scholarly journals Risk Factors for Placental Malaria, Sulfadoxine-pyrimethamine Doses, and Birth Outcomes in a Rural to Urban Prospective Cohort Study on the Bandiagara Escarpment and Bamako, Mali

2022 ◽  
Author(s):  
Claudius Vincenz ◽  
Zachary Dolo ◽  
Serou Saye ◽  
Jennie Lovett ◽  
Richard W. Lieberman ◽  
...  
Keyword(s):  
Cohort Study ◽  
Birth Weight ◽  
Primary School ◽  
Birth Outcomes ◽  
Placental Malaria ◽  
School Education ◽  
Placental Weight ◽  
Birth Length ◽  
Longitudinal Cohort ◽  
Hot Dry Season

Abstract BackgroundMalaria in Mali remains a primary cause of morbidity and mortality, with women at high risk during pregnancy for placental malaria (PM). We evaluated risk for PM and its association with birth outcomes in a rural to urban longitudinal cohort on the Bandiagara Escarpment and the District of Bamako. MethodsWe collected placental samples (N = 317) from 249 mothers who were participants in our longitudinal cohort study. A placental pathologist and research assistant evaluated the samples by histology in blinded fashion to assess PM infection stage and parasite density. We used generalized estimating equations (GEE) to model the odds of PM infection.ResultsPregnancies in Bamako, beyond secondary education, births in the rainy season (instead of the hot dry season), births in later years of the study, and births to women who had > 3 doses of sulfadoxine-pyrimethamine (SP) instead of no doses of SP were associated with reduced odds of experiencing PM (active and past infections combined). We found improved birth outcomes (+ 285 g birth weight, + 2 cm birth length, + 75 g placental weight) for women who had > 3 doses of SP compared to no doses, but did not detect a difference in birth weight or length for women who had 2 instead of > 3 SP doses. However, at 2 instead of > 3 doses placentas were 36 g lighter and the odds of low birth weight (< 2500 g) were 14% higher. Severe parasite densities were significantly associated with decreases in birth weight, birth length, and placental weight, as were chronic PM infections. The women who received no SP during pregnancy (7% of the study total) were younger and lacked primary school education. The women who received ≥ 3 doses of SP came from more affluent families.ConclusionsWomen who received no doses of SP during pregnancy experienced the most disadvantageous birth outcomes in both Bamako and on the Bandiagara Escarpment. Such women tended to be younger and to have had no primary school education. Targeting such women for antenatal care, which is the setting at which SP is most commonly administered in Mali, will have a more positive impact on public health than focusing on the increment from two to three doses of SP.

scholarly journals Associations of maternal caffeine intake with birth outcomes: results from the Lifeways Cross Generation Cohort Study

2018 ◽  
Vol 108 (6) ◽  
pp. 1301-1308 ◽  
Author(s):  
Ling-Wei Chen ◽  
Roisin Fitzgerald ◽  
Celine M Murrin ◽  
John Mehegan ◽  
Cecily C Kelleher ◽  
...  
Keyword(s):  
Cohort Study ◽  
Birth Weight ◽  
Birth Outcomes ◽  
Gestational Age ◽  
Birth Length ◽  
Caffeine Intake ◽  
Adverse Birth Outcomes ◽  
Dietary Intakes ◽  
Never Smokers ◽  
Adjusted Model

ABSTRACT Background Maternal caffeine intake is associated with adverse birth outcomes, but in most studies the primary caffeine source is coffee; the influence of tea caffeine remains unclear. Objective The aim of the study was to examine the association between maternal caffeine intake and birth outcomes in a population with tea as the predominant caffeine source. Design Data from 941 Irish mother-child pairs of the Lifeways Cross Generation Cohort Study were examined. Maternal dietary intakes in early pregnancy were assessed using a validated food-frequency questionnaire. Caffeine intake was derived from coffee, tea, soft drinks, and cocoa-containing foods and beverages. Associations of maternal caffeine intake with continuous (birth weight, birth length, and gestational age) and binary [low birth weight (LBW) (<2500 g) and preterm birth (PB) (<37 wk gestational age)] birth outcomes were investigated using multiple linear and logistic regressions, respectively, with adjustment for potential confounders. Results Tea was the predominant caffeine source (48%), followed by coffee (39%). In the fully adjusted model, maternal caffeine intake was associated with lower birth weight [β (95% CI): −71.9 (−105.4, −38.4) g · 100 mg–1 · d–1 caffeine increment], shorter birth length [−0.30 (−0.49, −0.11) cm], smaller head circumference [−0.12 (−0.24, −0.01) cm], and shorter gestational age [−0.13 (−0.25, −0.02) wk]; higher risks for LBW [OR (95% CI): 1.47 (1.14, 1.90)] and PB [1.36 (1.07, 1.74)] were also observed (all P < 0.05). The associations were robust to the exclusion of participants with pregnancy complications and in never smokers. Similar higher risks of adverse birth outcomes were observed for the highest caffeine intake categories from coffee [ORLBW: 3.10 (1.08, 8.89); ORPB: 2.74 (1.05, 7.16)] and tea [ORLBW: 2.47 (1.02, 6.01); ORPB: 2.56 (1.14, 5.75)], compared with the lowest intake categories (all P < 0.05). Conclusions Maternal caffeine intake from both coffee and tea is associated with adverse birth outcomes. This prospective observational study was registered at ISRCTN Registry as ISRCTN16537904.

