scholarly journals Clinical observation of different treatment strategies in pregnant women with COVID-19: a retrospective study

2020 ◽  
Author(s):  
Gang Lei ◽  
Jinghua Tian ◽  
Shuangqin Peng ◽  
Xiaoji Hu ◽  
Pei Zhang ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Clinical Characteristics ◽  
Virus Disease ◽  
Pregnancy Termination ◽  
Treatment Strategies ◽  
Fetal Malformation ◽  
Second Trimester ◽  
Fetal Outcomes ◽  
Spontaneous Miscarriage ◽  
Maternal And Neonatal Outcomes

Abstract Objective: this study aimed to clarify the clinical characteristics, obstetrical and fetal outcomes of patients with Corona Virus Disease 2019 (COVID-19) in different stage during pregnancy.Methods: 13 pregnant women with COVID-19 were admitted to Wuhan central hospital and Renmin hospital of Wuhan university between Jan 20 and march 20, 2020, including four patients in first and second trimester demanding for pregnancy termination, seven in first and second trimester and two in third trimester keeping pregnancy. The two groups’ clinical characteristics, treatment and maternal and fetal outcomes were observed and analyzed.Results: Most common clinical manifestation were fever and cough. Among the patients keeping pregnancy, one had a spontaneous miscarriage and fetal malformation was found in another one. Two patients who had a vaginal delivery presented good maternal and neonatal outcomes. All patients showed a good recovery. Conclusion: SARS-COV-2 infection could cause spontaneous miscarriage and fetal malformation in early pregnancy.

scholarly journals COVID-19 and Pregnancy Outcome: An Experience in ‘COVID-19 Management Designated’ Tertiary Care Hospital, Rawalpindi, Pakistan

2020 ◽  
Vol 24 (Supp-1) ◽  
pp. 85-91
Author(s):  
Shazia Syed ◽  
Humera Noreen ◽  
Humaira Masood ◽  
Ismat Batool ◽  
Hina Gul ◽  
...  
Keyword(s):  
Hepatic Encephalopathy ◽  
Pregnant Women ◽  
Clinical Characteristics ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Neonatal Outcomes ◽  
Categorical Variables ◽  
Care Hospital ◽  
Case Series Study ◽  
Maternal And Neonatal Outcomes

Background: The current COVID-19 pandemic has affected almost 17.3 million victims worldwide with mortality of almost 674K. Pregnancy is one of the most susceptible conditions for COVID-19 infection, but limited data is currently available about the clinical characteristics of pregnant women with the disease. Objective; to describe the clinical characteristics, co-morbidities, management, feto-maternal, and neonatal outcome in COVID-19 positive pregnant women. Methodology: A descriptive case series study was conducted in Obs/Gynae dept of Benazir Bhutto Tertiary Care Hospital, Rawalpindi, including all asymptomatic/symptomatic COVID-19 positive pregnant women and clinical suspects (COVID-19 PCR negative women) delivered in our hospital from 01st April 2020 to 31st July 2020. Their medical records were reviewed for clinical characteristics, management, feto-maternal and neonatal outcomes. Continuous variables were expressed in Mean & Range and Categorical variables as number & Percentage. Results: During the study period a total of 17 cases were reviewed. The mean maternal age was 28.94 yrs. Primigravida (07), Multipara (10). Mean gestational age was 37 wks (range; 30-41wks). Presenting symptomatology was varied. Asymptomatic; (29%), COVID-19 specific symptoms; fever & flu (12%), fever&cough (6%), shortness of breath(SOB) alone (6%), fever & SOB(6%) and pregnancy-related manifestations were labour pains (17%), eclampsia(6%), hydrocephalous fetus (6%) and hepatic encephalopathy(6%). The commonest co-morbidity was Hypertensive disorders of pregnancy (24%). Five women (29%) required ICU care. Lower segment caesarean sections(LSCS) (59%), vaginal delivery (41%). Eleven babies delivered with good Apgar score and birth weight. Two were early neonatal deaths (ENND) and 04 were received intra-uterine fetal deaths (IUDs). Fetal demise was associated with strong obstetric risk factors. Out of 13 live-born babies, RT-PCR Covid-19 testing was done in 10 (77%) cases and was negative. One mother was expired due to complications of hepatic encephalopathy, sepsis, and burst abdomen. Conclusion; The clinical course of COVID-19 disease in pregnancy seems to be no different from non-pregnant women. Clinical manifestations are diverse and infection contracted in the third trimester of pregnancy is associated with good feto-maternal and neonatal outcomes.

