scholarly journals Synthesis, Spectroscopic Properties, Anti-Breast Cancer and Anti-Microbial Studies of Some Metal Complexes for New Schiff Base Ligand Derived From Anthranilic Acid.

2021 ◽  
Author(s):  
Hanan F. Abd El-Halim ◽  
Gehad Mohamed ◽  
Walaa Mahmoud ◽  
Omnia El-Sayed
Keyword(s):  
Antimicrobial Activity ◽  
Schiff Base ◽  
Metal Complexes ◽  
Schiff Base Ligand ◽  
Anthranilic Acid ◽  
Metal Salt ◽  
Human Cancer ◽  
Free Ligand ◽  
Azomethine Nitrogen ◽  
Syncephalastrum Racemosum

Abstract 2,2’-((1Z-1’Z) (1,3-diphenylpropane-1,3-diylidene) bis (azanylylidene)) dibenzoic acid (H2L) Schiff base ligand, was obtained by condensation reaction between anthranilic acid and dibenzoyl methane in 2:1 ratio.A series of Cr(III), Mn(II), Fe(III), Co(II), Ni(II), Cu(II), Zn(II) and Cd(II) complexes was resulted from 1:1 (ligand: metal salt) reaction.The structural features of the synthesized ligand and its metal complexes was determined by elemental analyses, IR, 1H NMR, UV-Vis, ESR, mass spectra, conductivity and magnetic susceptibility measurements as well as thermal (TG/DTG) analyses. The analytical and spectroscopic tools showed that the complexes had composition of ML type with octahedral geometry. The IR results confirmed the tetradendate binding of the ligand involving two azomethine nitrogen atoms and two carboxylate oxygens. The Schiff base and its complexes have been screened for their antimicrobial activity against several bacterial organisms as (Streptococcus pneumoniae and Bacillus subtilis; Pseudomonas aeruginosa and Escherichia coli) and fungi (Aspergillus fumigatus; Syncephalastrum racemosum; Geotricum candidum and Candida albicans) by disk diffusion method.All the metal complexes have potent antimicrobial activity than the free ligand. Anticancer activity of the ligand and its metal complexes was evaluated against human cancer (MCF-7 cells viability).

Mn(II), Co(II), Ni(II), and Cu(II) complexes of amino acid derived Schiff base ligand: Synthesis, characterization and in-vitro antibacterial investigations

2021 ◽  
Vol 35 (1) ◽  
pp. 97-106
Author(s):  
A. O. Rajee ◽  
H. F. Babamale ◽  
A. Lawal ◽  
A. A. Aliyu ◽  
W. A. Osunniran ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Schiff Base ◽  
Amino Acid ◽  
Metal Complexes ◽  
Schiff Base Ligand ◽  
Free Ligand ◽  
Antimicrobial Activities ◽  
Azomethine Nitrogen ◽  
Bacterial Strains

Four complexes of Mn(II), Co(II), Ni(II) and Cu(II) with Schiff base ligand (H3L) derived from 2-amino-3-methylbutanoic acid and acetylacetonate were synthesized. All complexes were characterized by elemental analysis, Fourier-transform infrared spectroscopy and electronic spectroscopy. The results confirmed the coordination of the ligand to metals in tridentate fashion via the hydroxyl oxygen, the azomethine nitrogen and the enolic acetylacetonate oxygen. Antimicrobial activities were established for all complexes, free ligand and ciprofloxacin for comparison. Both the ligand and its metal complexes were active against Gram-positive and negative bacterial strains. The Cu(II) complex, showed highest antibacterial activity among the complexes screened. Other complexes displayed considerable antibacterial activity. Octahedral geometry was proposed for the metal(II) complexes with the Schiff base.                     KEY WORDS: Schiff base, Amino acid, Metal Complexes, Antibacterial agents   Bull. Chem. Soc. Ethiop. 2021, 35(1), 97-106. DOI: https://dx.doi.org/10.4314/bcse.v35i1.8

scholarly journals Synthesis, characterization, and biological studies of some biometal complexes

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Vinay Kumar Srivastava
Keyword(s):  
Antimicrobial Activity ◽  
Schiff Base ◽  
Metal Complexes ◽  
Anticancer Agents ◽  
Anthranilic Acid ◽  
Pathogenic Bacteria ◽  
Free Ligand ◽  
Binding Studies ◽  
Metal Acetate ◽  
Biological Studies

