scholarly journals Risk factors for rapid axial length elongation with low concentration atropine for myopia control

2020 ◽  
Author(s):  
Aicun Fu ◽  
Fiona Stapleton ◽  
Li Wei ◽  
Weiqun Wang ◽  
Bingxin Zhao ◽  
...  
Keyword(s):  
Axial Length ◽  
Multivariate Regression ◽  
Pupil Diameter ◽  
Anterior Chamber Depth ◽  
Control Treatment ◽  
Spherical Equivalent ◽  
Regression Analyses ◽  
Atropine Treatment ◽  
Univariate Analyses ◽  
Myopia Control

Abstract Three hundred and twenty-eight myopic children, randomized to use either 0.01% (N=166) or 0.02% (N=162) atropine were enrolled in this study. Gender, age, body mass index(BMI), parental myopia status, atropine concentration used, pupil diameter, amplitude of accommodation, spherical equivalent refractive error (SER), anterior chamber depth (ACD) and axial length (AL) were collected at baseline and 1 year after using atropine. Rapid AL elongation was defined as >0.36 mm growth per year. Univariate analyses showed that children with rapid AL elongation tend to be younger, have a smaller BMI, use of 0.01% atropine, narrow ACD, lower SER, shorter AL, smaller change in pupil diameter between 1 year and baseline (all P < 0.05). Multivariate regression analyses confirmed that rapid AL elongation was associated with children that were younger at baseline (P < 0.0001), use of 0.01% atropine (P = 0.04), a shorter baseline AL (P = 0.03) and a smaller change in pupil diameter between 1 year and baseline (P = 0.04). Younger children with shorter AL at baseline, less change in their pupil diameter with atropine treatment and using the lower of the two atropine concentrations may undergo rapid AL elongation over a 12 months myopia control treatment period.

scholarly journals Risk factors for rapid axial length elongation with low concentration atropine for myopia control

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Aicun Fu ◽  
Fiona Stapleton ◽  
Li Wei ◽  
Weiqun Wang ◽  
Bingxin Zhao ◽  
...  
Keyword(s):  
Axial Length ◽  
Pupil Diameter ◽  
Anterior Chamber Depth ◽  
Control Treatment ◽  
Spherical Equivalent ◽  
Regression Analyses ◽  
Multivariate Logistic Regression ◽  
Atropine Treatment ◽  
Univariate Analyses ◽  
Myopia Control

AbstractThree hundred and twenty-eight myopic children, randomized to use either 0.01% (N = 166) or 0.02% (N = 162) atropine were enrolled in this study. Gender, age, body mass index(BMI), parental myopia status, atropine concentration used, pupil diameter, amplitude of accommodation, spherical equivalent refractive error (SER), anterior chamber depth (ACD) and axial length (AL) were collected at baseline and 1 year after using atropine. Rapid AL elongation was defined as > 0.36 mm growth per year. Univariate analyses showed that children with rapid AL elongation tend to be younger, have a smaller BMI, use of 0.01% atropine, narrow ACD, lower SER, shorter AL, smaller change in pupil diameter between 1 year and baseline (all P < 0.05). Multivariate logistic regression analyses confirmed that rapid AL elongation was associated with children that were younger at baseline (P < 0.0001), use of 0.01% atropine (P = 0.04), a shorter baseline AL (P = 0.03) and a smaller change in pupil diameter between 1 year and baseline (P = 0.04). Younger children with shorter AL at baseline, less change in their pupil diameter with atropine treatment and using the lower of the two atropine concentrations may undergo rapid AL elongation over a 12 months myopia control treatment period.

scholarly journals A calculator proposal for estimating refractive error after 3 years using the onset biometric values in primary school children: a cohort study

2021 ◽  
Author(s):  
Feride Tuncer Orhan ◽  
Haluk Huseyin Gürsoy
Keyword(s):  
Primary School ◽  
Anterior Chamber ◽  
Refractive Error ◽  
Axial Length ◽  
Anterior Chamber Depth ◽  
Primary School Children ◽  
Optical Parameters ◽  
Spherical Equivalent ◽  
Final Data ◽  
The Mean

