Tracking the Features of CIMP-positive Glioma: A Systematic Review and Meta-Analysis

Abstract Backgrounds Controversy surrounding CpG island methylator phenotype (CIMP) in glioma exists with regard to its prognostic value.Methods PubMed, EMBASE, and Cochrane Library databases were searched for studies describing molecular and clinicopathological features, and overall survival of gliomas stratified by CIMP status. Associations of CIMP with outcome parameters were estimated using odds ratio (OR) or hazard ratios (HRs) with a 95% confidence interval (CI) using a fixed or random effects model.Results A total of 12 studies involving 2386 gliomas (1051 CIMP-positive and 1335 CIMP-negative) were included. Molecular analysis showed that CIMP is more frequent in IDH1-mutated gliomas (OR 229.07; 95% CI 138.72–378.26) and 1p19q LOH gliomas (OR 5.65; 95% CI 2.66–12.01), though CIMP was not associated with EGFR mutation (OR 0.14; 95% CI 0.05–0.43) or MGMT promoter methylation (OR 3.01; 95% CI 0.79–11.48). Clinicopathological analysis showed that CIMP is more frequent in oligodendroglioma (OR 5.51; 95% CI 3.95–7.70), but less frequent in glioblastoma (OR 0.14; 95% CI 0.10–0.19). However, CIMP was not associated with anaplastic oligoastrocytomas (OR 1.57; 95% CI 1.24-2.00) or oligoastrocytoma (OR 0.79; 95% CI 0.35–1.76). We found that CIMP-positive glioma was associated with a longer overall survival (HR -0.57; 95% CI -0.97– -0.16).Conclusions A CIMP-positive glioma has better prognosis and its own molecular features (such as IDH1 and 1p19q LOH mutations) and clinicopathological features. These conditions suggest CIMP could be used as an independent prognostic marker for glioma.

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Tracking the Correlation Between CpG Island Methylator Phenotype and Other Molecular Features and Clinicopathological Features in Human Colorectal Cancers: A Systematic Review and Meta-Analysis

Clinical and Translational Gastroenterology ◽

10.1038/ctg.2016.14 ◽

2016 ◽

Vol 7 (3) ◽

pp. e151 ◽

Cited By ~ 18

Author(s):

Liang Zong ◽

Masanobu Abe ◽

Jiafu Ji ◽

Wei-Guo Zhu ◽

Duonan Yu

Keyword(s):

Systematic Review ◽

Cpg Island ◽

Meta Analysis ◽

Clinicopathological Features ◽

Colorectal Cancers ◽

Cpg Island Methylator Phenotype ◽

Molecular Features ◽

Methylator Phenotype

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Association between risk factors, molecular features and CpG island methylator phenotype colorectal cancer among different age groups in a Taiwanese cohort

British Journal of Cancer ◽

10.1038/s41416-021-01300-5 ◽

2021 ◽

Author(s):

Kuo-Hsing Chen ◽

Liang-In Lin ◽

Chang-Tsu Yuan ◽

Li-Hui Tseng ◽

Yu-Liang Chao ◽

...

Keyword(s):

Colorectal Cancer ◽

Risk Factors ◽

Cpg Island ◽

Age Groups ◽

Cpg Island Methylator Phenotype ◽

Molecular Features ◽

Methylator Phenotype

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CpG Island Methylator Phenotype, Helicobacter pylori, Epstein-Barr Virus, and Microsatellite Instability and Prognosis in Gastric Cancer: A Systematic Review and Meta-Analysis

PLoS ONE ◽

10.1371/journal.pone.0086097 ◽

2014 ◽

Vol 9 (1) ◽

pp. e86097 ◽

Cited By ~ 23

Author(s):

Liang Zong ◽

Yasuyuki Seto

Keyword(s):

Gastric Cancer ◽

Systematic Review ◽

Helicobacter Pylori ◽

Epstein Barr Virus ◽

Cpg Island ◽

Meta Analysis ◽

Cpg Island Methylator Phenotype ◽

Barr Virus ◽

Epstein Barr ◽

Methylator Phenotype

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Meta-analysis of the prognostic value of CpG island methylator phenotype in rectal cancer

