The global prevalence of depression, anxiety, stress and insomnia among general population during COVID-19 pandemic: A systematic review and meta-analysis

Abstract This study aimed to examine research findings related to depression, anxiety, stress, and insomnia during the COVID-19 pandemic. This study also explored periodic changes in the prevalence of depression, anxiety, stress, and insomnia among the general people during this pandemic. We performed a meta-analysis by searching articles from several sources (PubMed, MEDLINE, and GOOGLE SCHOLAR). We used the random-effects models, subgroup analysis, and heterogeneity test approaches. Results show that the prevalence of depression, stress, and insomnia increased during March to April 2020 (30.51%, 29.4%, and 25% respectively) compared to the study period before February 2020 (25.25%, 16.27%, and 22.63% respectively) and followed in May to June 2020 (16.47%, 5.1%, and 19.86 respectively). The prevalence of depression and anxiety from k= 30 studies was 28.18% (95% CI: 23.81-32.54), and 29.57% (95% CI: 24.67-34.47), respectively. And the prevalence of stress (k=13) was 25.18% (95% CI: 14.82 – 35.54) and the prevalence of insomnia (k=12) was 23.50% (95% CI: 16.44 – 30.57). These prevalence estimates during the pandemic are very high compared to normal times. Hence, the governments and policymakers should apply proven strategies and interventions to avoid psychological adversity and improve overall mental health during the COVID-19 pandemic.

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Creativity and Mood Disorder: A Systematic Review and Meta-Analysis

Perspectives on Psychological Science ◽

10.1177/1745691617699653 ◽

2017 ◽

Vol 12 (6) ◽

pp. 1040-1076 ◽

Cited By ~ 20

Author(s):

Christa L. Taylor

Keyword(s):

Systematic Review ◽

Mood Disorder ◽

Meta Analysis ◽

Research Approach ◽

Significant Heterogeneity ◽

Random Effects Models ◽

Research Findings ◽

K 13 ◽

Meta Regression ◽

The Relationship

Although the belief that creativity is related to psychopathology is prevalent, empirical evidence is limited. Research findings relating to mood disorder in particular are mixed, possibly as a result of differing research approaches (e.g., assessing the creativity of individuals with versus without mood disorder opposed to the prevalence of mood disorder in creative versus noncreative individuals). Therefore, a systematic review and meta-analysis were conducted to investigate prior research examining the link between mood disorder and creativity from three distinct research approaches. Multilevel random effects models were used to calculate the overall effect size for studies that assessed (a) creativity in a clinical versus nonclinical sample ( k = 13), (b) mood disorder in a creative versus noncreative sample ( k = 10), and (c) the correlation between dimensional measures of creativity and mood disorder symptoms ( k = 15). Potential moderators were examined using meta-regression and subgroup analyses, as significant heterogeneity was detected among the effects in all three analyses. Results reveal a differential strength and pattern of effects across the three analyses, suggesting that the relationship between creativity and mood disorder differs according to the research approach. The theoretical implications of results and potential mechanisms responsible for the relationship between creativity and mood disorder are discussed.

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Prevalence of Depression among Healthcare Workers during the COVID-19 Outbreak: A Systematic Review and Meta-Analysis

Journal of Clinical Medicine ◽

10.3390/jcm10153406 ◽

2021 ◽

Vol 10 (15) ◽

pp. 3406

Author(s):

Beatriz Olaya ◽

María Pérez-Moreno ◽

Juan Bueno-Notivol ◽

Patricia Gracia-García ◽

Isabel Lasheras ◽

...

Keyword(s):

