scholarly journals Flexible Material Formulations for 3D Printing of Porous Beds with Applications in Bioprocess Engineering

2022 ◽  
Author(s):  
Simone Dimartino ◽  
Giuseppe Rafael Galindo-Rodriguez ◽  
Ursula Simon ◽  
Mariachiara Conti ◽  
Sulaiman Sarwar ◽  
...  
Keyword(s):  
3D Printing ◽  
Cost Effective ◽  
Packed Bed ◽  
Exchange Chromatography ◽  
Porous Network ◽  
Bioprocess Engineering ◽  
3D Print ◽  
Industrial Sectors ◽  
Flexible Material ◽  
Material Formulation

Abstract Background: 3D printing is revolutionizing many industrial sectors and has the potential to enhance also the biotechnology and bioprocessing fields. Here, we propose a new flexible material formulation to 3D print support matrices with complex, perfectly ordered morphology and with tuneable properties to suit a range of applications in bioprocess engineering. Findings: Supports for packed-bed operations were fabricated using functional monomers as the key ingredients, enabling matrices with bespoke chemistry such as charged groups, chemical moieties for further functionalization, and hydrophobic/hydrophilic groups. Other ingredients, e.g. crosslinkers and porogens, provide the opportunity to further tune the mechanical properties of the supports and the morphology of their porous network. Through this approach, we fabricated and demonstrated the operation of Schoen gyroid columns with I) positive and negative charges for ion-exchange chromatography, II) enzyme bioreactors with immobilized trypsin to catalyse hydrolysis, and III) bacterial biofilms bioreactors for fuel desulfurization. Conclusions: This study demonstrates a simple, cost-effective and flexible fabrication of customized 3D printed supports for different biotechnology and bioengineering applications.

scholarly journals Flexible material formulations for 3D printing of porous beds with applications in bioprocess engineering

2021 ◽  
Author(s):  
Simone Dimartino ◽  
Giuseppe Galindo Rodriguez ◽  
Ursula Simon ◽  
Mariachiara Conti ◽  
Sulaiman Sarwar ◽  
...  
Keyword(s):  
3D Printing ◽  
Cost Effective ◽  
Packed Bed ◽  
Exchange Chromatography ◽  
Porous Network ◽  
Bioprocess Engineering ◽  
3D Print ◽  
Industrial Sectors ◽  
Flexible Material ◽  
Material Formulation

3D printing is revolutionizing many industrial sectors and has the potential to enhance also the biotechnology and bioprocessing fields. Here, we propose a new flexible material formulation to 3D print support matrices with complex, perfectly ordered morphology and with tuneable properties to suit a range of applications in bioprocess engineering. Supports for packed-bed operations were fabricated using functional monomers as the key ingredients, enabling matrices with bespoke chemistry such as charged groups, chemical moieties for further functionalization, and hydrophobic/hydrophilic groups. Other ingredients, e.g. crosslinkers and porogens, provide the opportunity to further tune the mechanical properties of the supports and the morphology of their porous network. Through this approach, we fabricated and demonstrated the operation of Schoen gyroid columns with I) positive and negative charges for ion-exchange chromatography, II) enzyme bioreactors with immobilized trypsin to catalyse hydrolysis, and III) bacterial biofilms bioreactors for fuel desulfurization. We expect this approach will enable simple, cost-effective and flexible fabrication of customized supports in biotechnology and bioengineering.

3D printing in pharmacy

2020 ◽  
pp. 58-60
Author(s):  
Yuliya Prozherina ◽  
Keyword(s):  
3D Printing ◽  
Cost Effective ◽  
Drug Market ◽  
Dosage Forms ◽  
Fixed Dose ◽  
Major Step ◽  
Combination Drugs ◽  
Effective Technology ◽  
Dose Combination ◽  
Research Stage

3D printing of drugs is an innovative and cost-effective technology, which is a major step towards personalized medicine. This technology can be used for the development of controlled-release drugs; fixed-dose combination drugs, as well as for the creation of orodispersible dosage forms. The global 3D drug market is still largely at the research stage, but its rapid growth is expected in the coming decade [1].

scholarly journals Microstructured Surface Plasmon Resonance Sensor Based on Inkjet 3D Printing Using Photocurable Resins with Tailored Refractive Index