International Journal of Colorectal Disease ◽

10.1007/s00384-018-3108-5 ◽

2018 ◽

Vol 33 (8) ◽

pp. 995-1000 ◽

Cited By ~ 2

Author(s):

R. F. Kokelaar ◽

H. Jones ◽

J. Beynon ◽

M. E. Evans ◽

D. A. Harris

Keyword(s):

Rectal Cancer ◽

Prognostic Value ◽

Cpg Island ◽

Meta Analysis ◽

Cpg Island Methylator Phenotype ◽

Methylator Phenotype

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How theBRAFV600E Mutation Defines a Distinct Subgroup of Colorectal Cancer: Molecular and Clinical Implications

Gastroenterology Research and Practice ◽

10.1155/2018/9250757 ◽

2018 ◽

Vol 2018 ◽

pp. 1-14 ◽

Cited By ~ 14

Author(s):

Catherine E. Bond ◽

Vicki L. J. Whitehall

Keyword(s):

Colorectal Cancer ◽

Cpg Island ◽

Early Event ◽

Sporadic Colorectal Cancer ◽

Cpg Island Methylator Phenotype ◽

Distinct Subgroup ◽

Molecular Features ◽

Map Kinase Pathway ◽

Methylator Phenotype ◽

Kinase Pathway

TheBRAFoncogene is an integral component of the MAP kinase pathway, and an activating V600E mutation occurs in 15% of sporadic colorectal cancer. This is an early event in serrated pathway tumourigenesis, and theBRAFV600E has been commonly associated with the CpG island methylator phenotype, microsatellite instability (MSI), and a consistent clinical presentation including a proximal location and predilection for elderly females. A proportion of theBRAFmutant lesions remain as microsatellite stable (MSS), and in contrast to the MSI cancers, they have an aggressive phenotype and correlate with poor patient outcomes. Recent studies have found that they have clinical and molecular features of both theBRAFmutant/MSI and the conventionalBRAFwild-type cancers and comprise a distinct colorectal cancer subgroup. This review highlights the importance of theBRAFmutation occurring in colorectal cancer stratified for molecular background and discusses its prognostic and clinical significance.

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Are clinicopathological features of colorectal cancers with methylation in half of CPG island methylator phenotype panel markers different from those of CPG island methylator phenotype-high colorectal cancers?

Pathology ◽

10.1016/j.pathol.2015.12.418 ◽

2016 ◽

Vol 48 ◽

pp. S153

Author(s):

Ye-Young Rhee ◽

Jeong-Mo Bae ◽

Kyung-Ju Kim ◽

Xianyu Wen ◽

Young-Seok Song ◽

...

Keyword(s):

Cpg Island ◽

Clinicopathological Features ◽

Colorectal Cancers ◽

Cpg Island Methylator Phenotype ◽

Methylator Phenotype

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Clinical, Pathological, and Molecular Characteristics of CpG Island Methylator Phenotype in Colorectal Cancer: A Systematic Review and Meta-analysis

Translational Oncology ◽

10.1016/j.tranon.2018.07.008 ◽

2018 ◽

Vol 11 (5) ◽

pp. 1188-1201 ◽

Cited By ~ 21

Author(s):

Shailesh M. Advani ◽

Pragati Advani ◽

Stacia M. DeSantis ◽

Derek Brown ◽

Helena M. VonVille ◽

...

Keyword(s):

Colorectal Cancer ◽

Systematic Review ◽

Cpg Island ◽

Meta Analysis ◽

Molecular Characteristics ◽

Cpg Island Methylator Phenotype ◽

Methylator Phenotype

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Impact of Physical Activity on Cancer-Specific and Overall Survival of Patients with Colorectal Cancer

Gastroenterology Research and Practice ◽

10.1155/2013/340851 ◽

2013 ◽

Vol 2013 ◽

pp. 1-6 ◽

Cited By ~ 30

Author(s):

Gaetan Des Guetz ◽

Bernard Uzzan ◽

Thierry Bouillet ◽

Patrick Nicolas ◽

Kader Chouahnia ◽

...

