scholarly journals Beneficial effects of walnut (Juglans regia L.) oil-derived polyunsaturated fatty acid prevents oxidant status and hyperlipidemia in pregnant rats with diabetes

2020 ◽  
Author(s):  
Bingmei Sun ◽  
Hua Yan ◽  
Chao Li ◽  
Linlin Yin ◽  
Fei Li ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Fatty Acid ◽  
Gestational Diabetes ◽  
Polyunsaturated Fatty Acid ◽  
Juglans Regia ◽  
Diabetic Rats ◽  
Pregnant Rats ◽  
Beneficial Effects ◽  
Metabolism Disorder ◽  
Pregnant Diabetic

Abstract Background: Gestational diabetes mellitus has a long-term effect on pregnant women. Walnut (Juglans regia L.) oil-derived polyunsaturated fatty acid (PUFA) possesses multifarious pharmacological activities. This study investigated the beneficial effects of walnut oil-derived PUFA on glucose metabolism disorder, pregnancy outcomes, oxidative stress, and lipid metabolism disorder in gestational diabetes mellitus.Methods: The GDM rat model was generated by intraperitoneal injection of streptozotocin (40 mg/kg) on gestational day (GD) 6, GD7 and GD8. The differences between groups were estimated using one-way ANOVA followed by the Tukey’s multiple comparison test for post-hoc analysis.Results: The results indicated that PUFA could mitigate GDM in pregnant diabetic rats, as embodied by the decrease of fasting blood glucose and the increase of plasma insulin and hepatic glycogen levels. Also, PUFA could suppress oxidative stress in pregnant diabetic rats, as reflected by the decrease of malondialdehyde (MDA) content, an increase of superoxide dismutase (SOD), catalase (CAT) and gutathione peroxidase (GSH-Px) activities. PUFA could also mitigate the abnormal changes of lipid profiles in plasma and hepatic tissue. Moreover, the relative mRNA expression of sterol regulatory element-binding transcription factor-1 (SREBP-1), stearoyl-CoA desaturase-1 (SCD-1), fatty acid synthase (FAS), and acetyl-coenzyme A carboxylase (ACC), was suppressed by PUFA in pregnant diabetic rats.Conclusions: These results suggested that PUFA supplementation during the pregnancy is beneficial in preventing diabetic complications in pregnant rats.

scholarly journals Beneficial effects of walnut (Juglans regia L.) oil-derived polyunsaturated fatty acid prevents a prooxidant status and hyperlipidemia in pregnant rats with diabetes

2020 ◽  
Author(s):  
Bingmei Sun ◽  
Hua Yan ◽  
Chao Li ◽  
Linlin Yin ◽  
Fei Li ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Diabetes Mellitus ◽  
Fatty Acid ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Juglans Regia ◽  
Diabetic Rats ◽  
Pregnant Rats ◽  
Beneficial Effects ◽  
Pregnant Diabetic

Abstract Background: Gestational diabetes mellitus has a long-term effect on pregnant women. Walnut (Juglans regia L.) oil-derived polyunsaturated fatty acid (PUFA) possesses multifarious pharmacological activities. This study investigated the beneficial effects of walnut oil-derived PUFA on glucose metabolism, pregnancy outcomes, oxidative stress, and lipid metabolism in gestational diabetes mellitus.Methods: The GDM rat model was generated by intraperitoneal injection of streptozotocin (40 mg/kg) on gestational day (GD) 6, GD7 and GD8. The differences between groups were estimated using one-way ANOVA followed by the Tukey’s multiple comparison test for post-hoc analysis.Results: The results indicated that PUFA could mitigate GDM in pregnant diabetic rats, as embodied by the decrease of fasting blood glucose and the increase of plasma insulin and hepatic glycogen levels. Also, PUFA could suppress oxidative stress in pregnant diabetic rats, as reflected by the decrease of malondialdehyde (MDA) content, an increase of superoxide dismutase (SOD), catalase (CAT) and gutathione peroxidase (GSH-Px) activities. PUFA could also mitigate the abnormal changes of lipid profiles in plasma and hepatic tissue. Moreover, the relative mRNA expression of sterol regulatory element-binding transcription factor-1 (SREBP-1), stearoyl-CoA desaturase-1 (SCD-1), fatty acid synthase (FAS), and acetyl-coenzyme A carboxylase (ACC), was suppressed by PUFA in pregnant diabetic rats.Conclusions: These results suggested that PUFA supplementation during pregnancy is beneficial in preventing diabetic complications in pregnant rats.