Polymers ◽  
2021 ◽  
Vol 13 (15) ◽  
pp. 2518
Author(s):  
Nunzio Cennamo ◽  
Lorena Saitta ◽  
Claudio Tosto ◽  
Francesco Arcadio ◽  
Luigi Zeni ◽  
...  
Keyword(s):  
Surface Plasmon Resonance ◽  
3D Printing ◽  
Surface Plasmon ◽  
Plasmon Resonance ◽  
Optical Sensor ◽  
Low Cost ◽  
3D Print ◽  
Spr Sensor ◽  
Resonance Sensor ◽  
3D Printed

In this work, a novel approach to realize a plasmonic sensor is presented. The proposed optical sensor device is designed, manufactured, and experimentally tested. Two photo-curable resins are used to 3D print a surface plasmon resonance (SPR) sensor. Both numerical and experimental analyses are presented in the paper. The numerical and experimental results confirm that the 3D printed SPR sensor presents performances, in term of figure of merit (FOM), very similar to other SPR sensors made using plastic optical fibers (POFs). For the 3D printed sensor, the measured FOM is 13.6 versus 13.4 for the SPR-POF configuration. The cost analysis shows that the 3D printed SPR sensor can be manufactured at low cost (∼15 €) that is competitive with traditional sensors. The approach presented here allows to realize an innovative SPR sensor showing low-cost, 3D-printing manufacturing free design and the feasibility to be integrated with other optical devices on the same plastic planar support, thus opening undisclosed future for the optical sensor systems.

scholarly journals 3D-printing on textiles – an investigation on adhesion properties of the produced composite materials

2021 ◽  
Vol 28 (6) ◽  
Author(s):  
Maryna Gorlachova ◽  
Boris Mahltig
Keyword(s):  
3D Printing ◽  
Adhesive Properties ◽  
Adhesion Properties ◽  
Practical Applications ◽  
3D Print ◽  
3D Objects ◽  
Textile Fabrics ◽  
Polylactide Acid ◽  
Polyamide 6.6 ◽  
Textile Sector

AbstractThe actual paper is related to adhesive properties of 3D objects printed on cotton textile fabrics. For practical applications of 3D prints in the textile sector, the adhesion of the printed object on the textile substrate is an important issue. In the current study, two different types of polymers are printed on cotton – polylactide acid (PLA) and polyamide 6.6 (Nylon). Altogether six cotton fabrics differing in structure, weight and thickness are evaluated. Also, the effect of washing and enzymatic desizing is investigated. For printing parameters, best results are gained for elevated process temperatures, intermediate printing speed and low Z-distance between printing head and substrate. Also, a textile treatment by washing and desizing can improve the adhesion of an afterwards applied 3D print. The presented results are quite useful for future developments of 3D printing applications on textile substrates, e.g. to implement new decorative features or protective functions.

scholarly journals 3D Printed Imaging Platform for Portable Cell Counting

The Analyst ◽  
2021 ◽  
Author(s):  
Diwakar M. Awate ◽  
Cicero C. Pola ◽  
Erica Shumaker ◽  
Carmen L Gomes ◽  
Jaime Javier Juarez
Keyword(s):  
3D Printing ◽  
Point Of Care ◽  
Cost Effective ◽  
Cell Counting ◽  
Biomedical Sciences ◽  
Widespread Application ◽  
Resource Limited ◽  
Cost Effective Approach ◽  
3D Printed

Despite having widespread application in the biomedical sciences, flow cytometers have several limitations that prevent their application to point-of-care (POC) diagnostics in resource-limited environments. 3D printing provides a cost-effective approach...

scholarly journals Voronoi diagram and Monte-Carlo simulation based finite element optimization for cost-effective 3D printing

2021 ◽  
Vol 50 ◽  
pp. 101301
Author(s):  
A.Z. Zheng ◽  
S.J. Bian ◽  
E. Chaudhry ◽  
J. Chang ◽  
H. Haron ◽  
...  
Keyword(s):  
Monte Carlo Simulation ◽  
Finite Element ◽  
Monte Carlo ◽  
3D Printing ◽  
Voronoi Diagram ◽  
Cost Effective ◽  
Simulation Based

scholarly journals 3D Printed Microfluidic Devices for Drug Release Assays

Pharmaceutics ◽  
2020 ◽  
Vol 13 (1) ◽  
pp. 13
Author(s):  
Benzion Amoyav ◽  
Yoel Goldstein ◽  
Eliana Steinberg ◽  
Ofra Benny
Keyword(s):  
3D Printing ◽  
Drug Release ◽  
Particle Production ◽  
Cost Effective ◽  
Drug Dissolution ◽  
Cytotoxicity Test ◽  
High Durability ◽  
One Step ◽  
Cost Effective Alternative ◽  
Multiple Recycling

