scholarly journals Reinfection with SARS-CoV-2 in a splenectomized patient from Kocaeli, Turkey

2020 ◽  
Author(s):  
Müge Toygar Deniz ◽  
Sıla Akhan ◽  
Melih Berkay Esgin ◽  
Murat Sayan ◽  
Serap Argun Barış
Keyword(s):  
Case Presentation ◽  
Viral Release ◽  
Splenectomized Patient ◽  
New Treatments ◽  
Clinical Conditions

Abstract Background: The COVID-19 pandemic has resulted in more than 31 million cases diagnosed and 965,000 deaths as of September 21, 2020. As the number of cases increases, clinical conditions such as prolonged viral release, reinfection, and reactivation are being encountered more frequently.Case presentation: This article presents a case who was reinfected with COVID-19 and developed a more severe second disease unlike other cases in the literature.Conclusions: Reinfection in a splenectomy case may help researchers understand the pathogenesis of the disease and can be a guide for the development of vaccines and new treatments.

scholarly journals Convalescent Plasma as a Treatment for Severe Patients with SARS-CoV-2 Infection: A Case Report

2020 ◽  
Author(s):  
Chaoying Yong ◽  
Xinyu Deng ◽  
Yuyan Song ◽  
Wenguang Tian ◽  
Di Qi ◽  
...  
Keyword(s):  
Adverse Reactions ◽  
Small Samples ◽  
Plasma Therapy ◽  
Case Presentation ◽  
Randomized Controlled ◽  
Failure Treatment ◽  
Global Pandemic ◽  
Clinical Conditions ◽  
Antibody Levels ◽  
Severe Adverse Reactions

Abstract Background: Coronavirus disease 2019 (COVID-19) has become a global pandemic, affecting the lives of millions of people around the world.Although research including hydroxychloroquine, antiviral drugs and vaccines is under way, there is still no effective therapy applied for COVID-19.Case presentation: Here, we reported five cases of severe COVID-19 patients with respiratory failure treatment with supportable care and ABO-compatible convalescent plasma (CP).All the patients’ clinical conditions, laboratory results, viral nucleic acid results, and chest CT images, were improved. Meanwhile, all the patients recovered and no severe adverse reactions were found. We also followed up the antibody levels of some patients within 2 months after onset, but our study did not show the inherent relationship between CP treatment and changes in antibody levels due to small samples.Conclusions: Although short of evidence of randomized controlled trials, convalescent plasma therapy probably was a potentially safe and effective treatment for COVID-19.

scholarly journals The first Jordanian newborn delivered to COVID-19 infected mother with no evidence of vertical transmission: A case report.

2020 ◽  
Author(s):  
Mohammad Khassawneh ◽  
Wasim Khasawneh ◽  
Laila Al Zaghal ◽  
Wail Hayajneh ◽  
Fadel Abdelal
Keyword(s):  
Hospital Stay ◽  
Vertical Transmission ◽  
Direct Contact ◽  
Nasal Congestion ◽  
Age Groups ◽  
Rt Pcr ◽  
Infected Mother ◽  
Case Presentation ◽  
Two Samples ◽  
Clinical Conditions

Abstract Background: COVID-19 has been recently declared by WHO a global health pandemic. Theoretically, it might affect all age groups but it is not known if vertical transmission during pregnancy occurs. We hereby report a case about the first Jordanian newborn delivered to COVID-19 infected mother. Case presentation: A late preterm female was delivered by Cesarean section to COVID-19 mother who was diagnosed after presenting with a dry cough, nasal congestion, headache, and sore throat in the context of direct contact with other confirmed patients. The infant’s clinical examination was reassuring throughout the hospital stay. COVID-19 was not detected by RT-PCR tests performed on the amniotic fluid and on two samples of the newborn’s nasopharyngeal swabs indicating no vertical transmission of the virus. After 10 days of hospital stay and following two negative consecutive RT-PCR assays on the mother’s nasopharyngeal swabs, both the mother and the infant were discharged home in stable clinical conditions. Conclusion: Vertical transmission is not likely among the routes of COVID-19 transmission. However, data about more number of deliveries to COVID-19 infected mothers is needed to support this conclusion.

scholarly journals Neonates with coronavirus disease 2019 acquired from infected mothers: the incompatibility of maternal intensity and infant lung involvement: two case reports

