scholarly journals Association of Anemia with Rehabilitation Outcome for Subacute Geriatric Rehabilitation Patients in a Secondary Hospital in Malaysia

2021 ◽  
Author(s):  
Mann Leon Chin ◽  
Christopher WS Chan ◽  
Huey Ee Chong ◽  
Wee Kooi Cheah
Keyword(s):  
Barthel Index ◽  
Geriatric Rehabilitation ◽  
Mean Corpuscular Hemoglobin ◽  
Corpuscular Hemoglobin ◽  
Barthel Index Score ◽  
Rehabilitation Outcome ◽  
Score Improvement ◽  
The Mean ◽  
Secondary Hospital ◽  
Hemoglobin Threshold

Abstract Objective: To evaluate the effect of Anemia on Rehabilitation Outcome for Geriatric Subjects in Taiping Hospital Subacute Geriatric Rehabilitation Ward.Methodology: This was a retrospective study, with 126 subjects to compare the change in modified Barthel Index score of anemic and non anemic subjects.Results: 44% of subjects were anemic and the Mean corpuscular hemoglobin and Mean corpuscular volume for anemic subjects were 85.4pg and 29.8fL. Among anemic subjects 45.5% were Malay, 38.2% were Chinese, 14.5% were Indian and 1% were others. The Median(IQR) Modified Barthel Index (MBI) on admission for anemic subjects and non anemic subjects were insignificantly difference which were 47 (29, 63) and 36 (21, 59) respectively, (p=0.059). The median(IQR) of MBI improvement for non anemic subjects was found to be significantly higher than anemic subjects which were 14 (5, 26) and 8 (1, 18) (p=0.021). Subject with hemoglobin (hb) ≥ 9g/dL were significantly associated with MBI improvement of more than 20, p=0.014. Multiple linear regression revealed a significant linear relationship between age and MBI score improvement (p=0.010). Subjects 10 years younger showed a 3.55 score improvement in MBI.Conclusion: The study suggested that non-anemic subjects showed significant MBI improvement. Our study also suggested judicious transfusion practices to maintain a hemoglobin threshold of 9 g/dL might be able to improve subject’s functional outcome. These results should encourage further research with a larger elderly subject population to provide insights and awareness for the need to correct anemia in rehabilitation subjects.

scholarly journals Association of anemia with rehabilitation outcomes for subacute geriatric rehabilitation patients in a secondary hospital in malaysia

2021 ◽  
Vol 3 (4) ◽  
Author(s):  
Mann Leon Chin ◽  
Keyword(s):  
Barthel Index ◽  
Elderly Population ◽  
Geriatric Rehabilitation ◽  
Simple Linear Regression ◽  
Barthel Index Score ◽  
Clinical Frailty Scale ◽  
P Values ◽  
Rehabilitation Outcomes ◽  
Comorbidity Index ◽  
Secondary Hospital

Background: To evaluate the effects of anemia on rehabilitation outcomes for geriatric subjects in the Taiping Hospital subacute geriatric rehabilitation ward. Methods: This was a retrospective study with 126 subjects that compared the change in the modified Barthel Index score of anemic and non-anemic subjects. Results: In the study, 43.7% of subjects were anemic. Among anemic subjects, 45.5% were Malay, 38.2% were Chinese, 14.5% were Indian, and 1% were others. The median (Interquartile (IQR)) modified Barthel Index (MBI) on admission for anemic and non-anemic subjects was insignificantly different, at 47 (29, 63) and 36 (21, 59), respectively (P = 0.059). The median (IQR) of MBI improvement for non-anemic subjects was found to be significantly higher than for anemic subjects, which were 14 (5, 26) and 8 (1, 18; P = 0.021). Subjects with hemoglobin (hb) ≥ 9 g/dL were significantly associated with MBI improvement of more than 20, P = 0.009. Simple linear regression found that the P-values were not significant for albumin, creatinine, the Charlson comorbidity index, or the clinical frailty scale; hence, they were not significantly associated with rehabilitation outcome. Conclusions: The study suggested that non-anemic subjects showed significant MBI improvement. Our study also suggested that judicious practices to target a hb threshold of 9 g/dL might be able to improve a subject’s functional outcome. These results should encourage further research with a larger elderly population to provide insights and awareness for the need to treat anemia in rehabilitation subjects. Keywords: Geriatric, anemia, rehabilitation, modified barthel index

scholarly journals HEMATOLOGICAL CHARACTERIZATION OF BETA-THALASSEMIA IN SUDANESE PATIENTS

