scholarly journals BIRC7 and STC2 expression are associated with tumorigenesis and poor outcome in extrahepatic cholangiocarcinoma

2020 ◽  
Author(s):  
Jiequn Li ◽  
Zhulin Yang ◽  
Shengfu Huang ◽  
Daiqiang Li
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Diagnostic And Prognostic Application ◽  
Staining Technique ◽  
Clinicopathological Characteristics ◽  
Extrahepatic Cholangiocarcinoma ◽  
Node Metastasis ◽  
Diagnosis And Prognosis ◽  
Potential Biomarker ◽  
Prognostic Application

Abstract Background: Extrahepatic cholangiocarcinoma (EHCC) is a highly aggressive epithelial malignancy and has a poor prognosis for the insensitivity to therapies and difficulty in detection. Novel targets and biomarkers are urgently needed to develop for functional, diagnostic and prognostic application on EHCC.Methods: Immunohistochemical staining technique using the EnVision antibody complex was performed on the samples obtained from 100 EHCC，30 peritumoral extrahepatic biliary tract (EHBT), 10 EHBT adenomas and 15 normal EHBT tissues.Results: The positive rates of BIRC7 and STC2 expression in tissues obtained from peritumoral EHBT, EHBT adenomas and normal EHBT were significantly lower than those in EHCC tissues. BIRC7 and STC2 proteins were expressed at significantly higher levels in patients with lymph node metastasis, invasion of adjacent tissues, and higher TNM stage (III and/or IV) and unable to undergo resection (biopsy only). Kaplan-Meier survival curves indicated that significantly decreased overall survival rate in patients with positive-BIRC7 or positive-STC2 expression compared with patients of negative-BIRC7 or negative-STC2 expression, respectively. Cox-proportional regression analysis demonstrated that positive-BIRC7 and positive-STC2 expression, along with poor differentiation of EHCC, tumor size >3cm, lymph node metastasis, invasion of adjacent tissues and unable to undergo resection are independent prognostic factors of EHCC patients.Conclusions：The levels of BIRC7 and STC2 expression were correlated with clinicopathological characteristics of EHCC, and positive expression of BIRC7 and STC2 are associated with progression and poor clinical outcomes of EHCC. BIRC7 and STC2 might be a potential biomarker for EHCC diagnosis and prognosis.

scholarly journals BIRC7 and STC2 Expression Are Associated With Tumorigenesis and Poor Outcome in Extrahepatic Cholangiocarcinoma

2020 ◽  
Vol 19 ◽  
pp. 153303382097167
Author(s):  
Jiequn Li ◽  
Zhulin Yang ◽  
Shengfu Huang ◽  
Daiqiang Li
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Diagnostic And Prognostic Application ◽  
Staining Technique ◽  
Clinicopathological Characteristics ◽  
Extrahepatic Cholangiocarcinoma ◽  
Node Metastasis ◽  
Kaplan Meier ◽  
Potential Biomarker ◽  
Prognostic Application

Background: Extrahepatic cholangiocarcinoma (EHCC) is a highly aggressive epithelial malignancy and has a poor prognosis for the insensitivity to therapies and difficulty in detection. Novel targets and biomarkers are urgently needed to develop for functional, diagnostic and prognostic application on EHCC. Methods: Immunohistochemical staining technique using the EnVision antibody complex was performed on the samples obtained from 100 EHCC, 30 peritumoral extrahepatic biliary tract (EHBT), 10 EHBT adenomas and 15 normal EHBT tissues. Results: The positive rates of BIRC7 and STC2 expression in tissues obtained from peritumoral EHBT, EHBT adenomas and normal EHBT were significantly lower than those in EHCC tissues. BIRC7 and STC2 proteins were expressed at significantly higher levels in patients with lymph node metastasis, invasion of adjacent tissues, and higher TNM stage (III and/or IV) and unable to undergo resection (biopsy only). Kaplan-Meier survival curves indicated that significantly decreased overall survival rate in patients with positive-BIRC7 or positive-STC2 expression compared with patients of negative-BIRC7 or negative-STC2 expression, respectively. Cox-proportional regression analysis demonstrated that positive-BIRC7 and positive-STC2 expression, along with poor differentiation of EHCC, tumor size >3 cm, lymph node metastasis, invasion of adjacent tissues and unable to undergo resection are independent prognostic factors of EHCC patients. Conclusions: The levels of BIRC7 and STC2 expression were correlated with clinicopathological characteristics of EHCC, and positive expression of BIRC7 and STC2 are associated with progression and poor clinical outcomes of EHCC. BIRC7 and STC2 might be a potential biomarker for EHCC in clinic.

