The Link Between Plant-based Diet Indices With Biochemical Markers of Bone Turn Over, Inflammation and Insulin in Iranian Older Adults

Abstract Background: The association of plant base diets and biomarkers of bone, insulin, and inflammation is still unclear. Objectives: We investigated the associations between biomarkers of bone, insulin, and inflammation and three plant-based diet indices: an overall plant-based diet index (PDI); a healty plant-based diet index (hPDI); and an unhealthy plant-based diet index (uPDI).Methods: We included 178 elderly subjects who referred to health centers in Tehran. Blood and urine samples were collected to measure osteocalcin, The Human C-telopeptide of type Ⅰ collagen (u-CTX-I), highly sensitive C-reactive protein (hs-CRP) Parathyroid hormone (PTH), 25(OH) D and insulin resistance and sensitivity. We created an overall PDI, hPDI and uPDI from semi quantitative food-frequency questionnaire (FFQ) data. Results: Dietary groups of Vegetables (r=0.15, P=0.03), nuts (r=0.16, P=0.03), dairy (r=0.25, P=0.001), eggs (r=0.27, P<0.001), red meat and animal products (r=0.25, P=0.001) were directly correlated with osteocalcin. Refined grains were also had positive association with serum insulin concentration (r=0.14, P=0.04). PTH levels are inversely associated with PDI score (β=-0.18, P=0.01). Also serum insulin concentration was negatively associated with PDI score (β=-0.10, P=0.04). Urine CTX-1 levels was significantly associated with hPDI score (β=-0.06, P=0.04). u-CTX-1 levels are inversely associated with uPDI score. This significance did not change with the adjustment of the confounders (β=-0.28, P<0.001). Conclusions: more adherence to PDI and hPDI and less in uPDI may have beneficial effect on biomarkers of bone, inflammation, and insulin thus preserving chronic diseases.

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Age- and sex-related reference values for serum insulin concentration and its biological determinants in a French healthy population. The STANISLAS cohort

Clinical Chemistry and Laboratory Medicine (CCLM) ◽

10.1515/cclm.2004.233 ◽

2004 ◽

Vol 42 (10) ◽

Cited By ~ 9

Author(s):

Aurélie Francois ◽

Sandy Maumus ◽

Monique Vincent-Viry ◽

René Guéguen ◽

Gérard Siest ◽

...

Keyword(s):

Contraceptive Use ◽

Serum Insulin ◽

Density Lipoprotein ◽

Insulin Concentration ◽

Healthy Population ◽

Factors Affecting ◽

Serum Insulin Concentration ◽

Reference Limits ◽

Adults And Children ◽

Broad Variety

AbstractInsulin is involved in coronary heart disease through diabetes and metabolic syndrome. A great deal is known about insulin and its correlates, as well as factors related to changes in insulin. However, few studies consider the broad variety of correlates simultaneously. Therefore, the aims of the present study were to characterize the main factors of biological variation affecting serum insulin concentration and to establish reference limits of insulinemia in a presumably healthy French population. Insulin was measured using a microparticular enzymatic immunoassay. A total of 646 subjects aged 11–58 years from the STANISLAS cohort and divided into four groups of 162 males, 157 females, 163 boys and 164 girls, were included in the statistical analyses. In the whole population, serum insulin concentration varied from 0.80 to 54.60 µU/ml. Significant factors affecting insulin were age, gender, body mass index and glucose, in addition to alanine aminotransferase and high-density lipoprotein cholesterol in men, triglycerides and oral contraceptive use in women, and alkaline phosphatase in girls.In summary, we presented biological correlates of insulin in both healthy French male and female adults and children/adolescents and determined reference limits for insulin for each group. These results will contribute to a better interpretation of insulin data in further studies and laboratory investigations.