Microfluidics research for various applications, including drug delivery, cell-based assays and biomedical research has grown exponentially. Despite this technology’s enormous potential, drawbacks include the need for multistep fabrication, typically with lithography. We present a one-step fabrication process of a microfluidic chip for drug dissolution assays based on a 3D printing technology. Doxorubicin porous and non-porous microspheres, with a mean diameter of 250µm, were fabricated using a conventional “batch” or microfluidic method, based on an optimized solid-in-oil-in-water protocol. Microspheres fabricated with microfluidics system exhibited higher encapsulation efficiency and drug content as compared with batch formulations. We determined drug release profiles of microspheres in varying pH conditions using two distinct dissolution devices that differed in their mechanical barrier structures. The release profile of the “V” shape barrier was similar to that of the dialysis sac test and differed from the “basket” barrier design. Importantly, a cytotoxicity test confirmed biocompatibility of the printed resin. Finally, the chip exhibited high durability and stability, enabling multiple recycling sessions. We show how the combination of microfluidics and 3D printing can reduce costs and time, providing an efficient platform for particle production while offering a feasible cost-effective alternative to clean-room facility polydimethylsiloxane-based chip microfabrication.

Sustainability Analysis of Prototyping Processes

2017 ◽  
Vol 867 ◽  
pp. 290-293 ◽  
Author(s):  
Kandasamy Jayakrishna ◽  
P. Sanjay Guar ◽  
R. Senthilkumar ◽  
Nagarajan Aathis
Keyword(s):  
3D Printing ◽  
Quality Function Deployment ◽  
Model Building ◽  
Material Selection ◽  
Cost Effective ◽  
Vital Role ◽  
Poly Lactic Acid ◽  
Cnc Milling ◽  
Sustainability Analysis ◽  
Solid Works

Development of prototypes draws major focus in contemporary manufacturing organisations. Sustainability analysis and comparison of the prototype manufacturing process plays a vital role in deciding the sustainability level of the product. Sustainability of prototyping depends on model building material and model building process. In this paper based on the customer requirements, Environmental Conscious Quality Function Deployment (ECQFD) was carried out. Increased lives, strength, reduced toxicity of material with biodegradability were the major outputs of ECQFD. Cambridge Engineering Selector (CES) and Grey Relation Analysis (GRA) were used for material selection. Wood, ABS, Poly Lactic acid (PLA) and Lead were selected as cost efficient materials for the case product. A CAD model of the case product was developed and subjected to Life Cycle Analysis (LCA) using solid works sustainability express for the above materials. Prototypes of the case products where produced by wood carving, casting, CNC Milling and 3D printing by considering all input parameters required across each process. LCA was conducted using GaBi for the above process and the results were compared. From this study, it was observed that the case product developed using PLA with 3D printing technology had very less impact on environment and is considered as the best and cost effective prototyping method.

Effect of copper or carbon fiber addition to the 3D printing of polylactid samples

2020 ◽  
Vol 62 (7) ◽  
pp. 727-732
Author(s):  
L. Zárybnická ◽  
D. Machová ◽  
K. Dvořák
Keyword(s):  
3D Printing ◽  
Fused Deposition Modeling ◽  
Depth Of Field ◽  
3D Print ◽  
Fused Deposition ◽  
Printing Quality ◽  
Digital Microscope ◽  
Effect Of Copper ◽  
The Right

Abstract This paper presents the effect of additives on the quality of a product created by 3D print. The product is created by the most widely used 3D printing method - Fused Deposition Modeling (FDM). Polylactic acid (PLA) filaments are tested without and with the addition of carbon fibers or copper. The specimens are characterized by different methods, such as mechanical testing, measuring roughness by digital microscope with a large depth of field and thermal analysis. In fact, FDM is a problematic process with numerous criterions that affect printing quality. Printing parameters such as print temperature, pad temperature, print speed for 3D printing, printing orientation etc. have an important impact on the performance and quality of FDM components. Due to the correct parameters, the product of the required quality with a longer service life is obtained. The results of testing show that the quantity and choice of the right ingredient has a major impact on the mechanical properties and overall quality of the investigated product.

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