scholarly journals BIRC7 and STC2 expression is associated with tumorigenesis and poor outcome in extrahepatic cholangiocarcinoma

2020 ◽  
Author(s):  
Jiequn Li ◽  
Zhulin Yang ◽  
Shengfu Huang ◽  
Daiqiang Li
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Biliary Tract ◽  
Poor Prognosis ◽  
Diagnostic And Prognostic Application ◽  
Tumor Biomarker ◽  
Extrahepatic Cholangiocarcinoma ◽  
Node Metastasis ◽  
Diagnosis And Prognosis ◽  
Tumorigenesis And Progression

Abstract Background: Extrahepatic cholangiocarcinoma (EHCC) is a highly aggressive epithelial malignancy and has a poor prognosis for their insensitivity to therapies and difficulty in detection. Novel targets and biomarkers are urgently needed to develop for functional, diagnostic and prognostic application on EHCC. Methods: 100 EHCC tissues，30 peritumoral tissues, 10 adenoma and 15 normal biliary tract tissues were assayed using EnVision immunohistochemistry. Results: The expression of BIRC7 and STC2 proteins were higher in EHCC tissues than those in peritumoral tissues, adenoma and normal biliary tract tissues. The positive rates of BIRC7 and STC2 expression were significantly higher in cases with lymph node metastasis, invasion to surrounding tissues/organs, and TNM stage III and/or IV and unable to undergo resection (biopsy only). Kaplan-Meier survival curves demonstrated that the overall survival of positive-BIRC7 or positive-STC2 patients was significantly lower than those of negative-BIRC7 or negative-STC2, respectively. Cox-proportional regression analysis demonstrated that positive-BIRC7 and positive-STC2 expression, along with poor differentiation of EHCC, tumor size >3cm, lymph node metastasis, invasion to surrounding tissues/organs and unable to undergo resection are independent prognostic factors of EHCC patients. Conclusions: BIRC7 and STC2 are involved in the tumorigenesis and progression of EHCC, and positive expression of BIRC7 and STC2 are associated with poor prognosis in patients with EHCC. BIRC7 and STC2 might be a potential tumor biomarker for EHCC diagnosis and prognosis.

scholarly journals β-Catenin Expression Negatively Correlates with WIF1 and Predicts Poor Clinical Outcomes in Patients with Cervical Cancer

2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
Jinxiao Liang ◽  
Hui Zhou ◽  
Yongpai Peng ◽  
Xiaofei Xie ◽  
Ruixin Li ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Disease Free Survival ◽  
Intraepithelial Neoplasia ◽  
Clinicopathological Characteristics ◽  
Poor Prognostic Factor ◽  
Node Metastasis ◽  
Canonical Wnt ◽  
Wnt Inhibitory Factor 1

Aberrant activation of the canonical Wnt pathway plays a significant role in cervical cancer (CC). However, limited data show the correlation between the cancer clinicopathological characteristics and the key molecules such as β-catenin and Wnt inhibitory factor 1 (WIF1). In this study, β-catenin and WIF1 expression were analyzed by immunohistochemistry for 196 patients with CC, 39 with cervical intraepithelial neoplasia (CIN), and 41 with normal cervical epithelium (NCE). Significant overexpression of β-catenin was detected in CC (67.9%) when compared to CIN (43.6%) or NCE (34.1%), p<0.01, while low WIF1 expression was detected in CC (24.0%) when compared to CIN (59.0%) or NCE (58.5%), p<0.001. Negative correlation was shown between β-catenin and WIF1 expression (r=-0.637, p<0.001). In addition, multivariate analysis revealed that both lymph node metastasis and β-catenin expression were the independent prognostic factors not only for disease-free survival (HR = 5.029, p<0.001; HR = 2.588, p=0.035, resp.), but also for overall survival (HR = 5.058, p<0.001; HR = 2.873, p=0.031, resp.). Our findings indicate that, besides lymph node metastasis, β-catenin expression may also be a poor prognostic factor for CC while WIF1 could be a potential drug target for treatment of advanced CC.

scholarly journals Clinicopathological Characteristics of Lung Adenocarcinoma with Unexpected Lymph Node Metastasis

2017 ◽  
Vol 23 (4) ◽  
pp. 181-187 ◽  
Author(s):  
Tomohiro Haruki ◽  
Makoto Wakahara ◽  
Yuki Matsuoka ◽  
Ken Miwa ◽  
Kunio Araki ◽  
...  
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Lung Adenocarcinoma ◽  
Clinicopathological Characteristics ◽  
Node Metastasis

scholarly journals Overexpression of 14-3-3δ Predicts Poor Prognosis in Extrahepatic Cholangiocarcinoma Patients