Abstract Background Metal complexes Cu[C13H8O4N]22, Ni[Cl3H8O4N]23, and Co[C13H8O4N]24 of bioinorganic relevance have been synthesized with the Schiff base ligand 2-furylglyoxal–anthranilic acid (FGAA) [C13H9O4N] 1. All the complexes are well characterized by various spectral and physical methods. The antimicrobial activity of the complexes has been studied against some of the pathogenic bacteria and fungi. Results Results indicate that complexes have higher antimicrobial activity than the free ligand. This would suggest that chelation reduces considerably the polarity of the metal ions in the complexes which in turn increases the hydrophobic character of the chelate and thus enables permeation, through the lipid layer of microorganisms. All the complexes were assessed for their anticancer studies against a panel of selected cancer cells HOP62 and BT474 respectively. Results showed that the complexes are promising chemotherapeutic alternatives in the search of anticancer agents. The fluorescence quenching phenomenon is observed in the Schiff base metal complexes. Conclusion The octahedral transition metal complexes 2, 3, and 4 have been obtained by treatment of ligand 2-furylglyoxal-anthranilic acid (FGAA) 1 with metal acetate. Complexes under investigations have shown antimicrobial, potential anticancer, and the DNA binding studies. Graphical abstract

scholarly journals Synthesis, Spectroscopy, Theoretical, and Electrochemical Studies of Zn(II), Cd(II), and Hg(II) Azide and Thiocyanate Complexes of a New Symmetric Schiff-Base Ligand

2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
Morteza Montazerozohori ◽  
Kimia Nozarian ◽  
Hamid Reza Ebrahimi
Keyword(s):  
Schiff Base ◽  
Metal Complexes ◽  
Schiff Base Ligand ◽  
Structural Parameters ◽  
Free Ligand ◽  
Basis Set ◽  
Cyclic Voltammograms ◽  
Hybrid Functional ◽  
Ft Ir ◽  
C Nmr

Synthesis of zinc(II)/cadmium(II)/mercury(II) thiocyanate and azide complexes of a new bidentate Schiff-base ligand (L) with general formula of MLX2(M = Zn(II), Cd(II), and Hg(II)) in ethanol solution at room temperature is reported. The ligand and metal complexes were characterized by using ultraviolet-visible (UV-visible), Fourier transform infrared (FT-IR),1H- and13C-NMR spectroscopy and physical characterization, CHN analysis, and molar conductivity.1H- and13C-NMR spectra have been studied in DMSO-d6. The reasonable shifts of FT-IR and NMR spectral signals of the complexes with respect to the free ligand confirm well coordination of Schiff-base ligand and anions in an inner sphere coordination space. The conductivity measurements as well as spectral data indicated that the complexes are nonelectrolyte. Theoretical optimization on the structure of ligand and its complexes was performed at the Becke’s three-parameter hybrid functional (B3) with the nonlocal correlation of Lee-Yang-Parr (LYP) level of theory with double-zeta valence (LANL2DZ) basis set using GAUSSIAN 03 suite of program, and then some theoretical structural parameters such as bond lengths, bond angles, and torsion angles were obtained. Finally, electrochemical behavior of ligand and its complexes was investigated. Cyclic voltammograms of metal complexes showed considerable changes with respect to free ligand.

scholarly journals Synthesis, Characterization and Antimicrobial studies of Schiff base Ligand from amino acid L-arginine and its Cu(II), Ni(II),Co(II) complexesIJCTR.2019.130201

2020 ◽  
Vol 13 (2) ◽  
pp. 1-8
Author(s):  
R.K. Sree Devi ◽  
S. SudhaKumari
Keyword(s):  
Schiff Base ◽  
Metal Complexes ◽  
Schiff Base Ligand ◽  
Metal Ion ◽  
Electronic Absorption Spectra ◽  
Magnetic Data ◽  
Azomethine Nitrogen ◽  
Diffusion Method ◽  
Significant Activity ◽  
Antimicrobial Studies

Transition metal complexes of Cu(II), Ni(II), Co(II) with a Schiff base Ligand (R,Z)-2-(2-hydroxy-3-methoxybenzylideneamino)-5-guanidinopentanoic acid (HMA-GPA) was synthesized by the condensation of 2-hydroxy-3-methoxybenzaldehyde and L- Arginine. These were characterized by elemental analysis IR, UV, magnetic susceptibility and molar conductivity measurements. The IR spectra of the Ligand HMA-GPA and the metal complexes suggest that the Ligand coordinates the metal ion through azomethine nitrogen, carboxylate Oxygen and Oxygen of the phenolic -OH group. The electronic absorption spectra and magnetic data indicate the Cu(II), Ni(II)complexes to be square planar and Co(II) complex to be octahedral. The metal complexes and the ligand were subjected to antimicrobial studies by Kirby Bayer Disc-diffusion method and found to have significant activity against the selected bacterial and fungal strains under study.

scholarly journals Metal Complexes of Macrocyclic Schiff-Base Ligand: Preparation, Characterisation, and Biological Activity

