Stem Cells From Human Exfoliated Deciduous Teeth Attenuate Trigeminal Neuralgia in Rats By Inhibiting Endoplasmic Reticulum Stress
Abstract The treatment of trigeminal neuralgia remains a challenging issue. Stem cells from human exfoliated deciduous teeth (SHED) provide optimized therapy for chronic pain. This study aimed to investigate the mechanisms underlying the attenuation of trigeminal neuralgia by SHED. Our findings showed that local transplantation of SHED could relieve trigeminal neuralgia in rats. Further, transmission electron microscopy revealed swelling of endoplasmic reticulum in rats with trigeminal neuralgia. Moreover, SHED inhibited the tunicamycin-induced up-regulated expression of Bip mRNA and protein in vitro. Additionally, SHED decreased the up-regulated expression of Caspase12 mRNA and protein in the trigeminal ganglion of rats caused by trigeminal neuralgia after chronic constriction injury of the infraorbital nerve mode. Our findings demonstrated that SHED could alleviate pain by relieving endoplasmic reticulum stress which provide potential basic evidence for clinical pain treatment.