Comparison of Maternal and Fetal Outcomes in Pregnancies with Preterm Premature Rupture of Membrane (PPROM) Terminating in 34th or 36th Gestational Weeks: A Clinical Trial

present study, we aimed at studying maternal and neonatal outcomes in patients with terminated pregnancy in 34th and 36th gestational weeks. Materials and methods: 40 pregnant women, with PPROM who underwent pregnancy termination at 34 group (A) or 36 group (B) gestational weeks, were included to be evaluated and compared for maternal and neonatal outcomes. Type of delivery, birth complications, chorioamnoionitis, endometritis, sepsis, maternal mortality, infant gender, birth weight, Apgar scores, respiratory distress syndrome, Meconium-stained amniotic fluid, NICU admission, abruption, umbilical cord prolapse, maternal and neonatal outcomes were compared between the two groups. Results: There was no statistically significant difference between the two groups regarding maternal age, level of education, or gravity. The percentage of cases with birth weight between 1500 and 2500 g was significantly higher in group A P<0.001). Frequency of NICU admission in group A was significantly more than group B (P<0.001). In conclusion: Termination of pregnancy at 36 weeks compared to 34 weeks in pregnant women with PPROM is preferred in terms of neonatal outcomes and it is recommended; also, there might be no preference in terms of maternal outcomes.

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Fetal and Maternal Outcome Asymptomatic vs. Symptomatic Covid Positive Pregnant Women

10.53350/pjmhs2115103423 ◽

2021 ◽

Vol 15 (10) ◽

pp. 3423-3425

Author(s):

Amna Najam ◽

Samreen Fakeer Muhammad ◽

Samia Saifullah ◽

Maryam Shoaib ◽

Maria Anwar

Keyword(s):

Birth Weight ◽

Low Birth Weight ◽

Cesarean Section ◽

Pregnant Women ◽

Apgar Score ◽

Adverse Outcomes ◽

Maternal Outcomes ◽

Group A ◽

Nicu Admission ◽

Group B

Objective: The aim of this study is to compare the fetal and maternal outcomes in between asymptomatic and symptomatic COVID positive pregnant women. Study Design: Retrospective cohort study Place and Duration: The study was conducted at Gynae and Obs department of Sandeman Provincial Hospital, Quetta for duration of six months from November 2020 to April 2021. Methods: One hundred and ten pregnant women with ages 18-45 years had corona virus disease were presented. Informed written consent was taken from all patients for detailed demographics. COVID -19 was diagnosed by PCR. 55 patients had symptoms of coronavirus were included in group A and 55 patients did not show symptoms were included in group B. Frequency of pre-eclampsia, gestational diabetes mellitus and post-partum haemorrhage were calculated. Maternal adverse outcomes (cesarean section, instrumental delivery, induction of labor and prolong labor, hypertensive disorder) were calculated among both groups. Fetal outcomes perinatal mortality, Low birth weight, Low Apgar score and NICU admission were observed. SPSS 20.0 version was used to analyze all data. Results: Mean age of the patients in group A was 28.47±3.18 years with mean BMI 24.03±5.24 Kg/m2 and in group B mean age was 27.99±4.17 years with mean BMI 24.44±6.41 Kg/m2. Maternal outcomes (cesarean section, instrumental delivery, induction of labor and prolong labor,) in symptomatic group were significantly higher than that of asymptomatic group. Fetal outcomes, perinatal mortality in group A 9 (16.4%) and in group B was 5 (9.1%), low birth weight in group A was among 21 (38.2%) and in group B was 10 (18.2%), low apgar score in group A was 11 (20%) and in group B was 8 (14.4%), 15 (27.3%) in group A went to NICU admission and 3 (5.5%) patient in group II admitted to NICU. Conclusion: In this study we concluded that adverse outcomes among symptomatic COVID pregnant women were higher than that of asymptomatic coronavirus pregnant women in terms maternal and perinatal outcomes. Keywords: Pregnant women, Coronavirus, Symptomatic, Asymptomatic, Adverse Outcomes

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Advanced Maternal Age and Adverse Maternal and Neonatal Outcomes in Pregnant Women

Current Women s Health Reviews ◽

10.2174/1573404816999201009160848 ◽

2020 ◽

Vol 16 ◽

Author(s):

Reza Omani-Samani ◽

Saman Maroufizadeh ◽

Nafise Saedi ◽

Nasim Shokouhi ◽

Arezoo Esmailzadeh ◽

...