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Preperitoneal fat thickness in childhood obesity: Association with serum insulin concentration

Pediatrics International ◽

10.1046/j.1442-200x.2000.01197.x ◽

2000 ◽

Vol 42 (2) ◽

pp. 155-159 ◽

Cited By ~ 20

Author(s):

Akiho Tamura ◽

Tetsuo Mori ◽

Yoji Hara ◽

Atsushi Komiyama

Keyword(s):

Childhood Obesity ◽

Serum Insulin ◽

Insulin Concentration ◽

Serum Insulin Concentration ◽

Fat Thickness

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ROLE OF CARDIAC MARKERS IN CHRONIC RENAL FAILURE PATIENTS.

10.36106/ijsr/4303098 ◽

2020 ◽

pp. 81-82

Author(s):

Ramesh Chandra Thanna ◽

B K Agarwal ◽

Rakesh Romday ◽

Neha Sharma

Keyword(s):

Renal Failure ◽

Chronic Renal Failure ◽

Positive Association ◽

Morbidity And Mortality ◽

Control Group ◽

High Morbidity ◽

C Reactive Protein ◽

Reactive Protein ◽

Hs Crp

Introduction: Cardiovascular diseases (CVD) are known as important reasons of the increased morbidity and mortality observed in patients with chronic renal failure (CRF). The association of serum Interlukin-6 , homocysteine as well as other cardiovascular risk factors in relation to existence and cause of CVD were investigated. Method: In this study 200 CRF patients were recruited and further stratified into group with Male and Female as case groups. Those without renal failure were assigned as control group (n=200). Results: The patients with CRF showed a significant increase in plasma levels of Cpk-MB homocysteine and C-reactive protein (CRP) compared to control. The positive association were observed between homocysteine, Urea and Hs-CRP, IL_6 . It shows a significant Association of parameters in CRF . Conclusion: The results demonstrated elevation in plasma values IL-6 , homocysteine and HS-CRP in patients with CRF . However, these modifications may be lead to atherosclerosis and consequence CVD event. These parameters may be important with respect to the high morbidity and mortality of CVD found in patients with CRF.

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Glucose-induced changes in pancreatic islet blood flow mediated by central nervous system

AJP Endocrinology and Metabolism ◽

10.1152/ajpendo.1986.251.6.e644 ◽

1986 ◽

Vol 251 (6) ◽

pp. E644-E647 ◽

Cited By ~ 14

Author(s):

L. Jansson ◽

C. Hellerstrom

Keyword(s):

Central Nervous System ◽

Blood Flow ◽

Nervous System ◽

Glucose Concentration ◽

Serum Insulin ◽

Serum Glucose ◽

Insulin Concentration ◽

Similar Amount ◽

Serum Insulin Concentration ◽

Islet Blood Flow

Earlier experiments with the microsphere technique suggested that a heightened serum glucose concentration consistently leads to an increase in islet blood flow (IBF). Several lines of evidence suggest that this glucose-sensitive control mechanism is located at an extrapancreatic site. The purpose of this study was to define the possible role of the central nervous system in such a mechanism. D-glucose, L-glucose, 3-O-methylglucose, or saline were therefore infused into the carotid artery, each at a dose of 1 mg X kg body wt-1 X min-1 for 3 min, and the pancreatic and islet blood flows were measured. None of these substances affected the systemic serum glucose level. The intracarotid infusion of D-glucose, however, caused a rapid increase in both the serum insulin concentration and IBF. The blood flow to the whole pancreas nevertheless remained unchanged, indicating a redistribution of flow within the gland. Carotid infusion of the other test substances or a similar amount of D-glucose given in a femoral vein did not affect these parameters. Both the increase in serum insulin concentration and the increase in IBF caused by D-glucose could be abolished by vagotomy or administration of atropine. When the systemic blood glucose concentration was increased by intraperitoneal glucose administration (2 g/kg body wt), vagotomy blocked the increase in islet blood flow but not the concomitant insulin release. These observations suggest that the glucose-induced increase in IBF is mediated by vagal cholinergic influences.

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