Aim To evaluate consecutive measurements of the biometric parameters, age, and refraction error in a Turkish population at primary school age. Materials and Methods A total of 197 children aged between 7-12 years were included. The data of three consecutive measurements of children, who were examined at least once a year for three years using both cycloplegic auto-refractometry and optical biometry, were used in this retrospective study. Spherical equivalent <-0.50D was considered to be myopic; >+0.75D was considered to be hypermetropic. Age, gender, body mass index, spherical equivalent, axial length, anterior chamber depth, central corneal thickness, keratometry, and lens thickness were analyzed. The onset data obtained in 2013 whereas, the final data were from 2015. Logistic and Cox regression analyses were performed (p<0.05). Results The mean of the onset and the final spherical equivalents were 0.19D (0.56), and 0.08D (0.80), respectively. The myopia prevalence was increased among refractive errors in observation periods (univariable analysis p=0.029; multivariable analysis p=0.017). The onset axial length (HR:4.55, 95%CI:2.87-7.24, p<0.001), keratometry (HR:2.04, 95%CI:1.55-2.67, p<0.001) and age (HR:0.73, 95%CI: 0.57-0.92, p=0.009) correlated myopia progression. To calculate the estimated spherical equivalent, the onset data were included in the logistic regression model. The onset data of spherical equivalent (β=0.916, p<0.001), axial length (β=-0.451, p<0.001), anterior chamber depth (β=0.430, p=0.005) and keratometry (β=-0.172, p<0.001) were found to be significantly associated with the mean SE at the final data. Conclusions To calculate the estimated spherical equivalent following three years, an equation was proposed. The estimated refractive error of children can be calculated by using the proposed equation with the associated onset optical parameters.

scholarly journals Longitudinal changes in axial length in high myopia: a 4-year prospective study

2019 ◽  
Vol 104 (5) ◽  
pp. 600-603 ◽  
Author(s):  
Min Woo Lee ◽  
Seong-Eun Lee ◽  
Hyung-Bin Lim ◽  
Jung-Yeul Kim
Keyword(s):  
Axial Length ◽  
Mixed Models ◽  
High Myopia ◽  
Anterior Chamber Depth ◽  
Control Group ◽  
Longitudinal Changes ◽  
Corrected Visual Acuity ◽  
Consistent Increase ◽  
Univariate Analyses ◽  
Ophthalmic Disease

AimTo determine the longitudinal changes in the axial length (AL) in patients with high myopia without any other ophthalmic diseaseMethodsParticipants were divided into two groups: a high myopia group (60 eyes) without myopic degeneration, such as chorioretinal atrophy or posterior staphyloma, and a control group (60 eyes). Both groups were further divided into subgroups according to the AL: subgroup 1 (≥27.5 mm), subgroup 2 (26.0–27.5 mm), subgroup 3 (24.5–26.0 mm) and subgroup 4 (<24.5 mm). The ALs were measured five times at 1-year interval using an IOL master, and the AL was fitted with linear mixed models.ResultsIn the high myopia group, the AL showed a relatively constant increase at each visit, and they were significantly different with previous measurements at most visits, whereas the control group showed no significant change of AL. Subgroups 1,2 and 3 showed significant changes in AL over time (0.064, 0.032 and 0.012 mm/y, respectively). In univariate analyses, age, best-corrected visual acuity, baseline AL and anterior chamber depth were significantly correlated with changes in the AL in the high myopia group. In multivariate analysis, only baseline AL remained significant (p<0.001).ConclusionsMyopic eyes, including moderately myopic eyes, showed a consistent increase in AL over 4 years, and eyes with a longer baseline AL showed a greater increase in AL than eyes with a shorter AL.

scholarly journals Ocular Biometrics of Vietnamese Young Adults with Myopia

2019 ◽  
Vol 7 (24) ◽  
pp. 4283-4286
Author(s):  
Hien Thi Thu Nguyen ◽  
Dung Thi Thanh Nguyen ◽  
Dong Ngoc Pham ◽  
Anh Phuong Tran ◽  
Do Quyet ◽  
...  
Keyword(s):  
Anterior Chamber ◽  
Axial Length ◽  
Pearson Correlation ◽  
Anterior Chamber Depth ◽  
Spherical Equivalent ◽  
Central Cornea ◽  
Spherical Equivalent Refraction ◽  
Cornea Thickness ◽  
Central Cornea Thickness ◽  
Biometric Indices