2020 ◽  
Vol 2020 ◽  
pp. 1-6
Author(s):  
Qiao Wu ◽  
Hua Fan ◽  
Ren Lang ◽  
Xianliang Li ◽  
Xingmao Zhang ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Cpg Islands ◽  
Tumor Stage ◽  
Serum Markers ◽  
Extrahepatic Cholangiocarcinoma ◽  
Node Metastasis ◽  
Ca 242 ◽  
A Cell

The protein 14-3-3δ interacts with Trp53 to maintain G2 arrest and thus regulates the cell cycle. Though dysfunction of 14-3-3δ caused by hyper-methylation of CpG islands was reported in several carcinomas, the exact role of this protein in the development of extrahepatic cholangiocarcinoma has not been fully elucidated. Here, we aim at investigating the clinical relevance between 14-3-3δ and human extrahepatic cholangiocarcinoma. We collected extrahepatic cholangiocarcinoma specimens of 65 patients in Beijing Chao Yang Hospital and evaluated their 14-3-3δ expression using immunohistochemistry. We categorized the patients into different subgroups according to clinic pathological factors, such as sex, age, tumor size, pathological classification, lymph node metastasis status, tumor stage, and serum markers including CEA, CA-242, or CA19-9, and further evaluated the correlation between 14-3-3δ expression and these potential prognostic factors. As a result, we detected 14-3-3δ expression in 53 out of 65 specimens (81.5%), and the expression was positively correlated with TNM stage, lymph node metastasis, and overall survival. Our results suggest that 14-3-3δ serves as an oncogenic driver in extrahepatic cholangiocarcinoma tumorigenesis rather than a cell cycle regulator; the overexpression of 14-3-3δ might be frequently acquired by tumor cells to escape appropriate cell cycle regulation. Thus, 14-3-3δ could be a potential target for extrahepatic cholangiocarcinoma diagnosis and therapy.

scholarly journals Clinicopathological Characteristics of Colorectal Submucosal Carcinoma with Lymph Node Metastasis.

1993 ◽  
Vol 40 (3) ◽  
pp. 123-127 ◽  
Author(s):  
YASUMI ARAKI ◽  
HIROHARU ISOMOTO ◽  
KAZUO SHIROUZU ◽  
KAZUHIDE MIURA ◽  
HIROKI IWANAGA ◽  
...  
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Clinicopathological Characteristics ◽  
Node Metastasis

scholarly journals A Nomogram Predicting Central Lymph Node Metastasis for Patients with Papillary Thyroid Cancer

2021 ◽  
Author(s):  
Yu Min ◽  
Yang Feng ◽  
Ke Xiang ◽  
Hang Chen ◽  
Xing Wang ◽  
...  
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Clinical Decision ◽  
Clinicopathological Characteristics ◽  
Curve Analysis ◽  
Papillary Thyroid ◽  
Decision Curve Analysis ◽  
Node Metastasis ◽  
Central Lymph ◽  
Medical University

Abstract PurposeCentral lymph node metastasis (CLNM) has been regarded as a predictor of relatively poor prognosis in patients with papillary thyroid carcinoma (PTC). Our study aimed to identify the risk factors for CLNM and develop a nomogram helping clinical decisions.MethodA total of 1,054 patients underwent thyroidectomy between January 2019 and September 2020 in the Second Affiliated Hospital of Chongqing Medical University. Among these patients, 747 patients with histopathologically confirmed PTC were included in this retrospective study. The perioperative clinical data of these patients were reviewed and analyzed. Univariate and multivariate logistic regression were used to analyze the correlation between clinicopathological characteristics and CLNM. A nomogram model was subsequently established and validated by a decision curve analysis (DCA) curve.Result33.6% (251/747) patients with PTC were confirmed with CLNM. And the CLNM was determined in 31.4% (168/535) non- Hashimoto’s thyroiditis (HT) patients and 39.2% (83/212) HT patients, respectively. 4 clinicopathological factors including gender, age, size, and HT were confirmed significantly associated with CLNM. The established nomogram showed promising discrimination and consistency in the study group with a C-index of 0.703. The decision curve analysis showed the nomogram has clinical feasibility.ConclusionOur data suggested that male gender, younger age, larger tumor size, and HT condition played a pivotal role in promoting the CLNM of PTC patients. And the nomogram we developed can help surgeons make the individualized clinical decision in PTC patients during preoperative and interoperative management.

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