Systematic Review ◽

Healthcare Workers ◽

Mental Health Problems ◽

Meta Analysis ◽

Medical Doctors ◽

Cross Sectional ◽

Random Effects Models ◽

Pooled Prevalence ◽

Prevalence Of Depression ◽

Common Mental Health Problems

Background: There is evidence of a high psychological toll from the COVID-19 pandemic in healthcare workers. This paper was aimed at conducting a systematic review and meta-analysis of studies reporting levels of depression among healthcare workers during the COVID-19 and estimating the pooled prevalence of depression. Methods: We searched for cross-sectional studies listed on PubMed from 1 December 2019 to 15 September 2020 that reported prevalence of depression in healthcare workers, nurses, medical doctors, and COVID-19 frontline professionals. The pooled proportions of depression were calculated with random effects models. Results: We identified 57 studies from seventeen countries. The pooled prevalence of depression in healthcare workers was 24% (95% CI: 20%−28%), 25% for nurses (95% CI: 18%−33%), 24% for medical doctors (95% CI: 16%−31%), and 43% for frontline professionals (95% CI: 28%−59%). Conclusions: The proportion of depression in nurses and medical doctors during the COVID-19 pandemic was similar to that found in the general population as previously reported in other meta-analyses conducted with smaller numbers of studies. Importantly, almost half of the frontline healthcare workers showed increased levels of depression. There is need for a comprehensive, international response to prevent and treat common mental health problems in healthcare workers.

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Psychological distress among healthcare providers during COVID-19 in Asia: Systematic review and meta-analysis

PLoS ONE ◽

10.1371/journal.pone.0257983 ◽

2021 ◽

Vol 16 (10) ◽

pp. e0257983

Author(s):

Siew Mooi Ching ◽

Kar Yean Ng ◽

Kai Wei Lee ◽

Anne Yee ◽

Poh Ying Lim ◽

...

Keyword(s):

Meta Analysis ◽

Healthcare Providers ◽

Random Effects Model ◽

Depression And Anxiety ◽

Cross Sectional ◽

Funnel Plot ◽

Health And Wellbeing ◽

Pooled Prevalence ◽

Increased Risk ◽

Prevalence Of Depression

Introduction COVID-19 pandemic is having a devastating effect on the mental health and wellbeing of healthcare providers (HCPs) globally. This review is aimed at determining the prevalence of depression, anxiety, stress, fear, burnout and resilience and its associated factors among HCPs in Asia during the COVID-19 pandemic. Material and methods We performed literature search using 4 databases from Medline, Cinahl, PubMed and Scopus from inception up to March 15, 2021 and selected relevant cross-sectional studies. Publication bias was assessed using funnel plot. Random effects model was used to estimate the pooled prevalence while risk factors were reported in odds ratio (OR) with 95% CI. Results We included 148 studies with 159,194 HCPs and the pooled prevalence for depression was 37.5% (95%CI: 33.8–41.3), anxiety 39.7(95%CI: 34.3–45.1), stress 36.4% (95%CI: 23.2–49.7), fear 71.3% (95%CI: 54.6–88.0), burnout 68.3% (95%CI: 54.0–82.5), and low resilience was 16.1% (95%CI: 12.8–19.4), respectively. The heterogeneity was high (I2>99.4%). Meta-analysis reported that both females (OR = 1.48; 95% CI = 1.30–1.68) and nurses (OR = 1.21; 95%CI = 1.02–1.45) were at increased risk of having depression and anxiety [(Female: OR = 1.66; 95% CI = 1.49–1.85), (Nurse: OR = 1.36; 95%CI = 1.16–1.58)]. Females were at increased risk of getting stress (OR = 1.59; 95%CI = 1.28–1.97). Conclusion In conclusion, one third of HCPs suffered from depression, anxiety and stress and more than two third of HCPs suffered from fear and burnout during the COVID-19 pandemic in Asia.

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The Prevalence of Depression and Anxiety Symptoms among Overweight/Obese and Non-Overweight/Non-Obese Children/Adolescents in China: A Systematic Review and Meta-Analysis

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph16030340 ◽

2019 ◽

Vol 16 (3) ◽

pp. 340 ◽

Cited By ~ 10

Author(s):

Simeng Wang ◽

Qi Sun ◽

Lingling Zhai ◽

Yinglong Bai ◽

Wei Wei ◽

...