BACKGROUND: Myopia is most prevalent type of refraction error. In some Asian countries, the prevalence of myopia can be 80 – 90% in the population aged 17 – 18. AIM: To analyze the correlation between ocular biometric indices and refraction status in Vietnamese young myopes. METHODS: A prospective cross – section study was conducted in young myopes. Data on axial length, central cornea thickness, corneal topography & anterior chamber depth and spherical equivalent were collected. Independent Sample T Test and ANOVA test were used to compare between groups. The correlations between ocular biometry and myopic spherical equivalent refraction were examined by Pearson Correlation with the level of significance p < 0.05. RESULTS: Totally, 418 eyes from 209 patients were recruited. The average axial length, central cornea thickness, cornea refraction & anterior chamber depth were 25.68 ± 1.09 mm, 539.78 ± 32.665 µm, 43.16 ± 1.369 D, 3.30 ± 0.243 mm, respectively. The correlation between axial length and spherical equivalent refraction (SER) was high (r = - 0.742, p < 0.0001) while those between central cornea thickness and cornea refraction were negligible (r = - 0.107, p = 0.029; r = -0.123, p = 0.012; respectively). There was no correlation between anterior chamber depth and spherical equivalent refraction (r = 0.019, p = 0.697). CONCLUSION: Among ocular biometric indices, axial length was significantly correlated with spherical equivalent of young adult patients.

Chronological changes of the anterior chamber structure, axial length, and refraction in patients with Vogt–Koyanagi–Harada disease

2020 ◽  
pp. 112067212090203
Author(s):  
Tetsuya Muto ◽  
Shigeki Machida
Keyword(s):  
Visual Acuity ◽  
Anterior Chamber ◽  
Axial Length ◽  
Anterior Chamber Depth ◽  
Pulse Treatment ◽  
Spherical Equivalent ◽  
Foveal Thickness ◽  
Steroid Pulse ◽  
Corrected Visual Acuity ◽  
Best Corrected Visual Acuity

Purpose: To clarify the chronological changes in the anterior chamber structure and identify the spherical equivalent and axial length to assess the effects of steroid pulse treatment in patients with Vogt–Koyanagi–Harada disease with active uveitis. Methods: The anterior chamber condition, including anterior chamber volume, central anterior chamber depth, peripheral anterior chamber depth, anterior chamber angle, and pupil diameter, was measured using Pentacam, and axial length was measured using IOLMaster in patients with Vogt–Koyanagi–Harada disease between June 2015 and February 2018. Furthermore, the best-corrected visual acuity, spherical equivalent, and retinal foveola thickness were also analyzed. All patients were treated with steroid pulse. All these factors were compared before and at 1 and 6 months of treatment. Results: Significant changes were observed in the anterior chamber volume, central anterior chamber depth, peripheral anterior chamber depth, anterior chamber angle, axial length, best-corrected visual acuity, spherical equivalent, and retinal foveal thickness before and at 1 and 6 months of steroid pulse treatment ( P < 0.001, P < 0.001, P < 0.001, P = 0.0015, P = 0.027, P < 0.001, P = 0.0043, and P < 0.001, respectively). No significant difference was observed in the pupil diameter before and at 1 month and 6 months of steroid pulse treatment ( P = 0.11). Conclusion: The anterior chamber structure, axial length, best-corrected visual acuity, spherical equivalent, and retinal foveal thickness were dramatically changed by steroid pulse treatment in patients with Vogt–Koyanagi–Harada disease who develop active uveitis. These changes were completed within 1 month.

scholarly journals Renal Dysfunction Is an Independent Risk Factor for Poor Outcome in Acute Ischemic Stroke Patients Treated with Intravenous Thrombolysis: A New Cutoff Value

2017 ◽  
Vol 2017 ◽  
pp. 1-6
Author(s):  
Elyar Sadeghi-Hokmabadi ◽  
Demet Funda Baş ◽  
Mehdi Farhoudi ◽  
Aliakbar Taheraghdam ◽  
Daryoush Savadi Oskouei ◽  
...  
Keyword(s):  
Renal Dysfunction ◽  
Multivariate Regression ◽  
Independent Risk Factor ◽  
Intravenous Thrombolysis ◽  
Control Group ◽  
Regression Analyses ◽  
Stroke Patients ◽  
Poor Outcome ◽  
Symptomatic Intracerebral Hemorrhage ◽  
Univariate Analyses

