Effects of Green Cardamom Supplementation on Obesity and Diabetes Gene Expression Among Obese Women With Polycystic Ovary Syndrome; A Double Blind Randomized Controlled Trial

2021 ◽  
Author(s):  
Sahar Cheshmeh ◽  
Negin Elahi ◽  
Maysa Ghayyem ◽  
Elahe Mosayebi ◽  
Shima Moradi ◽  
...  
Keyword(s):  
Polycystic Ovary ◽  
Intervention Group ◽  
Obese Women ◽  
Ovary Syndrome ◽  
Low Calorie ◽  
Low Calorie Diet ◽  
Obesity And Diabetes ◽  
Genes Expression ◽  
Calorie Diet ◽  
Green Cardamom

Abstract BackgroundPolycystic ovary syndrome (PCOS) is an endocrine disease in which related obesity, metabolic disorders and is considered as one of the main causes of infertility in women. This trial was investigated the effects of green cardamom on obesity and diabetes genes expression among obese women with PCOS.Methods194 PCOS women were randomly divided two groups: intervention (n= 99; 3 g/day green cardamom) and control groups (n=95). All of them were given low calorie diet. Anthropometric, glycemic and androgen hormones were assessed before and after 16 weeks’ intervention. Fat mass and obesity-associated (FTO), Peroxisome proliferative activating Receptor-γ (PPAR-γ) Carnitine Palmitoyltransferase 1A (CPT1A), Acetyl-CoA Carboxylase Beta (ACAB), Leptin Receptor (LEPR), Gherlin, and lamin A/C (LAMIN) genes in PBMC were measured in each group using reverse transcription-polymerase chain reaction (RT-PCR) method.ResultsAnthropometric indices were significantly decreased after intervention in both two studied groups. Glycemic indices and androgen hormones were significantly improved in the intervention group. The expression level of FTO, CPT1A, LEPR, and LAMIN were significantly down-regulated (P<0.001), as well as, PPAR-y was significantly up-regulated in the intervention group after intervention with green cardamom (P<0.001). ConclusionThis current study showed that the administration of green cardamom is a beneficial approach for improving of anthropometric, glycemic and androgen hormones, as well as, obesity and diabetes genes expression in PCOS women under low calorie diet. This trial was registered with the Iranian Clinical Trials Registry (registration number: IRCT20200608047697N1). 1 August, 2020; https://www.irct.ir/trial/48748

Green Cardamom Plus Low Calorie Diet Can Decrease Inflammatory Genes Expression Among Obese Women With Poly Cystic Ovarian Syndrome, A Double Blind Randomized Clinical Trial

2021 ◽  
Author(s):  
Sahar Cheshmeh ◽  
Maysa Ghayyem ◽  
Firoozeh Khamooshi ◽  
Neda Heydarzadeh ◽  
Niloofar Hojati ◽  
...  
Keyword(s):  
Expression Level ◽  
Low Grade ◽  
Obese Women ◽  
Double Blind ◽  
Low Calorie ◽  
Low Calorie Diet ◽  
Genes Expression ◽  
Tnf Α ◽  
Calorie Diet ◽  
Green Cardamom

Abstract PurposePolycystic ovary syndrome (PCOS) is a common cause of endocrine disorder and infertility among womenin which is related with low grade inflammation. Therefore, this current randomized, double-blind, placebo-controlledclinical trial assessed the effects of green cardamom supplementation on inflammatory markers and gene expressionamong obese women with PCOS.MethodsWe included 194 obese PCOS women that gave all of them low calorie diet. These subjects were randomlydivided in two studied groups including intervention with 3 g/day green cardamom (n=99) and placebo groups (n=95).Anthropometric indices, androgen hormones, and inflammatory factors (tumor necrosis factor-a (TNF-α), Interleukin6 (IL-6), and C- reactive protein (CRP)) were assessed before and after four months intervention. Their TNF-α, IL-6,and CRP genes expression level were measured using reverse transcription-polymerase chain reaction (RT-PCR)method.ResultsAnthropometric indices were improved in both two studied groups (P<0.001). Among androgen hormonesluteinizing hormone, androstenedione, and dehydroepiandrosterone were significantly decreased (P<0.001), as wellas, follicle-stimulating hormone was significantly increased (P<0.001) in the green cardamom group. Our findingsshowed that TNF-α, IL-6, and CRP serum were significantly decreased after the intervention with green cardamomplus low calorie diet (P<0.001). In addition, the expression level of TNF-α and CRP genes were significantly decreasedin intervention groups (P<0.001).ConclusionsThis present study support the beneficial anti-inflammatory effect of green cardamom on theinflammatory status in the PCOS women.Level of evidenceLevel I, randomized clinical trialTrial registrationThis trial was registered with the Iranian Clinical Trials Registry (registration number:IRCT20200608047697N1). 1 August, 2020; https://www.irct.ir/trial/48748

scholarly journals Vegan or Low Calorie Diet for Weight Loss in Polycystic Ovary Syndrome Females: A Randomised Controlled Study