Keyword(s):

Birth Weight ◽

Preterm Birth ◽

Low Birth Weight ◽

Cesarean Section ◽

Pregnant Women ◽

Maternal Age ◽

Unwanted Pregnancy ◽

Advanced Maternal Age ◽

Neonatal Outcomes ◽

Maternal And Neonatal Outcomes

Background: Advanced maternal age is an important predictor for maternal and neonatal outcomes such as maternal mortality, low birth weight, stillbirth, preterm birth, cesarean section and preeclampsia. Objective: To determine the association of advanced maternal age and adverse maternal and neonatal outcomes in Iranian pregnant women. Methods: In this hospital-based cross-sectional study, 5117 pregnant women from 103 hospitals in Tehran, Iran, were participated in the study in 2015. The required data were gathered from hospitals which equipped to the department of obstetrics and gynecology. Advanced maternal age was considered as an independent variable and unwanted pregnancy, preeclampsia, preterm birth, cesarean section and low birth weight were considered as interested outcomes. Results: In our study, the prevalence of advanced maternal age was 12.08%. Advanced maternal age was significantly associated with higher risk of unwanted pregnancy (OR: 1.39, 95% CI: 1.12-1.73), preterm birth (OR: 1.75, 95% CI: 1.28- 2.39) and cesarean section (OR: 1.34, 95% CI: 1.03-1.74). In our study, there was no significant relationship between advanced maternal age and preeclampsia but this relationship could be clinically important (OR: 1.48, 95% CI: 0.99-2.20, P=0.052), and there is no significant relationship between advanced maternal age and low birth weight (OR: 1.08, 95% CI: 0.67-1.74, P=0.736). Conclusion: Advanced maternal age is associated with higher risk of unintended pregnancy, preterm birth and cesarean section but our findings did not support advanced maternal age as a risk factor associated with low birth weight.

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Comparison of Maternal and Perinatal Outcome in Pregnant Women with Hypothyroidism Diagnosed before Conception with Hypothyroidism Diagnosed during Pregnancy

Journal of Universal College of Medical Sciences ◽

10.3126/jucms.v2i2.11170 ◽

2014 ◽

Vol 2 (2) ◽

pp. 21-27

Author(s):

P Basnet ◽

N Aggrawal ◽

V Suri ◽

P Dutta ◽

K Mukhopadhyay

Keyword(s):

Birth Weight ◽

Pregnant Women ◽

Thyroid Function ◽

Early Pregnancy ◽

Perinatal Outcome ◽

Fetal Outcome ◽

Endocrine Disorder ◽

Fetal Birth Weight ◽

Group A ◽

Group B

BACKGROUND: Thyroid disorder is one of commonest endocrine disorder in women and hence constitutes a common endocrine disorder complicating pregnancy. Diagnosing and treating hypothyroidism preconceptionally and during early pregnancy appears to be a useful strategy to improve maternal and fetal outcome. OBJECTIVE: To compare the maternal and perinatal outcome in pregnant women with hypothyroidism diagnosed preconceptionally with hypothyroidism diagnosed during pregnancy. METHODS: A prospective study. One hundred pregnant women with hypothyroidism at less than 20 weeks Period of Gestation (POG) were recruited for the study and grouped into two groups: Group A-hypothyroidism diagnosed and on treatment before conception, Group B-hypothyroidism diagnosed and started on treatment during pregnancy. Both groups were intensively monitored during pregnancy with serial Thyroid Function Test (TFT) and thyroxine replacement doses were adjusted accordingly. Various maternal, perinatal and fetal outcome measures were studied in both groups prospectively till delivery. RESULTS: The maternal and fetal complications were comparable in the two groups, however the fetal birth weight was significantly higher in Group A versus Group B (2.89±0.485kg vs. 2.70±0.453kg; p=0.039). All the new born babies had normal thyroid function. CONCLUSION: Hypothyroidism diagnosed preconceptionally or during early pregnancy and treated appropriately has beneficial effect on fetal birth weight, and hence the total pregnancy outcome. Screening for thyroid dysfunction should be judiciously performed in all high risk women prior to a planned conception or during their first antenatal visit. DOI: http://dx.doi.org/10.3126/jucms.v2i2.11170 Journal of Universal College of Medical Sciences (2014) Vol.2(2): 21-27