Objective. This study was set to assess the effect of renal dysfunction on outcome of stroke patients treated with intravenous thrombolysis (IVT). Methods. This multicenter research involved 403 patients from January 2009 to March 2015. Patients were divided into two groups: (1) control group with GFR ≥ 45 mL/min/1.73 m2 and (2) low GFR group with GFR < 45 mL/min/1.73 m2. Outcome measurements were poor outcome (mRS 3–6) and mortality at 3 months and symptomatic intracerebral hemorrhage (SICH) within the first 24–36 hours. Univariate and multivariate regression analyses were performed, and odds ratios (ORs) were determined at 95% confidence intervals (CIs). Results. Univariate analyses determined that every decrease of GFR by 10 mL/min/1.73 m2 significantly increased the risk of poor outcome (OR 1.19, 95% CI 1.09–1.30, p<0.001) and mortality (OR 1.18, 95% CI 1.06–1.32, p=0.002). In multivariate regression, adjusted for all variables with p value < 0.1, low GFR (GFR < 45 versus GFR equal to or more than 45) was associated with poor outcome (OR adjusted 2.15, 95% CI 1.01–4.56, p=0.045). Conclusion. In IVT for acute stroke, renal dysfunction with GFR < 45 mL/min/1.73 m2 before treatment determined increased odds for poor outcome compared to GFR of more than 45 mL/min/1.73 m2.

scholarly journals Pupil barycenter configuration in patients with myopia and hyperopia

2021 ◽  
Author(s):  
Hacı Koç ◽  
Faruk Kaya
Keyword(s):  
Prospective Study ◽  
Pupil Diameter ◽  
Anterior Chamber Depth ◽  
Spherical Equivalent ◽  
Distance Measurements ◽  
Low Coherence ◽  
Significant Difference ◽  
Spherical Equivalent Refraction ◽  
Thickness Measurements ◽  
Optical Low Coherence Reflectometry

Abstract Purpose To compare the pupil barycenter configurations that can be used to calculate the kappa angle in terms of distance in patients with myopia and hyperopia. Method : This prospective study evaluated 394 eyes of 197 patients. The patients were divided into two groups according to their spherical equivalent values: the myopic group (mean spherical equivalent refraction < − 0.50 D) and the hyperopia group (mean spherical equivalent refraction > + 0.50 D). The two groups were further subdivided according to severity (myopic group: mild, <−0.50 and ≤ − 3.00 D; moderate, <−3.00 and ≤ − 6.00 D; severe, <−6.00 D; hyperopic group: mild, ≥+0.50 and ≤ + 2.00 D; moderate, >+2.00 and ≤ + 4.00 D; severe, >+4.00 D). The pupil and iris barycenter distance measurements and other parameters were obtained through optical low-coherence reflectometry. Results Of the 197 patients, 109 (55.3%) were female and 88 (44.7%) were male, and their age ranged from 7 to 60 years (mean, 35.16 ± 14.75 years). The average pupil barycenter measurements originating from the kappa angle distances were 0.38 ± 0.15 and 0.21 ± 0.11 mm in patients with hyperopia and myopia, respectively. Corneal and lens thickness measurements were higher in patients with hyperopia, whereas anterior chamber depth and pupil diameter measurements were higher in patients with myopia. No significant difference in astigmatism or white-to-white measurements was observed between patients with hyperopia and those with myopia. Conclusion The kappa angle distances are higher in hyperopia than in myopia. The pupil barycenter measurement from the kappa angle distance can be an alternative for the evaluation of the kappa angle.