O-221 Stage and morphology of the competent blastocyst are associated with pregnancy and birth outcomes; a multicenter cohort study

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
M L Groendahl ◽  
M. Buhl Borgstrøm ◽  
U. Schiøler Kesmodel
Keyword(s):  
Cohort Study ◽  
Birth Weight ◽  
Preterm Birth ◽  
Birth Outcomes ◽  
Gestational Age ◽  
Blastocyst Transfer ◽  
Singleton Pregnancy ◽  
Child Weight ◽  
Single Blastocyst Transfer ◽  
Pregnancy And Birth

Abstract Study question Do stage and morphology of the competent blastocyst associate with initial hCG rise, gestational age, preterm birth, child birth weight, length, and child sex? Summary answer Higher stage, TE- and ICM-scores associated with higher hCG-rise; ICM- and TE-scores associated with length at birth, and higher stage and TE-score associated with boys. What is known already Many studies have focused on the developmental stage and morphology of the blastocysts in order to find biomarkers of competence to improve the efficacy of assisted reproduction technology treatment. In contrast, the associations between blastocyst assessment score parameters (individually or by combined score) and perinatal outcome have only been reported in few and smaller single center studies, and conflicting results have been presented. In the present study, we focused on the in vitro cultured blastocyst leading to a live birth and how the stage and morphology of these competent blastocysts relate to implantation and birth outcomes. Study design, size, duration Multicenter historical cohort study based on exposure (blastocyst stage (1-6) and morphology (trophectoderm (TE) and inner cell mass (ICM): A,B,C)) and outcome data (serum human chorionic gonadotrophin (hCG), gestational age, preterm birth, child weight, length, and sex) from women undergoing single blastocyst transfer resulting in singleton pregnancy and birth. Data from 16 private and university-based facilities for clinical services and research from 2014 to 2018 was included. Participants/materials, setting, methods 7246 women, who underwent ovarian stimulation or Frozen-thawed-Embryo-Transfer with single blastocyst transfer resulting in singleton pregnancy were identified. Linking to the Danish Medical Birth Registry resulted in a total of 4842 women with live birth being included. Initial serum hCG value (IU/L) (11 days after transfer), gestational age (days), preterm birth (%) child weight (grams), length (cm) and sex. The analyses were adjusted for female age, BMI, smoking, center, diagnosis, parity, gestational age and sex. Main results and the role of chance Higher mean initial hCG was consistently positively associated with higher developmental stage (p &lt; 0.001), TE (p &lt; 0.001) and ICM score (p = 0.02); for stage 6, TE (A) and ICM (A): 508.4, 436.5 and 428.5 IU/L, respectively. No differences between blastocyst morphology (stage, TE, ICM), gestational age (mean 276.6 days), preterm birth (8.3%) and birth weight (mean 3461.7 gram) were statistically significant. While stage showed no association with length at birth (mean 51.6 cm), length at birth between blastocysts with a TE score C and a TE score A were statistically significant (mean difference 0.5 cm (0.07;0.83)) as was the length at birth between blastocysts with an ICM score B and C compared to score A, mean differences respectively 0.2 cm (0.02;0.31) and 0.5 cm (0.03;0.87). Stage and TE, but not ICM were associated with the sex of the child. Blastocysts transferred with stage score 5 compared to blastocysts transferred with score 3 had a 33% increased probability of being a boy (OR 1.33 (1.08;1.64)). Further, TE score B blastocysts compared to TE score A blastocysts had a 28% reduced probability of being a boy (OR 0.72 (0.62;0.82)). Limitations, reasons for caution The assessment scores of the blastocystś stage and morphology were based on subjective evaluation, and information bias may have influenced the results. By adjusting for center, we took the potential variation in scoring between clinics into considerations. Wider implications of the findings Stage and morphology of the competent blastocyst was associated with initial hCG rise suggesting an effect on implantation, which may be used in routine, everyday information to women and couples on the day of blastocyst transfer. Trial registration number j.nr.: VD-2018-282

Is hyperemesis gravidarum associated with placental weight and the placental weight-to-birth weight ratio? A population-based Norwegian cohort study