scholarly journals Beneficial effects of walnut (Juglans regia L.) oil-derived polyunsaturated fatty acid prevents a prooxidant status and hyperlipidemia in pregnant rats with diabetes

2020 ◽  
Vol 17 (1) ◽  
Author(s):  
Bingmei Sun ◽  
Hua Yan ◽  
Chao Li ◽  
Linlin Yin ◽  
Fei Li ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Diabetes Mellitus ◽  
Fatty Acid ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Juglans Regia ◽  
Diabetic Rats ◽  
Pregnant Rats ◽  
Beneficial Effects ◽  
Pregnant Diabetic

Abstract Background Gestational diabetes mellitus has a long-term effect on pregnant women. Walnut (Juglans regia L.) oil-derived polyunsaturated fatty acid (PUFA) possesses multifarious pharmacological activities. This study investigated the beneficial effects of walnut oil-derived PUFA on glucose metabolism, pregnancy outcomes, oxidative stress, and lipid metabolism in gestational diabetes mellitus. Methods The GDM rat model was generated by intraperitoneal injection of streptozotocin (40 mg/kg) on gestational day (GD) 6, GD7 and GD8. The differences between groups were estimated using one-way ANOVA followed by the Tukey’s multiple comparison test for post-hoc analysis. Results The results indicated that PUFA could mitigate GDM in pregnant diabetic rats, as embodied by the decrease of fasting blood glucose and the increase of plasma insulin and hepatic glycogen levels. Also, PUFA could suppress oxidative stress in pregnant diabetic rats, as reflected by the decrease of malondialdehyde content, an increase of superoxide dismutase, catalase and gutathione peroxidase activities. PUFA could also mitigate the abnormal changes of lipid profiles in plasma and hepatic tissue. Moreover, the relative mRNA expression of sterol regulatory element-binding transcription factor-1, stearoyl-CoA desaturase-1, fatty acid synthase, and acetyl-coenzyme A carboxylase, was suppressed by PUFA in pregnant diabetic rats. Conclusions These results suggested that PUFA supplementation during pregnancy is beneficial in preventing diabetic complications in pregnant rats.

scholarly journals Beneficial effects of walnut (Juglans regia L.) oil-derived polyunsaturated fatty acid prevents hyperlipidemia and oxidant status in pregnant rats with diabetes

2020 ◽  
Author(s):  
Bingmei Sun ◽  
Hua Yan ◽  
Chao Li ◽  
Linlin Yin ◽  
Fei Li ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Fatty Acid ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Polyunsaturated Fatty Acid ◽  
Juglans Regia ◽  
Diabetic Rats ◽  
Pregnant Rats ◽  
Beneficial Effects ◽  
Pregnant Diabetic

Abstract Background: Gestational diabetes mellitus has a long-term effect on pregnant women. Walnut (Juglans regia L.) oil-derived polyunsaturated fatty acid (PUFA) possesses multifarious pharmacological activities. This study investigated the beneficial effects of PUFA on the gestational diabetes mellitus (GDM) and to study the underlying mechanism in pregnant rats with diabetes.Methods: The GDM rat model was generated by intraperitoneal injection of streptozotocin (40 mg/kg) on gestational day (GD) 6, GD7 and GD8. The differences between groups were estimated using one-way ANOVA followed by the Tukey’s multiple comparison test for post-hoc analysis.Results: The results indicated that PUFA could mitigate GDM in pregnant diabetic rats, as embodied by the decrease of fasting blood glucose and the increase of plasma insulin and hepatic glycogen levels. Also, PUFA could suppress oxidative stress in pregnant diabetic rats, as reflected by the decrease of malondialdehyde (MDA) content, an increase of superoxide dismutase (SOD), catalase (CAT) and gutathione peroxidase (GSH-Px) activities. PUFA could also mitigate the abnormal changes of lipid profiles in plasma and hepatic tissue. Moreover, the relative mRNA expression of sterol regulatory element-binding transcription factor-1 (SREBP-1), stearoyl-CoA desaturase-1 (SCD-1), fatty acid synthase (FAS), and acetyl-coenzyme A carboxylase (ACC), was suppressed by PUFA in pregnant diabetic rats.Conclusions: These results suggested that PUFA supplementation during the pregnancy might be beneficial in preventing diabetic complications in the mother.

