽  
Midbrain Tumors

Abstract BACKGROUND AND IMPORTANCE Mesencephalic tectal gliomas represent a subset of midbrain tumors, which are more frequent in children than in adults. They usually become symptomatic when causing hydrocephalus by occluding the aqueduct. Because of their slow progression, due to their benign histology, they are characterized by a relatively good prognosis, although hydrocephalus might jeopardize patients’ prognosis. Treatment is usually represented by cerebrospinal fluid diversion associated or not with biopsy. CLINICAL PRESENTATION We report 2 illustrative cases of tectal gliomas in adults where endoscopic third ventriculostomy (ETV) and simultaneous endoscopic biopsy were obtained during the same operation by means of a single burr hole with a flexible endoscope. CONCLUSION We recommend using this overlooked neurosurgical tool for such cases, since it allows the surgeon to safely perform an ETV, then judge whether biopsy can be done or not, without harming the patient, and possibly achieving an important piece of information (histopathological diagnosis) to manage this subset of oncological patients.

scholarly journals Multifocal granular cell tumour of the biliary tree

2018 ◽  
Vol 11 (1) ◽  
pp. e226352
Author(s):  
Felip Vilardell ◽  
Marina Pardina ◽  
Jorge Juan Olsina ◽  
Xavier Matias-Guiu
Keyword(s):  
S100 Protein ◽  
Unknown Origin ◽  
Granular Cell ◽  
Biliary Tree ◽  
Cell Tumour ◽  
Granular Cell Tumour ◽  
Surgical Specimen ◽  
Multiple Metastases ◽  
Nodular Lesions ◽  
Portal Tracts

Fewer than 90 cases of granular cell tumour (GCT) of the biliary tract have been reported, including only five cases of multiple GCTs. We present the unusual case of a 40-year-old woman with multifocal GCTs affecting the intrahepatic biliary tree, which were initially suspected to be hepatic multiple metastases from a malignancy of unknown origin. The surgical specimen consisted of a hepatic segment in which five whitish nodular lesions were observed. On microscopic examination, nodular lesions were found in the portal tracts; these were composed of large polygonal cells with abundant highly granular cytoplasm. The nuclei were small and centrally located. The tumour cells tested diffusely positive for CD68-PGM1, S100 protein and α-inhibin, so a diagnosis of multifocal GCT of the biliary tree was made. Three years later, the patient is still alive and a MRI has shown no changes.

scholarly journals Clinical–pathological characteristics and short-term follow-up associated with proliferation, apoptosis and angiogenesis in a prospective cohort of patients with colorectal tumours

Tumor Biology ◽  
2019 ◽  
Vol 41 (4) ◽  
pp. 101042831983568
Author(s):  
Maximino Redondo ◽  
Cristina Abitei ◽  
Teresa Téllez ◽  
Rafael Fúnez ◽  
Teresa Pereda ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Prospective Cohort ◽  
Good Prognosis ◽  
Terminal Deoxynucleotidyl Transferase ◽  
Short Term ◽  
Ki 67 ◽  
Term Survival ◽  
Colorectal Tumour ◽  
Colorectal Cancer Patients

We investigate the clinical and pathological features related to variations in colorectal tumour apoptosis, proliferation and angiogenesis and the influence of the latter in short-term mortality (2 years); 551 tumour samples from a prospective cohort of patients with colorectal cancer were examined and tumour biology markers were determined as follows: percentage of apoptotic cells, by the terminal deoxynucleotidyl transferase (TdT) dUTP Nick-End Labeling technique; Ki-67 antigen, as a cell proliferation marker and density of microvessels (as a marker of angiogenesis). An increase in the percentage of cellular apoptosis is significantly related to the presence of poorly differentiated tumours, with vascular invasion (p < 0.001). The CD105 angiogenesis marker is not related to any clinical–pathological parameter except that of higher frequency in older patients (p = 0.03). Ki-67 is more frequently expressed in tumours with less nervous invasion (p = 0.05). Neither apoptosis nor angiogenesis present any significant association with short-term survival. The only marker clearly related to 2-year survival is Ki-67, which is shown to be a good prognostic factor in the multivariate analysis (hazard ratio = 0.49; 95% confidence interval = 0.27–0.90). Therefore, in a prospective cohort of colorectal cancer patients, only Ki-67 is a marker of good prognosis in short-term follow-up.

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