Placenta ◽  
2013 ◽  
Vol 34 (11) ◽  
pp. 990-994 ◽  
Author(s):  
K.F. Vandraas ◽  
Å.V. Vikanes ◽  
N.C. Støer ◽  
S. Vangen ◽  
P. Magnus ◽  
...  
Keyword(s):  
Cohort Study ◽  
Birth Weight ◽  
Hyperemesis Gravidarum ◽  
Weight Ratio ◽  
Population Based ◽  
Placental Weight

scholarly journals Physical birth outcomes in neonates prenatally exposed to buprenorphine - our first experiences

2019 ◽  
Vol 147 (11-12) ◽  
pp. 724-728
Author(s):  
Natasha Simonovska ◽  
Beti Zafirova-Ivanovska ◽  
Aleksandra Babulovska
Keyword(s):  
Birth Weight ◽  
Birth Outcomes ◽  
Apgar Score ◽  
Length Of Hospital Stay ◽  
Opioid Use Disorder ◽  
Chest Circumference ◽  
Birth Length ◽  
Comprehensive Treatment ◽  
Prenatally Exposed ◽  
Opioid Use

Introduction/Objective. Buprenorphine appears generally similar to, and in some cases superior to, methadone in terms of maternal, fetal, and neonatal outcomes. The objective of the study was to assess some physical birth outcomes in neonates prenatally exposed to buprenorphine. Methods. During a seven-year period, nine patients have been treated with buprenorphine during their pregnancy. All women underwent interview, clinical investigations, biochemical analysis, toxicological screening, viral markers for hepatitis B, C, HIV, with regular check-ups by an obstetrician and a psychiatrist. Newborn outcomes included: birth weight in grams, birth length in centimeters, physical anomalies, head/chest circumference in centimeters, Apgar score at 1 minute / 5 minutes, gestational age (weeks), newborn length of hospital stay in days, breast-feeding, the newborn?s need for pharmacologic treatment after delivery. Results. The mean birth weight was 2,991.11 ? 37 g; birth length was 49.44 ? 2.29 cm; head circumference was 33.11 ? 0.78 cm; chest circumference was 32.33 ? 1 cm; first minute Apgar score was 8.22, fifth minute 9.22; age at delivery was 38.77 ? 1.09 weeks; hospitalization after delivery 4.44 ? 1.13 days. None of the newborns had physical anomalies. Six of the newborns were breastfed. Conclusion. Buprenorphine is a safe and important part of a complete comprehensive treatment approach in pregnant women with opioid use disorder. Buprenorphine treatment of maternal opioid use disorder indicated a low risk of preterm birth, normal birth weight and length, head and chest circumference, Apgar score, short hospitalization after delivery.

scholarly journals The Mediating Role of Placental Weight Change in the Association Between Prenatal Exposure to Thallium and Birth Weight: A Prospective Birth Cohort Study

2021 ◽  
Vol 9 ◽  
Author(s):  
He Zhou ◽  
Xiaoli Sun ◽  
Yiding Wang ◽  
Yufeng Ye ◽  
Hanwei Chen ◽  
...  
Keyword(s):  
Cohort Study ◽  
Birth Weight ◽  
Prenatal Exposure ◽  
Inductively Coupled Plasma ◽  
First Trimester ◽  
Placental Weight ◽  
Birth Cohort Study ◽  
Third Trimester ◽  
Mediating Role

Background: Previous studies have demonstrated the embryotoxicity and fetotoxicity of thallium (Tl). However, the effects of prenatal exposure to Tl on birth weight and placental weight and the mediating role of placental weight in the association of Tl with birth weight remain unclear.Methods: We recruited 2,748 participants from the ongoing Prenatal Environment and Offspring Health Cohort (PEOH Cohort) study, which was initiated in 2016 in Guangzhou, China. The Tl concentrations in maternal urine samples collected during the first and third trimester were determined by inductively coupled plasma mass spectrometry. Birth weight and placental weight were extracted from maternal medical records.Results: Pregnant women exposed to the highest tertile of Tl in the first trimester (β = −42.7 g, 95% CI: −82.3, −3.1 g) and third trimester (β = −50.6 g, 95% CI: −99.0, −2.3 g) had babies with lower birth weights than those exposed to the lowest tertile. We also found significant negative associations of exposure to Tl concentrations in the first and third trimester with placental weight. Mediation analyses showed that 50.3% (95% CI: 15.9, 79.2%) and 33.5% (95% CI: 1.3, 80.3%) of the effects of Tl exposure in the first and third trimester on birth weight were mediated by decreased placental weight.Conclusion: Our results suggest that prenatal exposure to Tl is negatively associated with birth weight and that this association may be mediated by decreased placental weight.

scholarly journals Gestational Diabetes Independently Increases Birth Length and Augments the Effects of Maternal BMI on Birth Weight: A Retrospective Cohort Study