scholarly journals Beneficial effects of walnut (Juglans regia L.) oil-derived polyunsaturated fatty acid prevents hyperlipidemia and oxidant status in pregnant rats with diabetes

2020 ◽  
Author(s):  
Bingmei Sun ◽  
Hua Yan ◽  
Chao Li ◽  
Linlin Yin ◽  
Fei Li ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Fatty Acid ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Polyunsaturated Fatty Acid ◽  
Juglans Regia ◽  
Diabetic Rats ◽  
Pregnant Rats ◽  
Beneficial Effects ◽  
Pregnant Diabetic

Abstract Background: Gestational diabetes mellitus has a long-term effect on pregnant women. Walnut (Juglans regia L.) oil-derived polyunsaturated fatty acid (PUFA) possesses multifarious pharmacological activities. This study investigated the beneficial effects of PUFA on the gestational diabetes mellitus (GDM) and to study the underlying mechanism in pregnant rats with diabetes.Methods: The GDM rat model was generated by intraperitoneal injection of streptozotocin (40 mg/kg) on gestational day (GD) 6, GD7 and GD8. The differences between groups were estimated using one-way ANOVA followed by the Tukey’s multiple comparison test for post-hoc analysis.Results: The results indicated that PUFA could mitigate GDM in pregnant diabetic rats, as embodied by the decrease of fasting blood glucose and the increase of plasma insulin and hepatic glycogen levels. Also, PUFA could suppress oxidative stress in pregnant diabetic rats, as reflected by the decrease of malondialdehyde (MDA) content, an increase of superoxide dismutase (SOD), catalase (CAT) and gutathione peroxidase (GSH-Px) activities. PUFA could also mitigate the abnormal changes of lipid profiles in plasma and hepatic tissue. Moreover, the relative mRNA expression of sterol regulatory element-binding transcription factor-1 (SREBP-1), stearoyl-CoA desaturase-1 (SCD-1), fatty acid synthase (FAS), and acetyl-coenzyme A carboxylase (ACC), was suppressed by PUFA in pregnant diabetic rats.Conclusions: These results suggested that PUFA supplementation during the pregnancy might be beneficial in preventing diabetic complications in the mother.

scholarly journals Effects of Apocynin on Heart Muscle Oxidative Stress of Rats with Experimental Diabetes: Implications for Mitochondria

Antioxidants ◽  
2021 ◽  
Vol 10 (3) ◽  
pp. 335
Author(s):  
Estefanía Bravo-Sánchez ◽  
Donovan Peña-Montes ◽  
Sarai Sánchez-Duarte ◽  
Alfredo Saavedra-Molina ◽  
Elizabeth Sánchez-Duarte ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Insulin Sensitivity ◽  
Cardiac Tissue ◽  
Diabetic Rats ◽  
Oxidase Inhibitor ◽  
Beneficial Effects ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Transport Chain ◽  
Male Wistar Rats