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Can early surgery improve the outcome of patients with meconium peritonitis? A single-center experience over 16 years

BMC Pediatrics ◽

10.1186/s12887-019-1844-5 ◽

2019 ◽

Vol 19 (1) ◽

Author(s):

Yi Jiang ◽

Weihua Pan ◽

Wenjie Wu ◽

Weipeng Wang ◽

Suna Sun ◽

...

Keyword(s):

Birth Weight ◽

Survival Rate ◽

Gastrointestinal Disease ◽

Early Stage ◽

Significant Risk ◽

Early Operation ◽

Meconium Peritonitis ◽

Significant Difference ◽

Group A ◽

Group B

Abstract Background In the last century, meconium peritonitis(MP)was once a highly fatal gastrointestinal. disease With the development of fetal radiological technology, abnormal signs, such as pseudocysts, can. be detected during the fetal period so that more patients can be diagnosed prenatally and receive surgery. in the early stage of life. The survival rate of MP has increased up to 80% in recent years. According to. a review of the treatment and outcomes of patients diagnosed with MP, we evaluated the influence of. early operation on survival rate and discussed the risk factors of prognosis. Methods We collected 79 cases of patients diagnosed with MP who were treated in our department. from October 2001 to December 2017. They were divided into 2 groups. Patients in group A were born. in our hospital. Patients in group B were born in a local hospital with suspicion of MP and then transferred. to our department. Results The birth weight (BW) and gestational age (GA) of patients were higher in group A than in. group B. There was no significant difference in the proportion of premature and low birth weight (LBW). patients between the two groups (p = 0.422, p = 0.970). Their age at the time of surgery was younger in. group A than in group B (1.4 ± 2.0 vs. 6.9 ± 14.9, p < 0.001). The overall survival rate of group A was higher. than that of group B (95.0% vs. 79.5%, p = 0.038). The prognosis of premature patients was worse than. that of full-term infants for both groups (p = 0.012). Conclusions Prematurity is a significant risk factor related to death for MP patients. The survival rate. of MP patients can be improved by early operation during the neonatal period.

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Will women’s choice of position in first stage of labor affect labor process?

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20201215 ◽

2020 ◽

Vol 9 (4) ◽

pp. 1515

Author(s):

Shubha Rao ◽

Shylabhirami Sridharan ◽

Akhila Vasudeva ◽

Roopa P. S.

Keyword(s):

Pregnant Women ◽

Neonatal Outcome ◽

Total Duration ◽

Labor Process ◽

Recumbent Position ◽

Observation Study ◽

Significant Difference ◽

Group A ◽

Group B ◽

Type Of Delivery

Background: Controlling the process of childbirth has disabled the parturient to embrace the most spontaneous position of delivery but constricting her to assume a recumbent position. Objective of this study was to study if alternating comfortable maternal positioning i.e., recumbent and alternative position have any influence in the process of labor, type of delivery, neonatal well-being.Methods: Study conducted an observation study on term pregnant women. Study inclusion criteria included all term pregnant women. Exclusion criteria included multiple pregnancies, preterm patient, severe pre-eclampsia, and eclampsia, preterm premature rupture of membranes, sever intrauterine growth restricted fetus. The measured date were maternal general characteristics, duration of labor process, type of delivery and neonatal outcome. Patients were divided into two groups. Group A - if they spent more than 50% in a recumbent position and Group B - any other alternating position.Results: A total 250 women were equally included in this study. The demographic characteristics were matched in both groups and found no significant difference. In the process of labor, Group B had a difference of 1 hours as compared to Group A and the rate of cervical dilation was also faster in Group B. Both of these variables were found to be statistically significant. However, there were no significant difference in the terms of type of delivery and neonatal outcome.Conclusions: The ancient practice of recumbent position during labor is to be discarded as alternating maternal position during the process of labor may a positive influence on the total duration labor. However even though it may or may not have an influence on the other outcome such as route of delivery and neonatal outcome, it is best to encourage women to move and deliver in the most comfortable position.