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Riyadh M. Ahmed ◽  
Enaam I. Yousif ◽  
Hasan A. Hasan ◽  
Mohamad J. Al-Jeboori
Keyword(s):  
Biological Activity ◽  
Schiff Base ◽  
Metal Complexes ◽  
Schiff Base Ligand ◽  
Condensation Reaction ◽  
Free Ligand ◽  
Inhibition Zone ◽  
Square Planar ◽  
Planar Geometries ◽  
Macrocyclic Schiff Base

A new macrocyclic multidentate Schiff-base ligand Na4L consisting of two submacrocyclic units (10,21-bis-iminomethyl-3,6,14,17-tricyclo[17.3.1.18,12]tetracosa-1(23),2,6,8,10,12(24),13,17,19,21,-decaene-23,24-disodium) and its tetranuclear metal complexes with Mn(II), Co(II), Ni(II), Cu(II), and Zn(II) are reported. Na4L was prepared via a template approach, which is based on the condensation reaction of sodium 2,4,6-triformyl phenolate with ethylenediamine in mole ratios of 2 : 3. The tetranuclear macrocyclic-based complexes were prepared from the reaction of the corresponding metal chloride with the ligand. The mode of bonding and overall geometry of the compounds were determined through physicochemical and spectroscopic methods. These studies revealed tetrahedral geometries about Mn, Co, and Zn atoms. However, square planar geometries have been suggested for NiIIand CuIIcomplexes. Biological activity of the ligand and its metal complexes against Gram positive bacterial strainStaphylococcus aureusand Gram negative bacteriaEscherichia colirevealed that the metal complexes become more potentially resistive to the microbial activities as compared to the free ligand. However, these metal complexes do not exhibit any effects on the activity ofPseudomonas aeruginosabacteria. There is therefore no inhibition zone.

scholarly journals Synthesis, Physical Characterization of M(III) Transition Metal Complexes Derived from Thiodihydrazide and 5-tert-Butyl-2-hydroxy-3-(3-phenylpent-3-yl) Benzaldehyde

2012 ◽  
Vol 9 (4) ◽  
pp. 2119-2127 ◽  
Author(s):  
Gajendra Kumar ◽  
Rajeev Johari ◽  
Shoma Devi
Keyword(s):  
Schiff Base ◽  
Metal Complexes ◽  
Schiff Base Ligand ◽  
Metal Ion ◽  
Magnetic Measurements ◽  
Metal Salt ◽  
Magnetic Moments ◽  
Metal Centers ◽  
H Nmr

A Schiff base ligand was synthesized by reacting 5-tert-butl-2-hydroxy-3-(3-phenylpent-3-yl) benzaldehyde and thiodihydrazide (2:1) and a series of metal complexes with this new ligand were synthesized by reaction with Cr (III), Mn (III), and Fe (III) metal salt in methanolic medium. The Schiff base ligand and its complexes have been characterized with the help of elemental analysis, conductance measurements, magnetic measurements and their structure configuration have been determined by various spectroscopic (electronic, IR,1H NMR,13C NMR, GCMS) techniques. Electronic and magnetic moments of the complexes indicate that the geometries of the metal centers were octahedral. IR spectral data suggest that ligand behaves as a tetradentate ligand with ONNO donor sequence towards the metal ion.

scholarly journals Synthesis, Characterization and Biological Evaluation of New Schiff Base Ligand derived from 3-hydroxy-benzaldehyde and p-toluidine and its Divalent Metal Ions

2020 ◽  
Vol 71 (4) ◽  
pp. 47-58
Author(s):  
Noreen Mazhar ◽  
Mehwish Aftab ◽  
Tariq Mahmud ◽  
Muhammadasim Raza Basra ◽  
Mansoor Akhtar ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Schiff Base ◽  
Metal Complexes ◽  
Schiff Base Ligand ◽  
Protein Denaturation ◽  
Condensation Reaction ◽  
Free Ligand ◽  
Biological Evaluation ◽  
Divalent Metal ◽  
Anti Inflammatory

A new Schiff base ligand (L) and its transition divalent metal complexes were prepared by the condensation reaction; Reaction was carried out at 70-80 oC by refluxing equimolar ratio of toluidine and aldehyde by continuous stirring for 5-6 hours. Synthesized ligand and Ni(II), Fe(II), Co(II), Mn(II) and Zn(II) bimetallic complexes were characterized by using FT-IR, UV-visible spectroscopy, AAS, Single crystal X-ray analysis, 1H-NMR, molar conductance. Compounds were screened against two fungus Candida glabrata and Candida albicans by agar tube dilution protocol. In vivo anti-inflammatory activity via induced paw edema method and in vitro results by heat induced protein denaturation method were checked. Synthesized compounds were also showed antioxidant activity by using DPPH (diphenylpicrylhydrazyl) and Trolox was used as standard. These studies show that ligand and almost all metal complexes are reactive towards biological assays against reported standard drugs. Zn-L indicates more activeness for antioxidant activity and free ligand while Co-L recognized as more effective anti-inflammatory drug.

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