Clinical severity of COVID-19 and general characteristics of Koreans

Mapping Intimacies ◽

10.21203/rs.3.rs-106697/v1 ◽

2020 ◽

Author(s):

Jean Kyung Paik ◽

Jung Hyun Kwak

Keyword(s):

Liver Disease ◽

Autoimmune Disease ◽

Kidney Disease ◽

Respiratory Diseases ◽

Clinical Symptoms ◽

Medical Center ◽

Epidemiological Data ◽

Clinical Severity ◽

National Medical ◽

Information Manager

Abstract This study aimed to investigate the associations between clinical severity of COVID-19 and general characteristics of the subjects using epidemiological data of 5,601 patients with confirmed COVID-19 in Korea. The subjects of this study were diagnosed with COVID-19 from January 20 to April 30, 2020. The subjects of this study acquired information on patients with confirmed COVID-19 from the Korea Disease Control & Prevention Agency, National Medical Center and the Health Information Manager in hospitals. We found that severity of COVID-19 was greater among patients aged > 60 years, with obesity, clinical symptoms, respiratory diseases, kidney disease, and other diseases (chronic liver disease, rheumatism/autoimmune disease, and dementia). Among the variables, women had reduced clinical severity of COVID-19. Therefore, people with these factors are more susceptible to COVID-19, and they require special attention.

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Viral Dynamics Matter in COVID-19 Pneumonia: the success of early treatment with hydroxychloroquine and azithromycin in Lebanon

10.1101/2020.05.28.20114835 ◽

2020 ◽

Author(s):

Amanda Chamieh ◽

Claude Afif ◽

Gerard El-Hajj ◽

Omar Zmerli ◽

Isabelle Djaffar-Jureidini ◽

...

Keyword(s):

Clinical Cure ◽

Clinical Symptoms ◽

Medical Center ◽

Good Condition ◽

Standard Of Care ◽

Clinical Severity ◽

Viral Dynamics ◽

Early Administration ◽

High Severity ◽

Laboratory Markers

1.Abstract1.1.Background/PurposeWe share our experience in COVID-19 pneumonia management at Saint George Hospital University Medical Center (SGHUMC) in Lebanon. In the absence of a standard of care, early diagnosis and opt-in therapy with Hydroxychloroquine and Azithromycin were offered.1.2.MethodsWe reviewed records of COVID-19 pneumonia patients from March 16-April 26 2020. Based on NEWS score, we stratified patients as A: low B: medium, and C: high clinical severity and obtained pharmacotherapy data. Chest-CT-severity-score (CTSS) was used. We defined clinical cure as resolution of symptoms and biomarkers and virologic cure as a PCR above 35 cycles(Ct).1.3.ResultsWe recorded 21 COVID-19 pneumonia patients of whom 19 opted for treatment. Clinical symptoms and laboratory markers at presentation did not significantly correlate with severity. Lower initial viral load significantly correlated with lower levels of clinical and radiological severity (p=0.038). Virologic cure, Ct>35, by day 10, was only 33% in high severity significantly less than categories A and B. We observed 100% clinical cure at day 10 in Category-A, 67% in B, and 33% in C(p<0.05). Patients with the lowest severity had the fastest virologic cure in a mean of 5.8 days from diagnosis, shortest hospitalization and earlier radiological improvement(p<0.005). Ultimately, 18 patients were discharged home in good condition and one remains in the ICU.1.4.ConclusionViral dynamics matter in COVID-19 pneumonia. An early control of replication may be crucial in averting complications. Early administration of Hydroxychloroquine and Azithromycin potentially explains our 94.7% success rate in treating a fairly complex cohort of COVID-19 pneumonia.

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Family History of Autoimmune Disease in Patients with Aicardi-Goutières Syndrome

Clinical and Developmental Immunology ◽

10.1155/2012/206730 ◽

2012 ◽

Vol 2012 ◽

pp. 1-6 ◽

Cited By ~ 4

Author(s):

Johanna L. Schmidt ◽

Ivana Olivieri ◽

Jodie M. Vento ◽

Elisa Fazzi ◽

Heather Gordish-Dressman ◽

...