2021 ◽  
Vol 15 (1) ◽  
Author(s):  
Somayeh Moeindarbary ◽  
Azam Pourhoseini ◽  
Parvaneh Layegh ◽  
Zahra Shahriari ◽  
Faezeh Fayyaz ◽  
...  
Keyword(s):  
Case Reports ◽  
World Health ◽  
The Novel ◽  
Lung Involvement ◽  
Case Presentation ◽  
Postnatal Transmission ◽  
Good General Condition ◽  
Severity Of The Disease ◽  
Health Organization ◽  
Clinical Conditions

Abstract Background The outbreak of coronavirus disease 2019 (COVID-19) caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was declared a public health emergency by the World Health Organization on January 30, 2020. The results of recent studies have suggested that neonates may present symptoms of COVID-19. Although the presentation of the disease in neonates is known to vary, only a limited number of studies have investigated newborns infected with COVID-19. Case presentation This study presents two Asian cases of newborns with COVID-19. Maternal–fetal or postnatal transmission was suggested based on the simultaneity of maternal infection. Chest radiography in one of the neonates showed severe lung involvement. Despite support and resuscitation attempts, the poor clinical condition of the neonate led to his death. However, the two mothers and one of the neonates were discharged from the hospital in good general condition. Conclusion The neonates had worse clinical conditions than the mothers, and the intensity of pneumonia and level of lung involvement in the newborns were not associated with the stage and severity of the disease in the mothers with COVID-19.

scholarly journals Osteodiscitis Post- COVID-19 Infection: A Case Series

2021 ◽  
Author(s):  
Majid Rezvani ◽  
Amirhosein Zohrevand ◽  
Najmeh Namazee ◽  
Soheil Fallahpour ◽  
Saeid Saghaei ◽  
...  
Keyword(s):  
Infectious Disease ◽  
Common Factor ◽  
Case Series ◽  
Case Presentation ◽  
Screw Insertion ◽  
Retrospective Assessment ◽  
Pedicular Screw ◽  
The Mean ◽  
Almost All ◽  
Clinical Conditions

Abstract Background: Coronavirus disease (COVID-19) is an infectious disease. It affects almost all organs of the human body. Lumbar osteodiscitis is an infection of the vertebral body and disc. The association of COVID-19 with osteodiscitis has not been reported in the literature so far. The purpose of this study was to describe a series of four cases manifested as post-COVID-19 osteodiscitis.Case presentation: We performed a retrospective assessment of the clinical, radiological, and microbiological features of adult post-COVID-19 patients who underwent surgery for unstable lumbar osteodiscitis at our hospital. The mean age of patients was 45.8±7.8 years. All the patients were treated according to their clinical conditions through a combined surgical approach as laminectomy, facetectomy, pedicular screw insertion, and fusion. The clear causes of infection were not recognized by routine methods, and COVID-19 was the only common factor in patients in the last 6 to 8 weeks.Conclusions: This case series suggest that osteodiscitis could be one of the possible side effects after COVID-19 infection.

scholarly journals Management skin manifestation of multisystem inflammatory syndrome associated with SARS-CoV-2

2022 ◽  
Vol 19 (1) ◽  
Author(s):  
Yeter Eylul Bayram ◽  
Dilek Yildiz-Sevgi ◽  
Ayse Yavuz ◽  
Merve Cancetin ◽  
Mehmet Yavuz Gurler
Keyword(s):  
Joint Pain ◽  
Skin Lesions ◽  
Laboratory Findings ◽  
Case Presentation ◽  
Patient Morbidity ◽  
Disease Condition ◽  
The Usa ◽  
Serious Disease ◽  
Clinical Conditions ◽  
Inflammatory Syndrome

Abstract Background Multisystem inflammatory syndrome (MIS), which develops after a past covid-19 infection. MIS can be described in different tissue inflammation, including the heart, lung, kidney, brain, skin, eye, and or gastrointestinal organs at the presence of COVID-19. Initially, MIS was described in Europe in children infected with SARS-CoV-2, then it was recently seen in the USA in 2020. MIS is a rare but serious disease condition associated with COVID-19 that can affect children (MIS-C) and adults (MIS-A). Case presentation A 44-year-old male who showed MIS-A in 59-day after his first covid-19 contact history. The patient presented to our emergency department with complaints of high fever, nausea, weakness, redness of the eyes, headache, and joint pain. On the second day of his hospitalization, a maculopapular skin lesion was seen in most of the skin. His fever could not be controlled even given paracetamol and broad effective antibiotics. His clinical, radiological, and laboratory findings showed that he had MIS-A. The patient was given intravenous pulse methylprednisolone and intravenous immunoglobulin (IVIG). These treatments, then, resulted in improvement of his clinical conditions, including fever and skin lesions, on the second day of the treatment. The patient was discharged in 14 days after the treatment. Conclusion This report indicated that diagnosis and treatment of MIS-A could result in reducing patient morbidity and mortality.