2014 ◽  
Vol 2 ◽  
Author(s):  
Magdalena Byström ◽  
Anthony Liu ◽  
Ann Elizabeth Quinton ◽  
Bernard Linton Champion ◽  
Kristy Mann ◽  
...  
Keyword(s):  
Cohort Study ◽  
Birth Weight ◽  
Gestational Diabetes ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Birth Length ◽  
Maternal Bmi

scholarly journals Foetal Macrosomia and Foetal-Maternal Outcomes at Birth

2018 ◽  
Vol 2018 ◽  
pp. 1-9 ◽  
Author(s):  
Sahruh Turkmen ◽  
Simona Johansson ◽  
Marju Dahmoun
Keyword(s):  
Cohort Study ◽  
Birth Weight ◽  
Partial Pressure ◽  
Birth Outcomes ◽  
Retrospective Cohort ◽  
Normal Group ◽  
Maternal Outcomes ◽  
Perineal Tear ◽  
Delivery Outcomes ◽  
Partial Pressure Of Co2

To investigate how macrosomia affects foetal-maternal birth outcomes, we conducted a retrospective cohort study of singleton pregnant women who gave birth at gestational age ≥37+0 weeks. The patients were divided into three groups according to birth weight: “macrosomia” group, ≥4500 g, n=285; “upper-normal” group, 3500–4499 g, n=593; and “normal” group, 2500–3499 g, n=495. Foetal-maternal and delivery outcomes were compared among the three groups after adjustment for confounders. Caesarean section was more frequent in the macrosomia group than in upper-normal and normal groups. The duration of labour (p < 0.05) and postpartum care at the hospital (p < 0.001) were the highest in the macrosomia group. Increased birth weight was associated with higher risks of shoulder dystocia (p < 0.001), increased bleeding volume (p < 0.001), and perineal tear (p < 0.05). The Apgar score at 5 minutes (p < 0.05), arterial cord pH (p < 0.001), and partial pressure of O2 (p < 0.05) were lower, while the arterial cord partial pressure of CO2 was higher (p < 0.001), in the macrosomia group. Macrosomia has potentially serious impacts for neonate and mother as a result of a complicated and occasionally traumatic delivery.

scholarly journals Early registration for antenatal care was associated with improved birth outcomes in a low-income community in Harare

2020 ◽  
Author(s):  
Tonderayi Mathew Matsungo ◽  
Shingai Mudzuri ◽  
Prosper Chopera
Keyword(s):  
Birth Weight ◽  
Antenatal Care ◽  
Pregnant Women ◽  
Birth Outcomes ◽  
Head Circumference ◽  
Apgar Score ◽  
First Trimester ◽  
Birth Length ◽  
Delivery Mode ◽  
Early Registration

Abstract Background : The World Health Organization (WHO) recommends early registration, regular and consistent attendance of antenatal care (ANC) sessions for all pregnant women. Specifically, if ANC services promote evidence-based practices this improves pregnancy outcomes and reduce maternal mortality. Yet there are worrying gaps in knowledge of antenatal care services in Zimbabwe. Objectives: To determine the relationship between early registration and frequency of ANC visits on birth weight, birth length, head circumference, Apgar score, birth complications, delivery mode, preterm birth and duration of labour among women aged 15-49 from Hatcliffe Polyclinic, Harare. Methods: This was a health facility based analytical cross-sectional study. An interviewer administered questionnaire was used to collect data. Data was entered and analysed using SPSS version 20. Descriptive statistics, and associations between dependent and independent variables were determined using Pearson’s Chi-square and Fisher’s exact test. Ethical approval was granted from the Medical Research Council of Zimbabwe (MRCZ/B/1438). Results: A total of 75 mother child pairs were interviewed. Most (77.3%) had more than four ANC visits. Only 36% registered early (during first trimester). Most of the children had normal birth weight ≥2500g (80.3%), birth length ≥47cm, (76%), head circumference ≥33cm (80%), and Apgar score ≥7 (96%). A positive association was observed between number of ANC visits and birth weight [Odds ratio (OR) 7.6; 95% Confidence Interval (CI) 1.6, 36.4 (p=0.013)], birth length [OR 6.1; 95%CI 1.8, 20.1 (p=0.010)], and head circumference [OR 4.3; 95% CI 1.3, 14.8 (p=0.013)]. Positive associations were also observed between timing of registration and birth weight [OR 1.2; 95% 1.05, 1.36 (p=0.045)], birth length [OR 0.16; 95% CI 0.03, 0.76 (p=0.012)]. Conclusions: In this study increased frequency and early registration for ANC visits had a positive relationship with birth weight, birth length and head circumference. These findings show the need for improving the uptake of ANC services, early registration for ANC in the first trimester and adoption of community wide strategies to ensure that pregnant women attend all recommended visits for improved birth outcomes in this and related settings.

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