Global, regional, and national prevalence of diabetes mellitus in patients with pulmonary tuberculosis: a systematic review and meta-analysis
Abstract Background:Both TB and DM are major global public health problem. We estimated the global, regional, and national prevalence of diabetes mellitus in population with pulmonary tuberculosis.Methods:We assessed observational studies of diabetes mellitus in people with pulmonary tuberculosis, using PubMed and Embase electronic bibliographic databases in English language, to identify articles published until August 31, 2018. We included original research that reported the prevalence of diabetes mellitus in pulmonary tuberculosis or had enough data to compute these estimates. Studies were excluded if they did not provide primary data or were case studies and reviews. 2 authors independent extraction of articles and collected detailed information using predefined questionnaire. The country-specific random-effects meta-analyses for countries with two or more available studies and a fractional response regression model to predict individual studies prevalence of diabetes mellitus in pulmonary tuberculosis for countries with one or no study. The study is registered with PROSPERO, registration number CRD42018101989.Results. We identified 18042 studies, and 127 were retained for data extraction across 46 countries. The global prevalence of diabetes mellitus in patients with pulmonary tuberculosis were estimated to be 12.07% (95%CI: 10.43-14.85). The prevalence was 13.38% (95%CI: 11.16-16.05) in region of Americas, 13.34% (95%CI: 12.82-14.61) in European region, 12.68% (95%CI: 9.15-16.37) in South-East Asia, 12.56% (95%CI: 11.79-22.70) in Western Pacific region, 10.95% (95%CI: 9.04-17.83) in Eastern Mediterranean region and 7.54% (95%CI: 6.51-8.77) in African region. The country with the highest estimated prevalence was Mauritius (39.65%, 95%CI: 4.22-90.74).Conclusion: Pulmonary tuberculosis combined diabetes mellitus is still prevalent.