2020 ◽  
pp. 5-7
Author(s):  
RABAB HASSAN ELSHAIKH ◽  
SANAA ELFATIH HUSSEIN
Keyword(s):  
Iron Deficiency ◽  
Hemoglobin Concentration ◽  
Mean Value ◽  
Beta Thalassemia ◽  
Mean Corpuscular Hemoglobin ◽  
Corpuscular Hemoglobin ◽  
Significant Difference ◽  
Hematological Analysis ◽  
The Mean

Thalassemia is common inherited disorder among humans, and they represent a major public health problem in many areas of the world. The study aimed to the measurement of hematological characterization of beta-thalassemia in Sudanese patients. Blood samples from 61 beta-thalassemic patients were collected after written consent form obtained from all participants. The frequency of adults (>18 years) was 45 (73.8%) and children’s (<18 years) was 16 (26.2%); the frequency of male was 27 (44.3%) and 34 were female (55.7%). Hemoglobin estimation and red cell indices were carried out using the automatic blood cell counter Sysmex K × 21N. The results showed that Hb and RBCs indices were varied between mild to moderate and severe decreasing, hemoglobin concentration (Hb) with the mean value of 9.6 g/dL, with minimum value of 6.1 g/dl and maximum of 11.9 g/dl, while RBCs were increased in all patients, mean value 5.2 c/l, mean corpuscular volume mean was 58.9 fl, hematocrit was 30.4, mean corpuscular hemoglobin (MCH) 18.8 pg, mean corpuscular hemoglobin concentration (MCHC) was 31.7pg, and RDW was 18.8%. The method used for hemoglobin electrophoresis was capillary electrophoresis, Hb pattern shows increased HbA2 and HbF, the mean of HbA is 78.3%, HbF is 2.3%, and HbA2 is 6.5% with the min. value of 3.6% and max. of 12.2%. While the mean of serum iron was 82.75 μg/dl, 7 patients showed low level, 19 high level, and 35 were normal level. Comparison of hematological analysis (HbA2) in thalassemic patients coexisted with iron deficiency and without result was insignificant difference (p=0.645), this result disagrees with references that say iron deficiency masking HbA2. Nevertheless, the association between HbA2 and HbF revealed a statistically significant difference (p<0.013) and HbA2 with Hb was insignificant (p=0.260).

scholarly journals Blood Donation in Nigeria: Standard of the Donated Blood

2012 ◽  
Vol 4 (02) ◽  
pp. 094-097 ◽  
Author(s):  
Nwogoh Benedict ◽  
Awodu Omolade Augustina ◽  
Bazuaye Godwin Nosakhare
Keyword(s):  
Blood Donation ◽  
Hematological Parameters ◽  
Hemoglobin Concentration ◽  
Mean Corpuscular Hemoglobin ◽  
Corpuscular Hemoglobin ◽  
Mean Cell Volume ◽  
Benin City ◽  
Cell Counts ◽  
Significant Difference ◽  
The Mean

ABSTRACT Objective: The objective was to determine the basic hematological parameters of remunerated blood donors in Benin City and to compare them with those of voluntary donors. Materials and Methods: This is a prospective study conducted in a tertiary health facility in Benin City. Pretransfusion samples were obtained from blood bags after gentle mixing and analyzed for hematological parameters. Samples were analyzed using the hematology autoanalyzer MODEL SYSMEX KN21. Result: A total of 215 samples were obtained comprising 160 remunerated (paid) and 55 voluntary donor samples. In the paid donors, the mean hemoglobin concentration (Hb) and hematocrit (HCT) 7.7±2.9 and 28.8±8.5 respectively. This was significantly lower than those of voluntary donors who had 13.9±1.2 and 42.2±3.3 with P < 0.001. The mean values of the red cell counts (RBC), white cell counts (WBC), mean cell volume (MCV), mean corpuscular hemoglobin (MCH), and mean corpuscular hemoglobin concentration (MCHC) were significantly lower in paid donors as P-values were <0.001. MCV was significantly low but not compared to the other parameters as P=0.04. There was no significant difference in the platelet count. Conclusion: Paid donors in Benin City have significantly lower hematological parameters than controls.

scholarly journals Hematological parameters of Hoplias malabaricus (Characiformes: Erythrinidae) parasitized by Monogenea in lagoons in Pirassununga, Brazil