Diabetes mellitus (DM) constitutes one of the public health problems today. It is characterized by hyperglycemia through a defect in the β-cells function and/or decreased insulin sensitivity. Apocynin has been tasted acting directly as an NADPH oxidase inhibitor and reactive oxygen species (ROS) scavenger, exhibiting beneficial effects against diabetic complications. Hence, the present study’s goal was to dissect the possible mechanisms by which apocynin could mediate its cardioprotective effect against DM-induced oxidative stress. Male Wistar rats were assigned into 4 groups: Control (C), control + apocynin (C+A), diabetes (D), diabetes + apocynin (D+A). DM was induced with streptozotocin. Apocynin treatment (3 mg/kg/day) was applied for 5 weeks. Treatment significantly decreased blood glucose levels and insulin resistance in diabetic rats. In cardiac tissue, ROS levels were higher, and catalase enzyme activity was reduced in the D group compared to the C group; the apocynin treatment significantly attenuated these responses. In heart mitochondria, Complexes I and II of the electron transport chain (ETC) were significantly enhanced in the D+A group. Total glutathione, the level of reduced glutathione (GSH) and the GSH/ oxidized glutathione (GSSG) ratio were increased in the D+A group. Superoxide dismutase (SOD) and the glutathione peroxidase (GSH-Px) activities were without change. Apocynin enhances glucose uptake and insulin sensitivity, preserving the antioxidant defense and mitochondrial function.

scholarly journals New Perspectives of S-Adenosylmethionine (SAMe) Applications to Attenuate Fatty Acid-Induced Steatosis and Oxidative Stress in Hepatic and Endothelial Cells

Molecules ◽  
2020 ◽  
Vol 25 (18) ◽  
pp. 4237 ◽  
Author(s):  
Laura Vergani ◽  
Francesca Baldini ◽  
Mohamad Khalil ◽  
Adriana Voci ◽  
Pietro Putignano ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Endothelial Cells ◽  
Fatty Acid ◽  
Lipid Accumulation ◽  
Endothelium Dysfunction ◽  
Beneficial Effects ◽  
Mitochondrial Fatty Acid ◽  
Oxidant Production ◽  
Pleiotropic Functions ◽  
And Oxidative Stress

S-adenosylmethionine (SAMe) is an endogenous methyl donor derived from ATP and methionine that has pleiotropic functions. Most SAMe is synthetized and consumed in the liver, where it acts as the main methylating agent and in protection against the free radical toxicity. Previous studies have shown that the administration of SAMe as a supernutrient exerted many beneficial effects in various tissues, mainly in the liver. In the present study, we aimed to clarify the direct effects of SAMe on fatty acid-induced steatosis and oxidative stress in hepatic and endothelial cells. Hepatoma FaO cells and endothelial HECV cells exposed to a mixture of oleate/palmitate are reliable models for hepatic steatosis and endothelium dysfunction, respectively. Our findings indicate that SAMe was able to significantly ameliorate lipid accumulation and oxidative stress in hepatic cells, mainly through promoting mitochondrial fatty acid entry for β-oxidation and external triglyceride release. SAMe also reverted both lipid accumulation and oxidant production (i.e., ROS and NO) in endothelial cells. In conclusion, these outcomes suggest promising beneficial applications of SAMe as a nutraceutical for metabolic disorders occurring in fatty liver and endothelium dysfunction.

Finishing diets used in beef and lamb production in Northern Ireland: results of a questionnaire survey

2009 ◽  
Vol 2009 ◽  
pp. 137-137
Author(s):  
A J McAfee ◽  
E Duffy ◽  
G Cuskelly ◽  
A Fearon ◽  
J Wallace ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Northern Ireland ◽  
Human Health ◽  
Polyunsaturated Fatty Acid ◽  
Strong Evidence ◽  
Questionnaire Survey ◽  
Pufa Content ◽  
Finishing Diets ◽  
Beneficial Effects ◽  
Feeding Regimes

Ruminant feeding regimes that include grass finishing are known to increase the n-3 polyunsaturated fatty acid (n-3 PUFA) content of beef and lamb. By contrast, concentrate finishing produces meat with increased n-6 PUFA concentrations. There is strong evidence that increasing the ratio of n-3: n-6 PUFA in the diet has beneficial effects for human health. In Northern Ireland, it is likely that feeding regimes are predominantly grass-based; therefore beef and lamb could contain appreciable amounts of n-3 PUFA. However, an analysis of types of finishing diets used by farms in Northern Ireland has not been done. The aim of this study was to assess the frequency of grass and concentrate finishing in farms in Northern Ireland.

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