Keyword(s):

Meta Analysis ◽

Depression Scale ◽

Middle School Student ◽

Chinese Economy ◽

Anxiety Symptoms ◽

Depression Symptoms ◽

Depression And Anxiety ◽

Obese Children ◽

Prevalence Of Depression ◽

Scale Types

With the dramatic growth of the Chinese economy, the number of children/adolescents with being overweight/having obesity is increasing, which has a certain impact on their psychology, such as depression and anxiety symptoms. Our purpose was to conduct a meta-analysis to assess the prevalence and odds ratios of depression and anxiety symptoms among overweight/obese children/adolescents and non-overweight/obese children/adolescents in China. As of July 2018, the three most comprehensive computerized academic databases in China have been systematically screened, namely China national knowledge infrastructure (CNKI) databases, Wanfang databases and Vip databases. The same operations are performed in PubMed and Web of Science (SCIE) databases without language restrictions. Case-control studies on prevalence of depression and anxiety symptoms in overweight/obese children/adolescents in China were analyzed. Study selection and evaluation were performed independently by three authors. Unweighted prevalence, pooled random-effects estimates of odds ratio (OR), and 95% confidence intervals (CI) were all calculated. A total of 11 eligible studies involving 17,894 subjects were included. The prevalence of depression and anxiety symptoms in overweight/obese children/adolescents was significantly higher than that in non-overweight/non-obese children/adolescents (depression: 21.73% vs. 17.96%, OR = 1.46, 95% CI: 1.14, 1.87, p = 0.003; anxiety: 39.80% vs. 13.99%, OR = 1.47, 95% CI: 1.21, 1.79, p < 0.001). Subgroup analyses conducted according to scale types showed that scale types have certain significance to evaluate the relationship between depression symptoms and overweight/obesity. The OR of depression symptoms between overweight/obese children/adolescents and non-overweight/non-obese children/adolescents was greatest on the Middle School Student Mental Health Scale (MSSMHS) was 2.06 (95% CI: 1.41, 3.02, I2 = 0.00%), Center for Epidemiologic Studies Depression Scale (CES-D) was 1.03 (95% CI: 0.84, 1.25, I2 = 0.00%), and Children’s Depression Inventory (CDI) was 1.21 (95% CI: 1.02, 1.42, I2 = 0.00%). We concluded that the prevalence of depression and anxiety symptoms in overweight/obese children/adolescents in China is higher than that in the non-overweight/obese children/adolescents. The results of the study indicate that the prevalence of depression and anxiety symptoms among overweight/obese children/adolescents in Chinese medical institutions should receive more attention. Physical exercise and psychological interventions should be strengthened to prevent psychological problems. However, because of some clear limitations (no clinical interview and few studies), these results should be interpreted with caution.

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Prevalence of depression, anxiety and stress in china during COVID-19 pandemic: A systematic review with meta-analysis

The International Journal of Psychiatry in Medicine ◽

10.1177/0091217420978005 ◽

2020 ◽

pp. 009121742097800

Author(s):

Syeda Beenish Bareeqa ◽

Syed Ijlal Ahmed ◽

Syeda Sana Samar ◽

Waqas Yasin ◽

Sani Zehra ◽

...

Keyword(s):

Mental Health ◽

Meta Analysis ◽

Early Period ◽

Depression And Anxiety ◽

Health Issues ◽

Eligibility Criteria ◽

Pooled Prevalence ◽

Care Workers ◽

Prevalence Of Depression ◽

Novel Coronavirus

Background The novel coronavirus disease which is believed to have initially originated in Wuhan city of China at the end of 2019 was declared as pandemic by March 2020 by WHO. This pandemic significantly impacted the mental health of communities around the globe. This project draws data from available research to quantify COVID-19 mental health issues and its prevalence in China during the early period of the COVID-19 crisis. It is believed that this pooling of data will give fair estimate of the effects of the COVID-19 pandemic on mental health. Methods We conducted this study in accordance with PRISMA guidelines 2009. The protocol for this review is registered and published in PROSPERO (CRD42020182893). The databases used were Pubmed, Medline, Google scholar and Scopus. The studies were extracted according to pre-defined eligibility criteria and risk of bias assessment was conducted. The Meta-analysis was done using OpenMeta [analyst]. Results Total of 62382 participants in nineteen studies fulfilled the eligibility criteria. Stress was the most prevalent (48.1%) mental health consequence of Covid-19 pandemic, followed by depression (26.9%) and anxiety (21.8%). After performing subgroup analysis, prevalence of depression and anxiety in both females and frontline health care workers were high as compared to the prevalence in general Chinese population. Conclusion The prevalence of depression and anxiety is moderately high whereas pooled prevalence of stress was found to be very high in Chinese people during this Covid-19 crisis.