2020 ◽  
Vol 14 (1-2) ◽  
Author(s):  
Shubhra Saraswat
Keyword(s):  
Weight Loss ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Randomized Study ◽  
Vegan Diet ◽  
Controlled Study ◽  
Ovary Syndrome ◽  
Low Calorie ◽  
Low Calorie Diet ◽  
Calorie Diet

ABSTRACT The primary aim of this randomized study is to find the effect of a diet based intervention (vegan diet and low-calorie diet) among women suffering from polycystic ovary syndrome (PCOS). Overweight and obese (BMI- 33.7 ± 4.8 kg/m2) women with PCOS (n = 21; age, 33.1 ± 4.4 years) were assessed to participate in a 90 days randomized weight loss study delivered and guided through diet and nutrition counseling (personalized and group). Body weight, BMI and waist circumference and dietary intakes were assessed three times at 0, 45 and 90 days. It was hypothesized that weight loss would be more in the vegan group. All data were statistically analyzed and presented as median (inter quartile range). Vegan participants reported significant weight loss at Day 90, “1.8% (“5.0%, “0.9%) vegan, 0.0% (“1.2%, 0.3%) low-cal; P = .04), Vegan participants showed a greater decrease in energy (“265 (“469, 0)) kcal/d) and fat intake “8.2% (“9.8%, 0%) energy) at Day 90 compared with low-cal participants (0 (0, 173)) kcal/d, P = .02; 0 (0, 3.7%) energy, P = .02). The results suggest that following a vegan diet can be more effective for achieving weight loss in addition to better nutrient intake profile in women with PCOS; however, a bigger sample size is required to validate these results.

scholarly journals The experiences of women with polycystic ovary syndrome on a very low-calorie diet

2016 ◽  
Vol Volume 8 ◽  
pp. 299-310 ◽  
Author(s):  
John Love ◽  
John McKenzie ◽  
Efsevia Anastasia Nikokavoura ◽  
Iain Broom ◽  
Catherine Rolland ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Very Low Calorie Diet ◽  
Ovary Syndrome ◽  
Low Calorie ◽  
Low Calorie Diet ◽  
Calorie Diet ◽  
Experiences Of Women

scholarly journals Efficacy of Octreotide-LAR in Dieting Women with Abdominal Obesity and Polycystic Ovary Syndrome

2005 ◽  
Vol 90 (7) ◽  
pp. 3854-3862 ◽  
Author(s):  
Alessandra Gambineri ◽  
Laura Patton ◽  
Rosaria De Iasio ◽  
Barbara Cantelli ◽  
Graciela Estela Cognini ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Outcome Measures ◽  
Polycystic Ovary ◽  
Fat Distribution ◽  
Ovary Syndrome ◽  
Octreotide Lar ◽  
Low Calorie ◽  
Low Calorie Diet ◽  
Igf I ◽  
Calorie Diet

Abstract Context: Somatostatin reduces LH, GH, and insulin, and somatostatin receptors are present at the ovarian level; somatostatin analogs are thus potential candidates for treatment of the polycystic ovary syndrome (PCOS). Objective: The purpose of this study was to evaluate the effect of octreotide-LAR, a long-acting somatostatin analog, in anovulatory abdominal obese women with PCOS. Design: A single-blind, placebo-controlled study was performed, lasting for 7 months. Setting: The patients were ambulatory throughout the study. Patients: Twenty PCOS subjects were enrolled. Eighteen completed the study. Interventions: A low-calorie diet was given during the first month, a low-calorie diet plus octreotide-LAR (10 mg; n = 10 subjects) or placebo (n = 10 subjects) was then given, with one im injection every 28 d (for 6 months). Main Outcome Measures: The main outcome measures were clinical features, computerized tomography measurement of fat distribution, androgens, GH, IGF-I, IGF-binding proteins (IGFBPs), fasting and glucose-stimulated insulin, and ovulation. Results: Octreotide had no additional effect in reducing body fat or improving fat distribution than placebo. Conversely, octreotide produced an additional decrease in fasting (P = 0.018) and glucose-stimulated (P = 0.038) insulin levels, an increase in IGFBP-2 (P = 0.042) and IGFBP-3 (P = 0.047), and an improvement in hirsutism (P = 0.004). Moreover, a trend toward greater reductions in testosterone (P = 0.061) and androstenedione (P = 0.069) was observed in women treated with octreotide-LAR compared with those given placebo. All women treated with octreotide ovulated at the end of the study compared with only one of those receiving placebo (P &lt; 0.001). Conclusions: Octreotide-LAR may be usefully applied to hypocalorically dieting, abdominal obese PCOS women to improve hyperandrogenism and the insulin-IGF-I system. Restoration of ovulatory menstrual cycles appears to be another advantage of this treatment.

