Serum fructosamine targeting the treatment of gestational diabetes mellitus

Background: Currently,the blood glucose control in women with gestational diabetes (GDM) in Vietnam has been still based on the criteria applied for non-pregnant diabetic patients, while these GDM patients require more specific criteria in order to get a better care of the women and the good delivery outcome. Objective: To determine serum fructosamine target as a supporting test for the treatment and follow-up of GDM. Methodology: A prospective study was done in 451women with GDM at Cho Ray Hospital from August 2016 to March 2019.At least 2 of 3 tests (Go, G2 and HbA1c) and serum fructosamine were determined every 2-3 week-up until delivery. Result: The target fructosamine reference value at Cho Ray Hospital was 188.5±42.3µmol/L. Conclusion: The specific target of serum fructosamine in GDM treatment at Cho Ray hospital should be £188.5 ± 42.3mmol/L.

Beneficial effects of walnut (Juglans regia L.) oil-derived polyunsaturated fatty acid prevents a prooxidant status and hyperlipidemia in pregnant rats with diabetes

Background Gestational diabetes mellitus has a long-term effect on pregnant women. Walnut (Juglans regia L.) oil-derived polyunsaturated fatty acid (PUFA) possesses multifarious pharmacological activities. This study investigated the beneficial effects of walnut oil-derived PUFA on glucose metabolism, pregnancy outcomes, oxidative stress, and lipid metabolism in gestational diabetes mellitus. Methods The GDM rat model was generated by intraperitoneal injection of streptozotocin (40 mg/kg) on gestational day (GD) 6, GD7 and GD8. The differences between groups were estimated using one-way ANOVA followed by the Tukey’s multiple comparison test for post-hoc analysis. Results The results indicated that PUFA could mitigate GDM in pregnant diabetic rats, as embodied by the decrease of fasting blood glucose and the increase of plasma insulin and hepatic glycogen levels. Also, PUFA could suppress oxidative stress in pregnant diabetic rats, as reflected by the decrease of malondialdehyde content, an increase of superoxide dismutase, catalase and gutathione peroxidase activities. PUFA could also mitigate the abnormal changes of lipid profiles in plasma and hepatic tissue. Moreover, the relative mRNA expression of sterol regulatory element-binding transcription factor-1, stearoyl-CoA desaturase-1, fatty acid synthase, and acetyl-coenzyme A carboxylase, was suppressed by PUFA in pregnant diabetic rats. Conclusions These results suggested that PUFA supplementation during pregnancy is beneficial in preventing diabetic complications in pregnant rats.

Beneficial effects of walnut (Juglans regia L.) oil-derived polyunsaturated fatty acid prevents a prooxidant status and hyperlipidemia in pregnant rats with diabetes

Background: Gestational diabetes mellitus has a long-term effect on pregnant women. Walnut (Juglans regia L.) oil-derived polyunsaturated fatty acid (PUFA) possesses multifarious pharmacological activities. This study investigated the beneficial effects of walnut oil-derived PUFA on glucose metabolism, pregnancy outcomes, oxidative stress, and lipid metabolism in gestational diabetes mellitus.Methods: The GDM rat model was generated by intraperitoneal injection of streptozotocin (40 mg/kg) on gestational day (GD) 6, GD7 and GD8. The differences between groups were estimated using one-way ANOVA followed by the Tukey’s multiple comparison test for post-hoc analysis.Results: The results indicated that PUFA could mitigate GDM in pregnant diabetic rats, as embodied by the decrease of fasting blood glucose and the increase of plasma insulin and hepatic glycogen levels. Also, PUFA could suppress oxidative stress in pregnant diabetic rats, as reflected by the decrease of malondialdehyde (MDA) content, an increase of superoxide dismutase (SOD), catalase (CAT) and gutathione peroxidase (GSH-Px) activities. PUFA could also mitigate the abnormal changes of lipid profiles in plasma and hepatic tissue. Moreover, the relative mRNA expression of sterol regulatory element-binding transcription factor-1 (SREBP-1), stearoyl-CoA desaturase-1 (SCD-1), fatty acid synthase (FAS), and acetyl-coenzyme A carboxylase (ACC), was suppressed by PUFA in pregnant diabetic rats.Conclusions: These results suggested that PUFA supplementation during pregnancy is beneficial in preventing diabetic complications in pregnant rats.