scholarly journals Comparison of Maternal and Fetal Outcomes in Pregnancies with Preterm Premature Rupture of Membrane (PPROM) Terminating in 34th or 36th Gestational Weeks: A Clinical Trial

2017 ◽  
Vol 5 (2) ◽  
pp. 3
Author(s):  
Shamsi Abbasalizadeh ◽  
Rana Bagherifard ◽  
Farshad Mahdavi ◽  
Fatemeh Abbasaizadeh ◽  
Shiva Raouf
Keyword(s):  
Birth Weight ◽  
Pregnant Women ◽  
Pregnancy Termination ◽  
Neonatal Outcomes ◽  
Birth Complications ◽  
Significant Difference ◽  
Group A ◽  
Maternal And Neonatal Outcomes ◽  
Nicu Admission ◽  
Group B

present  study,  we aimed at studying maternal  and  neonatal  outcomes  in  patients with terminated pregnancy in 34th  and  36th  gestational  weeks. Materials and methods: 40 pregnant women, with PPROM who underwent pregnancy termination at 34 group (A) or 36 group (B) gestational weeks, were included to be evaluated and compared for maternal and neonatal outcomes. Type of delivery, birth complications, chorioamnoionitis, endometritis, sepsis, maternal mortality, infant gender, birth weight, Apgar scores, respiratory distress syndrome, Meconium-stained amniotic fluid, NICU admission, abruption, umbilical cord prolapse, maternal and neonatal outcomes were compared between the two groups.  Results: There was no statistically significant difference between the two groups regarding maternal age, level of education, or gravity. The percentage of cases with birth weight between 1500 and 2500 g was significantly higher in group A P<0.001). Frequency of NICU admission in group A was significantly more than group B (P<0.001). In conclusion: Termination of pregnancy at 36 weeks compared to 34 weeks in pregnant women with PPROM is preferred in terms of neonatal outcomes and it is recommended; also, there might be no preference in terms of  maternal outcomes. 

scholarly journals Clinical characteristics, maternal and neonatal outcomes of pregnant women with SARS-CoV-2 infection in Turkey

2021 ◽  
Vol 122 (02) ◽  
pp. 152-157
Author(s):  
M. Ozsurmeli ◽  
H. Terzi ◽  
M. Hocaoglu ◽  
R. A. Bilir ◽  
T. Gunay ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Clinical Characteristics ◽  
Neonatal Outcomes ◽  
Maternal And Neonatal Outcomes

scholarly journals Influence of Second-Trimester Ultrasound Markers for Down Syndrome in Pregnant Women of Advanced Maternal Age

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Mariza Rumi Kataguiri ◽  
Edward Araujo Júnior ◽  
Luiz Claudio Silva Bussamra ◽  
Luciano Marcondes Machado Nardozza ◽  
Antonio Fernandes Moron
Keyword(s):  
Down Syndrome ◽  
Pregnant Women ◽  
Maternal Age ◽  
Advanced Maternal Age ◽  
Nonparametric Tests ◽  
Fetal Malformation ◽  
Second Trimester ◽  
Chi Square ◽  
Exact Test ◽  
Chi Square Test