Keyword(s):

Physical Activity ◽

Colorectal Cancer ◽

Overall Survival ◽

Meta Analysis ◽

Fixed Effect Model ◽

Cochrane Library ◽

Hazard Ratios ◽

Effect Model ◽

Keywords Colorectal Cancer ◽

The Cochrane Library

Background. Physical activity (PA) reduces incidence of colorectal cancer (CRC). Its influence on cancer-specific (CSS) and overall survival (OS) is controversial.Methods. We performed a literature-based meta-analysis (MA) of observational studies, using keywords “colorectal cancer, physical activity, and survival” in PubMed and EMBASE. No dedicated MA was found in the Cochrane Library. References were cross-checked. Pre- and postdiagnosis PA levels were assessed by MET. Usually, “high” PA was higher than 17 MET hour/week. Hazard ratios (HRs) for OS and CSS were calculated, with their 95% confidence interval. We used more conservative adjusted HRs, since variables of adjustment were similar between studies. When higher PA was associated with improved survival, HRs for detrimental events were set to <1. We used EasyMA software and fixed effect model whenever possible.Results. Seven studies (8056 participants) were included, representing 3762 men and 4256 women, 5210 colon and 1745 rectum cancers. Mean age was 67 years. HR CSS for postdiagnosis PA (higher PA versus lower) was 0.61 (0.44–0.86). The corresponding HR OS was 0.62 (0.54–0.71). HR CSS for prediagnosis PA was 0.75 (0.62–0.91). The corresponding HR OS was 0.74 (0.62–0.89).Conclusion. Higher PA predicted a better CSS. Sustained PA should be advised for CRC. OS also improved (reduced cardiovascular risk).

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Prognostic and clinicopathological significance of YAP in Colorectal carcinoma: A systematic review and meta-analysis

10.21203/rs.3.rs-33708/v1 ◽

2020 ◽

Author(s):

Lu Dai ◽

Xiao Jin ◽

Jiayan Wang ◽

Yilan Ma ◽

Haihao Yan ◽

...

Keyword(s):

Meta Analysis ◽

Great Influence ◽

Tumor Location ◽

Clinicopathological Features ◽

Expression Level ◽

Cochrane Library ◽

Hazard Ratios ◽

Clinicopathological Significance ◽

Prediction Of Prognosis ◽

The Relationship

Abstract Background: YAP is a protein encoded by the YAP gene in humans. Numerous studied showed that YAP expressed in colorecal carcinoma (CRC) and has a association with poor clinical outcomes. However, the association between YAP expression level with prognostic and clinicopathological features in CRC patients remains unclear. Therefore, we performed a meta-analysis to investigate the prognostics effect of YAP expression on CRC patients.Methods: A systematic search of the PubMed, Web of Science, Cochrane Library and Embase databases was conducted based on predefined selection criteria in April 26, 2020. The correlation between YAP expression level and survival outcomes or clinicopathological characteristic was analyzed by hazard ratios (HR) or odds ratios (OR) at 95% confdence intervals (CI).Results: 12 studies were included, with a total of 2286 CRC patients,in our meta-analysis.the results show the relationship between YAP expression level with overall survival (OS) in CRC patients HR (2.02, 95%CI 1.67-2.44 I2 =19.7% P= 0.25) . In addition to clinicpathological features, CRC patients with overexpression of YAP were tend to advanced TNM stage(OR:2.99, 95%CI 2.11-4.25, I2=0.0%, P=0.699), lymph node metastasis(OR:3.73, 95% CI 2.63-5.30, I2=4.8%, P=0.386), distant metastasis(OR:3.03, 95% CI 1.21-7.56, I2=65.3%, P=0.021), tumor invasion depth HR (2.82 95%CI 1.65-4.83 I2=0.0%, p=0.413), but have no associated with sex, tumor size, tumor location and tumor differentiation.Conclusion: The results of this meta-analysis show that high expression of YAP tended to have a worse progosis and have great influence on clinicpathological features. which means YAP may serve as a promising indicator in the prediction of prognosis and clinicopathological features in CRC patients.

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