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Clinical evaluation of anesthesia for high-risk cesarean section at a tertiary medical center: retrospective study for 8 years (2009–2016)

Journal of International Medical Research ◽

10.1177/0300060519859749 ◽

2019 ◽

Vol 47 (9) ◽

pp. 4365-4373

Author(s):

HW Kang ◽

WY Kim ◽

SJ Jin ◽

YH Kim ◽

TJ Min ◽

...

Keyword(s):

Risk Factors ◽

Birth Weight ◽

High Risk ◽

Gestational Age ◽

Perioperative Outcomes ◽

Apgar Scores ◽

Maternal Risk ◽

Group A ◽

Nicu Admission ◽

Group B

Objective The number of high-risk pregnancies is increasing in tertiary medical centers. Therefore, we investigated perioperative outcomes based on risk factors to ascertain proper maternal and neonatal management. Methods We reviewed the medical records of patients receiving cesarean sections over an 8-year period. Clinical parameters for anesthesia and the neonatal outcome were compared among high-risk groups after subdivision by the number of clinical risk factors. The groups were as follows: group A (one risk factor), group B (two risk factors), and group C (three or more risk factors). Results Patient age, estimated blood loss (EBL), and volume of transfused red blood cell (RBC) were higher in group B than group A. Birth weight, 1- and 5-minute Apgar scores, and gestational age were lower while the frequency of neonatal intensive care unit (NICU) admission was higher in group B than group A. Group C patients were significantly older than group A or B patients. Birth weight, 1- and 5-minute Apgar scores and gestational age were significantly lower while frequency of NICU admission was higher in group C than group A and B. Conclusion The number of maternal risk factors was positively associated with adverse outcomes in the neonates.

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Effect of Hemiovariectomy on reproductive performance in Chinchila Rabbits.

Nigerian Journal of Animal Production ◽

10.51791/njap.v36i1.1205 ◽

2021 ◽

Vol 36 (1) ◽

pp. 167-174

Author(s):

C. A. Eze ◽

C. P. Nwodo ◽

E. O. Ogbu

Keyword(s):

Birth Weight ◽

Litter Size ◽

Conception Rate ◽

Control Group ◽

Significant Difference ◽

Negative Effect ◽

Group A ◽

Group B ◽

The Right ◽

Reproductive Indices

This work evaluates the effects of hemiovariectomi (37 some reproductive indices such as conception rate, birth weight and birth litter size in Chinchilla breed of rabbits. Thirty females and six males were used for the experiment. The males were examined for breeding soundness before using them to cross the females. The experiment was replicated in two batches of three groups of five females and a male each at different periods. Hemi-ovariectomy was carried out in the right ovary of 10 does (Group A) and left ovary of another 10 does (Group B). Ten females in Group C were not ovariectomised and served as the control group. All groups were served at reproductive maturity by rotating the bucks. Pregnancy was diagnosed using a standard method. The reproductive indices evaluated included conception rate, birth weight and birth litter size. Data were analyzed using percentages, ratios, and analysis of variance (ANOVA) was computed where necessary. Results showed that hemi ovariectomy significantly (P<0.01) reduced the mean litter size, Group A (2.50+58), Group B (3.00+0.71), control (Group C) (6.20+0.84). However, there was increased mean litter birth weight which, differed significantly (P<0.01) from that of the control (27.06), Group A (33.64+1.86) and Group B (33.93=1.75). Also, the conception rate in the treated groups averaged 65% while the control was 80%. There was no significant difference (P>0.05) between the groups in the interval from the introduction of the huck to the does to the time of conception. It is concluded thai hemiovariectomy has negative effect on the conception rate and birth litter size but has positive effect on birth litter weight. The procedure has shown that in highly priced breed of animal with unilateral ovarian uilments such an animal can still be used for breeding using the healthy ovary: The procedure could also be a more reliable method of birth control in pet animals as well as a means of producing heavy weight offspring.