scholarly journals A Low Glycemic Index Decreases Inflammation by Increasing the Concentration of Uric Acid and the Activity of Glutathione Peroxidase (GPx3) in Patients with Polycystic Ovary Syndrome (PCOS)

Molecules ◽  
2019 ◽  
Vol 24 (8) ◽  
pp. 1508 ◽  
Author(s):  
Małgorzata Szczuko ◽  
Marta Zapalowska-Chwyć ◽  
Radosław Drozd
Keyword(s):  
Uric Acid ◽  
Polycystic Ovary Syndrome ◽  
Glutathione Peroxidase ◽  
Glycemic Index ◽  
Dietary Intervention ◽  
Polycystic Ovary ◽  
Ovary Syndrome ◽  
Low Calorie ◽  
Low Calorie Diet ◽  
Calorie Diet

Introduction: According to a review of the literature, there is a lack of data on the mechanisms that participate in the suppression of inflammation that accompanies polycystic ovary syndrome (PCOS). Additionally, the changes in oxidative status resulting from a low-calorie diet have not been studied in a group of women with PCOS, and the oxidation and reduction processes associated with PCOS have not been explained. Material and methods: The study involved 49 women who were diagnosed with PCOS according to Rotterdam’s criteria, and 24 women voluntarily agreed to a three-month dietary intervention. The dietary intervention was carried out for 3 months. Glutathione peroxidase (GPx3) activity, the Ferric reducing ability of plasma, and uric acid concentration were measured spectrophotometrically both before and after the intervention. Statistical analysis was performed with the Statistica 10.0 software package, and a Pearson’s correlation matrix was generated. Results: A lower concentration of GPx3 was observed in women with PCOS (before the dietetic intervention began) compared with the GPx3 levels in healthy women. A relationship was shown between GPx3 levels and the concentration of prolactin, insulin on fasting, and triglycerides. After the dietary intervention, increases in uric acid and GPx3 activity were noted, as well as numerous relationships between anthropometric and biochemical parameters. The ferric reducing/antioxidant power did not change significantly. Conclusions: Inhibiting the effect of prolactin (by the level of reactive oxygen species) on the activity of GPx3 could be a starting point for the increase in antioxidative stress and the development of the inflammatory state associated with PCOS pathophysiology. Following a low-calorie diet with a lower glycemic index is proposed to silence inflammation by increasing the concentration of uric acid. During GPx3 mobilization, women with PCOS have a higher demand for selenium, and its deficiencies may contribute to disordered thyroid hormone synthesis. The three-month dietary intervention did not silence redox processes in the examined group of women.

scholarly journals Lipoprotein Metabolism in Normolipidemic Obese Women during Very Low Calorie Diet

1991 ◽  
Vol 37 (Supplement) ◽  
pp. S57-S64 ◽  
Author(s):  
Tetsuo SHOJI ◽  
Yoshiki NISHIZAWA ◽  
Hidenori KOYAMA ◽  
Satoshi HAGIWARA ◽  
Hideyuki ARATANI ◽  
...  
Keyword(s):  
Lipoprotein Metabolism ◽  
Obese Women ◽  
Very Low Calorie Diet ◽  
Low Calorie ◽  
Low Calorie Diet ◽  
Calorie Diet

scholarly journals Low-Calorie Diet Plus Interval Exercise Training Improves Metabolic Flexibility and Insulin Sensitivity in Obese Women

2018 ◽  
Vol 50 (5S) ◽  
pp. 222
Author(s):  
Nicole M. Gilbertson ◽  
Natalie Z.M. Eichner ◽  
Emily M. Heiston ◽  
Monique Francois ◽  
Julian M. Gaítan ◽  
...  
Keyword(s):  
Insulin Sensitivity ◽  
Exercise Training ◽  
Metabolic Flexibility ◽  
Obese Women ◽  
Low Calorie ◽  
Interval Exercise ◽  
Low Calorie Diet ◽  
Calorie Diet
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