Keyword(s):

Autoimmune Disease ◽

Medical Center ◽

Family Members ◽

Disease Diagnosis ◽

Washington Dc ◽

Chi Square ◽

National Medical ◽

History Of ◽

Number Of Individuals ◽

Syndrome Association

Purpose. The purpose of this study was to explore anecdotal evidence for an increase in the prevalence of autoimmune diseases in family members of patients with Aicardi-Goutières syndrome (AGS).Methods. Pedigrees of patients and controls were analyzed using chi-square and logistic regression to assess differences in reports of autoimmune disease among family members of cases and controls. Data was collected at Children's National Medical Center in Washington, DC, USA and at the International Aicardi-Goutières Syndrome Association Scientific Headquarters, C. Mondino National Institute of Neurology in Pavia, Italy.Results. The number of individuals with reported autoimmune disease is significantly related to having a family member with AGS (χ2=6.25,P=0.01); 10% (35/320) of relatives of patients with AGS had a reported autoimmune disease diagnosis compared to 5% (18/344) of relatives of controls. There was a greater percent of maternal relatives of patients with AGS reporting autoimmune disease (14.6%), compared to controls (6.8%), with the association being statistically significant. The association was not significant for paternal relatives.Conclusion. The prevalence of autoimmune disease in relatives of children with AGS is significantly increased compared to controls. More research is needed to better understand this association.

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COVID-19 Comorbidity and Non-Communicable Diseases (NCDs) General Reference Hospital (HGR), Niamey, Niger

Journal of Infectiology ◽

10.29245/2689-9981/2021/1.1165 ◽

2021 ◽

Vol 4 (1) ◽

pp. 7-13

Author(s):

MAHAMANE SANI Mahamane Aminou ◽

GBAGUIDI Aichatou Diawara ◽

MIGITABA Hassane Moctar ◽

SANI Rabiou ◽

EMOUD TCHOLI Idrissa ◽

...

Keyword(s):

Intensive Care ◽

Respiratory Diseases ◽

Health Workers ◽

Clinical Symptoms ◽

Average Length ◽

Communicable Disease ◽

Clinical Severity ◽

General Reference ◽

Cross Sectional ◽

Reference Hospital

The COVID-19 infection has highlighted the most vulnerable patients. Indeed, COVID-19 patients suffering from another pathology including NCDs such as Arterial Hypertension (Hypertension), diabetes, cancers and respiratory diseases are paying a heavy price for this pandemic. We undertook a study in Niger to better document this comorbidity in a cross-sectional study that brought together patients hospitalized at the Niamey General Reference Hospital for COVID-19 infection and suffering from one or more NCDs. Among 273 patients hospitalized from March 19 to June 03, 2020, 34.8% had a non-communicable disease associated with COVID-19. The average age of the patients was 55 years (22 years to 94 years) and the sex ratio was 2.64 (72.5 % men and 27.5% women). Hypertension was the most represented NCD with 24.5%, followed by diabetes in 17.9% of cases, respiratory diseases 3.66% and other diseases (Heart disease, Obesity, Dyslipidemia, Gout, Chronic renal failure) with 3%. Health workers were the most affected by the disease with 38.6% of cases. The average consultation time was 3.77 days with extremes ranging from 1 to 8 days. The clinical symptoms characterizing the two main groups of patients (hypertensive and diabetic) were almost identical. It consisted mainly of cough, fever, chills, sore throat and rhinorrhea. According to the WHO clinical criteria for the severity of COVID-19, 34 patients or 16.11% were severe and 177 patients or 83% moderate. The clinical severity of the disease is significantly correlated with the patient's age (over 50 years) and the presence of an NCD associated with COVID-19. A total of 35.8% were hospitalized in intensive care in the NCD and COVID-19 group and 14.6% in the NCD group (p <0.001). The average length of patient hospitalization was 6.87 days overall, it was 7 days in intensive care. In 61.7% of cases the length of hospitalization was greater than 4 days. There was 22.1% in the NCD group and 7.3% in the just COVID-19 group (p <0.001). A total of 90.6% of registered deaths occurred in intensive care.