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The Effect of Artemisinin-based Combination Therapy (ACT) Antimalaria Drugs on Liver Enzymes in Pregnancy

Journal of Advances in Medical and Pharmaceutical Sciences ◽

10.9734/jamps/2018/v19i430093 ◽

2019 ◽

pp. 1-6

Author(s):

Ajibade Oluwagbenga Oyeyemi ◽

Ayobola Abimbola Sonuga

Keyword(s):

Pregnant Women ◽

Malaria Parasite ◽

Harmful Effect ◽

Antenatal Clinic ◽

Significant Difference ◽

Group A ◽

Student’S T ◽

Group B ◽

And Control ◽

In Pregnancy

Aims: Artemisinin-based Combination Therapies (ACTs) are employed as first-line agents in malaria chemotherapy. This study is aimed at assessing the effects of ACTs on renal function of pregnant women. Study Design: Comparative study. Place and Duration of Study: Pregnant women aged 18 to 50 years were recruited from antenatal clinic of Obstetrics and Gynecology Department of Ekiti State Hospital, Ado Ekiti, Nigeria between 2016 and 2018 Methodology: One hundred and eighty pregnant women were grouped into three which include: Sixty pregnant women with malaria parasite on ACT drugs (Group A), sixty pregnant women with malaria parasite not on ACT drugs (Group B), sixty pregnant women without malaria parasite (Group C/control). Plasma Aspartate Aminotransferase (AST), Alkaline Phosphatase (ALP), Alanine Transaminase (ALT) and Lactate Dehydrogenase (LDH) activities were evaluated by standard methods. The data collected were analyzed using one-way analysis of variance (ANOVA) and Student’s t test to compare the data between the test groups and control. Results: Results showed there was a significant decrease (P=.05) in Body Mass Index in the pregnant women with malaria on ACT and those that were not on ACT when compared with control (24.1± 0.32 versus (25+ 2.30 vs 27± 1.62). A significant increase (P=.05) occurred in the levels of ALP,AST, ALT and LDH in pregnant women with malaria not on ACT drugs when compared the control (168.45±0.19, 10.0±0.27, 8.19±0.25, 4.5±0.21) versus (143.20±0.12, 8.71±0.30, 5.99±0.21, 2.08±0.19),while no significant difference occurred in the levels of ALP,AST, ALT and LDH in pregnant women with malaria on ACT when compared with control (141.60±0.78, 8.02±0.32, 6.10±0.30, 2.75+ 0.20) vs (143.20±0.12, 8.71±0.30, 5.99±0.21, 2.08±0.19). Conclusion: Normal therapeutic dose of ACT has no harmful effect on the liver in pregnancy.

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Study of comparison of maternal and fetal outcomes in spontaneous labour and induced labour

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20213861 ◽

2021 ◽

Vol 10 (10) ◽

pp. 3915

Author(s):

Apurva A. Mankar ◽

Bhaskar K. Murthy ◽

Vaibhav B. Patil

Keyword(s):