The objective of the present study was to evaluate the influence of second-trimester ultrasound markers on the incidence of Down syndrome among pregnant women of advanced maternal age. This was a retrospective cohort study on 889 singleton pregnancies between the 14th and 30th weeks, with maternal age ≥ 35 years, which would undergo genetic amniocentesis. The second-trimester ultrasound assessed the following markers: increased nuchal fold thickness, cardiac hyperechogenic focus, mild ventriculomegaly, choroid plexus cysts, uni- or bilateral renal pyelectasis, intestinal hyperechogenicity, single umbilical artery, short femur and humerus length, hand/foot alterations, structural fetal malformation, and congenital heart disease. To investigate differences between the groups with and without markers, nonparametric tests consisting of the chi-square test or Fisher’s exact test were used. Moreover, odds ratios with their respective 95% confidence intervals were calculated. Out of the 889 pregnant women, 131 (17.3%) presented markers and 758 (82.7%) did not present markers on the second-trimester ultrasound. Increased nuchal fold (P<0.001) and structural malformation (P<0.001) were the markers most associated with Down syndrome. The presence of one marker increased the relative risk 10.5-fold, while the presence of two or more markers increased the risk 13.5-fold. The presence of markers on the second-trimester ultrasound, especially thickened nuchal fold and structural malformation, increased the risk of Down syndrome among pregnant women with advanced maternal age.

Cancer during pregnancy – clinical characteristics, treatment outcomes and prognosis for mothers and infants

2018 ◽  
Vol 46 (1) ◽  
pp. 35-45 ◽  
Author(s):  
Katarina Jeremic ◽  
Aleksandar Stefanovic ◽  
Jelena Dotlic ◽  
Sasa Kadija ◽  
Olivera Kontic ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Clinical Characteristics ◽  
Malignant Tumors ◽  
Combined Therapy ◽  
Second Trimester ◽  
Improved Outcomes ◽  
Good State ◽  
Term Delivery ◽  
A Prospective Study ◽  
Future Condition

AbstractObjective:To assess which obstetrical characteristics and treatment improved outcomes and prognosis of pregnant women with malignancy.Methods:A prospective study, undertaken between 2005 and 2014, involving 35 pregnant women who were diagnosed with malignant tumors during pregnancy. Patients were followed-up for 1 year after delivery. The pregnancy course and outcome and parameters that could influence the condition of mother and fetus were evaluated.Results:Most malignancies were hematological, diagnosed in the second trimester and treated with combined therapy (surgery/adjuvant) after pregnancy. Most fetuses were in good state throughout pregnancy, but were delivered by caesarean section (CS) before term. Adjuvant therapy during pregnancy mostly caused transitory deterioration of fetal conditions. The majority of both mothers and infants were in a good state 12 months postpartum, although numerous mothers were still ill and on therapy. Surviving pregnancy and preventing tumors progression during pregnancy were the best predictors of mothers’ future condition (P=0.022). High birthweight and term delivery were the most important factors for good outcome of the infants (P=0.001).Conclusions:If the tumor is not progressing, pregnancy should be continued as long as possible to obtain adequate birthweight of the infant. Second trimester surgery is safe, while other therapies should preferably be applied after delivery.

scholarly journals Characteristics and Treatment Strategies of Different Clinical Types in Patients with Corona Virus Disease 2019

2020 ◽  
Author(s):  
Fangfang Liu ◽  
Chengcheng Ji ◽  
Jiajun Luo ◽  
Weiwei Wu ◽  
Junchang Zhang ◽  
...  
Keyword(s):  
T Lymphocyte ◽  
Clinical Characteristics ◽  
General Type ◽  
Virus Disease ◽  
Treatment Strategies ◽  
Clearance Time ◽  
Virus Clearance ◽  
Corona Virus ◽  
Significant Difference ◽  
Critical Patients