2013 ◽  
Vol 22 (4) ◽  
pp. 457-462 ◽  
Author(s):  
Lincoln Lima Corrêa ◽  
Letícia Cucolo Karling ◽  
Ricardo Massato Takemoto ◽  
Paulo Sérgio Ceccarelli ◽  
Marlene Tiduko Ueta
Keyword(s):  
Condition Factor ◽  
Hematological Parameters ◽  
Hemoglobin Concentration ◽  
Good Health ◽  
Blood Parameters ◽  
Mean Corpuscular Hemoglobin ◽  
Corpuscular Hemoglobin ◽  
Hoplias Malabaricus ◽  
Relative Condition Factor ◽  
The Mean

Hematology is an important pathological and diagnostic tool. This paper describes the hematological parameters of 76 specimens of Hoplias malabaricus infested with monogenean parasites, which were collected from two lagoons. The hematological parameters included: erythrocyte count (Er), microhematocrit (Hct), hemoglobin (Hb), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH) and mean corpuscular hemoglobin concentration (MCHC). The blood parameters showed no significant changes associated with the infestation. Water temperature was found to be negatively correlated with MCV and Hct, with values of rs= −0.52, p<0.0001 and rs= −0.48, p<0.0001, respectively. The mean Relative Condition Factor was Kn=1.01, indicating good health conditions of the fish in these lagoons. No correlation was found between the monogenean infestation and the blood parameters, or between the environmental factors and the monogeneans.

HEMATOLOGY OF THE INDIAN ELEPHANT (ELEPHAS MAXIMUS)

1967 ◽  
Vol 45 (6) ◽  
pp. 985-991 ◽  
Author(s):  
G. Nirmalan ◽  
S. G. Nair ◽  
K. J. Simon
Keyword(s):  
Blood Gases ◽  
Erythrocyte Count ◽  
Elephas Maximus ◽  
Mean Corpuscular Hemoglobin ◽  
Corpuscular Hemoglobin ◽  
Erythrocyte Sedimentation ◽  
The Mean ◽  
Primitive State ◽  
Indian Elephant ◽  
Very High

Blood samples from 11 baby elephants, 14 tuskers, and 16 females comprising 5 pregnant and 11 nonpregnant nonlactating elephants (Elephas maximus) were analyzed to assess the hematological values and the influence of age, sex, and pregnancy on these. The results obtained show that, compared with other mammals, the erythrocyte count in the blood of elephants is low and the mean corpuscular volume (m.c.v.), mean corpuscular hemoglobin (m.c.h.), and erythrocyte sedimentation rate (e.s.r.) are high. The very high values for m.c.v. and m.c.h. and the low erythrocyte count seen in elephants suggest that in the evolution of blood though they are more advanced than reptiles and birds in having eliminated the nuclei from the erythrocytes, they are still in the primitive state compared with the other mammals in as much as their erythrocytes have not attained the efficiency in the transportation of blood gases that results from a reduction in size to facilitate numerical increase. A low erythrocyte count and packed cell volume, a high e.s.r., an increase in neutrophils, and a decrease in the percentage of lymphocytes and eosinophils characterize pregnancy. In baby elephants there is an increase in the total leucocyte and lymphocyte counts and a decrease in eosinophils.

scholarly journals The Anemia of the Di Guglielmo Syndrome

Blood ◽  
1959 ◽  
Vol 14 (4) ◽  
pp. 334-363 ◽  
Author(s):  
MARIO BALDINI ◽  
HUGH H. FUDENBERG ◽  
KATSUHIRO FUKUTAKE ◽  
WILLIAM DAMESHEK ◽  
Angela Pasquarriello
Keyword(s):  
Bone Marrow ◽  
Vitamin B12 ◽  
Cell Survival ◽  
Great Increase ◽  
Red Cells ◽  
Mean Corpuscular Hemoglobin ◽  
Red Cell ◽  
Corpuscular Hemoglobin ◽  
Red Cell Survival ◽  
The Mean