Beneficial effects of walnut (Juglans regia L.) oil-derived polyunsaturated fatty acid prevents oxidant status and hyperlipidemia in pregnant rats with diabetes

Background: Gestational diabetes mellitus has a long-term effect on pregnant women. Walnut (Juglans regia L.) oil-derived polyunsaturated fatty acid (PUFA) possesses multifarious pharmacological activities. This study investigated the beneficial effects of walnut oil-derived PUFA on glucose metabolism disorder, pregnancy outcomes, oxidative stress, and lipid metabolism disorder in gestational diabetes mellitus.Methods: The GDM rat model was generated by intraperitoneal injection of streptozotocin (40 mg/kg) on gestational day (GD) 6, GD7 and GD8. The differences between groups were estimated using one-way ANOVA followed by the Tukey’s multiple comparison test for post-hoc analysis.Results: The results indicated that PUFA could mitigate GDM in pregnant diabetic rats, as embodied by the decrease of fasting blood glucose and the increase of plasma insulin and hepatic glycogen levels. Also, PUFA could suppress oxidative stress in pregnant diabetic rats, as reflected by the decrease of malondialdehyde (MDA) content, an increase of superoxide dismutase (SOD), catalase (CAT) and gutathione peroxidase (GSH-Px) activities. PUFA could also mitigate the abnormal changes of lipid profiles in plasma and hepatic tissue. Moreover, the relative mRNA expression of sterol regulatory element-binding transcription factor-1 (SREBP-1), stearoyl-CoA desaturase-1 (SCD-1), fatty acid synthase (FAS), and acetyl-coenzyme A carboxylase (ACC), was suppressed by PUFA in pregnant diabetic rats.Conclusions: These results suggested that PUFA supplementation during the pregnancy is beneficial in preventing diabetic complications in pregnant rats.

Beneficial effects of walnut (Juglans regia L.) oil-derived polyunsaturated fatty acid prevents hyperlipidemia and oxidant status in pregnant rats with diabetes

Background: Gestational diabetes mellitus has a long-term effect on pregnant women. Walnut (Juglans regia L.) oil-derived polyunsaturated fatty acid (PUFA) possesses multifarious pharmacological activities. This study investigated the beneficial effects of PUFA on the gestational diabetes mellitus (GDM) and to study the underlying mechanism in pregnant rats with diabetes.Methods: The GDM rat model was generated by intraperitoneal injection of streptozotocin (40 mg/kg) on gestational day (GD) 6, GD7 and GD8. The differences between groups were estimated using one-way ANOVA followed by the Tukey’s multiple comparison test for post-hoc analysis.Results: The results indicated that PUFA could mitigate GDM in pregnant diabetic rats, as embodied by the decrease of fasting blood glucose and the increase of plasma insulin and hepatic glycogen levels. Also, PUFA could suppress oxidative stress in pregnant diabetic rats, as reflected by the decrease of malondialdehyde (MDA) content, an increase of superoxide dismutase (SOD), catalase (CAT) and gutathione peroxidase (GSH-Px) activities. PUFA could also mitigate the abnormal changes of lipid profiles in plasma and hepatic tissue. Moreover, the relative mRNA expression of sterol regulatory element-binding transcription factor-1 (SREBP-1), stearoyl-CoA desaturase-1 (SCD-1), fatty acid synthase (FAS), and acetyl-coenzyme A carboxylase (ACC), was suppressed by PUFA in pregnant diabetic rats.Conclusions: These results suggested that PUFA supplementation during the pregnancy might be beneficial in preventing diabetic complications in the mother.