scholarly journals Acute vision loss in a patient with chronic esophageal stenosis

2020 ◽  
Vol 3 (1) ◽  
pp. 193-197
Author(s):  
Joshua Paul ◽  
Yi Zhang ◽  
Justin Sun
Keyword(s):  
Vision Loss ◽  
Esophageal Stenosis ◽  
African American Female ◽  
Ilm Peeling ◽  
Case Presentation ◽  
Posterior Hyaloid ◽  
Ocular Coherence Tomography ◽  
Pars Plana ◽  
Clinical Conditions

Abstract: Purpose: To describe a unique cause of Valsalva Retinopathy (VR) with an alternative surgical approach to chronic non-clearing pre-foveal hemorrhage. Method: Case presentation. Results: A 45-year-old African American female presented with acute vision loss from 20/20 to count fingers (CF) in her right eye. Ophthalmoscopy and ocular coherence tomography (OCT) showed old yellow-red pre-retinal opacityscuring the fovea. After 1 month of conservative management with no improvement, Pars Plana Vitrectomy (PPV) with posterior hyaloid membrane removal without ILM peeling was performed with the patient’s best-corrected visual acuity (BCVA) dramatically improved to 20/25. Discussion: We raise the question regarding the role of ILM peeling in treating premacular hemorrhage. Even without ILM peeling, our patient’s hemorrhage resolved after the procedure. This suggests that PPV combined with posterior hyaloid removal is a safer and effective alternative to surgical treatment in patients with certain clinical conditions. In addition, we provide clear evidence to support the location of the hemorrhage in VR as both sub-hyaloid and sub-ILM.

scholarly journals Hemoglobin life-threatening value (1.9 g/dl) in good general condition: a pediatric case-report

2021 ◽  
Vol 47 (1) ◽  
Author(s):  
Emilia Parodi ◽  
Lorenzo Riboldi ◽  
Ugo Ramenghi
Keyword(s):  
General Condition ◽  
Intravenous Iron ◽  
Deficiency Anemia ◽  
Case Presentation ◽  
Chronic Anemia ◽  
Iron Supplements ◽  
Packed Red Blood Cells ◽  
Good General Condition ◽  
Life Threatening ◽  
Clinical Conditions

Abstract Background We report a pediatric patient presenting in good general condition despite a hemoglobin value of 1,9 g/dL, which is normally regarded as life-threatening. Case presentation An African 5 years-old girl presented to our Emergency Department (ED) for worsening asthenia, within a clinical picture of good general condition. The hemoglobin value at admission was 1,9 g/dL. The subsequent diagnostic-therapeutic pathway highlighted the presence of two different causes, both well known to be responsible for chronic anemia (with slow reduction of hemoglobin values): iron deficiency anemia (IDA) due to a very low dietary intake of iron-rich foods, and homozygous sickle cell disease (HbSS). She received transfusions of packed red blood cells (overall 15 ml/kg) and subsequently intravenous iron preparations (total amount 200 mg) followed by oral iron supplements. The Hb value at discharge, 10 days after the admission, was 9.8 g/dL. Conclusions When approaching a picture of severe anemia, we suggest pediatricians take into consideration clinical conditions rather than laboratory values and to take advantage of detailed anamnestic data in order to make the diagnosis.

scholarly journals Double false-negative traps in urine routine test: a case report

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Xiang Qian ◽  
Hanyu Liang ◽  
Zhen Ren
Keyword(s):  
Case Report ◽  
Clinical Laboratory ◽  
False Negative ◽  
Occult Blood ◽  
Chronic Glomerulonephritis ◽  
Routine Test ◽  
Case Presentation ◽  
Combined Use ◽  
Clinical Conditions ◽  
Chemical Analyzer