Axial Length and White to White Corneal Diameter in Eyes with Keratoconus

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Omnia Talaat Abd elwahab ◽  
Dina Ezzat Mansour ◽  
Maged Maher Salib Roshdy ◽  
Ahmed Taha Ismail ◽  
Omnia Talaat Abd elwahab
Keyword(s):  
Axial Length ◽  
Corneal Thickness ◽  
Anterior Chamber Depth ◽  
Normal Group ◽  
Control Group ◽  
Spherical Equivalent ◽  
Lens Thickness ◽  
Significant Difference ◽  
The Mean ◽  
Corneal Diameter

Abstract Objective To study the axial length (AL) and white to white (WTW) corneal diameter in keratoconus (KC) eyes and compare them to normal eyes. Methods Sixty-three eyes of 53 patients were included in this cross-sectional observational study divided into KC group comprised of 28 eyes of 18 patients and control group comprised of 35 eyes of 35 patients based on clinical and tomographic findings. All subjects were examined using rotating Scheimpflug corneal tomography (Pentacam HR; Oculyzer II) for central corneal thickness (CCT), thinnest corneal thickness (TCT), keratometric values, anterior chamber depth (ACD) and lens thickness, and by optical biometry (IOLMaster 500) for axial length (AL) measurements. Vitreous cavity length (VCL) was calculated by subtracting the values of CCT, ACD (internal), and lens thickness from the AL. White to white (WTW) corneal diameter was measured using Placido-based tomography (Topolyzer VARIO). Results The mean age was 31.27±8.65 years(30.39 ± 9.31) in the KC group and .(31.74 ± 8.38) in the non KC group. The KC group included 28 eyes their mean spherical equivalent (SE) was -3.16 ± 2.42 and the control group 35 healthy eyes including 23 ametropic eyes with mean spherical equivalent (SE) (-3.95±4.50 D) and 12 emmetropic eyes with mean SE (-0.19±0.40 D). The mean VCL was significantly greater in normal eyes (17.45 ±1.34 mm) compared with KC (16.77±1.18 mm) (P = 0.037), while the mean ACD (internal) was significantly greater in KC eyes compared to normal (P = 0.020) and the lens thickness showed no statistically significant difference. The greater VCL in the normal group was compensated by the greater ACD in the KC group causing the total AL to have no statistically significant difference (normal eyes =24.44 ±1.38 mm and KC eyes= 24.21 ±1.31 mm) (P = 0.513). There was no statistically significant difference in the WTW corneal diameter between KC and normal eyes (11.81 ±0.35 mm in the normal group compared to 11.79 ±0.35 mm in the KC group) (P = 0.835). Conclusion VCL was significantly greater in normal eyes compared with those eyes with KC. AL and WTW showed no difference between the two groups.

scholarly journals Safety and efficacy of 0.02% and 0.01% atropine on controlling myopia progression: a 2-year clinical trial

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Can Cui ◽  
Xiujuan Li ◽  
Yong Lyu ◽  
Li Wei ◽  
Bingxin Zhao ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Refractive Error ◽  
Pupil Diameter ◽  
Control Group ◽  
Spherical Equivalent ◽  
Myopia Progression ◽  
Safety And Efficacy ◽  
Single Vision ◽  
And Control ◽  
Myopia Control

AbstractFour hundred myopic children randomly received atropine 0.02% (n = 138) or 0.01% (n = 142) in both eyes once-nightly or only wore single-vision spectacles (control group) (n = 120) for 2 years. Spherical equivalent refractive error (SER), axial length (AL), pupil diameter (PD), and amplitude of accommodation (AMP) were measured every 4 months. After 2 years, the SER changes were − 0.80 (0.52) D, − 0.93 (0.59) D and − 1.33 (0.72) D and the AL changes were 0.62 (0.29) mm, 0.72 (0.31) mm and 0.88 (0.35) mm in the 0.02% and 0.01% atropine groups and control group, respectively. There were significant differences between changes in SER and AL in the three groups (all P < 0.001). The changes in SER and AL in the 2nd year were similar to the changes in the 1st year in the three groups (all P > 0.05). From baseline to 2 years, the overall decrease in AMP and increase in PD were not significantly different in the two atropine groups, whereas the AMP and PD in the control group remained stable (all P > 0.05). 0.02% atropine had a better effect on myopia control than 0.01% atropine, and its effects on PD and AMP were similar to 0.01% atropine. 0.02% or 0.01% atropine controlled myopia progression and AL elongation synchronously and had similar effects on myopia control each year.

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