Birth Weight ◽

Fetal Distress ◽

Induction Of Labor ◽

Fetal Outcomes ◽

Neonatal Deaths ◽

Induction Group ◽

Spontaneous Labour ◽

Group A ◽

Maternal And Neonatal Outcomes ◽

Group B

Background: There has been consistent proportionate increase in the cases of induction of labor, but both maternal and neonatal effects of it remain poorly analysed previously. The present study was undertaken with the objective of comparison of maternal and fetal outcomes between groups of patients undergoing induction of labor and those having spontaneous labor.Methods: In this comparative prevalence study, the participants selected by predefined criteria were divided into 2 groups on the basis of progression of labor. They were spontaneous labor (group A) and induction of labor (group B). All the participants were assessed for various relevant maternal and neonatal outcomes and valid comparisons drawn.Results: A total of 1300 participants were studied. Proportion of patients requiring caesarean section was significantly higher in induction group (39.17%) against the spontaneous labor group (15.37%), with fetal distress being the commonest indication in both groups. The commonest complication noted was postpartum hemorrhage (PPH) (2.96% in group A and 1.98% in group B, p<0.05). Mean birth weight of babies was 2.76±0.42 kgs in spontaneous labor group and 2.68±0.48 kgs in induction of labor group (p>0.05). Incidences of NICU admissions and neonatal deaths were significantly higher in induction of labor group.Conclusions: Induction of labor should be employed judiciously by assessing the maternal and fetal condition and confirming relevant indication and should only be done if continuation of pregnancy is relatively more hazardous to either mother or baby.

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Maternal and neonatal outcomes in COVID-19 infected pregnancies: a prospective cohort study

Journal of Travel Medicine ◽

10.1093/jtm/taaa158 ◽

2020 ◽

Vol 27 (7) ◽

Author(s):

Reihaneh Pirjani ◽

Reihaneh Hosseini ◽

Tahereh Soori ◽

Maryam Rabiei ◽

Ladan Hosseini ◽

...

Keyword(s):

Cohort Study ◽

Pregnant Women ◽

Neonatal Intensive Care ◽

Neonatal Outcomes ◽

Control Group ◽

Adjusted Risk ◽

Adjusted Risk Ratio ◽

Significant Difference ◽

Maternal And Neonatal Outcomes ◽

Delivery Type

Abstract Background Despite the large number of pregnant women with the coronavirus disease 2019 (COVID-19), there is not enough analytical study to compare maternal and fetal consequences of COVID-19 infected with non-infected pregnancies. This cohort study aimed to compare maternal and fetal consequences of COVID-19 infected with non-infected pregnancies. Methods We included pregnant women with and without COVID-19 who were admitted to Arash Hospital in Tehran, Iran, from 1 March to 1 September 2020. Clinical features, treatments, and maternal and fetal outcomes were assessed. Results A total of 199 women enrolled, including 66 COVID-19 infected and 133 non-infected pregnant women prospectively. Caesarean section was carried out in total 105 women (52.76%). A significant difference was found in term of delivery type between COVID-19 infected and non-infected pregnant women [adjusted risk ratio (aRR): 1.31, 95% confidence interval (CI): 1.04, 1.65, P = 0.024]. No significant association was found between COVID-19 infection and preterm birth (aRR: 1.16, 95% CI: 0.54, 2.48, P = 0.689), low birth weight (aRR: 1.13, 95% CI: 0.55, 2.31, P = 0.723), gestational diabetes (aRR: 1.67, 95% CI: 0.81, 3.42, P = 0.160), pre-eclampsia (aRR: 2.02, 95% CI: 0.42, 6.78, P = 0.315), intrauterine growth restriction (aRR: 0.16, 95% CI: 0.02, 1.86, P = 0.145), preterm rupture of membrane (aRR: 0.19, 95% CI: 0.02, 2.20, P = 0.186), stillbirth (aRR: 1.41, 95% CI: 0.08, 18.37, P = 0.614), postpartum haemorrhage (aRR: 1.84, 95% CI: 0.39, 8.63, P = 0.185), neonatal intensive care unit (ICU) admission (aRR: 1.84, 95% CI: 0.77, 4.39, P = 0.168) and neonatal sepsis (aRR: 0.84, 95% CI: 0.48, 1.48, P = 0.568). The percentage of patients (4/66, 6.06%) being admitted to the ICU was significantly higher than the control group (0%) (P < 0.001). Conclusion Basically, although pregnancy and neonatal outcomes were not significantly different, the need for ICU care for pregnant women with COVID-19 was significantly higher compared with those without COVID-19.

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