Abstract The physiopathology of the anemia of the Di Guglielmo syndrome (erythremic myelosis) was studied in 11 patients with the acute and chronic varieties of the disease. Ferrokinetic studies were performed in three additional patients. 1. The anemia was normochromic and macrocytic; in contrast to the mean corpuscular volume, which was elevated, the mean corpuscular hemoglobin was often normal. In several patients the mean corpuscular hemoglobin concentration was slightly lower than normal, suggesting slight hypochromia. 2. Reticulocytes were often increased but bore no relationship to the degree of the anemia nor to the shortening of the red cell life span. The reticulocyte count is an unreliable index of blood production in this disease. 3. The degree of erythroblastemia was highly variable. No direct correlation existed between the degree of erythroblastemia and the acuteness of the disease, nor was there any relationship between the degree of erythroblastemia and either the degree of anemia or the degree of erythrocytic destruction. 4. The bone marrow showed striking erythroblastic hyperplasia. This was usually of the megaloblastic type. Primitive erythroblasts (erythrogones) were conspicuous. The erythroblastic hyperplasia was out of proportion to the relatively minor reticulocytosis or the relatively slight diminution in red cell survival. 5. The nucleated red cells of the marrow showed variable numbers of megaloblasts and megaloblastoid forms, suggesting the presence of a vitamin B12 deficiency (pernicious anemia). However, the vitamin B12 concentration of the serum was elevated, and there was no response to the administration of vitamin B12 or folic acid. 6. Varying numbers of erythroblasts in the bone marrow and in the peripheral blood showed periodic acid-Schiff (PAS)-positive granules in the cytoplasm. No chemical abnormalities of hemoglobin could be detected either by the method of paper electrophoresis or by the alkali denaturation test. 7. Diminished red cell survival was present in most cases, but it was of a relatively slight degree. It was due to an "intracorpuscular" defect of the red cells. 8. The often great increase in fecal urobilinogen output as compared with a relatively minor rate of red cell destruction suggests "heme pigment diversion" or increased destruction of precursor red cells, as in pernicious anemia, where the same phenomenon has been observed. 9. The great increase in the number of erythroid cells in the bone marrow and the increased rate of iron turnover as compared with the relatively minor increase in red cell destruction and iron utilization point to an "ineffective" type of erythropoiesis. The high degree of "ineffective erythropoiesis" seen in this disease may be characteristic of the neoplastic proliferation of the red cell series. 10. In conclusion, the anemia of the Di Guglielmo syndrome is due to a combined disturbance: (1) an "ineffective" type of erythropoiesis of marked degree, perhaps due to an acquired (neoplastic) defect in the uptake or utilization of B12 by the erythroblasts and (2) increased hemolysis resulting from the increased destruction of defective red cells.

scholarly journals CT assessment of the increased density of cerebral vessels in plateau region

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Haiting Zhou ◽  
Tsering Tashi ◽  
Deli Zhao ◽  
Sonam Tsring ◽  
Hongwei Liang ◽  
...  
Keyword(s):  
Basal Ganglia ◽  
Superior Sagittal Sinus ◽  
Lacunar Infarction ◽  
Ct Scans ◽  
Mean Corpuscular Hemoglobin ◽  
Corpuscular Hemoglobin ◽  
Sagittal Sinus ◽  
The Mean ◽  
Brain Parenchymal ◽  
The Brain

AbstractIn this study, the relationship between the brain parenchymal density, the cerebral vessel density, the mean corpuscular hemoglobin (MCH) content, the mean corpuscular hemoglobin concentration (MCHC), and the morbidity associated with lacunar infarction of residents living in either the plains or the plateau regions were analyzed and compared for their potential clinical implications. Clinical data from the brain CT scans of individuals living in either the plain or plateau regions (129 each) were collected. Specifically, the CT values for basal ganglia, the middle cerebral artery, and the superior sagittal sinus, along with the number of patients with lacunar infarction, were collected. In addition, the MCH and MCHC values were measured in blood samples collected within 48 h following the CT scans. For statistical analysis, an independent sample t-test, Pearson's correlation test (permutation test), and Chi-squared test were employed. The inhabitants of the plateau had a significantly higher CT value of basal ganglia, the middle cerebral artery, and superior sagittal sinus and also higher levels of MCH and MCHC in the blood (ps < 0.001) than the inhabitants of the plains region. Further, there was a significant positive correlation between the three aforementioned CT values and the MCH and MCHC findings. However, no significant differences were found in the morbidity of lacunar infarction between these two regions (p > 0.05). The inhabitants in the plateau have a significantly higher brain parenchymal density, higher CT value for cerebral vessels density, and higher blood MCH and MCHC levels in comparison with individuals occupying the plains. Concurrently, the parenchymal density and the CT values are shown to be positively correlated with the MCH and MCHC content in the blood.

scholarly journals Antiplasmodial Activity of Methanolic Extract of Asparagus officinalis L. Stem on Plasmodium berghei Infected Mice