AbstractBackgroundUrinalysis is one of the most commonly performed tests in clinical practice and supplies important information for a series of clinical conditions, including renal and urinary tract diseases. The clinical laboratory often completes urinalysis through the combined use of urinary dry-chemistry and formed-element analyzers. Urine red blood cell (RBC) morphology test is often used to discriminate the source of hematuria by manual microscopy.Case presentationIn this case report, we describe a 39-year-old woman with chronic glomerulonephritis (CGN) who underwent both urine routine test and RBC morphology test. Her RBC count was in the normal range and the occult blood test was negative in routine test, while the RBC morphology test indicated the presence of non-homogeneous hematuria.ConclusionsTherefore, we analyzed the causes of false-negative result on the urine chemical analyzer and the automatic microscope system, respectively.

scholarly journals Treatment of Six COVID-19 Patients with Convalescent Plasma

2021 ◽  
Author(s):  
Can Jin ◽  
Shucheng Zhang ◽  
Bohan Li ◽  
Linlin Wu ◽  
Shihao Yi ◽  
...  
Keyword(s):  
Symptom Relief ◽  
Chest Imaging ◽  
Test Results ◽  
Plasma Transfusion ◽  
Clinical Trial Registry ◽  
Plasma Therapy ◽  
Systemic Corticosteroids ◽  
Single Center Study ◽  
New Treatments ◽  
Clinical Conditions

Abstract Objective The global mortality toll of coronavirus disease 2019 (COVID-19) is rapidly increasing. Current antiviral therapy is insufficient, so it is crucial to develop new treatments. We assessed the efficacy of convalescent plasma transfusion for COVID-19 patients.Methods This retrospective, single-center study was conducted on six COVID-19 patients treated with convalescent plasma at Guizhou Provincial Jiangjunshan Hospital in China, from January 29 to April 30, 2020; the final follow-up data was collected on May 20, 2020. The efficacy of convalescent plasma was evaluated symptom relief and improvements in laboratory indicators and chest imaging abnormalities. Results Following treatment with convalescent plasma, the laboratory indicators and chest imaging examination of patients 1–3 changed from abnormal to normal. Regarding the relapsed patients (patients 4–6), two obtained negative severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) real-time polymerase chain reaction (RT-PCR) test results on consecutive throat swabs after receiving convalescent plasma therapy (on days 24 and 3 for patients 4 and 6, respectively). Patient 5 received only one round of convalescent plasma transfusion; this patient’s laryngeal swab test results for SARS-CoV-2 have remained consistently positive so far.Conclusions The clinical conditions of six patients with COVID-19 improved following treatment with antiviral drugs and systemic corticosteroids combined with appropriate rounds of convalescent plasma therapy, indicating that infusion with convalescent plasma may be beneficial for patients with COVID-19.This study was registered in Chinese Clinical Trial Registry Center. (CCTR number: ChiCTR 2000033056, registered 19 May 2020)

scholarly journals Hemoglobin Life-threatening Value (1.9 g/dl) in Good General Condition: a Pediatric Case-report.

2021 ◽  
Author(s):  
Emilia Parodi ◽  
Lorenzo Riboldi ◽  
Ugo Ramenghi
Keyword(s):  
General Condition ◽  
Intravenous Iron ◽  
Deficiency Anemia ◽  
Case Presentation ◽  
Chronic Anemia ◽  
Iron Supplements ◽  
Packed Red Blood Cells ◽  
Good General Condition ◽  
Life Threatening ◽  
Clinical Conditions

Abstract Background: we report a pediatric patient presenting in good general condition despite an hemoglobin value of 1,9 g/dL, which is normally regarded as life-threatening. Case presentation: an African 5 years-old girl presented to our Emergency Department (ED) for worsening asthenia, within a clinical picture of good general condition. The hemoglobin value at admission was 1,9 g/dL. The subsequent diagnostic-therapeutic pathway highlighted the presence of two different causes, both well known to be responsible for chronic anemia (with slow reduction of hemoglobin values): iron deficiency anemia (IDA) due to a very low dietary intake of iron-rich foods, and homozygous sickle cell disease (HbSS). She received transfusions of packed red blood cells (overall 15 ml/kg) and subsequently intravenous iron preparations (total amount 200 mg) followed by oral iron supplements. The Hb value at discharge, 10 days after the admission, was 9.8 g/dL.Conclusions: when approaching a picture of severe anemia, we suggest pediatricians to take into consideration clinical conditions rather than laboratory values and to take advantage of detailed anamnestic data in order to make the diagnosis.

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