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Ethnic variation in the prevalence of depression and anxiety in primary care: A systematic review and meta-analysis

Psychiatry Research ◽

10.1016/j.psychres.2011.05.020 ◽

2012 ◽

Vol 195 (3) ◽

pp. 91-106 ◽

Cited By ~ 28

Author(s):

Ilaria Tarricone ◽

Elisa Stivanello ◽

Francesca Poggi ◽

Vanessa Castorini ◽

Maila Valentina Marseglia ◽

...

Keyword(s):

Systematic Review ◽

Primary Care ◽

Meta Analysis ◽

Depression And Anxiety ◽

Ethnic Variation ◽

Prevalence Of Depression

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Meta-Analysis of Prevalence of Depression in Dental Students during COVID-19 Pandemic

Medicina ◽

10.3390/medicina57111278 ◽

2021 ◽

Vol 57 (11) ◽

pp. 1278

Author(s):

Javier Santabárbara ◽

Naiara Ozamiz-Etxebarria ◽

Nahia Idoiaga ◽

Beatriz Olaya ◽

Juan Bueno-Novitol

Keyword(s):

Mental Health ◽

College Students ◽

Response Rate ◽

Negative Impact ◽

Meta Analysis ◽

Dental Students ◽

Random Effects Models ◽

Health And Wellbeing ◽

Pooled Prevalence ◽

Prevalence Of Depression

Background and Objectives: The COVID-19 pandemic has a negative impact on the mental health of the population in general, and in college students in particular. Dental students have seen their teaching altered and their clinical practice reduced. This study was aimed at conducting a systematic review and meta-analysis of studies reporting levels of depression among dental students during the COVID-19 and estimating the pooled prevalence of depression. Materials and Methods: Medline via PubMed and other databases were searched for studies on the prevalence of depression in dental undergraduates, published from 1 December 2019 to 1 September 2021. The pooled proportions of depression were calculated with random effects models. Results: We identified 13 studies from 9 countries. The pooled prevalence of depression in dental students was 37% (95% CI: 26–49%) with no variation due to gender, response rate or methodological quality. We only found a significantly higher prevalence of depression in studies from Asia compared to Europe and America. Conclusions: Our results suggest that dental students are suffering from higher levels of depression compared with the general population or other college students during the COVID-19 pandemic, with differences across regions. Measures to improve mental health and wellbeing of dental students during the pandemic are needed.

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Prevalence of depression among physicians: A comprehensive meta-analysis

Romanian Medical Journal ◽

10.37897/rmj.2021.3.1 ◽

2021 ◽

Vol 68 (3) ◽

pp. 327-337

Author(s):

Andreea Raluca Adam ◽

◽

Florinda Tinela Golu ◽

Keyword(s):

Elder Abuse ◽

Meta Analysis ◽

Medical Personnel ◽

Prevalence Studies ◽

Summary Estimate ◽

Effective Strategies ◽

Pooled Prevalence ◽

Prevalence Estimates ◽

Prevalence Of Depression ◽

Comprehensive Search

Depression among medical personnel is recognized worldwide as a serious problem, yet quantitative syntheses of prevalence studies are rare. We proceeded quantify and understand prevalence variation among physicians at the global levels. For this meta-analysis, we searched 6 databases, including: PsycINFO, Web of Science, PubMed, ProQuest using a comprehensive search strategy to identify prevalence of the physicians’ depression studies in the literature, published from inception of 1979. Studies reporting estimates of depression prevalence in physicians were included in the analyses. Studies quality was assessed with a prevalence risk of bias tool. Meta-regression was used to explore heterogeneity of the moderators we included in the analysis. Of the 3,156 studies initially identified, 33 were eligible for inclusion. These studies were geographically diverse (15 countries). The pooled prevalence rate for overall elder abuse was .243 (CI [.188; .306]; p<.001). Meta-analysis of studies that included overall abuse revealed heterogeneity. Significant associations were found between overall prevalence estimates and region, but not for sampling allocation and severity of depression. In this meta-analysis, the summary estimate of the prevalence of depression among physicians is 24.3%, ranging from 2% to 65.3 % depending on the region from the studies. Further research is needed to identify effective strategies for preventing and treating depression among physicians.

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