2016 ◽  
Vol 59 (2) ◽  
pp. 99-104
Author(s):  
Joseph Bamidele Minari ◽  
Adewale. Agboola Odutuga ◽  
Fisayo Abraham Bamisaye ◽  
Leye Jonathan Babatola
Keyword(s):  
Plasmodium Berghei ◽  
Methanolic Extract ◽  
Hemoglobin Concentration ◽  
Antiplasmodial Activity ◽  
Asparagus Officinalis ◽  
Mean Corpuscular Hemoglobin ◽  
Corpuscular Hemoglobin ◽  
Phytochemical Constituents ◽  
The Mean ◽  
Oral Doses

This study aims at investigating the antiplasmodial activity of methanolic extract of Asparagusofficinalis L. stem on Plasmodium berghei infected mice. To investigate this, the mice were infected withP.berghei to cause malaria. The mice were simultaneously given oral doses (20, 40 and 60 mg/kg bodyweight) of methanolic extract of A. officinalis L. stem. The phytochemical constituents of the extractrevealed the presence of alkaloids, phenolics, cardiac glycosides, flavonoids, terpenoid and steroid. Theextract administered to the infected mice significantly suppressed the parasite. The extract also significantly(P<0.05) reduced the activities of serum aspatate aminotransferase (AST), alkaline phosphate (ALP),alanine aminotransferase (ALT). White blood corpuscles (WBC), red blood corpuscles (RBC), hemoglobin(HGB), packed cell volume (PCV), platelets (PLT) and the mean corpuscular hemoglobin concentration(MCHC) showed significant (P<0.05) increase after the administration of the extract while mean corpuscularvolume (MCV) and the mean corpuscular hemoglobin (MCH) showed significant (P<0.05) reduction.Present findings suggests that the plant extract contains phytochemicals that have antiplasmodial andhepatoprotective properties.

scholarly journals Hematological and biochemical profiles of Mangalarga Marchador mares in the transition period bred on pasture

2019 ◽  
Vol 71 (6) ◽  
pp. 1765-1772
Author(s):  
M.O. Silva ◽  
J.D. Ribeiro Filho ◽  
W.M.F. Dantas ◽  
F.L. Valente ◽  
B.M. Ribeiro ◽  
...  
Keyword(s):  
Red Blood Cells ◽  
Blood Cells ◽  
Transition Period ◽  
Hemoglobin Concentration ◽  
Diameter Distribution ◽  
Mean Corpuscular Hemoglobin ◽  
Early Lactation ◽  
Corpuscular Hemoglobin ◽  
Biochemical Profiles ◽  
The Mean

ABSTRACT The present study aimed to evaluate the effects of the transition period on hematological and biochemical constituents in Mangalarga Marchador mares. Forty-eight mares were used to form a maintenance group (MG) and transition group (TG), formed by pregnant mares and, after delivery, infants. Blood samples were collected at the following times: T-60 (60 d pre-delivery), T-30 (30 d pre-delivery), T-15 (15 d pre-delivery), T0 (first 6h post-delivery), T15 (15 d post-delivery), T30 (30 d post-delivery), and T60 (60 d post-delivery). The TG had lower values (P< 0.05) of red blood cells, hematocrit and hemoglobin at T0, T15, T30 and T60 times than MG. The mean corpuscular volume was lower in MG (P< 0.05) than in TG (T0, T15, T30 and T60) and mean corpuscular hemoglobin concentration was higher (P< 0.05) in MG than in TG (T15, T30 and T60). On the other hand, the diameter distribution of red blood cells presented a lower value (P< 0.05) in MG than in TG (T15 and T30). Mares in transition period presented regenerative anemia. The results demonstrate physiological metabolic variations of different intensities during pregnancy, delivery and early lactation.

Hematological studies of barren-ground caribou

1968 ◽  
Vol 46 (5) ◽  
pp. 1031-1036 ◽  
Author(s):  
E. H. McEwan
Keyword(s):  
Blood Urea Nitrogen ◽  
Protein Intake ◽  
Mean Corpuscular Hemoglobin ◽  
Corpuscular Hemoglobin ◽  
Barren Ground ◽  
Plasma Electrolytes ◽  
The Mean ◽  
Calcium And Phosphorus ◽  
Cell Volumes ◽  
Phosphorus Levels

Erythrocyte, hemoglobin, packed-cell volumes, and total and differential leucocyte counts from wild caribou are compared with values determined for captive animals maintained on a high plane of nutrition. The mean corpuscular hemoglobin of lactating female caribou, about 30%, differed from the normal value of 34%, suggesting that some of the wild caribou may suffer from hypo-chromic anemia. Plasma electrolytes and calcium and phosphorus levels were slightly lower in wild than captive caribou. The blood urea nitrogen level was about 28% higher in captive than wild caribou, because of differences in protein intake.

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