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Plasma Fibrin Stabilising Factor (F. S. F.) Activity in Normal Subjects and Patients with Chronic Liver Disease

Thrombosis and Haemostasis ◽

10.1055/s-0038-1653516 ◽

1969 ◽

Vol 21 (01) ◽

pp. 134-143 ◽

Cited By ~ 9

Author(s):

W. D Walls ◽

M. S Losowsky

Keyword(s):

Liver Disease ◽

Chronic Liver Disease ◽

Clinical Improvement ◽

Quantitative Estimation ◽

Kinetic Method ◽

Normal Subjects ◽

Chronic Liver ◽

Clinical Severity ◽

Plasma Fibrinogen ◽

Normal Range

SummaryA kinetic method for the quantitative estimation of plasma F.S.F. activity is described and discussed.This method was applied to normal subjects and to patients with chronic liver disease. The plasma F.S.F. activity was uninfluenced by either sex or age, and the normal range has been defined.A significant decrease in plasma F.S.F. activity was observed in patients with chronic liver disease. Subnormal levels of activity were found in 25% of such patients but were unrelated to episodes of abnormal haemorrhage. Plasma F.S.F. activity tended to be lower in patients with disease of greater clinical severity. In 2 patients showing clinical improvement there was an increase in plasma F. S. F. activity.It was confirmed that plasma fibrinogen levels increase with age.

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Dry Needling Can Be An Alternative Treatment for Hemifacial Spasm

Biomedical Journal of Indonesia: Jurnal Biomedik Fakultas Kedokteran Universitas Sriwijaya ◽

10.32539/bji.v6i2.11802 ◽

2020 ◽

Vol 6 (2) ◽

pp. 20-28

Author(s):

Selly Marisdina ◽

Henry Sugiharto ◽

A Pradian

Keyword(s):

Botulinum Toxin ◽

Hemifacial Spasm ◽

Alternative Treatment ◽

Epidemiological Data ◽

Clinical Severity ◽

Decompression Surgery ◽

Dry Needling ◽

Significant Difference ◽

Microvascular Decompression Surgery ◽

Botulinum Toxin Injections

Back Ground: Hemifacial spasm is one of movement disorder case that commonly found in daily clinical practice. Epidemiological data are very limited, the average prevalence is 11 per 100,000 population, 14.5 per 100,000 in women and 7.4 per 100,000 in men. In Germany, the estimated prevalence is 8000 to 9000 peoples.1 The incidence of women is more than that of men with a ratio of 2:1. Based on Yaltho and Jankovic study in 2011, out of 215 patients, the ratio of men to women was 1:1.8.2 One study in Indonesia also reported that most of the subjects were female (64.7%).3 Treatment with botulinum toxin injections is preferred to microvascular decompression surgery therapy, but this injection is only effective in a few months and quite expensive. This study is the first study to assess the effectiveness of dry needling on clinical improvement of hemifacial spasm compared to standard therapy of botulinum toxin injection.Methods: The study design was quasi experimental. Total of 24 subjects were divided into two groups. The first group underwent dry needling intervention while the other had botulinum injection. Clinical severity before and after treatment in both groups was assessed using Jankovic and HFS7 scores.Results: In dry needling group there were significant differences between Jankovic and HFS7 score at baseline and at week 1, 2, 3 and 4. While in botox group significant differences were also Jankovic and HFS7 score at baseline and at weeks 2 and 4. There were also a significant difference of Jankovic and HFS7 score when we compared dry needling group to botulinum toxin group.Conclusion: Dry needling can be an alternative treatment for hemifacial spasm, although clinical improvements based on Jankovic and HFS7 scores in dry needling group were not as effective as those with botulinum toxin injections.

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