scholarly journals Neuromodulatory Mechanisms оf a Memory Loss Preventive Effect of Alpha-Lipoic Acid in an Experimental Rat Model of Dementia

2021 ◽  
Author(s):  
Hristian Staykov ◽  
Maria Lazarova ◽  
Yozljam Hassanova ◽  
Miroslava Stefanova ◽  
Lyubka Tancheva ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Lipoic Acid ◽  
Rat Model ◽  
Memory Impairment ◽  
Ache Activity ◽  
Memory Loss ◽  
Exploratory Behaviour ◽  
Alpha Lipoic Acid ◽  
Preventive Effect ◽  
The Brain

Abstract This study evaluates some of the neuromodulatory mechanisms of the memory loss preventive effect of alpha-lipoic acid (ALA) in a scopolamine (Sco)-induced rat model of an Alzheimer’s disease (AD) type dementia. Our results confirmed that Sco administration induces significant memory impairment, worsens exploratory behaviour and habituation; it increases acetylcholinesterase (AChE) activity and induces pathological monoamine content changes in the brain prefrontal cortex and hippocampus. ALA administration prevented to a large extent Sco-induced memory impairment; it also improved exploratory behaviour and preserved habituation; it decreased AChE activity, reversing it to Control group levels and corrected aberrant monoamine levels in the brain prefrontal cortex and hippocampus. According to the data available, this is the first time that ALA-induced changes in AChE and monoamine levels in the brain prefrontal cortex and hippocampus (brain structures related to learning and memory) have been demonstrated in a Sco-induced rat model of AD type dementia.

scholarly journals Oxidative Stress in 5/6 Nephrectomized Rat Model: Effect of Alpha-Lipoic Acid

Renal Failure ◽  
2012 ◽  
Vol 34 (7) ◽  
pp. 907-914 ◽  
Author(s):  
Xiaofang Yu ◽  
Hong Liu ◽  
Jianzhou Zou ◽  
Jiaming Zhu ◽  
Xunhui Xu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Lipoic Acid ◽  
Rat Model ◽  
Alpha Lipoic Acid

scholarly journals The Effect of Alpha-Lipoic Acid on Myringosclerosis in a Rat Model

2015 ◽  
Vol 10 (3) ◽  
pp. 222-227 ◽  
Author(s):  
Arzu Tatar ◽  
Ozgur Yoruk ◽  
Deniz Unal ◽  
Jale Selli ◽  
Muhammed Yayla ◽  
...  
Keyword(s):  
Lipoic Acid ◽  
Rat Model ◽  
Alpha Lipoic Acid

Chondroprotective effects of alpha-lipoic acid in a rat model of osteoarthritis

2016 ◽  
Vol 50 (7) ◽  
pp. 767-780 ◽  
Author(s):  
Ji Wang ◽  
Huijun Sun ◽  
Zhuodong Fu ◽  
Mozhen Liu
Keyword(s):  
Lipoic Acid ◽  
Rat Model ◽  
Alpha Lipoic Acid

Evaluation of Cucurbita maxima Extract against Scopolamine- Induced Amnesia in Rats: Implication of Tumour Necrosis Factor Alpha

2014 ◽  
Vol 69 (9-10) ◽  
pp. 407-417 ◽  
Author(s):  
Talha Jawaid ◽  
Ashok K. Shakya ◽  
Hefazat Hussain Siddiqui ◽  
Mehnaz Kamal
Keyword(s):  
Body Weight ◽  
Memory Impairment ◽  
Ache Activity ◽  
Seed Oil ◽  
Necrosis Factor Alpha ◽  
Tnf Α ◽  
Factor Alpha ◽  
The Brain ◽  
And Oxidative Stress ◽  
Necrosis Factor

AbstractCucurbita maxima (CM) seed oil is commonly used in Indian folk medicine to treat various ailments. We have investigated the effect of CM seed oil on memory impairment induced by scopolamine in rats. Male adult Wistar rats were administered scopolamine 1 mg/kg body weight, i.p. or 1:25 mg/kg body weight, s.c. to induce memory impairment. The nootropic agent piracetam 100 mg/kg body weight, i.p. and CM seed oil 100 and 200 mg/kg body weight, p.o. were administered daily for five consecutive days. The memory function was evaluated in the Morris water maze (MWM) test, the social recognition test (SRT), the elevated plus maze (EPM) test, and the pole climbing test (PCT). Acetylcholinesterase (AChE) activity and oxidative stress parameters were estimated in the cortex, hippocampus, and cerebellum of the brains after completion of the behavioural studies. The effects of scopolamine on the levels of the tumour necrosis factor alpha (TNF-α) transcript were also investigated. Scopolamine caused memory impairment in all the behavioural paradigms along with a significant increase in the AChE activity and oxidative stress in the brain. Scopolamine also caused a significant increase in the expression of TNF-α in the hippocampus. CM seed oil exhibited antiamnesic activity as indicated by a significant reduction in the latency time in the MWM test and decreased social interaction during trial 2 in the SRT. Further, treatment with CM seed oil significantly decreased the AChE activity and malondialdehyde levels and increased the glutathione level in brain regions. CM seed oil also significantly decreased the expression of TNF-α in the hippocampus. The effect of CM seed oil on behavioural and biochemical parameters was comparable to that observed in rats treated with piracetam. These results indicate that CM seed oil may exert antiamnesic activity which may be attributed to the inhibition of AChE and inflammation as well as its antioxidant activity in the brain.

scholarly journals Alpha lipoic acid attenuates oxidative stress-induced damage macromolecules in the brain of rats with sepsis-associated encephalopathy

Critical Care ◽  
2014 ◽  
Vol 18 (S2) ◽  
Author(s):  
LG Danielski ◽  
M Michels ◽  
D Florentino ◽  
A Viera ◽  
A Lauriano ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Lipoic Acid ◽  
Alpha Lipoic Acid ◽  
The Brain
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