Abstract Objective To describe the epidemiological and clinical characteristics of patients with Corona Virus Disease 2019 (COVID19) in Beijing. To analyze the treatment strategies especially the application of corticosteroids in patients with severe pneumonia.Methods We collected information on demographic characteristics, exposure history, clinical characteristics, treatment and outcomes of the 65 confirmed cases of COVID19 at the 5th Medical Center of PLA General Hospital from Jan 20 to Feb 23, 2020. The final follow-up date observed was Feb 29, 2020. Results The number of patients with mild, general, severe, and critical type were 10 (15.38%), 32 (49.23%), 8 (12.31%), and 15 (23.08%), respectively. The median incubation period was 6 days. Notable outliers were 1 patient at 16 days and 1 patient at 21 days. In lymphocyte subgroup analysis, decreases in total, T, CD4, and CD8 lymphocytes were more common as the disease worsened (All P<0.05). Methylprednisolone was applied to 31 (47.69%) patients with pneumonia, including 10 (31.25%) general, 8 (100%) severe, and 13 (86.67%) critical patients, respectively. Corticosteroids inhibited Interleukin-6(IL-6) production (P=0.0215) but did not affect T lymphocyte (P=0.0796). There was no significant difference between patients using lower dose (≤2mg/kg.d) and higher dose (>2mg/kg.d) methylprednisolone in inhibiting IL-6 production (P=0.5856). Thirty of 31 patients (96.77%) had stopped methylprednisolone due to improvement of pneumonia. Virus RNA clearance time lengthened with disease progression (P=0.0001). In general type, there was no significant difference in virus clearance time between patients with (15, 12-19 days) and without (14.5, 11-18 days) (P=0.7372) methylprednisolone use. Conclusions Lymphocyte, especially T lymphocyte, in severe and critical patients showed a dramatic decrease. Application of lower dose corticosteroids (≤2mg/kg.d) could inhibit IL-6 production (a representative of cytokines) as effectively as a higher dose. Proper use corticosteroids in general type patients did not delay virus clearance. Authors Fangfang Liu and Chengcheng Ji contributed equally to this work.

scholarly journals Continued use of Warfarin in lower dose has safe maternal and neonatal outcomes in pregnant women with Prosthetic Heart Valves

2021 ◽  
Vol 37 (4) ◽  
Author(s):  
Shafaq Nadeem ◽  
Shahbaz Ahmad Khilji ◽  
Faisal Ali ◽  
Anjum Jalal
Keyword(s):  
Birth Weight ◽  
Pregnant Women ◽  
Valve Replacement ◽  
Prosthetic Valve ◽  
Heart Valves ◽  
Prosthetic Heart Valves ◽  
Fetal Outcomes ◽  
Maternal And Neonatal Outcomes ◽  
Continued Use ◽  
Pregnant Mothers

Background and Objective: There has been concerns regarding the safety of Warfarin in pregnant females due to its teratogenic potential. At the same time warfarin provides best anticoagulation in patients with prosthetic valves. Various dosage regimes have been tried to strike a balance between safety of mother and the avoidance of congenital anomalies in the newborn. This study was conducted to observe the effect of Warfarin in pregnant mothers taking different doses of warfarin, and their neonatal outcome, in our outdoor patients. Methods: This is a cross sectional observational study conducted at the Faisalabad Institute of Cardiology. The pregnant mothers taking warfarin for prosthetic valve replacement who presented to our specialized clinic between November 2016 to April 2017 were included in the study. These included a total of 75 females between the age of 20-35 years. To compare the dose related effect of warfarin, two groups of the patients were formed. One group comprised of patients taking warfarin ≤5mg while the other group consisted of those who were taking >5mg of warfarin daily. These patients were followed till their delivery. The information was collected about the maternal and fetal outcomes. The maternal outcomes including mode of delivery/miscarriage, peripartum bleeding and any valve related thromboembolic complications. The fetal outcomes included birth weight, maturity, embryopathy and congenital anomaly in the baby. Results: Patient’s mean age was 29.25±3.75 years. The mitral valve replacement was present in 60% patients (n=45) while 25.3% patients (n=19) had aortic valve replacement and 14.7% patients (n=11) had double valve replacement. In this group 30 patients (40%) had taken <5 mg warfarin and 45 patients (60%) had received >5 mg warfarin medicine. Miscarriages, cesarean sections, low birth weight and prematurity were more common in patients receiving warfarin >5 mg with p-values 0.005, 0.046, 0.01 and 0.033 respectively. No case of fetal embryopathy was found in both groups. Conclusion: No case of embryopathy was found in each group which signifies that warfarin in lower doses is safe anticoagulant in patients with prosthetic valve replacements. doi: https://doi.org/10.12669/pjms.37.4.3924 How to cite this:Nadeem S, Khilji SA, Ali F, Jalal A. Continued use of Warfarin in lower dose has safe maternal and neonatal outcomes in pregnant women with Prosthetic Heart Valves. Pak J Med Sci. 2021;37(4):---------. doi: https://doi.org/10.12669/pjms.37.4.3924 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Sign in / Sign up

Export Citation Format

Share Document