<p>The increasing future methane (CH<sub>4</sub>) leads to changes in the lifetime of CH<sub>4</sub> and in the Hydroxyl radical (OH) and (O<sub>3</sub>) mixing ratios and distribution in the lower atmosphere. With increasing CH<sub>4</sub> the lifetime of CH<sub>4</sub> and the O<sub>3</sub> mixing ratios in the troposphere will increase, the tropospheric OH mixing ratios will decrease (Winterstein et al., 2019; Zhao et al., 2019). The CH<sub>4</sub> changes, together with the future Nitrous oxide (N<sub>2</sub>O) and temperature increase, will lead to a different tropospheric chemistry. For example, substances as acetone (CH<sub>3</sub>COCH<sub>3</sub>), ethane (C<sub>2</sub>H<sub>6</sub>), formic acid (HCOOH) or peroxy acetyl nitrate (PAN) will change their distribution and mixing ratios.</p><p>In different studies we could show that EMAC (ECHAM/MESSy Atmospheric Chemistry, J&#246;ckel et al., 2010) has the ability to simulate some of the mentioned tropospheric substances in comparison to results of the GLORIA (Gimballed Limb Observer for Radiance Imaging of the Atmosphere) instrument, used on board of the research aircrafts Geophysica and HALO during the STRATOCLIM (July/August 2017) and WISE (August to October 2017) campaigns (Johansson et al., 2020; Wetzel et al., 2020).&#160; &#160;</p><p>In this study, we will additional show the first results of the simulated future changes of tropospheric chemistry (especially with focus on CH<sub>3</sub>COCH<sub>3</sub>, C<sub>2</sub>H<sub>6</sub>, HCOOH and PAN and the upper troposphere) related to the future increase of CH<sub>4</sub>, N<sub>2</sub>O and temperature change as a result of climate change. For these we use different EMAC simulations from the project ESCiMo (Earth System Chemistry Integrated Modelling, J&#246;ckel et al., 2016).</p><p>We will present some results of the comparison of EMAC to GLORIA and results with regard to the future development of the (upper) tropospheric chemistry in EMAC. &#160;&#160;&#160;</p>